6ZME: SARS-CoV-2 Nsp1
SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex. Determined by electron microscopy at 3.0 Å resolution. Released 12 Aug 2020.
- Method
- Electron microscopy
- Resolution
- 3.0 Å
- Organisms
- Homo sapiens, Severe acute respiratory syndrome coronavirus 2
- Chains
- 88
- Atoms
- 233,375
- Mol. weight
- 4093.88 kDa
- Ligands
- MG, ZN, SF4, ADP
- Released
- 12 Aug 2020
Explore 6ZME in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6ZME contains 555 α-helices and 616 β-strands across 83 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain CA: 10 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-37 | 23 | |
| β-strand | 44 | 1 | 43 |
| α-helix | 45-62 | 18 | |
| β-strand | 73-81 | 9 | 44 |
| β-strand | 85 | 1 | 45 |
| β-strand | 99 | 1 | 43 |
| β-strand | 105-114 | 10 | 44 |
| β-strand | 117-126 | 10 | 44 |
| α-helix | 129-130 | 2 | |
| β-strand | 131 | 1 | 46 |
| β-strand | 133 | 1 | 46 |
| α-helix | 138-156 | 19 | |
| α-helix | 163-176 | 14 | |
| β-strand | 180-181 | 2 | 44 |
| β-strand | 185-187 | 3 | 47 |
| β-strand | 201-203 | 3 | 47 |
| α-helix | 207-212 | 6 | |
| β-strand | 222-231 | 10 | 44 |
| β-strand | 238 | 1 | 45 |
| β-strand | 247-249 | 3 | 48 |
| α-helix | 260-272 | 13 | |
| β-strand | 278 | 1 | 48 |
| α-helix | 287-298 | 12 | |
| β-strand | 302-304 | 3 | 48 |
| α-helix | 306-308 | 3 | |
| β-strand | 309 | 1 | 45 |
| β-strand | 317-326 | 10 | 44 |
| β-strand | 329-331 | 3 | 44 |
| α-helix | 352-359 | 8 | |
Chain CE: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-38 | 22 | |
| α-helix | 44-80 | 37 | |
| α-helix | 169-187 | 19 | |
| α-helix | 193-205 | 13 | |
Chain CF: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 153-160 | 8 | |
| α-helix | 166-178 | 13 | |
Chain CH: 14 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-26 | 18 | |
| β-strand | 35-39 | 5 | 86 |
| α-helix | 45-60 | 16 | |
| α-helix | 66-82 | 17 | |
| α-helix | 88-89 | 2 | |
| β-strand | 93-100 | 8 | 86 |
| β-strand | 108-114 | 7 | 86 |
| β-strand | 124-127 | 4 | 86 |
| β-strand | 146-151 | 6 | 87 |
| β-strand | 155-161 | 7 | 87 |
| β-strand | 166-173 | 8 | 87 |
| α-helix | 176-179 | 4 | |
| α-helix | 184-186 | 3 | |
| α-helix | 187-212 | 26 | |
| β-strand | 214 | 1 | 88 |
| β-strand | 219 | 1 | 88 |
| β-strand | 224-228 | 5 | 87 |
| α-helix | 232-237 | 6 | |
| α-helix | 244-247 | 4 | |
| β-strand | 250-255 | 6 | 87 |
| α-helix | 261-295 | 35 | |
| β-strand | 301-303 | 3 | 89 |
| α-helix | 305-313 | 9 | |
| β-strand | 317-323 | 7 | 89 |
| β-strand | 329-334 | 6 | 90 |
| β-strand | 342-346 | 5 | 90 |
| α-helix | 348-352 | 5 | |
| β-strand | 367-373 | 7 | 90 |
| α-helix | 374-381 | 8 | |
| β-strand | 389-392 | 4 | 89 |
| α-helix | 397-405 | 9 | |
| β-strand | 409-413 | 5 | 89 |
Chain CI: 29 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-11 | 7 | 71 |
| α-helix | 25-28 | 4 | |
| α-helix | 30-34 | 5 | |
| β-strand | 39-40 | 2 | 72 |
| β-strand | 49-50 | 2 | 72 |
| α-helix | 60-64 | 5 | |
| β-strand | 70-76 | 7 | 71 |
| α-helix | 77-81 | 5 | |
| β-strand | 83-86 | 4 | 73 |
| β-strand | 93-95 | 3 | 73 |
| β-strand | 105-109 | 5 | 73 |
| α-helix | 116-124 | 9 | |
| α-helix | 140-147 | 8 | |
| α-helix | 151-161 | 11 | |
| α-helix | 164-166 | 3 | |
| β-strand | 167-169 | 3 | 73 |
| β-strand | 183 | 1 | 74 |
| α-helix | 184-190 | 7 | |
| α-helix | 197-204 | 8 | |
| β-strand | 213 | 1 | 74 |
| α-helix | 219-232 | 14 | |
| β-strand | 238-241 | 4 | 73 |
| α-helix | 249-262 | 14 | |
| β-strand | 269-272 | 4 | 73 |
| α-helix | 276-282 | 7 | |
| β-strand | 285-292 | 8 | 73 |
| β-strand | 296-303 | 8 | 73 |
| α-helix | 305-314 | 10 | |
| β-strand | 316-317 | 2 | 75 |
| β-strand | 322-323 | 2 | 75 |
| β-strand | 346-350 | 5 | 76 |
| β-strand | 354-356 | 3 | 77 |
| β-strand | 361-365 | 5 | 77 |
| β-strand | 367-370 | 4 | 76 |
| β-strand | 374-378 | 5 | 77 |
| α-helix | 385-393 | 9 | |
| α-helix | 405-406 | 2 | |
| β-strand | 409-411 | 3 | 77 |
| β-strand | 423 | 1 | 78 |
| α-helix | 424-431 | 8 | |
| α-helix | 434-437 | 4 | |
