8XVG: Human NuA4/TIP60 complex
Structure of human NuA4/TIP60 complex. Determined by electron microscopy at 9.4 Å resolution. Released 24 Jul 2024.
- Method
- Electron microscopy
- Resolution
- 9.4 Å
- Organism
- Homo sapiens
- Chains
- 14
- Atoms
- 68,358
- Mol. weight
- 1405.75 kDa
- Ligands
- IHP, ADP
- Released
- 24 Jul 2024
Explore 8XVG in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8XVG contains 515 α-helices and 289 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 23 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 11 |
| β-strand | 26 | 1 | 12 |
| α-helix | 31 | 1 | |
| β-strand | 32 | 1 | 12 |
| α-helix | 33 | 1 | |
| β-strand | 35-36 | 2 | 13 |
| β-strand | 39-40 | 2 | 13 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 14 |
| β-strand | 65-69 | 5 | 15 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 15 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-118 | 11 | |
| β-strand | 120-130 | 11 | 16 |
| β-strand | 133-141 | 9 | 17 |
| β-strand | 156-162 | 7 | 17 |
| β-strand | 167-172 | 6 | 17 |
| α-helix | 174-182 | 9 | |
| β-strand | 190-193 | 4 | 17 |
| β-strand | 194 | 1 | 16 |
| β-strand | 199-202 | 4 | 17 |
| α-helix | 222-224 | 3 | |
| β-strand | 230-239 | 10 | 16 |
| α-helix | 240-247 | 8 | |
| α-helix | 255-257 | 3 | |
| β-strand | 270 | 1 | 18 |
| α-helix | 272-276 | 5 | |
| α-helix | 277-288 | 12 | |
| β-strand | 292-296 | 5 | 16 |
| β-strand | 298-302 | 5 | 15 |
| α-helix | 304-306 | 3 | |
| α-helix | 309-318 | 10 | |
| β-strand | 326-330 | 5 | 15 |
| β-strand | 336-337 | 2 | 19 |
| α-helix | 338 | 1 | |
| β-strand | 345-346 | 2 | 19 |
| α-helix | 347-349 | 3 | |
| α-helix | 352-355 | 4 | |
| β-strand | 358-362 | 5 | 15 |
| α-helix | 364-367 | 4 | |
| α-helix | 368-382 | 15 | |
| β-strand | 386 | 1 | 20 |
| α-helix | 388-400 | 13 | |
| α-helix | 403-420 | 18 | |
| β-strand | 425 | 1 | 20 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 21 |
| α-helix | 440-447 | 8 | |
Chain B: 22 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 22 |
| α-helix | 24-26 | 3 | |
| β-strand | 33 | 1 | 23 |
| β-strand | 39 | 1 | 23 |
| β-strand | 43 | 1 | 24 |
| β-strand | 46 | 1 | 24 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 11 |
| β-strand | 72-77 | 6 | 21 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 21 |
| α-helix | 115-124 | 10 | |
| β-strand | 127-137 | 11 | 25 |
| β-strand | 138 | 1 | 26 |
| β-strand | 141 | 1 | 27 |
| β-strand | 161 | 1 | 28 |
| β-strand | 172 | 1 | 28 |
| α-helix | 176-179 | 4 | |
| β-strand | 192 | 1 | 27 |
| β-strand | 195 | 1 | 26 |
| α-helix | 227-229 | 3 | |
| β-strand | 234-242 | 9 | 25 |
| α-helix | 246-249 | 4 | |
| α-helix | 256-259 | 4 | |
| α-helix | 273-283 | 11 | |
| β-strand | 289-293 | 5 | 25 |
| β-strand | 295-299 | 5 | 21 |
| α-helix | 301-303 | 3 | |
| β-strand | 305 | 1 | 29 |
| α-helix | 306-315 | 10 | |
| α-helix | 321-322 | 2 | |
| β-strand | 323-328 | 6 | 21 |
| β-strand | 332-334 | 3 | 30 |
| α-helix | 335 | 1 | |
| β-strand | 336 | 1 | 29 |
| β-strand | 341-343 | 3 | 30 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-359 | 6 | 21 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-377 | 14 | |
| β-strand | 382 | 1 | 31 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-415 | 17 | |
| β-strand | 421 | 1 | 31 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 32 |
| α-helix | 435 | 1 | |
| α-helix | 436-441 | 6 | |
| α-helix | 442-445 | 4 | |
Chain C: 24 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-14 | 2 | |
| β-strand | 15 | 1 | 33 |
| β-strand | 23 | 1 | 34 |
| β-strand | 26 | 1 | 35 |
| β-strand | 32 | 1 | 35 |
| β-strand | 35-36 | 2 | 36 |
| β-strand | 38 | 1 | 34 |
| β-strand | 39-40 | 2 | 36 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 22 |
| β-strand | 65-67 | 3 | 32 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 32 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-119 | 12 | |
| β-strand | 121-137 | 17 | 37 |
