7OB9: Human RNA Polymerase I in elongation state

Cryo-EM structure of human RNA Polymerase I in elongation state. Determined by electron microscopy at 2.7 Å resolution. Released 8 Dec 2021.

Method: Electron microscopy
Resolution: 2.7 Å
Organism: Homo sapiens
Chains: 16
Atoms: 36,345
Mol. weight: 639.02 kDa
Ligands: MG, ZN
Released: 8 Dec 2021

Explore 7OB9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OB9 contains 198 α-helices and 229 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 83 helices, 64 β-strands

Element	Residues	Length	Sheet
β-strand	12-19	8	1
α-helix	22-28	7
β-strand	31-32	2	2
β-strand	35	1	3
β-strand	39	1	4
β-strand	45	1	4
α-helix	46	1
β-strand	49	1	3
β-strand	79-88	10	2
α-helix	93-101	9
β-strand	103	1	5
β-strand	110	1	5
α-helix	114-128	15
α-helix	134-148	15
α-helix	150-152	3
α-helix	161-171	11
α-helix	182-194	13
α-helix	195-199	5
β-strand	215-218	4	6
β-strand	222-225	4	6
β-strand	255-256	2	6
α-helix	258-279	22
α-helix	294-297	4
β-strand	298-304	7	2
α-helix	305-306	2
α-helix	307-309	3
α-helix	323-345	23
α-helix	387-402	16
α-helix	417-421	5
α-helix	428-431	4
β-strand	435-437	3	7
β-strand	440-447	8	8
β-strand	455-459	5	8
α-helix	460-463	4
β-strand	467-471	5	9
α-helix	477-486	10
β-strand	494-498	5	9
β-strand	504-506	3	9
α-helix	507-508	2
α-helix	512-521	10
β-strand	537-541	5	9
α-helix	542	1
β-strand	547-551	5	8
α-helix	558-560	3
β-strand	561-569	9	8
β-strand	575-577	3	8
α-helix	579-581	3
α-helix	582-585	4
β-strand	593-597	5	8
α-helix	602-610	9
β-strand	613	1	8
α-helix	614-616	3
β-strand	619	1	10
β-strand	626	1	10
α-helix	632-641	10
β-strand	647-648	2	11
α-helix	650-660	11
α-helix	667-669	3
β-strand	675-677	3	12
β-strand	681	1	12
β-strand	682-683	2	11
α-helix	684-693	10
α-helix	701-703	3
β-strand	705-707	3	13
α-helix	713-715	3
α-helix	720-724	5
α-helix	729-731	3
β-strand	737-740	4	13
β-strand	743-746	4	13
α-helix	761-768	8
α-helix	771-791	21
β-strand	804	1	14
α-helix	806-819	14
α-helix	824-831	8
α-helix	839-849	11
α-helix	857-880	24
β-strand	885	1	14
α-helix	893-899	7
α-helix	906-913	8
β-strand	918	1	15
β-strand	921	1	16
β-strand	924	1	16
α-helix	925-929	5
α-helix	945-948	4
β-strand	950	1	15
β-strand	954	1	17
β-strand	958	1	17
α-helix	961-996	36
β-strand	1000-1001	2	18
β-strand	1007-1008	2	18
β-strand	1014-1016	3	18
α-helix	1019-1021	3
β-strand	1024	1	19
α-helix	1026-1028	3
α-helix	1037-1041	5
α-helix	1044-1048	5
α-helix	1063-1078	16
α-helix	1088-1091	4
α-helix	1092-1096	5
α-helix	1098-1101	4
α-helix	1115-1125	11
α-helix	1132-1137	6
α-helix	1140-1145	6
α-helix	1146-1149	4
α-helix	1161-1180	20
α-helix	1189-1202	14
β-strand	1204	1	19
α-helix	1205-1206	2
α-helix	1211-1220	10
α-helix	1222-1225	4
α-helix	1244-1249	6
α-helix	1250-1254	5
β-strand	1264-1267	4	20
β-strand	1268	1	21
α-helix	1269	1
α-helix	1272-1285	14
β-strand	1289	1	22
α-helix	1290-1293	4
β-strand	1294-1299	6	23
β-strand	1302-1304	3	24
β-strand	1312-1314	3	24
β-strand	1317-1321	5	23
α-helix	1324-1326	3
α-helix	1335-1341	7
α-helix	1342-1346	5
α-helix	1347-1358	12
α-helix	1500-1506	7
β-strand	1514-1517	4	23
β-strand	1524-1528	5	23
β-strand	1531-1532	2	24
α-helix	1540-1550	11
β-strand	1552	1	22
β-strand	1559-1566	8	20
β-strand	1577-1582	6	20
α-helix	1585-1587	3
β-strand	1595	1	21
α-helix	1597-1599	3
β-strand	1601-1602	2	20
α-helix	1605-1611	7
α-helix	1614-1629	16
α-helix	1638-1648	11
α-helix	1662-1664	3
α-helix	1668-1674	7
α-helix	1677-1687	11
β-strand	1690-1691	2	1
α-helix	1696-1701	6
β-strand	1713-1718	6	25