| α-helix | 439-441 | 3 | |
| α-helix | 442-446 | 5 | |
| α-helix | 447-449 | 3 | |
| α-helix | 451-454 | 4 | |
| β-strand | 458 | 1 | 78 |
| α-helix | 459-461 | 3 | |
| α-helix | 464-477 | 14 | |
| β-strand | 482-486 | 5 | 77 |
| α-helix | 494-511 | 18 | |
| β-strand | 514-518 | 5 | 77 |
| α-helix | 522-528 | 7 | |
| β-strand | 531-536 | 6 | 77 |
| β-strand | 542-549 | 8 | 77 |
| α-helix | 551-562 | 12 | |
| β-strand | 566-568 | 3 | 79 |
| α-helix | 569 | 1 | |
| β-strand | 575-577 | 3 | 79 |
| α-helix | 583-591 | 9 | |
Chain La: 8 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-11 | 5 | |
| α-helix | 42-48 | 7 | |
| β-strand | 53 | 1 | 148 |
| α-helix | 65-68 | 4 | |
| β-strand | 72-73 | 2 | 18 |
| α-helix | 75-78 | 4 | |
| α-helix | 84-92 | 9 | |
| β-strand | 97-98 | 2 | 116 |
| β-strand | 100-102 | 3 | 19 |
| α-helix | 103-106 | 4 | |
| β-strand | 110-111 | 2 | 18 |
| β-strand | 123-126 | 4 | 19 |
| β-strand | 128-129 | 2 | 18 |
| α-helix | 131-140 | 10 | |
| β-strand | 143-146 | 4 | 19 |
Chain LA: 7 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-5 | 2 | |
| α-helix | 8-12 | 5 | |
| β-strand | 18 | 1 | 22 |
| α-helix | 30-32 | 3 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 23 |
| β-strand | 58-64 | 7 | 23 |
| β-strand | 71-77 | 7 | 23 |
| β-strand | 79 | 1 | 24 |
| β-strand | 83 | 1 | 25 |
| β-strand | 86-91 | 6 | 23 |
| β-strand | 101-103 | 3 | 23 |
| β-strand | 111-113 | 3 | 26 |
| β-strand | 116-117 | 2 | 27 |
| β-strand | 124-126 | 3 | 27 |
| β-strand | 134-140 | 7 | 26 |
| β-strand | 145-150 | 6 | 26 |
| β-strand | 154-159 | 6 | 26 |
| β-strand | 163-165 | 3 | 23 |
| β-strand | 166 | 1 | 26 |
| β-strand | 169 | 1 | 24 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-192 | 11 | |
| β-strand | 193 | 1 | 22 |
| β-strand | 224-225 | 2 | 28 |
| α-helix | 229-230 | 2 | |
| β-strand | 237-238 | 2 | 28 |
Chain Lb: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-18 | 7 | |
| α-helix | 22-24 | 3 | |
| α-helix | 37-48 | 12 | |
| α-helix | 49-51 | 3 | |
| α-helix | 54-73 | 20 | |
| α-helix | 92-100 | 9 | |
| α-helix | 106-116 | 11 | |
75 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 28S ribosomal RNA | L5 | RNA | 5066 | Homo sapiens | |
| 5S ribosomal RNA | L7 | RNA | 121 | Homo sapiens | |
| 5.8S ribosomal RNA | L8 | RNA | 157 | Homo sapiens | |
| 60S ribosomal protein L8 | LA | protein | 257 | Homo sapiens | P62917 (AlphaFold model) |
| 60S ribosomal protein L3 | LB | protein | 403 | Homo sapiens | P39023 (AlphaFold model) |
| 60S ribosomal protein L4 | LC | protein | 427 | Homo sapiens | P36578 (AlphaFold model) |
| 60S ribosomal protein L5 | LD | protein | 297 | Homo sapiens | P46777 (AlphaFold model) |
| 60S ribosomal protein L6 | LE | protein | 288 | Homo sapiens | Q02878 |
| 60S ribosomal protein L7 | LF | protein | 248 | Homo sapiens | P18124 |
| 60S ribosomal protein L7a | LG | protein | 266 | Homo sapiens | P62424 |
| 60S ribosomal protein L9 | LH | protein | 192 | Homo sapiens | P32969 |
| 60S ribosomal protein L10-like | LI | protein | 214 | Homo sapiens | Q96L21 |
76 more molecules are not listed.
Sequence of entity 1 (L5), FASTA
>6ZME_1 28S ribosomal RNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGGGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGCCGG
GUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAGCCG
ACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAA
GGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGA
AGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCA
AAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCCC
UACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAA
GAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGAA
UAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGUCCG
CCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCCGGU
GAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGCGCG
CCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUA
CACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCC
GUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGA
AAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGU
UACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUC
CUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCA
CCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCU
ACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAG
ACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUU
AUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGCGG
AGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCCCCC
CCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCGGGGU
CCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCUGGAAAGGCGGCCGCCCCC
UCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGACGACC
UGCUUCUGGGUCGGGGUUUC
Sequence of entity 2 (L7), FASTA
>6ZME_2 5S ribosomal RNA (chains L7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
U
Sequence of entity 3 (L8), FASTA
>6ZME_3 5.8S ribosomal RNA (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU
Sequence of entity 4 (LA), FASTA
>6ZME_4 60S ribosomal protein L8 (chains LA)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN
Sequence of entity 5 (LB), FASTA
>6ZME_5 60S ribosomal protein L3 (chains LB)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 6 (LC), FASTA
>6ZME_6 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTT
EEKKPAA
Sequence of entity 7 (LD), FASTA
>6ZME_7 60S ribosomal protein L5 (chains LD)
MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY
KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Sequence of entity 8 (LE), FASTA
>6ZME_8 60S ribosomal protein L6 (chains LE)
MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRS
AMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTED
VPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLV
LNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKY
EITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF
Sequence of entity 9 (LF), FASTA
>6ZME_9 60S ribosomal protein L7 (chains LF)
MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKE
YRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNG
TFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLG
KYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQI
NRLIRRMN
Sequence of entity 10 (LG), FASTA
>6ZME_10 60S ribosomal protein L7a (chains LG)
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRY
IRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEK
KAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVP
YCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGN
VLGPKSVARIAKLEKAKAKELATKLG
Sequence of entity 11 (LH), FASTA
>6ZME_11 60S ribosomal protein L9 (chains LH)
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE
Sequence of entity 12 (LI), FASTA
>6ZME_12 60S ribosomal protein L10-like (chains LI)
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQL
SSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 256 |
| ZN | Zinc ion | Zn | 8 |
| SF4 | Iron/sulfur cluster | Fe4 S4 | 2 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
Primary citation
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Thoms, M., Buschauer, R., Ameismeier, M. et al. Science (2020) 369:1249-1255. DOI 10.1126/science.abc8665 · PubMed
Other PDB entries of the same protein (UniProt P62917 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8A3D 1.67 Å, Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
- 29IW 1.77 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. Cells treated with NT-2.
- 8QYX 1.78 Å, Human 60S ribosomal subunit
- 8QOI 1.9 Å, Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical…
- 9O3W 1.9 Å, Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9C3H 2.0 Å, Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
- 29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
- 9TV2 2.1 Å, 80S ribosomes from primary B-cells infected with delta v-snoRNA1 EBV
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
- 29IX 2.2 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. NT-2 added to purified…
Browse structure collections
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