| β-strand | 157-162 | 6 | 37 |
| β-strand | 167-172 | 6 | 37 |
| α-helix | 174-176 | 3 | |
| β-strand | 187-192 | 6 | 37 |
| β-strand | 200-206 | 7 | 37 |
| β-strand | 215 | 1 | 38 |
| β-strand | 220 | 1 | 37 |
| α-helix | 222-224 | 3 | |
| β-strand | 229-239 | 11 | 37 |
| α-helix | 240-248 | 9 | |
| α-helix | 256-261 | 6 | |
| α-helix | 272-273 | 2 | |
| α-helix | 274-278 | 5 | |
| α-helix | 279-288 | 10 | |
| β-strand | 292-295 | 4 | 37 |
| β-strand | 298-302 | 5 | 32 |
| α-helix | 304-306 | 3 | |
| α-helix | 309-319 | 11 | |
| β-strand | 326-330 | 5 | 32 |
| β-strand | 336-337 | 2 | 39 |
| α-helix | 338 | 1 | |
| β-strand | 345-346 | 2 | 39 |
| α-helix | 347-349 | 3 | |
| α-helix | 352-357 | 6 | |
| β-strand | 359-360 | 2 | 32 |
| α-helix | 363-367 | 5 | |
| α-helix | 368-382 | 15 | |
| β-strand | 386 | 1 | 40 |
| α-helix | 388-400 | 13 | |
| α-helix | 403-420 | 18 | |
| β-strand | 425 | 1 | 40 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 41 |
| α-helix | 439 | 1 | |
| α-helix | 440-445 | 6 | |
Chain D: 22 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 42 |
| β-strand | 33 | 1 | 43 |
| β-strand | 39 | 1 | 43 |
| β-strand | 42-43 | 2 | 44 |
| β-strand | 46-47 | 2 | 44 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 33 |
| β-strand | 72-77 | 6 | 41 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 41 |
| α-helix | 105-107 | 3 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-135 | 9 | 45 |
| β-strand | 137-144 | 8 | 38 |
| β-strand | 147-149 | 3 | 38 |
| β-strand | 158-164 | 7 | 38 |
| β-strand | 169-174 | 6 | 38 |
| α-helix | 175 | 1 | |
| α-helix | 176-184 | 9 | |
| β-strand | 191-196 | 6 | 38 |
| β-strand | 204-207 | 4 | 38 |
| α-helix | 221-227 | 7 | |
| β-strand | 236-243 | 8 | 45 |
| α-helix | 244-247 | 4 | |
| α-helix | 248-251 | 4 | |
| α-helix | 256-260 | 5 | |
| α-helix | 273-286 | 14 | |
| β-strand | 289-293 | 5 | 45 |
| β-strand | 295-299 | 5 | 41 |
| α-helix | 301-303 | 3 | |
| α-helix | 306-315 | 10 | |
| β-strand | 323-328 | 6 | 41 |
| β-strand | 332-334 | 3 | 46 |
| α-helix | 335 | 1 | |
| β-strand | 341-343 | 3 | 46 |
| α-helix | 348-353 | 6 | |
| β-strand | 355-359 | 5 | 41 |
| α-helix | 360-362 | 3 | |
| α-helix | 364-378 | 15 | |
| β-strand | 382 | 1 | 47 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-416 | 18 | |
| β-strand | 421 | 1 | 47 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 48 |
| α-helix | 436-442 | 7 | |
| α-helix | 443-445 | 3 | |
Chain E: 24 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 15 | 1 | 49 |
| β-strand | 23 | 1 | 50 |
| β-strand | 36 | 1 | 51 |
| β-strand | 38 | 1 | 50 |
| β-strand | 39 | 1 | 51 |
| α-helix | 43-58 | 16 | |
| β-strand | 61 | 1 | 42 |
| β-strand | 65-67 | 3 | 48 |
| α-helix | 76-87 | 12 | |
| β-strand | 93-97 | 5 | 48 |
| α-helix | 98-101 | 4 | |
| α-helix | 108-119 | 12 | |
| β-strand | 120-134 | 15 | 52 |
| β-strand | 137-138 | 2 | 52 |
| β-strand | 142 | 1 | 38 |
| β-strand | 153-154 | 2 | 38 |
| β-strand | 157-162 | 6 | 52 |
| β-strand | 167-172 | 6 | 52 |
| α-helix | 174-176 | 3 | |
| α-helix | 177-182 | 6 | |
| β-strand | 189-194 | 6 | 52 |
| β-strand | 201-206 | 6 | 52 |
| α-helix | 207-209 | 3 | |
| β-strand | 214-215 | 2 | 53 |
| β-strand | 220-221 | 2 | 52 |
| α-helix | 222-225 | 4 | |
| β-strand | 229-237 | 9 | 52 |
| α-helix | 240-248 | 9 | |
| α-helix | 272-273 | 2 | |
| α-helix | 274-278 | 5 | |
| α-helix | 279-289 | 11 | |
| β-strand | 292-296 | 5 | 52 |
| β-strand | 298-302 | 5 | 48 |
| α-helix | 304-306 | 3 | |
| β-strand | 308 | 1 | 54 |
| α-helix | 309-318 | 10 | |
| β-strand | 326-330 | 5 | 48 |
| β-strand | 336-337 | 2 | 55 |
| α-helix | 338 | 1 | |
| β-strand | 339 | 1 | 54 |
| β-strand | 345-346 | 2 | 55 |
| α-helix | 347-349 | 3 | |
| α-helix | 352-355 | 4 | |
| β-strand | 358-360 | 3 | 48 |
| α-helix | 364-367 | 4 | |
| α-helix | 368-382 | 15 | |
| β-strand | 386 | 1 | 56 |
| α-helix | 388-400 | 13 | |
