7ABF: Human pre-Bact-1 spliceosome core structure
Human pre-Bact-1 spliceosome core structure. Determined by electron microscopy at 3.9 Å resolution. Released 9 Dec 2020.
- Method
- Electron microscopy
- Resolution
- 3.9 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 15
- Atoms
- 25,904
- Mol. weight
- 1005.87 kDa
- Ligands
- MG, GTP, IHP
- Released
- 9 Dec 2020
Explore 7ABF in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7ABF contains 145 α-helices and 118 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 62 helices, 43 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 65-70 | 6 | |
| α-helix | 86-94 | 9 | |
| α-helix | 99-102 | 4 | |
| α-helix | 109-111 | 3 | |
| β-strand | 117 | 1 | 3 |
| β-strand | 118-120 | 3 | 4 |
| β-strand | 127-129 | 3 | 4 |
| α-helix | 137-157 | 21 | |
| α-helix | 232-242 | 11 | |
| α-helix | 260-269 | 10 | |
| α-helix | 310-315 | 6 | |
| α-helix | 317-320 | 4 | |
| α-helix | 370-371 | 2 | |
| α-helix | 375-378 | 4 | |
| α-helix | 399-405 | 7 | |
| α-helix | 441-459 | 19 | |
| β-strand | 483 | 1 | 4 |
| β-strand | 486 | 1 | 3 |
| α-helix | 489-510 | 22 | |
| β-strand | 516-517 | 2 | 5 |
| β-strand | 525-526 | 2 | 5 |
| α-helix | 544-565 | 22 | |
| α-helix | 573-586 | 14 | |
| α-helix | 598-616 | 19 | |
| α-helix | 633-660 | 28 | |
| α-helix | 678-695 | 18 | |
| α-helix | 708-721 | 14 | |
| α-helix | 733-762 | 30 | |
| α-helix | 770-796 | 27 | |
| α-helix | 803-820 | 18 | |
| β-strand | 825 | 1 | 6 |
| α-helix | 835-850 | 16 | |
| α-helix | 860-872 | 13 | |
| α-helix | 874-887 | 14 | |
| α-helix | 893-894 | 2 | |
| β-strand | 895 | 1 | 7 |
| β-strand | 896-898 | 3 | 8 |
| β-strand | 907-909 | 3 | 8 |
| α-helix | 913-933 | 21 | |
| β-strand | 940 | 1 | 9 |
| α-helix | 947-948 | 2 | |
| α-helix | 949-954 | 6 | |
| α-helix | 955-960 | 6 | |
| β-strand | 973-980 | 8 | 9 |
| α-helix | 990-1000 | 11 | |
| β-strand | 1001 | 1 | 6 |
| α-helix | 1003-1013 | 11 | |
| β-strand | 1018 | 1 | 7 |
| α-helix | 1037-1052 | 16 | |
| α-helix | 1056-1062 | 7 | |
| α-helix | 1077-1081 | 5 | |
| β-strand | 1085-1090 | 6 | 9 |
| β-strand | 1094-1101 | 8 | 9 |
| α-helix | 1103-1116 | 14 | |
| α-helix | 1144-1160 | 17 | |
| β-strand | 1174-1178 | 5 | 9 |
| β-strand | 1186-1188 | 3 | 10 |
| β-strand | 1193-1195 | 3 | 10 |
| β-strand | 1198 | 1 | 11 |
| β-strand | 1215-1217 | 3 | 12 |
| β-strand | 1224-1227 | 4 | 12 |
| β-strand | 1229-1231 | 3 | 10 |
| α-helix | 1234-1248 | 15 | |
| α-helix | 1256-1270 | 15 | |
| α-helix | 1276-1280 | 5 | |
| α-helix | 1282-1299 | 18 | |
| α-helix | 1314-1317 | 4 | |
| β-strand | 1334-1335 | 2 | 13 |
| α-helix | 1336 | 1 | |
| α-helix | 1337-1339 | 3 | |
| β-strand | 1341-1342 | 2 | 14 |
| β-strand | 1345 | 1 | 15 |
| β-strand | 1350 | 1 | 15 |
| β-strand | 1353-1354 | 2 | 14 |
| β-strand | 1362-1363 | 2 | 13 |
| α-helix | 1368-1371 | 4 | |
| α-helix | 1375-1399 | 25 | |
| α-helix | 1405-1408 | 4 | |
| α-helix | 1419-1422 | 4 | |
| α-helix | 1427-1431 | 5 | |
| α-helix | 1437-1442 | 6 | |
| α-helix | 1468-1477 | 10 | |
| α-helix | 1480-1484 | 5 | |
| α-helix | 1529-1537 | 9 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1553-1554 | 2 | 16 |
| β-strand | 1561-1562 | 2 | 16 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1599 | 19 | |
| β-strand | 1606-1611 | 6 | 17 |
| β-strand | 1629-1633 | 5 | 17 |
| β-strand | 1638 | 1 | 18 |
| β-strand | 1640-1644 | 5 | 17 |
| β-strand | 1656 | 1 | 18 |
| β-strand | 1659-1662 | 4 | 17 |
| β-strand | 1665-1667 | 3 | 19 |
| α-helix | 1671-1673 | 3 | |
| α-helix | 1676-1689 | 14 | |
| β-strand | 1700-1701 | 2 | 17 |
| β-strand | 1704-1706 | 3 | 19 |
| β-strand | 1711-1713 | 3 | 19 |
