7F4G: RPAP2-bound RNA polymerase II
Structure of RPAP2-bound RNA polymerase II. Determined by electron microscopy at 2.78 Å resolution. Released 7 Jul 2021.
- Method
- Electron microscopy
- Resolution
- 2.78 Å
- Organisms
- Sus scrofa, Homo sapiens
- Chains
- 13
- Atoms
- 27,957
- Mol. weight
- 587.3 kDa
- Ligands
- ZN
- Released
- 7 Jul 2021
Explore 7F4G in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7F4G contains 140 α-helices and 188 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 44 helices, 46 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 365 | 1 | 1 |
| β-strand | 367-369 | 3 | 2 |
| β-strand | 377-380 | 4 | 2 |
| α-helix | 382-385 | 4 | |
| β-strand | 389-393 | 5 | 3 |
| α-helix | 399-408 | 10 | |
| β-strand | 416-420 | 5 | 3 |
| β-strand | 426-428 | 3 | 3 |
| β-strand | 445-449 | 5 | 3 |
| β-strand | 455-457 | 3 | 2 |
| β-strand | 471-476 | 6 | 2 |
| β-strand | 482-484 | 3 | 2 |
| β-strand | 501 | 1 | 1 |
| β-strand | 504 | 1 | 2 |
| α-helix | 509-518 | 10 | |
| β-strand | 520 | 1 | 2 |
| α-helix | 540-548 | 9 | |
| α-helix | 557-564 | 8 | |
| α-helix | 574 | 1 | |
| β-strand | 575 | 1 | 4 |
| α-helix | 576-577 | 2 | |
| β-strand | 579-581 | 3 | 5 |
| β-strand | 585 | 1 | 5 |
| α-helix | 588-595 | 8 | |
| β-strand | 602 | 1 | 6 |
| β-strand | 605 | 1 | 7 |
| β-strand | 627 | 1 | 7 |
| β-strand | 629-630 | 2 | 6 |
| β-strand | 635-637 | 3 | 6 |
| α-helix | 642-645 | 4 | |
| α-helix | 652-659 | 8 | |
| α-helix | 663-683 | 21 | |
| α-helix | 696-722 | 27 | |
| α-helix | 727-728 | 2 | |
| α-helix | 734-757 | 24 | |
| α-helix | 765-771 | 7 | |
| α-helix | 778-785 | 8 | |
| β-strand | 789-790 | 2 | 8 |
| β-strand | 793 | 1 | 9 |
| β-strand | 796 | 1 | 9 |
| α-helix | 817-820 | 4 | |
| β-strand | 822-823 | 2 | 8 |
| α-helix | 833-867 | 35 | |
| β-strand | 872-873 | 2 | 10 |
| β-strand | 879-880 | 2 | 10 |
| β-strand | 886-888 | 3 | 10 |
| α-helix | 891-893 | 3 | |
| β-strand | 896 | 1 | 11 |
| β-strand | 902-904 | 3 | 12 |
| α-helix | 915-920 | 6 | |
| β-strand | 934 | 1 | 13 |
| α-helix | 936-943 | 8 | |
| α-helix | 947-969 | 23 | |
| β-strand | 977-979 | 3 | 12 |
| α-helix | 983-993 | 11 | |
| β-strand | 1002 | 1 | 13 |
| α-helix | 1006-1016 | 11 | |
| α-helix | 1028-1037 | 10 | |
| α-helix | 1039-1048 | 10 | |
| α-helix | 1053-1056 | 4 | |
| α-helix | 1062-1077 | 16 | |
| β-strand | 1080 | 1 | 11 |
| α-helix | 1081-1082 | 2 | |
| α-helix | 1087-1096 | 10 | |
| α-helix | 1097-1100 | 4 | |
| α-helix | 1120-1128 | 9 | |
| β-strand | 1140-1142 | 3 | 14 |
| α-helix | 1151-1161 | 11 | |
| β-strand | 1164 | 1 | 15 |
| β-strand | 1170-1177 | 8 | 16 |
| α-helix | 1190-1197 | 8 | |
| β-strand | 1210-1216 | 7 | 16 |
| α-helix | 1219-1223 | 5 | |
| α-helix | 1228-1238 | 11 | |
| α-helix | 1240-1242 | 3 | |
| β-strand | 1243-1247 | 5 | 16 |
| β-strand | 1256-1261 | 6 | 16 |
| α-helix | 1278-1280 | 3 | |
| α-helix | 1281-1291 | 11 | |
| β-strand | 1299 | 1 | 15 |
| β-strand | 1307-1310 | 4 | 14 |
| β-strand | 1319-1322 | 4 | 17 |
| β-strand | 1328-1331 | 4 | 17 |
| β-strand | 1335-1338 | 4 | 14 |
| α-helix | 1343-1346 | 4 | |
| α-helix | 1362-1368 | 7 | |
| α-helix | 1371-1387 | 17 | |
| α-helix | 1395-1404 | 10 | |
| β-strand | 1471-1475 | 5 | 18 |
| α-helix | 1477-1480 | 4 | |
Chain B: 43 helices, 61 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-36 | 15 | |