| α-helix | 403-408 | 6 | |
| α-helix | 410-420 | 11 | |
| β-strand | 425 | 1 | 56 |
| α-helix | 427-436 | 10 | |
| β-strand | 438 | 1 | 57 |
| α-helix | 440-443 | 4 | |
Chain F: 22 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22 | 1 | 14 |
| β-strand | 33 | 1 | 58 |
| β-strand | 39 | 1 | 58 |
| β-strand | 42 | 1 | 59 |
| β-strand | 47 | 1 | 59 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 49 |
| β-strand | 72-76 | 5 | 57 |
| α-helix | 83-93 | 11 | |
| β-strand | 100-104 | 5 | 57 |
| α-helix | 105-108 | 4 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-145 | 19 | 53 |
| β-strand | 160-164 | 5 | 53 |
| β-strand | 169-174 | 6 | 53 |
| α-helix | 176-184 | 9 | |
| β-strand | 192-196 | 5 | 53 |
| β-strand | 201-205 | 5 | 53 |
| α-helix | 210-213 | 4 | |
| α-helix | 226-228 | 3 | |
| β-strand | 233-243 | 11 | 53 |
| α-helix | 244-248 | 5 | |
| β-strand | 261 | 1 | 18 |
| α-helix | 269-270 | 2 | |
| α-helix | 271-277 | 7 | |
| α-helix | 278-286 | 9 | |
| β-strand | 289-293 | 5 | 53 |
| β-strand | 295-299 | 5 | 57 |
| α-helix | 301-303 | 3 | |
| α-helix | 306-315 | 10 | |
| α-helix | 322 | 1 | |
| β-strand | 323-327 | 5 | 57 |
| β-strand | 332-334 | 3 | 60 |
| α-helix | 335 | 1 | |
| β-strand | 341-343 | 3 | 60 |
| α-helix | 348-351 | 4 | |
| β-strand | 354-358 | 5 | 57 |
| α-helix | 364-377 | 14 | |
| β-strand | 382 | 1 | 61 |
| α-helix | 384-396 | 13 | |
| α-helix | 399-416 | 18 | |
| β-strand | 421 | 1 | 61 |
| α-helix | 423-432 | 10 | |
| β-strand | 434 | 1 | 15 |
| α-helix | 436-441 | 6 | |
| α-helix | 442-445 | 4 | |
Chain G: 11 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 61-62 | 2 | 62 |
| β-strand | 74 | 1 | 63 |
| α-helix | 84-88 | 5 | |
| α-helix | 93-94 | 2 | |
| β-strand | 95-100 | 6 | 64 |
| α-helix | 103-105 | 3 | |
| β-strand | 111-116 | 6 | 64 |
| α-helix | 117-119 | 3 | |
| α-helix | 125-129 | 5 | |
| α-helix | 140-145 | 6 | |
| α-helix | 154-167 | 14 | |
| α-helix | 171-177 | 7 | |
| α-helix | 188-206 | 19 | |
| α-helix | 230-244 | 15 | |
| α-helix | 248-274 | 27 | |
Chain H: 56 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 741-750 | 10 | |
| α-helix | 764-765 | 2 | |
| β-strand | 766-767 | 2 | 65 |
| α-helix | 768 | 1 | |
| β-strand | 772 | 1 | 66 |
| α-helix | 775-857 | 83 | |
| α-helix | 1057-1065 | 9 | |
| α-helix | 1067-1072 | 6 | |
| β-strand | 1077-1079 | 3 | 67 |
| α-helix | 1086-1100 | 15 | |
| β-strand | 1107-1111 | 5 | 67 |
| α-helix | 1113-1115 | 3 | |
| α-helix | 1116-1125 | 10 | |
| β-strand | 1132-1133 | 2 | 67 |
| α-helix | 1141-1145 | 5 | |
| β-strand | 1157-1161 | 5 | 67 |
| α-helix | 1162-1165 | 4 | |
| α-helix | 1169-1172 | 4 | |
| β-strand | 1179-1183 | 5 | 67 |
| α-helix | 1185-1188 | 4 | |
| α-helix | 1195-1200 | 6 | |
| β-strand | 1206-1211 | 6 | 67 |
| α-helix | 1219-1229 | 11 | |
| α-helix | 1256-1263 | 8 | |
| α-helix | 1273-1276 | 4 | |
| β-strand | 1283-1290 | 8 | 68 |
| α-helix | 1294-1304 | 11 | |
| α-helix | 1308-1312 | 5 | |
| α-helix | 1318-1331 | 14 | |
| α-helix | 1335-1338 | 4 | |
| α-helix | 1345-1347 | 3 | |
| α-helix | 1349-1351 | 3 | |
| β-strand | 1353-1354 | 2 | 69 |
| α-helix | 1358-1361 | 4 | |
| α-helix | 1378-1382 | 5 | |
| α-helix | 1386-1393 | 8 | |
| α-helix | 1396-1398 | 3 | |
| α-helix | 1728-1740 | 13 | |
| α-helix | 1741-1743 | 3 | |
| α-helix | 1751-1754 | 4 | |
| α-helix | 1791-1797 | 7 | |
| β-strand | 1811-1812 | 2 | 69 |
| α-helix | 1819-1833 | 15 | |
| α-helix | 1839-1844 | 6 | |
| α-helix | 1845-1847 | 3 | |
| α-helix | 1851-1853 | 3 | |
| α-helix | 1855-1859 | 5 | |
| α-helix | 1862-1877 | 16 | |
| β-strand | 1881-1884 | 4 | 68 |
| α-helix | 1888-1901 | 14 | |
| β-strand | 1905-1908 | 4 | 68 |
| α-helix | 1914-1924 | 11 | |
| β-strand | 1932-1935 | 4 | 68 |
| β-strand | 1951-1954 | 4 | 68 |
| α-helix | 1963-1974 | 12 | |
| β-strand | 1980-1987 | 8 | 68 |
| α-helix | 1991-1997 | 7 | |
| α-helix | 2001-2004 | 4 | |
| α-helix | 2019-2023 | 5 | |
| α-helix | 2149-2179 | 31 | |