| β-strand | 1715-1718 | 4 | 17 |
| α-helix | 1719 | 1 | |
| α-helix | 1723-1734 | 12 | |
| α-helix | 1738-1751 | 14 | |
Chain A4: 15 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 700-720 | 21 | |
| α-helix | 857-887 | 31 | |
| α-helix | 888-892 | 5 | |
| α-helix | 897-909 | 13 | |
| α-helix | 918-925 | 8 | |
| α-helix | 931-934 | 4 | |
| α-helix | 939-966 | 28 | |
| α-helix | 977-980 | 4 | |
| α-helix | 983-986 | 4 | |
| α-helix | 988-991 | 4 | |
| α-helix | 997-1024 | 28 | |
| α-helix | 1032-1039 | 8 | |
| α-helix | 1042-1050 | 9 | |
| α-helix | 1055-1059 | 5 | |
| α-helix | 1064-1079 | 16 | |
Chain G: 1 helix, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 191-193 | 3 | |
| β-strand | 194-199 | 6 | 34 |
| β-strand | 210-212 | 3 | 35 |
| β-strand | 219-221 | 3 | 35 |
| β-strand | 228-231 | 4 | 35 |
| β-strand | 240-242 | 3 | 35 |
| β-strand | 251-254 | 4 | 36 |
| β-strand | 261-264 | 4 | 36 |
| β-strand | 291-296 | 6 | 37 |
| β-strand | 303-307 | 5 | 37 |
| β-strand | 312-313 | 2 | 37 |
| β-strand | 336-337 | 2 | 38 |
| β-strand | 346-347 | 2 | 38 |
| β-strand | 354-355 | 2 | 39 |
| β-strand | 367-368 | 2 | 39 |
| β-strand | 388 | 1 | 40 |
| β-strand | 397 | 1 | 40 |
| β-strand | 416-419 | 4 | 41 |
| β-strand | 429-431 | 3 | 41 |
| β-strand | 439 | 1 | 42 |
| β-strand | 446 | 1 | 42 |
| β-strand | 467-470 | 4 | 34 |
| β-strand | 476-480 | 5 | 34 |
| β-strand | 487-491 | 5 | 34 |
Chain I: 11 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 23-30 | 8 | |
| α-helix | 46-52 | 7 | |
| β-strand | 60-61 | 2 | 1 |
| β-strand | 66-67 | 2 | 1 |
| α-helix | 69-80 | 12 | |
| α-helix | 84-91 | 8 | |
| α-helix | 98-109 | 12 | |
| α-helix | 113-120 | 8 | |
| α-helix | 121-123 | 3 | |
| β-strand | 129-133 | 5 | 2 |
| β-strand | 139-143 | 5 | 2 |
| α-helix | 144-152 | 9 | |
| α-helix | 161-162 | 2 | |
| α-helix | 165-167 | 3 | |
| α-helix | 168-174 | 7 | |
Chain K: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 272-313 | 42 | |
Chain N: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 80-81 | 2 | 32 |
| β-strand | 88-89 | 2 | 32 |
| α-helix | 93-99 | 7 | |
| α-helix | 103-108 | 6 | |
| α-helix | 118-128 | 11 | |
| α-helix | 129-133 | 5 | |
Chain q: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-7 | 4 | 33 |
| β-strand | 14-16 | 3 | 33 |
| α-helix | 25-35 | 11 | |
| β-strand | 42-45 | 4 | 33 |
| α-helix | 57-60 | 4 | |
| β-strand | 68-72 | 5 | 33 |
Chain Q: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-15 | 3 | |
| α-helix | 19-33 | 15 | |
| α-helix | 44-46 | 3 | |
| α-helix | 47-61 | 15 | |
| α-helix | 62-66 | 5 | |
| α-helix | 74-80 | 7 | |
| α-helix | 86-93 | 8 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Protein BUD31 homolog | Q | protein | 144 | Homo sapiens | P41223 (AlphaFold model) |
| Pre-mRNA-splicing factor 38A | I | protein | 312 | Homo sapiens | Q8NAV1 (AlphaFold model) |
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| 116 kDa U5 small nuclear ribonucleoprotein component | r | protein | 972 | Homo sapiens | Q15029 (AlphaFold model) |
| Zinc finger matrin-type protein 2 | N | protein | 199 | Homo sapiens | Q96NC0 |
| Ubiquitin-like protein 5 | q | protein | 73 | Homo sapiens | Q9BZL1 |
| Spliceosome-associated protein CWC15 homolog | R | protein | 229 | Homo sapiens | Q9P013 |
| U5 small nuclear RNA | 5 | RNA | 116 | Homo sapiens | |
| U6 small nuclear RNA | 6 | RNA | 106 | Homo sapiens | |
| WW domain-binding protein 11 | X | protein | 641 | Homo sapiens | Q9Y2W2 |
| SNW domain-containing protein 1 | v | protein | 536 | Homo sapiens | Q13573 |
| Pleiotropic regulator 1 | G | protein | 514 | Homo sapiens | O43660 |
3 more molecules are not listed.