| α-helix | 41-49 | 9 | |
| α-helix | 50-54 | 5 | |
| α-helix | 55-59 | 5 | |
| β-strand | 91-93 | 3 | 19 |
| β-strand | 97-98 | 2 | 20 |
| β-strand | 106-107 | 2 | 20 |
| α-helix | 110-116 | 7 | |
| β-strand | 121-129 | 9 | 19 |
| β-strand | 143-153 | 11 | 19 |
| α-helix | 168-172 | 5 | |
| β-strand | 185-187 | 3 | 21 |
| β-strand | 190-193 | 4 | 21 |
| β-strand | 196-200 | 5 | 22 |
| α-helix | 201 | 1 | |
| β-strand | 206-208 | 3 | 23 |
| β-strand | 215-223 | 9 | 23 |
| β-strand | 233-240 | 8 | 23 |
| β-strand | 256-259 | 4 | 23 |
| β-strand | 263 | 1 | 24 |
| β-strand | 267-268 | 2 | 23 |
| α-helix | 269-274 | 6 | |
| α-helix | 282-285 | 4 | |
| α-helix | 295-301 | 7 | |
| α-helix | 302-304 | 3 | |
| α-helix | 314-322 | 9 | |
| β-strand | 325 | 1 | 24 |
| α-helix | 332-341 | 10 | |
| α-helix | 342-346 | 5 | |
| α-helix | 361-376 | 16 | |
| α-helix | 381-384 | 4 | |
| α-helix | 388-390 | 3 | |
| β-strand | 391-394 | 4 | 22 |
| α-helix | 396-425 | 30 | |
| α-helix | 431-433 | 3 | |
| α-helix | 438-450 | 13 | |
| β-strand | 468-469 | 2 | 21 |
| α-helix | 470-471 | 2 | |
| α-helix | 475-481 | 7 | |
| β-strand | 484-486 | 3 | 22 |
| α-helix | 491-493 | 3 | |
| α-helix | 503-505 | 3 | |
| β-strand | 509 | 1 | 25 |
| β-strand | 523-525 | 3 | 22 |
| β-strand | 526 | 1 | 25 |
| β-strand | 531-532 | 2 | 26 |
| α-helix | 539-547 | 9 | |
| β-strand | 551-552 | 2 | 27 |
| β-strand | 565-569 | 5 | 27 |
| β-strand | 572-577 | 6 | 27 |
| α-helix | 580-591 | 12 | |
| β-strand | 602-606 | 5 | 27 |
| β-strand | 611-615 | 5 | 27 |
| β-strand | 621-627 | 7 | 26 |
| β-strand | 628-629 | 2 | 28 |
| β-strand | 632-633 | 2 | 28 |
| α-helix | 637-644 | 8 | |
| α-helix | 654-657 | 4 | |
| β-strand | 662-666 | 5 | 26 |
| α-helix | 669-671 | 3 | |
| α-helix | 679-682 | 4 | |
| β-strand | 695-696 | 2 | 26 |
| α-helix | 700-703 | 4 | |
| α-helix | 714-716 | 3 | |
| α-helix | 719-728 | 10 | |
| β-strand | 732 | 1 | 29 |
| β-strand | 734 | 1 | 30 |
| β-strand | 748-751 | 4 | 30 |
| β-strand | 755 | 1 | 31 |
| β-strand | 759-760 | 2 | 32 |
| α-helix | 762-764 | 3 | |
| β-strand | 776-782 | 7 | 33 |
| β-strand | 794-797 | 4 | 33 |
| α-helix | 798-802 | 5 | |
| β-strand | 808-818 | 11 | 30 |
| β-strand | 827-829 | 3 | 34 |
| β-strand | 848 | 1 | 35 |
| β-strand | 853 | 1 | 36 |
| β-strand | 854 | 1 | 35 |
| β-strand | 859-860 | 2 | 30 |
| β-strand | 865-867 | 3 | 36 |
| β-strand | 869-871 | 3 | 34 |
| β-strand | 890-891 | 2 | 34 |
| β-strand | 894-895 | 2 | 36 |
| β-strand | 902-911 | 10 | 30 |
| β-strand | 917-927 | 11 | 30 |
| β-strand | 934-937 | 4 | 33 |
| β-strand | 942-949 | 8 | 33 |
| α-helix | 951-953 | 3 | |
| β-strand | 956-957 | 2 | 37 |
| β-strand | 965-967 | 3 | 33 |
| α-helix | 969-971 | 3 | |
| α-helix | 973-975 | 3 | |
| α-helix | 978-993 | 16 | |
| β-strand | 997-998 | 2 | 32 |
| α-helix | 1009-1015 | 7 | |
| β-strand | 1025-1026 | 2 | 33 |
| β-strand | 1028-1029 | 2 | 37 |
| α-helix | 1035 | 1 | |
| β-strand | 1036 | 1 | 37 |
| α-helix | 1037 | 1 | |
| α-helix | 1040 | 1 | |
| β-strand | 1041-1050 | 10 | 33 |
| β-strand | 1051 | 1 | 29 |
Chain C: 8 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-15 | 8 | 38 |
| β-strand | 18-24 | 7 | 38 |
| α-helix | 28-40 | 13 | |
| β-strand | 44-55 | 12 | 39 |
| α-helix | 61-69 | 9 | |
| α-helix | 72 | 1 | |