Chain B: 46 helices, 70 β-strands

Element	Residues	Length	Sheet
α-helix	27-28	2
α-helix	33-36	4
α-helix	40-60	21
α-helix	62-63	2
β-strand	64-67	4	26
β-strand	72-83	12	26
α-helix	84-85	2
β-strand	86	1	27
α-helix	87-88	2
β-strand	97	1	27
α-helix	100-105	6
β-strand	111	1	28
β-strand	113-122	10	26
β-strand	125-135	11	26
β-strand	138	1	28
β-strand	140	1	29
α-helix	153-158	6
α-helix	161-162	2
β-strand	169-172	4	29
β-strand	175-178	4	29
β-strand	181-185	5	30
α-helix	186	1
β-strand	191-194	4	31
α-helix	196-200	5
β-strand	205-215	11	31
β-strand	221-229	9	31
β-strand	234-239	6	31
β-strand	244-248	5	31
α-helix	249-256	8
α-helix	261-268	8
α-helix	276-291	16
α-helix	297-307	11
α-helix	320-330	11
α-helix	339-357	19
α-helix	363-365	3
α-helix	369-371	3
β-strand	372-375	4	30
α-helix	377-405	29
α-helix	428-436	9
β-strand	455-456	2	29
α-helix	462-465	4
α-helix	466-468	3
β-strand	471-473	3	30
α-helix	477-480	4
α-helix	491-493	3
β-strand	497	1	32
β-strand	511-513	3	30
β-strand	514	1	32
β-strand	519-520	2	33
α-helix	530-536	7
β-strand	540-541	2	34
α-helix	550-552	3
β-strand	553-558	6	34
β-strand	562-567	6	34
α-helix	571-584	14
β-strand	594-598	5	34
α-helix	607-608	2
β-strand	609-613	5	34
β-strand	619-625	7	33
β-strand	630-635	6	33
α-helix	636-639	4
β-strand	658-660	3	33
α-helix	671-673	3
α-helix	677-679	3
α-helix	682-691	10
β-strand	695	1	35
β-strand	712-714	3	36
β-strand	718	1	37
β-strand	722-723	2	38
α-helix	726-729	4
α-helix	732-734	3
β-strand	738-741	4	39
β-strand	743-745	3	40
β-strand	757-760	4	40
α-helix	761-765	5
β-strand	771-780	10	36
β-strand	792-794	3	41
β-strand	818-819	2	36
β-strand	824-830	7	41
β-strand	836-840	5	41
β-strand	847-855	9	36
β-strand	866-873	8	36
β-strand	882-884	3	39
β-strand	890-892	3	39
β-strand	893-897	5	40
β-strand	913-915	3	40
α-helix	917-919	3
α-helix	927-941	15
β-strand	945-946	2	38
α-helix	958-968	11
β-strand	976-977	2	42
β-strand	980	1	43
β-strand	987	1	43
α-helix	988	1
β-strand	992-993	2	42
β-strand	994	1	40
β-strand	997-1001	5	39
β-strand	1002	1	35
α-helix	1006-1008	3
β-strand	1011-1013	3	8
β-strand	1018	1	44
β-strand	1025	1	44
β-strand	1027	1	45
β-strand	1034	1	45
β-strand	1035-1037	3	7
α-helix	1039-1046	8
α-helix	1051-1055	5
α-helix	1056-1060	5
β-strand	1065-1070	6	46
β-strand	1075	1	46
β-strand	1079-1081	3	47
α-helix	1082-1084	3
β-strand	1096-1098	3	47
β-strand	1107-1112	6	46
α-helix	1114-1124	11
β-strand	1128-1134	7	1

Chain C: 15 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	42-48	7
β-strand	50-57	8	48
β-strand	60-66	7	48
α-helix	70-82	13
β-strand	86-97	12	49
α-helix	103-111	9
α-helix	114	1
β-strand	115-116	2	50
α-helix	119-121	3
α-helix	124-126	3
β-strand	138-145	8	49
β-strand	147-148	2	51
α-helix	159-162	4
β-strand	163-164	2	51
β-strand	167-168	2	52
α-helix	170-172	3
β-strand	173-175	3	49
α-helix	181-184	4
β-strand	191-192	2	50
β-strand	200-201	2	52
β-strand	207-217	11	49
α-helix	223-225	3
β-strand	228-232	5	48
β-strand	235-241	7	48
β-strand	246	1	53
α-helix	248-255	8
β-strand	262-266	5	53
β-strand	271-275	5	53
α-helix	278-280	3
α-helix	286-288	3
α-helix	293-295	3
β-strand	297-312	16	48
α-helix	318-343	26