Sequence of entity 1 (Q), FASTA
>7ABF_1 Protein BUD31 homolog (chains Q)
MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYI
FDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICR
VPKSKLEVGRIIECTHCGCRGCSG
Sequence of entity 2 (I), FASTA
>7ABF_2 Pre-mRNA-splicing factor 38A (chains I)
MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGV
YGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYL
EPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPR
VSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPR
RRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERS
KKSHKKSRRGNE
Sequence of entity 3 (A), FASTA
>7ABF_3 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 4 (r), FASTA
>7ABF_4 116 kDa U5 small nuclear ribonucleoprotein component (chains r)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 5 (N), FASTA
>7ABF_5 Zinc finger matrin-type protein 2 (chains N)
MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLES
KLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLD
QVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEED
DEMAAVMGFSGFGSTKKSY
Sequence of entity 6 (q), FASTA
>7ABF_6 Ubiquitin-like protein 5 (chains q)
MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDY
EIHDGMNLELYYQ
Sequence of entity 7 (R), FASTA
>7ABF_7 Spliceosome-associated protein CWC15 homolog (chains R)
MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFR
RELEERERAAAREKNRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEEDEDFEEE
SDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPSQPQA
NFKVKRRWDDDVVFKNCAKGVDDQKKDKRFVNDTLRSEFHKKFMEKYIK
Sequence of entity 8 (5), FASTA
>7ABF_8 U5 small nuclear RNA (chains 5)
AUACUCUGGUUUCUCUUCAGAUCGCAUAAAUCUUUCGCCUUUUACUAAAGAUUUCCGUGG
AGAGGAACAACUCUGAGUCUUAACCCAAUUUUUUGAGCCUUGCCUUGGCAAGGCUA
Sequence of entity 9 (6), FASTA
>7ABF_9 U6 small nuclear RNA (chains 6)
GUGCUCGCUUCGGCAGCACAUAUACUAAAAUUGGAACGAUACAGAGAAGAUUAGCAUGGC
CCCUGCGCAAGGAUGACACGCAAAUUCGUGAAGCGUUCCAUAUUUU
Sequence of entity 10 (X), FASTA
>7ABF_10 WW domain-binding protein 11 (chains X)
MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKL
DEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQ
LSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAV
SILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRKVGFALDLPPRRRDEDMLYSPEL
AQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDTDKSDGESDGDEFVHRDNGERDNNE
EKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEDDDEDD
SDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPP
LRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPP
GPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNL
IQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFVPTALRVRRENKGATAAPQRKS
EDDSAVPLAKAAPKSGPSVPVSVQTKDDVYEAFMKEMEGLL
Sequence of entity 11 (v), FASTA
>7ABF_11 SNW domain-containing protein 1 (chains v)
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Sequence of entity 12 (G), FASTA
>7ABF_12 Pleiotropic regulator 1 (chains G)
MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPT
SKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE
SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK
KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL
SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI
DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV
AGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLT
VNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA
EADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
Primary citation
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Townsend, C., Leelaram, M.N., Agafonov, D.E. et al. Science (2020) 370. DOI 10.1126/science.abc3753 · PubMed
Other PDB entries of the same protein (UniProt P41223 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9S2E 2.4 Å, Human intron-lariat spliceosome-Aquarius (ILSaqr)
- 4OED 2.79 Å, Crystal structure of AR-LBD bound with co-regulator peptide
- 8C6J 2.8 Å, Human spliceosomal PM5 C* complex
- 6ID1 2.86 Å, Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex)…
- 6ID0 2.9 Å, Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1…
- 4OKB 2.95 Å, Crystal structure of W741L-AR-LBD bound with co-regulator peptide
- 6ICZ 3.0 Å, Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom
- 8I0R 3.0 Å, The cryo-EM structure of human Bact-I complex
- 8I0T 3.0 Å, The cryo-EM structure of human Bact-III complex
- 8I0V 3.0 Å, The cryo-EM structure of human post-Bact complex
- 7QTT 3.1 Å, Structural organization of a late activated human spliceosome (Baqr, core region)
- 8Q7N 3.1 Å, cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)
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