| β-strand | 2186 | 1 | 63 |
| α-helix | 2189-2192 | 4 | |
| β-strand | 2198-2200 | 3 | 70 |
| β-strand | 2206-2208 | 3 | 70 |
| β-strand | 2212 | 1 | 71 |
| α-helix | 2213-2218 | 6 | |
| β-strand | 2224 | 1 | 66 |
| α-helix | 2228-2232 | 5 | |
| β-strand | 2234-2236 | 3 | 72 |
| α-helix | 2330-2333 | 4 | |
| α-helix | 2334-2345 | 12 | |
| α-helix | 2365-2372 | 8 | |
| α-helix | 2383-2397 | 15 | |
| α-helix | 2409-2414 | 6 | |
| α-helix | 2420-2439 | 20 | |
| α-helix | 2457-2465 | 9 | |
| α-helix | 2472-2474 | 3 | |
| α-helix | 2475-2490 | 16 | |
6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Isoform 2 of Transformation/transcription domain-associated protein | L | protein | 3830 | Homo sapiens | Q9Y4A5 |
| RuvB-like 1 | A, C, E | protein | 456 | Homo sapiens | Q9Y265 (AlphaFold model) |
| RuvB-like 2 | B, D, F | protein | 463 | Homo sapiens | Q9Y230 (AlphaFold model) |
| DNA methyltransferase 1-associated protein 1 | G | protein | 467 | Homo sapiens | Q9NPF5 (AlphaFold model) |
| Isoform 2 of E1A-binding protein p400 | H | protein | 3123 | Homo sapiens | Q96L91 |
| Actin-like protein 6A | I, J | protein | 429 | Homo sapiens | O96019 |
| ACTB protein (Fragment) | K | protein | 375 | Homo sapiens | P60709 |
| Isoform 2 of Enhancer of polycomb homolog 1 | M | protein | 813 | Homo sapiens | Q9H2F5 |
| Vacuolar protein sorting-associated protein 72 homolog | N | protein | 364 | Homo sapiens | Q15906 |
Sequence of entity 1 (L), FASTA
>8XVG_1 Isoform 2 of Transformation/transcription domain-associated protein (chains L)
MAFVATQGATVVDQTTLMKKYLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYST
FLEHIIPRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRF
LETENEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIP
ENTVPPPEMVGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYK
LNIHNVVAEFVPLIMNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQE
LVTKYSQQMVKGMLQLLSNCPAETAHLRKELLIAAKHILTTELRNQFIPCMDKLFDESIL
IGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSC
KLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAV
EAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPFEKQGEKDKEDKQT
FQVTDCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQAL
DIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVE
RISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELSNLYLKLFKLVFGS
VSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFL
PLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQT
LVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGG
SNRKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYR
RQAWEVIKCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQ
ALTGAFMSAVIKDLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSE
ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSY
IVERLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSN
GAVAMAKTTLEQLLMRCATPLKDEERAEEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQA
MHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPPKKHLLRHQPANAQIGLMEGNTFCTTLQP
RLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLP
QSREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSL
TLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNEMKICSAII
NLFHLIPAAPQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEAT
LNDPQWSRMFMSFLKHKDARPLRDVLAANPNRFITLLLPGGAQTAVRPGSPSTSTMRLDL
QFQAIKIISIIVKNDDSWLASQHSLVSQLRRVWVSENFQERHRKENMAATNWKEPKLLAY
CLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKNYSIAQKRALFFRFVD
FNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLDP
EKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLSKACVDPA
CKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDG
HQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSAMQRLGFTPSV
TIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSVSSSIKRGLSVDSAQEV
KRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTNTAGSP
GEVLSRRCVNLLKTALRPDMWPKSELKLQWFDKLLMTVEQPNQVNYGNICTGLEVLSFLL
TVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLMSIFPTEPSTSSVASKYEE
LECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQ
KMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKS
PDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFL
DLVNYVYRDETLSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVT
CSQNWEAMGNHFWIKQCIELLLAVCEKSTPIGTSCQGAMLPSITNVINLADSHDRAAFAM
VTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTPKTKELSEKDIGNQLHMLTNRHDKF
LDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCS
GSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKG
LSLQIKPKQTTEFYEQESITPPQQEILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAI
AYEQHGFFEQAQESYEKAMDKAKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALT
EYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEE
QQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNL
GRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVTAYENSSQHDPSSNN
AMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIRQQVKCYLQL
AGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAAVQMH
DVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFD
DDKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPI
RTLYLTLKIEQRERYKSDPGPIRATAPMWRCSRIMHMQRELHPTLLSSLEGIVDQMVWFR
ENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLVSTFGVGLENVSNVS
TMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKLKKWIKILE
AKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRVEIVQKH
NTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLFF
TVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQA
SHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLN
RLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLT
ASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDSQQLVS
LVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMDPAWHPWL
Sequence of entity 2 (A, C, E), FASTA
>8XVG_2 RuvB-like 1 (chains A, C, E)
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Sequence of entity 3 (B, D, F), FASTA
>8XVG_3 RuvB-like 2 (chains B, D, F)
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
Sequence of entity 4 (G), FASTA
>8XVG_4 DNA methyltransferase 1-associated protein 1 (chains G)
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYAL
LYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEE
GKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDH
QQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQ
VAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAE
KPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEEL
VHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAE
PAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
Sequence of entity 5 (H), FASTA
>8XVG_5 Isoform 2 of E1A-binding protein p400 (chains H)
MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQ
LMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSY
IQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQI
SLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQ
SPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGV
LLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPE
MAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQ
NDLDIEEEEEEEEEEEEKSEVINDEQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQ
SKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPST
GPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPN
VPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPR
PLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSP
AQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLL
EEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTARE
IECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGR
KRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLP
SSQWPRPKPDGEDTSGEEDADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKD
IADVTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILAD
EAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHR
ELKAKRQEWAEPNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVF
TLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRL
HRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVN
VLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLI
GLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGR
TVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRH
QPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQA
RLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGS
VLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAV
NALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICA
LPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIP
PVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFD
SGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQEL
MRSFNRDRRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDI
HIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFP
VKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSD
SENMPCDEEPSQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAW
EFWNLKTLQEREARLRLEQEEAELLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQD
DSDIYLDSVMCLMYEATPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRS
LFDRATPGLLKIRREGKEQKKNILLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWAL
LQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGK
SKNNRPLRTSQIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHAS
VLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQ
PPPPLPQPQAAGSQPPAGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTI
KTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVH
TQPPPRAVGSPATATPDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQA
TGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQI
QGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQ
QQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKP
PVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQ
QKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQ
QVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTAT
AQVVQQKLIQQQVVTTASAPLQTPGAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKP
PCQ
Sequence of entity 6 (I, J), FASTA
>8XVG_6 Actin-like protein 6A (chains I, J)
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP
Sequence of entity 7 (K), FASTA
>8XVG_7 ACTB protein (Fragment) (chains K)
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Sequence of entity 8 (M), FASTA
>8XVG_8 Isoform 2 of Enhancer of polycomb homolog 1 (chains M)
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIP
IIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAA
LPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQT
GNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHH
LDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSD
NDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQK
QQLAQIQQQQANSNSSTNTSQGFVSKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIG
VNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAAN
SATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVP
SSSSVDSVPRENHESEKPALNNIADNTVAMEVT
Sequence of entity 9 (N), FASTA
>8XVG_9 Vacuolar protein sorting-associated protein 72 homolog (chains N)
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 9 |
Primary citation
Structure of the human TIP60 complex. Chen, K., Wang, L., Yu, Z. et al. Nat Commun (2024) 15:7092-7092. DOI 10.1038/s41467-024-51259-z · PubMed
Other PDB entries of the same protein (UniProt Q9Y4A5), best resolution first:
- 9CAF 2.35 Å, Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite…
- 9RDK 2.41 Å, Cryo-EM structure of the human SAGA co-activator complex
- 7KTR 2.93 Å, Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core)
- 9CAD 3.05 Å, Cryo-EM structure of the TRRAP lobe of the native human TIP60 complex (composite…
- 8XVV 3.2 Å, The TRRAP module of human NuA4/TIP60 complex
- 9C47 3.4 Å, TRRAP module of the human TIP60 complex
- 8QRI 3.5 Å, TRRAP and EP400 in the human Tip60 complex
- 8H7G 3.7 Å, Cryo-EM structure of the human SAGA complex
Browse structure collections
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