6ZMW: Human 48S translational initiation complex
Structure of a human 48S translational initiation complex. Determined by electron microscopy at 3.7 Å resolution. Released 23 Sept 2020.
- Method
- Electron microscopy
- Resolution
- 3.7 Å
- Organism
- Homo sapiens
- Chains
- 57
- Atoms
- 118,155
- Mol. weight
- 2403.16 kDa
- Ligands
- MG, ZN
- Released
- 23 Sept 2020
Explore 6ZMW in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6ZMW contains 472 α-helices and 462 β-strands across 54 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 14 helices, 47 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 187-190 | 4 | 19 |
| α-helix | 199-210 | 12 | |
| α-helix | 212-214 | 3 | |
| β-strand | 217-219 | 3 | 20 |
| β-strand | 225 | 1 | 21 |
| β-strand | 228 | 1 | 21 |
| α-helix | 229-230 | 2 | |
| β-strand | 232-235 | 4 | 19 |
| β-strand | 236-237 | 2 | 20 |
| α-helix | 243-249 | 7 | |
| β-strand | 264 | 1 | 19 |
| α-helix | 287-291 | 5 | |
| α-helix | 295-298 | 4 | |
| β-strand | 309-310 | 2 | 22 |
| β-strand | 315-319 | 5 | 22 |
| β-strand | 328-333 | 6 | 22 |
| β-strand | 338-342 | 5 | 23 |
| β-strand | 348-353 | 6 | 23 |
| β-strand | 356-361 | 6 | 23 |
| β-strand | 366-372 | 7 | 23 |
| β-strand | 378-381 | 4 | 24 |
| β-strand | 387-396 | 10 | 24 |
| β-strand | 402-408 | 7 | 24 |
| β-strand | 414-417 | 4 | 24 |
| β-strand | 430-431 | 2 | 25 |
| β-strand | 438-442 | 5 | 25 |
| β-strand | 445-450 | 6 | 25 |
| β-strand | 455-456 | 2 | 25 |
| α-helix | 460-463 | 4 | |
| β-strand | 465 | 1 | 25 |
| β-strand | 469-472 | 4 | 26 |
| β-strand | 479-483 | 5 | 26 |
| α-helix | 484-486 | 3 | |
| β-strand | 491-496 | 6 | 26 |
| β-strand | 503 | 1 | 26 |
| β-strand | 507-509 | 3 | 26 |
| β-strand | 515-519 | 5 | 27 |
| β-strand | 525-531 | 7 | 27 |
| β-strand | 542-548 | 7 | 27 |
| β-strand | 556-560 | 5 | 27 |
| β-strand | 565-570 | 6 | 28 |
| α-helix | 571 | 1 | |
| β-strand | 576-581 | 6 | 28 |
| α-helix | 584-586 | 3 | |
| β-strand | 587-594 | 8 | 28 |
| β-strand | 600-609 | 10 | 28 |
| β-strand | 613 | 1 | 29 |
| β-strand | 616 | 1 | 30 |
| β-strand | 623 | 1 | 30 |
| β-strand | 626 | 1 | 29 |
| β-strand | 638 | 1 | 30 |
| β-strand | 639 | 1 | 31 |
| β-strand | 644 | 1 | 31 |
| β-strand | 656-659 | 4 | 32 |
| β-strand | 666-669 | 4 | 32 |
| β-strand | 680-683 | 4 | 32 |
| β-strand | 692-695 | 4 | 32 |
| α-helix | 704-706 | 3 | |
| α-helix | 714-717 | 4 | |
| α-helix | 737-744 | 8 | |
| α-helix | 749-763 | 15 | |
Chain 2: 3 helices, 36 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-6 | 3 | 1 |
| β-strand | 13-18 | 6 | 2 |
| β-strand | 25-29 | 5 | 2 |
| β-strand | 34-37 | 4 | 3 |
| β-strand | 44-48 | 5 | 3 |
