7D8H: CRTC1 pSer64 peptide

CRTC1 pSer64 peptide in complex with 14-3-3 zeta. Determined by X-ray diffraction at 2.42 Å resolution. Released 24 Feb 2021.

Method: X-ray diffraction
Resolution: 2.42 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,931
Mol. weight: 31.24 kDa
Released: 24 Feb 2021

Explore 7D8H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7D8H contains 12 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 0 β-strands

Element	Residues	Length
α-helix	3-15	13
α-helix	19-30	12
α-helix	35-37	3
α-helix	38-68	31
α-helix	73-100	28
α-helix	101-105	5
α-helix	112-130	19
α-helix	136-159	24
α-helix	165-180	16
α-helix	187-201	15
α-helix	203-205	3
α-helix	211-228	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
14-3-3 protein zeta/delta	A	protein	265	Homo sapiens	P63104 (AlphaFold model)
CRTC1 pSer64 peptide	B	protein	11	Homo sapiens	Q6UUV9 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7D8H_1 14-3-3 protein zeta/delta (chains A)
MGSSHHHHHHSSGLVPRGSHMDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEE
RNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSL
LEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEM
QPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQL
LRDNLTLWTSDTQGDEAEAGEGGEN

Sequence of entity 2 (B), FASTA

>7D8H_2 CRTC1 pSer64 peptide (chains B)
QYYGGSLPNVN

Primary citation

Structural Insights into the Interaction Between CRTCs and 14-3-3. Chen, H., Zhang, H., Chen, P. et al. J Mol Biol (2021) 433:166874-166874. DOI 10.1016/j.jmb.2021.166874 · PubMed

Other PDB entries of the same protein (UniProt P63104 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2O02 1.5 Å, Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure…
6F09 1.59 Å, Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
7ZIT 1.79 Å, 14-3-3 in complex with SARS-COV2 N phospho-peptide
9UJ2 1.8 Å, 14-3-3 zeta chimera with the S202R peptide of SARS-CoV-2 N (residues 200-213)
6ZFG 1.85 Å, 14-3-3 zeta chimera with 18E6 and fusicoccin
6F08 1.9 Å, 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)
6ZFD 1.9 Å, 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus
4FJ3 1.95 Å, 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide
5EXA 1.95 Å, Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
8P1H 1.95 Å, Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic…
8A9G 1.96 Å, Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by…
1QJA 2.0 Å, 14-3-3 zeta/phosphopeptide complex (mode 2)

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