| β-strand | 73 | 1 | 40 |
| β-strand | 99-106 | 8 | 39 |
| β-strand | 113-116 | 4 | 41 |
| β-strand | 121-122 | 2 | 39 |
| β-strand | 129 | 1 | 40 |
| β-strand | 149-153 | 5 | 41 |
| β-strand | 158-168 | 11 | 39 |
| α-helix | 174-176 | 3 | |
| β-strand | 182-186 | 5 | 38 |
| α-helix | 200-202 | 3 | |
| α-helix | 204-206 | 3 | |
| α-helix | 218-220 | 3 | |
| β-strand | 229-234 | 6 | 38 |
| α-helix | 241-267 | 27 | |
Chain D: 8 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16 | 1 | 55 |
| β-strand | 21 | 1 | 55 |
| α-helix | 34-49 | 16 | |
| α-helix | 55-58 | 4 | |
| α-helix | 59-70 | 12 | |
| α-helix | 77-88 | 12 | |
| α-helix | 94-103 | 10 | |
| α-helix | 108-114 | 7 | |
| α-helix | 116-118 | 3 | |
| α-helix | 124-136 | 13 | |
Chain E: 9 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-23 | 20 | |
| β-strand | 26 | 1 | 42 |
| α-helix | 37-44 | 8 | |
| β-strand | 60-63 | 4 | 43 |
| β-strand | 64 | 1 | 42 |
| β-strand | 71-74 | 4 | 43 |
| β-strand | 75 | 1 | 44 |
| β-strand | 81-82 | 2 | 45 |
| α-helix | 84-95 | 12 | |
| α-helix | 96-98 | 3 | |
| β-strand | 101 | 1 | 43 |
| β-strand | 104-106 | 3 | 44 |
| β-strand | 109-110 | 2 | 45 |
| α-helix | 112-119 | 8 | |
| β-strand | 126 | 1 | 43 |
| β-strand | 129-131 | 3 | 44 |
| α-helix | 139-141 | 3 | |
| β-strand | 147-150 | 4 | 46 |
| α-helix | 153-163 | 11 | |
| α-helix | 167-169 | 3 | |
| β-strand | 172-173 | 2 | 46 |
| α-helix | 178-183 | 6 | |
| β-strand | 190-195 | 6 | 46 |
| β-strand | 203-209 | 7 | 46 |
Chain F: 3 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 56 | 1 | 47 |
| α-helix | 59-74 | 16 | |
| α-helix | 77-79 | 3 | |
| α-helix | 89-98 | 10 | |
| β-strand | 104-108 | 5 | 18 |
| β-strand | 116-119 | 4 | 18 |
| β-strand | 124 | 1 | 47 |
Chain G: 5 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-13 | 11 | 18 |
| α-helix | 15-17 | 3 | |
| α-helix | 22-34 | 13 | |
| β-strand | 38-39 | 2 | 18 |
| β-strand | 43-54 | 12 | 18 |
| α-helix | 55-57 | 3 | |
| β-strand | 58-59 | 2 | 18 |
| α-helix | 60 | 1 | |
| β-strand | 66-77 | 12 | 18 |
| β-strand | 84-92 | 9 | 56 |
| β-strand | 96-101 | 6 | 56 |
| β-strand | 104-109 | 6 | 56 |
| α-helix | 110-112 | 3 | |
| β-strand | 117-120 | 4 | 57 |
| β-strand | 127-130 | 4 | 57 |
| β-strand | 136-137 | 2 | 57 |
| β-strand | 142-153 | 12 | 56 |
| β-strand | 156-162 | 7 | 56 |
| β-strand | 169-170 | 2 | 56 |
Chain H: 1 helix, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-14 | 11 | 5 |
| β-strand | 25-33 | 9 | 5 |
| β-strand | 38-44 | 7 | 5 |
| β-strand | 55-61 | 7 | 5 |
| β-strand | 74 | 1 | 4 |
| α-helix | 83-84 | 2 | |
| β-strand | 90-101 | 12 | 5 |
| β-strand | 111-118 | 8 | 5 |
| β-strand | 121-128 | 8 | 5 |
| β-strand | 140-145 | 6 | 5 |
| β-strand | 147-148 | 2 | 5 |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| RPB1 | A | protein | 1970 | Sus scrofa | A0A8D1DPV6 |
| DNA-directed RNA polymerase subunit beta | B | protein | 1174 | Sus scrofa | I3LGP4 (AlphaFold model) |
| DNA-directed RNA polymerase II subunit RPB3 | C | protein | 275 | Sus scrofa | I3LCH3 (AlphaFold model) |
| DNA-directed RNA polymerase II subunit E | E | protein | 210 | Sus scrofa | I3LSI7 (AlphaFold model) |
| DNA-directed RNA polymerase II subunit F | F | protein | 127 | Sus scrofa | A0A4X1VEK9 |
