7M98: ATAD2 bromodomain

ATAD2 bromodomain complexed with histone H4K5ac (res 1-10) ligand. Determined by X-ray diffraction at 1.6 Å resolution. Released 22 Sept 2021.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,406
Mol. weight: 19.19 kDa
Released: 22 Sept 2021

Explore 7M98 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7M98 contains 7 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	980-1002	23
α-helix	1004-1009	6
α-helix	1021-1024	4
α-helix	1031-1039	9
α-helix	1046-1063	18
α-helix	1069-1092	24
α-helix	1095-1108	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ATPase family AAA domain-containing protein 2	A	protein	152	Homo sapiens	Q6PL18 (AlphaFold model)
Histone H4	B	protein	15	Homo sapiens	P62805 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7M98_1 ATPase family AAA domain-containing protein 2 (chains A)
GPLGSEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD
YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
LRDTAYAIIKEELDEDFEQLAEEIQESRKKRG

Sequence of entity 2 (B), FASTA

>7M98_2 Histone H4 (chains B)
SGRGKGGKGLGKGGA

Primary citation

Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain. Evans, C.M., Phillips, M., Malone, K.L. et al. Int J Mol Sci (2021) 22. DOI 10.3390/ijms22179128 · PubMed

Other PDB entries of the same protein (UniProt Q6PL18 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5R4V 1.29 Å, XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in…
7Z9H 1.34 Å, ATAD2 in complex with PepLite-Asp
7Z9N 1.34 Å, ATAD2 in complex with PepLite-Val
7PPX 1.35 Å, ATAD2 in complex with FragLite3
8RU5 1.36 Å, ATPase family AAA domain containing 2 with crystallization epitope mutations V1022R:Q1027E
5R4X 1.4 Å, XChem fragment screen -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2 in…
5QXN 1.41 Å, PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with DF826
5QXP 1.41 Å, PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with TCJ732
7QYK 1.43 Å, ATAD2 in complex with FragLite18
7R0Y 1.43 Å, ATAD2 in complex with PepLite-Glu
5R4F 1.44 Å, PanDDA analysis group deposition of ground-state model of ATAD2
7QYL 1.44 Å, ATAD2 in complex with FragLite23

Browse structure collections

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