Histone H4 (H4C1) is a 103-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62805.
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The mean pLDDT of this model is 89.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:36435862). The octamer wraps approximately 147 bp of DNA. Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (PubMed:33857403). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3F9X | X-ray | 1.25 Å | E/F/G/H=16-25 |
| 8PEF | X-ray | 1.28 Å | B=10-26 |
| 5TEG | X-ray | 1.3 Å | D/E=17-24 |
| 3UVW | X-ray | 1.37 Å | B=2-12 |
| 8UK5 | X-ray | 1.4 Å | B=2-15 |
| 1ZKK | X-ray | 1.45 Å | E/F/G/H=16-25 |
| 4YY6 | X-ray | 1.45 Å | Z=2-12 |
| 2BQZ | X-ray | 1.5 Å | B/F=18-26 |
| 3F9Y | X-ray | 1.5 Å | E/F=16-25 |
| 3QZT | X-ray | 1.5 Å | B=13-22 |
| 4YYI | X-ray | 1.5 Å | C/F=2-12 |
| 4YYM | X-ray | 1.5 Å | Z=2-12 |
| 5FFW | X-ray | 1.5 Å | C=2-11 |
| 4YYD | X-ray | 1.52 Å | Z=2-12 |
| 8B5C | X-ray | 1.58 Å | B=2-13 |
| 3F9W | X-ray | 1.6 Å | E/F/G/H=16-25 |
| 3F9Z | X-ray | 1.6 Å | E/F/G/H=16-25 |
| 6RXS | X-ray | 1.6 Å | B=13-23 |
| 6VO5 | X-ray | 1.6 Å | C/D=2-21 |
| 7M98 | X-ray | 1.6 Å | B=2-16 |
Showing 20 of 618 experimental structures (best resolution first).
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