TRPC4 in complex with inhibitor GFB-9289. Determined by electron microscopy at 3.15 Å resolution. Released 9 Dec 2020.
Explore 7B16 in 3D Show helices and sheets RCSB PDB PDBe
7B16 contains 148 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 31-42 | 12 | |
| α-helix | 45-58 | 14 | |
| α-helix | 73-79 | 7 | |
| α-helix | 83-91 | 9 | |
| α-helix | 99-106 | 8 | |
| α-helix | 109-116 | 8 | |
| α-helix | 145-151 | 7 | |
| α-helix | 155-164 | 10 | |
| α-helix | 168-173 | 6 | |
| α-helix | 189-203 | 15 | |
| α-helix | 206-211 | 6 | |
| α-helix | 216-233 | 18 | |
| α-helix | 235-237 | 3 | |
| α-helix | 238-256 | 19 | |
| α-helix | 262-269 | 8 | |
| α-helix | 287-294 | 8 | |
| α-helix | 298-301 | 4 | |
| α-helix | 306-315 | 10 | |
| α-helix | 326-338 | 13 | |
| α-helix | 340-347 | 8 | |
| α-helix | 356-358 | 3 | |
| α-helix | 362-383 | 22 | |
| α-helix | 403-424 | 22 | |
| α-helix | 433-457 | 25 | |
| α-helix | 473-490 | 18 | |
| α-helix | 491-497 | 7 | |
| α-helix | 502-511 | 10 | |
| α-helix | 514-538 | 25 | |
| β-strand | 551 | 1 | 1 |
| β-strand | 558 | 1 | 1 |
| α-helix | 564-572 | 9 | |
| α-helix | 581-583 | 3 | |
| α-helix | 593-606 | 14 | |
| α-helix | 607-611 | 5 | |
| α-helix | 612-627 | 16 | |
| α-helix | 632-644 | 13 | |
| α-helix | 655-657 | 3 | |
| α-helix | 699-719 | 21 | |
| α-helix | 732-752 | 21 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily c member 4a | A, B, C, D | protein | 915 | Danio rerio | U3N7D8 (AlphaFold model) |
>7B16_1 Transient receptor potential cation channel subfamily c member 4a (chains A, B, C, D) GSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFK ININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK PSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVE CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAE YEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARLKLAIKYRQKEF VAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIR KPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQ MWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAV FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY YENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATM FGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNII PSPKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAM IRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKSTRANKSDTSASDVSHPEGSLQ YSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSAVVLTEPILKDKARSDFPKDF TDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLAGKVEQDVNESKCLMEEDERV LEEQEMEHIASSHEH
| ID | Name | Formula | Copies |
|---|---|---|---|
| SKQ | 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{H}-pyridazin-6-o… | C14 H19 Cl N4 O2 | 4 |
| CA | Calcium ion | Ca | 4 |
| LPP | 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate | C35 H69 O8 P | 4 |
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Vinayagam, D., Quentin, D., Yu-Strzelczyk, J. et al. Elife (2020) 9. DOI 10.7554/eLife.60603 · PubMed
Other PDB entries of the same protein (UniProt U3N7D8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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