| β-strand | 57-60 | 4 | 4 |
| β-strand | 67-71 | 5 | 4 |
| β-strand | 75-77 | 3 | 4 |
| β-strand | 90-91 | 2 | 4 |
| β-strand | 99 | 1 | 5 |
| β-strand | 101 | 1 | 6 |
| β-strand | 107-111 | 5 | 6 |
| β-strand | 122-126 | 5 | 6 |
| β-strand | 128 | 1 | 7 |
| α-helix | 129-131 | 3 | |
| β-strand | 133 | 1 | 7 |
| β-strand | 140-142 | 3 | 6 |
| β-strand | 153-154 | 2 | 8 |
| α-helix | 156-158 | 3 | |
| β-strand | 161-162 | 2 | 8 |
| β-strand | 163-164 | 2 | 9 |
| β-strand | 170-171 | 2 | 9 |
| β-strand | 173-174 | 2 | 10 |
| β-strand | 179-180 | 2 | 10 |
| β-strand | 195 | 1 | 5 |
| β-strand | 204-206 | 3 | 11 |
| β-strand | 207 | 1 | 12 |
| β-strand | 211-215 | 5 | 11 |
| β-strand | 222-227 | 6 | 11 |
| β-strand | 232 | 1 | 12 |
| β-strand | 237 | 1 | 12 |
| α-helix | 238 | 1 | |
| β-strand | 243-248 | 6 | 12 |
| β-strand | 265-271 | 7 | 12 |
| β-strand | 277-284 | 8 | 12 |
| β-strand | 293 | 1 | 13 |
| β-strand | 300 | 1 | 13 |
| β-strand | 301-303 | 3 | 1 |
| β-strand | 309-311 | 3 | 1 |
Chain 3: 17 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-15 | 13 | |
| α-helix | 19-21 | 3 | |
| α-helix | 23-25 | 3 | |
| α-helix | 26-38 | 13 | |
| α-helix | 44-56 | 13 | |
| α-helix | 58-60 | 3 | |
| α-helix | 63-74 | 12 | |
| α-helix | 81-87 | 7 | |
| α-helix | 91-94 | 4 | |
| α-helix | 97-110 | 14 | |
| α-helix | 114-120 | 7 | |
| α-helix | 126-129 | 4 | |
| α-helix | 138-149 | 12 | |
| β-strand | 152-153 | 2 | 125 |
| α-helix | 155-161 | 7 | |
| α-helix | 167-177 | 11 | |
| β-strand | 180 | 1 | 125 |
| β-strand | 187-188 | 2 | 125 |
| α-helix | 192-195 | 4 | |
| α-helix | 207-215 | 9 | |
Chain 4: 8 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 93 | 1 | 42 |
| α-helix | 96-108 | 13 | |
| β-strand | 118-122 | 5 | 43 |
| β-strand | 130 | 1 | 42 |
| β-strand | 133-135 | 3 | 43 |
| α-helix | 150-163 | 14 | |
| β-strand | 168-173 | 6 | 43 |
| α-helix | 181-190 | 10 | |
| β-strand | 198-202 | 5 | 44 |
| β-strand | 213-217 | 5 | 44 |
| α-helix | 245-255 | 11 | |
| α-helix | 266-289 | 24 | |
| α-helix | 301-303 | 3 | |
| α-helix | 306-314 | 9 | |
| α-helix | 320-352 | 33 | |
Chain 5: 18 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 184-206 | 23 | |
| α-helix | 209-217 | 9 | |
| α-helix | 223-246 | 24 | |
| α-helix | 253-255 | 3 | |
| α-helix | 256-262 | 7 | |
| α-helix | 263-267 | 5 | |
| α-helix | 275-289 | 15 | |
| α-helix | 298-302 | 5 | |
| α-helix | 312-325 | 14 | |
| α-helix | 329-334 | 6 | |
| α-helix | 336-341 | 6 | |
| α-helix | 358-374 | 17 | |
| α-helix | 388-400 | 13 | |
| α-helix | 406-416 | 11 | |
| α-helix | 439-461 | 23 | |
| α-helix | 472-480 | 9 | |
| α-helix | 491-496 | 6 | |
| β-strand | 504-505 | 2 | 126 |