| DNA-directed RNA polymerases I, II, and III subunit RPABC3 | H | protein | 150 | Sus scrofa | I3LCB2 |
| DNA-directed RNA polymerase II subunit RPB9 | I | protein | 125 | Sus scrofa | P60899 |
| RPB10 | J | protein | 67 | Sus scrofa | A0A8W4F9W9 |
| RNA_pol_L_2 domain-containing protein | K | protein | 117 | Sus scrofa | F1RKE4 |
| RPB12 | L | protein | 58 | Sus scrofa | A0A4X1TRS6 |
| RPAP2 | R | protein | 612 | Homo sapiens | Q8IXW5 |
| DNA-directed RNA polymerase II subunit RPB4 | D | protein | 142 | Sus scrofa | A0A287ADR4 |
1 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>7F4G_1 RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Sequence of entity 2 (B), FASTA
>7F4G_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Sequence of entity 3 (C), FASTA
>7F4G_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
Sequence of entity 4 (E), FASTA
>7F4G_4 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Sequence of entity 5 (F), FASTA
>7F4G_5 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD
Sequence of entity 6 (H), FASTA
>7F4G_6 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF
Sequence of entity 7 (I), FASTA
>7F4G_7 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE
Sequence of entity 8 (J), FASTA
>7F4G_8 RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK
Sequence of entity 9 (K), FASTA
>7F4G_9 RNA_pol_L_2 domain-containing protein (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE
Sequence of entity 10 (L), FASTA
>7F4G_10 RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
Sequence of entity 11 (R), FASTA
>7F4G_11 RPAP2 (chains R)
MADFAGPSSAGRKAGAPRCSRKAAGTKQTSTLKQEDASKRKAELEAAVRKKIEFERKALH
IVEQLLEENITEEFLMECGRFITPAHYSDVVDERSIVKLCGYPLCQKKLGIVPKQKYKIS
TKTNKVYDITERKSFCSNFCYQASKFFEAQIPKTPVWVREEERHPDFQLLKEEQSGHSGE
EVQLCSKAIKTSDIDNPSHFEKQYESSSSSTHSDSSSDNEQDFVSSILPGNRPNSTNIRP
QLHQKSIMKKKAGHKANSKHKDKEQTVVDVTEQLGDCKLDSQEKDATCELPLQKVNTQSS
SNSTLPERLKASENSESEYSRSEITLVGISKKSAEHFKRKFAKSNQVSRSVSSSVQVCPE
VGKRNLLKVLKETLIEWKTEETLRFLYGQNYASVCLKPEASLVKEELDEDDIISDPDSHF
PAWRESQNSLDESLPFRGSGTAIKPLPSYENLKKETEKLNLRIREFYRGRYVLGEETTKS
QDSEEHDSTFPLIDSSSQNQIRKRIVLEKLSKVLPGLLVPLQITLGDIYTQLKNLVRTFR
LTNRNIIHKPAEWTLIAMVLLSLLTPILGIQKHSQEGMVFTRFLDTLLEELHLKNEDLES
LTIIFRTSCLPE
Sequence of entity 12 (D), FASTA
>7F4G_12 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 5 |
Primary citation
RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Wang, X., Qi, Y., Wang, Z. et al. Cell Rep (2022) 39:110732-110732. DOI 10.1016/j.celrep.2022.110732 · PubMed
Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:
- 9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
- 7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
- 8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
- 8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
- 7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
- 8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
- 8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
- 8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
- 8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
- 8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
- 8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…
- 7NVS 2.8 Å, RNA polymerase II core pre-initiation complex with closed promoter DNA in proximal…
Browse structure collections
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