Cryo-EM structure of hDisp1NNN-3C. Determined by electron microscopy at 3.61 Å resolution. Released 8 Dec 2021.
Explore 7E2G in 3D Show helices and sheets RCSB PDB PDBe
7E2G contains 45 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 182-185 | 4 | |
| α-helix | 189-209 | 21 | |
| α-helix | 212-214 | 3 | |
| α-helix | 231-242 | 12 | |
| β-strand | 300-306 | 7 | 1 |
| α-helix | 316-325 | 10 | |
| α-helix | 326-331 | 6 | |
| α-helix | 354-360 | 7 | |
| α-helix | 373-385 | 13 | |
| α-helix | 386-388 | 3 | |
| α-helix | 423-429 | 7 | |
| α-helix | 447-449 | 3 | |
| β-strand | 452-459 | 8 | 1 |
| α-helix | 465-471 | 7 | |
| β-strand | 483-488 | 6 | 1 |
| α-helix | 496-502 | 7 | |
| α-helix | 505-521 | 17 | |
| α-helix | 526-544 | 19 | |
| α-helix | 545-549 | 5 | |
| α-helix | 558-561 | 4 | |
| α-helix | 562-586 | 25 | |
| α-helix | 593-620 | 28 | |
| α-helix | 621-623 | 3 | |
| α-helix | 628-658 | 31 | |
| α-helix | 688-704 | 17 | |
| α-helix | 705-709 | 5 | |
| α-helix | 710-715 | 6 | |
| α-helix | 720-737 | 18 | |
| α-helix | 743-745 | 3 | |
| α-helix | 749-751 | 3 | |
| β-strand | 755 | 1 | 2 |
| α-helix | 760-763 | 4 | |
| α-helix | 764-768 | 5 | |
| α-helix | 769-771 | 3 | |
| α-helix | 773-776 | 4 | |
| α-helix | 784-785 | 2 | |
| β-strand | 786 | 1 | 3 |
| β-strand | 789-790 | 2 | 4 |
| α-helix | 821-834 | 14 | |
| β-strand | 840 | 1 | 5 |
| α-helix | 852-858 | 7 | |
| α-helix | 886-900 | 15 | |
| α-helix | 911-912 | 2 | |
| β-strand | 913-914 | 2 | 6 |
| β-strand | 920-922 | 3 | 6 |
| β-strand | 924-925 | 2 | 4 |
| β-strand | 928 | 1 | 3 |
| β-strand | 929 | 1 | 5 |
| α-helix | 938-952 | 15 | |
| α-helix | 973-1003 | 31 | |
| α-helix | 1006-1030 | 25 | |
| α-helix | 1038-1049 | 12 | |
| α-helix | 1051-1058 | 8 | |
| α-helix | 1073-1095 | 23 | |
| β-strand | 1102 | 1 | 2 |
| α-helix | 1103-1121 | 19 | |
| α-helix | 1122-1127 | 6 | |
| α-helix | 1128-1129 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein dispatched homolog 1,Protein dispatched homolog 1 | D | protein | 1518 | Homo sapiens | Q96F81 (AlphaFold model) |
>7E2G_1 Protein dispatched homolog 1,Protein dispatched homolog 1 (chains D) MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNG TVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPH SEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKS YAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNM VKNTGYKATLANYPFKYADEQASSLEVLFQGPGSEVDWNFHKDSFFCDVPSDRYSRVVFT SSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSS CQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQ ILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITG IEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLY RVVFHFEFFPFMNLTALIILVGIGANNAFVLCDVWNYTKFDKPHAETSETVSITLQHAAL SMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNI FTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFL ALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMP ITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQ DFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLD SKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGW FVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGS LVLLGWELNVLESVTISVAVGLSVNFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMA ALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLP KKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASHSCTAPE KTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHTVCHFFS LNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQAVEGFV HPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRSIEEHLP KMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVELSLSQT DASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPNMEANVP AVLTHSELSGESLLIKTL
| ID | Name | Formula | Copies |
|---|---|---|---|
| Y01 | Cholesterol hemisuccinate | C31 H50 O4 | 11 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 4 |
Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Li, W., Wang, L., Wierbowski, B.M. et al. Nat Commun (2021) 12:6966-6966. DOI 10.1038/s41467-021-27257-w · PubMed
Other PDB entries of the same protein (UniProt Q96F81 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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