| β-strand | 514-515 | 2 | 126 |
| α-helix | 527-548 | 22 | |
Chain 6: 17 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-24 | 7 | |
| α-helix | 30-32 | 3 | |
| α-helix | 64-67 | 4 | |
| α-helix | 88-90 | 3 | |
| α-helix | 99-105 | 7 | |
| α-helix | 106-108 | 3 | |
| α-helix | 117-127 | 11 | |
| α-helix | 155-167 | 13 | |
| α-helix | 175-191 | 17 | |
| α-helix | 199-211 | 13 | |
| α-helix | 263-266 | 4 | |
| α-helix | 269-277 | 9 | |
| α-helix | 281-284 | 4 | |
| α-helix | 297-300 | 4 | |
| α-helix | 308-317 | 10 | |
| β-strand | 322 | 1 | 34 |
| β-strand | 332 | 1 | 34 |
| α-helix | 342-345 | 4 | |
| α-helix | 348-354 | 7 | |
Chain 8: 14 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 33-35 | 3 | |
| β-strand | 38-39 | 2 | 70 |
| α-helix | 43-50 | 8 | |
| β-strand | 65-68 | 4 | 71 |
| β-strand | 71 | 1 | 70 |
| β-strand | 75-76 | 2 | 70 |
| β-strand | 80 | 1 | 71 |
| α-helix | 98-104 | 7 | |
| β-strand | 116-122 | 7 | 71 |
| α-helix | 131-143 | 13 | |
| β-strand | 148-152 | 5 | 71 |
| β-strand | 165-166 | 2 | 71 |
| β-strand | 168-169 | 2 | 72 |
| α-helix | 171-175 | 5 | |
| β-strand | 198-199 | 2 | 72 |
| α-helix | 212-223 | 12 | |
| α-helix | 229-234 | 6 | |
| α-helix | 235-240 | 6 | |
| α-helix | 248-272 | 25 | |
| α-helix | 273-278 | 6 | |
| α-helix | 281 | 1 | |
| α-helix | 282-287 | 6 | |
| α-helix | 306-308 | 3 | |
| α-helix | 316-350 | 35 | |
Chain 9: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-23 | 21 | |
46 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Eukaryotic translation initiation factor 3 subunit I | 2 | protein | 325 | Homo sapiens | Q13347 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit B | 1 | protein | 814 | Homo sapiens | P55884 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit M | 6 | protein | 374 | Homo sapiens | Q7L2H7 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit F | 4 | protein | 357 | Homo sapiens | O00303 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit A | u | protein | 1382 | Homo sapiens | Q14152 |
| Eukaryotic translation initiation factor 3 subunit E | v | protein | 445 | Homo sapiens | P60228 |
| 40S ribosomal protein S6 | S | protein | 249 | Homo sapiens | P62753 |
| Eukaryotic translation initiation factor 3 subunit C | y | protein | 913 | Homo sapiens | Q99613 |
| Eukaryotic translation initiation factor 3 subunit H | 8 | protein | 352 | Homo sapiens | O15372 |
| 40S ribosomal protein S7 | G | protein | 194 | Homo sapiens | P62081 |
| 40S ribosomal protein S27 | H | protein | 84 | Homo sapiens | P42677 |
| 40S ribosomal protein S21 | K | protein | 83 | Homo sapiens | P63220 |
45 more molecules are not listed.
