7F4G: RPAP2-bound RNA polymerase II

Structure of RPAP2-bound RNA polymerase II. Determined by electron microscopy at 2.78 Å resolution. Released 7 Jul 2021.

Method
Electron microscopy
Resolution
2.78 Å
Organisms
Sus scrofa, Homo sapiens
Chains
13
Atoms
27,957
Mol. weight
587.3 kDa
Ligands
ZN
Released
7 Jul 2021

Explore 7F4G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7F4G contains 140 α-helices and 188 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 44 helices, 46 β-strands

ElementResiduesLengthSheet
β-strand36511
β-strand367-36932
β-strand377-38042
α-helix382-3854
β-strand389-39353
α-helix399-40810
β-strand416-42053
β-strand426-42833
β-strand445-44953
β-strand455-45732
β-strand471-47662
β-strand482-48432
β-strand50111
β-strand50412
α-helix509-51810
β-strand52012
α-helix540-5489
α-helix557-5648
α-helix5741
β-strand57514
α-helix576-5772
β-strand579-58135
β-strand58515
α-helix588-5958
β-strand60216
β-strand60517
β-strand62717
β-strand629-63026
β-strand635-63736
α-helix642-6454
α-helix652-6598
α-helix663-68321
α-helix696-72227
α-helix727-7282
α-helix734-75724
α-helix765-7717
α-helix778-7858
β-strand789-79028
β-strand79319
β-strand79619
α-helix817-8204
β-strand822-82328
α-helix833-86735
β-strand872-873210
β-strand879-880210
β-strand886-888310
α-helix891-8933
β-strand896111
β-strand902-904312
α-helix915-9206
β-strand934113
α-helix936-9438
α-helix947-96923
β-strand977-979312
α-helix983-99311
β-strand1002113
α-helix1006-101611
α-helix1028-103710
α-helix1039-104810
α-helix1053-10564
α-helix1062-107716
β-strand1080111
α-helix1081-10822
α-helix1087-109610
α-helix1097-11004
α-helix1120-11289
β-strand1140-1142314
α-helix1151-116111
β-strand1164115
β-strand1170-1177816
α-helix1190-11978
β-strand1210-1216716
α-helix1219-12235
α-helix1228-123811
α-helix1240-12423
β-strand1243-1247516
β-strand1256-1261616
α-helix1278-12803
α-helix1281-129111
β-strand1299115
β-strand1307-1310414
β-strand1319-1322417
β-strand1328-1331417
β-strand1335-1338414
α-helix1343-13464
α-helix1362-13687
α-helix1371-138717
α-helix1395-140410
β-strand1471-1475518
α-helix1477-14804
Chain B: 43 helices, 61 β-strands
ElementResiduesLengthSheet
α-helix22-3615
α-helix41-499
α-helix50-545
α-helix55-595
β-strand91-93319
β-strand97-98220
β-strand106-107220
α-helix110-1167
β-strand121-129919
β-strand143-1531119
α-helix168-1725
β-strand185-187321
β-strand190-193421
β-strand196-200522
α-helix2011
β-strand206-208323
β-strand215-223923
β-strand233-240823
β-strand256-259423
β-strand263124
β-strand267-268223
α-helix269-2746
α-helix282-2854
α-helix295-3017
α-helix302-3043
α-helix314-3229
β-strand325124
α-helix332-34110
α-helix342-3465
α-helix361-37616
α-helix381-3844
α-helix388-3903
β-strand391-394422
α-helix396-42530
α-helix431-4333
α-helix438-45013
β-strand468-469221
α-helix470-4712
α-helix475-4817
β-strand484-486322
α-helix491-4933
α-helix503-5053
β-strand509125
β-strand523-525322
β-strand526125
β-strand531-532226
α-helix539-5479
β-strand551-552227
β-strand565-569527
β-strand572-577627
α-helix580-59112
β-strand602-606527
β-strand611-615527
β-strand621-627726
β-strand628-629228
β-strand632-633228
α-helix637-6448
α-helix654-6574
β-strand662-666526
α-helix669-6713
α-helix679-6824
β-strand695-696226
α-helix700-7034
α-helix714-7163
α-helix719-72810
β-strand732129
β-strand734130
β-strand748-751430
β-strand755131
β-strand759-760232
α-helix762-7643
β-strand776-782733
β-strand794-797433
α-helix798-8025
β-strand808-8181130
β-strand827-829334
β-strand848135
β-strand853136
β-strand854135
β-strand859-860230
β-strand865-867336
β-strand869-871334
β-strand890-891234
β-strand894-895236
β-strand902-9111030
β-strand917-9271130
β-strand934-937433
β-strand942-949833
α-helix951-9533
β-strand956-957237
β-strand965-967333
α-helix969-9713
α-helix973-9753
α-helix978-99316
β-strand997-998232
α-helix1009-10157
β-strand1025-1026233
β-strand1028-1029237
α-helix10351
β-strand1036137
α-helix10371
α-helix10401
β-strand1041-10501033
β-strand1051129
Chain C: 8 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand8-15838
β-strand18-24738
α-helix28-4013
β-strand44-551239
α-helix61-699
α-helix721
β-strand73140
β-strand99-106839
β-strand113-116441
β-strand121-122239
β-strand129140
β-strand149-153541
β-strand158-1681139
α-helix174-1763
β-strand182-186538
α-helix200-2023
α-helix204-2063
α-helix218-2203
β-strand229-234638
α-helix241-26727
Chain D: 8 helices, 2 β-strands
ElementResiduesLengthSheet
β-strand16155
β-strand21155
α-helix34-4916
α-helix55-584
α-helix59-7012
α-helix77-8812
α-helix94-10310
α-helix108-1147
α-helix116-1183
α-helix124-13613
Chain E: 9 helices, 15 β-strands
ElementResiduesLengthSheet
α-helix4-2320
β-strand26142
α-helix37-448
β-strand60-63443
β-strand64142
β-strand71-74443
β-strand75144
β-strand81-82245
α-helix84-9512
α-helix96-983
β-strand101143
β-strand104-106344
β-strand109-110245
α-helix112-1198
β-strand126143
β-strand129-131344
α-helix139-1413
β-strand147-150446
α-helix153-16311
α-helix167-1693
β-strand172-173246
α-helix178-1836
β-strand190-195646
β-strand203-209746
Chain F: 3 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand56147
α-helix59-7416
α-helix77-793
α-helix89-9810
β-strand104-108518
β-strand116-119418
β-strand124147
Chain G: 5 helices, 14 β-strands
ElementResiduesLengthSheet
β-strand3-131118
α-helix15-173
α-helix22-3413
β-strand38-39218
β-strand43-541218
α-helix55-573
β-strand58-59218
α-helix601
β-strand66-771218
β-strand84-92956
β-strand96-101656
β-strand104-109656
α-helix110-1123
β-strand117-120457
β-strand127-130457
β-strand136-137257
β-strand142-1531256
β-strand156-162756
β-strand169-170256
Chain H: 1 helix, 10 β-strands
ElementResiduesLengthSheet
β-strand4-14115
β-strand25-3395
β-strand38-4475
β-strand55-6175
β-strand7414
α-helix83-842
β-strand90-101125
β-strand111-11885
β-strand121-12885
β-strand140-14565
β-strand147-14825

