Pre-mRNA-splicing factor 38A (PRPF38A) is a 312-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8NAV1.
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The mean pLDDT of this model is 71.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 31% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing as a component of the spliceosome
Component of the spliceosome B complex (PubMed:26673105, PubMed:28781166). Interacts (via N-terminal interaction domain) with ZMAT2 and MFAP1 (Probable) (PubMed:27773687)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4RZ9 | X-ray | 1.28 Å | A=1-179 |
| 4RZA | X-ray | 1.9 Å | A=1-205 |
| 5F5S | X-ray | 2.4 Å | A=1-179 |
| 8H6K | EM | 2.7 Å | 4L=1-312 |
| 8Q7N | EM | 3.1 Å | I=1-312 |
| 8QPE | EM | 3.1 Å | I=1-312 |
| 6AHD | EM | 3.8 Å | Z=1-312 |
| 7ABF | EM | 3.9 Å | I=1-312 |
| 8QZS | EM | 4.1 Å | I=1-312 |
| 7AAV | EM | 4.2 Å | I=1-312 |
| 5O9Z | EM | 4.5 Å | I=1-312 |
| 8QO9 | EM | 5.29 Å | I=1-312 |
| 7ABG | EM | 7.8 Å | I=1-312 |
| 7ABI | EM | 8.0 Å | I=1-312 |
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