Sequence of entity 1 (2), FASTA
>6ZMW_1 Eukaryotic translation initiation factor 3 subunit I (chains 2)
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
SSGGEDGYVRIHYFDPQYFEFEFEA
Sequence of entity 2 (1), FASTA
>6ZMW_2 Eukaryotic translation initiation factor 3 subunit B (chains 1)
MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEA
GPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSR
AQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEA
DGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKTKGYIFLEYASP
AHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEA
ECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALW
GGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHC
ESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA
FWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGV
VTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKI
ELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWD
PTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQI
KKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRG
GVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE
Sequence of entity 3 (6), FASTA
>6ZMW_3 Eukaryotic translation initiation factor 3 subunit M (chains 6)
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV
ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR
YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA
ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL
LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE
LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN
LNKVKNSLLSLSDT
Sequence of entity 4 (4), FASTA
>6ZMW_4 Eukaryotic translation initiation factor 3 subunit F (chains 4)
MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPG
QTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTL
LGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDIT
EHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYA
YYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
Sequence of entity 5 (u), FASTA
>6ZMW_5 Eukaryotic translation initiation factor 3 subunit A (chains u)
MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVD
LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTEAAKEESQQMVLDIEDLDN
IQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQ
AFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSA
ISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLY
HLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLG
LQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEK
EPELQQYVPQLQNNTILRLLQQVSQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDL
QVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPA
HILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAE
LQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIED
LEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIK
DMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFE
ERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEE
LREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWR
KGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRR
GMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRR
GLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPR
RGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPW
RNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEE
REWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWR
DSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDR
VEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTV
RR
Sequence of entity 6 (v), FASTA
>6ZMW_6 Eukaryotic translation initiation factor 3 subunit E (chains v)
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKN
LYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADK
HGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQ
NWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQP
QYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLY
VNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKL
NMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAM
NIEKKLNQNSRSEAPNWATQDSGFY
Sequence of entity 7 (S), FASTA
>6ZMW_7 40S ribosomal protein S6 (chains S)
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQG
FPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKD
IPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLV
TPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
TSKSESSQK
Sequence of entity 8 (y), FASTA
>6ZMW_8 Eukaryotic translation initiation factor 3 subunit C (chains y)
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEEL
TNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNEL
WEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDS
DSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGE
WERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQI
AAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANPNIFV
GENILEESENLHNADQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVC
AIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENE
GEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQH
ADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQ
EQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRV
GERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLV
RKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQ
TVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMR
RGGYRQQQSQTAY
Sequence of entity 9 (8), FASTA
>6ZMW_9 Eukaryotic translation initiation factor 3 subunit H (chains 8)
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGT
EVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWY
QSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEK
DFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLG
KNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEED
LSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
Sequence of entity 10 (G), FASTA
>6ZMW_10 40S ribosomal protein S7 (chains G)
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAI
IIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSR
TLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKL
TGKDVNFEFPEFQL
Sequence of entity 11 (H), FASTA
>6ZMW_11 40S ribosomal protein S27 (chains H)
MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCS
TVLCQPTGGKARLTEGCSFRRKQH
Sequence of entity 12 (K), FASTA
>6ZMW_12 40S ribosomal protein S21 (chains K)
MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIR
RMGESDDSILRLAKADGIVSKNF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 89 |
| ZN | Zinc ion | Zn | 2 |
Primary citation
Structure of a human 48Stranslational initiation complex. Brito Querido, J., Sokabe, M., Kraatz, S. et al. Science (2020) 369:1220-1227. DOI 10.1126/science.aba4904 · PubMed
Other PDB entries of the same protein (UniProt Q13347 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6ZP4 2.9 Å, SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
- 8PJ5 2.9 Å, Structure of human 48S translation initiation complex after eIF2 release prior 60S…
- 8PJ6 2.9 Å, Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and…
- 6ZON 3.0 Å, SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1
- 8PJ4 3.2 Å, Structure of human 48S translation initiation complex after eIF5 release (48S-4)
- 8PJ1 3.4 Å, Structure of human 48S translation initiation complex in open codon scanning state (48S-1)
- 8PJ2 3.4 Å, Structure of human 48S translation initiation complex in AUG recognition state after…
- 7A09 3.5 Å, Structure of a human ABCE1-bound 43S pre-initiation complex - State III
- 8OZ0 3.5 Å, Structure of a human 48S translation initiation complex with eIF4F and eIF4A
- 8XXN 3.6 Å, Cryo-EM structure of the human 43S ribosome with PDCD4
- 8PJ3 3.7 Å, Structure of human 48S translation initiation complex upon transfer of initiator tRNA to…
- 6ZVJ 3.8 Å, Structure of a human ABCE1-bound 43S pre-initiation complex - State II
Browse structure collections
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