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
RPB1Aprotein1970Sus scrofaA0A8D1DPV6
DNA-directed RNA polymerase subunit betaBprotein1174Sus scrofaI3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3Cprotein275Sus scrofaI3LCH3 (AlphaFold model)
DNA-directed RNA polymerase II subunit EEprotein210Sus scrofaI3LSI7 (AlphaFold model)
DNA-directed RNA polymerase II subunit FFprotein127Sus scrofaA0A4X1VEK9
DNA-directed RNA polymerases I, II, and III subunit RPABC3Hprotein150Sus scrofaI3LCB2
DNA-directed RNA polymerase II subunit RPB9Iprotein125Sus scrofaP60899
RPB10Jprotein67Sus scrofaA0A8W4F9W9
RNA_pol_L_2 domain-containing proteinKprotein117Sus scrofaF1RKE4
RPB12Lprotein58Sus scrofaA0A4X1TRS6
RPAP2Rprotein612Homo sapiensQ8IXW5
DNA-directed RNA polymerase II subunit RPB4Dprotein142Sus scrofaA0A287ADR4

1 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>7F4G_1 RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN
Sequence of entity 2 (B), FASTA
>7F4G_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
Sequence of entity 3 (C), FASTA
>7F4G_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
Sequence of entity 4 (E), FASTA
>7F4G_4 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ
Sequence of entity 5 (F), FASTA
>7F4G_5 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD
Sequence of entity 6 (H), FASTA
>7F4G_6 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF
Sequence of entity 7 (I), FASTA
>7F4G_7 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE
Sequence of entity 8 (J), FASTA
>7F4G_8 RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK
Sequence of entity 9 (K), FASTA
>7F4G_9 RNA_pol_L_2 domain-containing protein (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE
Sequence of entity 10 (L), FASTA
>7F4G_10 RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
Sequence of entity 11 (R), FASTA
>7F4G_11 RPAP2 (chains R)
MADFAGPSSAGRKAGAPRCSRKAAGTKQTSTLKQEDASKRKAELEAAVRKKIEFERKALH
IVEQLLEENITEEFLMECGRFITPAHYSDVVDERSIVKLCGYPLCQKKLGIVPKQKYKIS
TKTNKVYDITERKSFCSNFCYQASKFFEAQIPKTPVWVREEERHPDFQLLKEEQSGHSGE
EVQLCSKAIKTSDIDNPSHFEKQYESSSSSTHSDSSSDNEQDFVSSILPGNRPNSTNIRP
QLHQKSIMKKKAGHKANSKHKDKEQTVVDVTEQLGDCKLDSQEKDATCELPLQKVNTQSS
SNSTLPERLKASENSESEYSRSEITLVGISKKSAEHFKRKFAKSNQVSRSVSSSVQVCPE
VGKRNLLKVLKETLIEWKTEETLRFLYGQNYASVCLKPEASLVKEELDEDDIISDPDSHF
PAWRESQNSLDESLPFRGSGTAIKPLPSYENLKKETEKLNLRIREFYRGRYVLGEETTKS
QDSEEHDSTFPLIDSSSQNQIRKRIVLEKLSKVLPGLLVPLQITLGDIYTQLKNLVRTFR
LTNRNIIHKPAEWTLIAMVLLSLLTPILGIQKHSQEGMVFTRFLDTLLEELHLKNEDLES
LTIIFRTSCLPE
Sequence of entity 12 (D), FASTA
>7F4G_12 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn5

Primary citation

RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Wang, X., Qi, Y., Wang, Z. et al. Cell Rep (2022) 39:110732-110732. DOI 10.1016/j.celrep.2022.110732 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

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