Chain E: 12 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	6-23	18
β-strand	26	1	54
α-helix	30-33	4
α-helix	37-43	7
β-strand	60-63	4	55
β-strand	64	1	54
β-strand	71-75	5	55
α-helix	84-96	13
β-strand	101-106	6	55
α-helix	109-111	3
α-helix	112-120	9
β-strand	126-131	6	55
α-helix	133-135	3
α-helix	139-141	3
β-strand	147-150	4	56
α-helix	151-152	2
α-helix	153-162	10
β-strand	172-173	2	56
α-helix	178-183	6
α-helix	185-186	2
β-strand	190-196	7	56
β-strand	202-209	8	56

Chain F: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	57
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-98	10
α-helix	104	1
β-strand	105-108	4	25
β-strand	117-119	3	25
α-helix	120-122	3
β-strand	124	1	57

Chain G: 4 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	30-32	3
α-helix	35-40	6
β-strand	50-59	10	25
α-helix	61-63	3
α-helix	67-78	12
β-strand	83	1	58
β-strand	88	1	58
β-strand	89-105	17	25
β-strand	112-123	12	25
β-strand	130-138	9	59
β-strand	143-147	5	59
β-strand	151-155	5	59
β-strand	176-180	5	59
β-strand	183	1	59
β-strand	195	1	59

Chain H: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	4-15	12	12
β-strand	25-32	8	12
β-strand	38-44	7	12
β-strand	55-61	7	12
α-helix	85-87	3
β-strand	90-92	3	12
β-strand	94-101	8	12
β-strand	112-118	7	12
β-strand	121-126	6	12
β-strand	140-147	8	12

Chain I: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	14	1	60
β-strand	19	1	61
α-helix	25	1
β-strand	26	1	61
α-helix	27-30	4
β-strand	35-37	3	62
α-helix	38	1
β-strand	44-46	3	62
α-helix	47-52	6
β-strand	54	1	24
β-strand	57-60	4	23

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA1	A	protein	1720	Homo sapiens	O95602 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA2	B	protein	1135	Homo sapiens	Q9H9Y6 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase I subunit RPA43	G	protein	338	Homo sapiens	Q3B726
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase I subunit RPA12	I	protein	126	Homo sapiens	Q9P1U0
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803
DNA-directed RNA polymerase I subunit RPA34	N	protein	510	Homo sapiens	O15446

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7OB9_1 DNA-directed RNA polymerase I subunit RPA1 (chains A)
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR

Sequence of entity 2 (B), FASTA

>7OB9_2 DNA-directed RNA polymerase I subunit RPA2 (chains B)
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

Sequence of entity 3 (C), FASTA

>7OB9_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (E), FASTA

>7OB9_4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 5 (F), FASTA

>7OB9_5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 6 (G), FASTA

>7OB9_6 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALS
PRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADF
VIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFE
VFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEV
DSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSS
GYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL

Sequence of entity 7 (H), FASTA

>7OB9_7 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 8 (I), FASTA

>7OB9_8 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVV
FHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKF
QEKEDS

Sequence of entity 9 (J), FASTA

>7OB9_9 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 10 (K), FASTA

>7OB9_10 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 11 (L), FASTA

>7OB9_11 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 12 (N), FASTA

>7OB9_12 DNA-directed RNA polymerase I subunit RPA34 (chains N)
MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRH
VPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEG
PQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQ
VTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLE
PLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGME
PEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESP
GGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTS
TKKKKKKKERGHTVTEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEE
MPGPPLNSESGEEAPTGRDKKRKQQQQQPV

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	6

Primary citation

Cryo-EM structures of human RNA polymerase I. Misiaszek, A.D., Girbig, M., Grotsch, H. et al. Nat Struct Mol Biol (2021) 28:997-1008. DOI 10.1038/s41594-021-00693-4 · PubMed

Other PDB entries of the same protein (UniProt O95602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7VBB 2.81 Å, Structure of the post state human RNA Polymerase I Elongation Complex
7VBA 2.89 Å, Structure of the pre state human RNA Polymerase I Elongation Complex
7VBC 3.01 Å, Back track state of human RNA Polymerase I Elongation Complex
7OBA 3.1 Å, Cryo-EM structure of human RNA Polymerase I in complex with RRN3
7OBB 3.3 Å, Cryo-EM structure of human RNA Polymerase I Open Complex
8A43 4.09 Å, Human RNA polymerase I

Browse structure collections

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