7OBB: Human RNA Polymerase I Open Complex

Cryo-EM structure of human RNA Polymerase I Open Complex. Determined by electron microscopy at 3.3 Å resolution. Released 8 Dec 2021.

Method: Electron microscopy
Resolution: 3.3 Å
Organism: Homo sapiens
Chains: 15
Atoms: 33,048
Mol. weight: 629.78 kDa
Ligands: ZN
Released: 8 Dec 2021

Explore 7OBB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7OBB contains 166 α-helices and 240 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 79 helices, 62 β-strands

Element	Residues	Length	Sheet
β-strand	14-19	6	1
α-helix	22-28	7
β-strand	32	1	2
β-strand	39	1	3
α-helix	44	1
β-strand	45	1	3
α-helix	46	1
β-strand	80-88	9	2
α-helix	93-100	8
β-strand	103	1	4
β-strand	110	1	4
α-helix	114-129	16
α-helix	137-148	12
α-helix	159-170	12
α-helix	182-197	16
β-strand	215-218	4	5
β-strand	222-225	4	5
β-strand	255	1	5
α-helix	258-279	22
β-strand	298-303	6	2
α-helix	304-306	3
α-helix	323-344	22
α-helix	388-402	15
α-helix	417-421	5
β-strand	436-437	2	6
β-strand	440-444	5	7
β-strand	445-447	3	8
β-strand	455	1	7
β-strand	457	1	8
β-strand	458-459	2	9
α-helix	460-465	6
β-strand	467-470	4	10
α-helix	477-486	10
β-strand	497-498	2	10
β-strand	504	1	10
α-helix	512-519	8
β-strand	537-541	5	10
α-helix	542	1
β-strand	547-551	5	7
α-helix	558-560	3
β-strand	561-565	5	7
α-helix	566	1
β-strand	568-569	2	9
β-strand	575-577	3	8
α-helix	581-583	3
β-strand	593-597	5	7
α-helix	603-610	8
β-strand	613	1	7
β-strand	619	1	11
β-strand	626	1	11
α-helix	634-641	8
α-helix	650-660	11
β-strand	675-677	3	12
β-strand	681	1	12
α-helix	684-695	12
α-helix	701-704	4
β-strand	717	1	13
α-helix	720-722	3
β-strand	740	1	14
β-strand	743	1	14
α-helix	751-754	4
α-helix	761-764	4
α-helix	772-786	15
β-strand	804	1	15
α-helix	810-813	4
α-helix	818-820	3
α-helix	825-831	7
α-helix	839-849	11
α-helix	858-865	8
α-helix	872-880	9
β-strand	885	1	15
α-helix	893-899	7
α-helix	908-913	6
β-strand	921	1	16
β-strand	924	1	16
α-helix	926-928	3
α-helix	945-948	4
α-helix	961-980	20
α-helix	987-994	8
α-helix	1000	1
β-strand	1001	1	17
α-helix	1002	1
β-strand	1007-1008	2	17
β-strand	1014-1016	3	17
α-helix	1019-1021	3
β-strand	1024	1	18
α-helix	1027-1032	6
α-helix	1034-1036	3
α-helix	1037-1041	5
α-helix	1044-1048	5
α-helix	1063-1078	16
α-helix	1088-1096	9
α-helix	1098-1101	4
α-helix	1107-1109	3
α-helix	1115-1122	8
α-helix	1123-1127	5
α-helix	1134-1137	4
α-helix	1142-1145	4
α-helix	1161-1179	19
α-helix	1189-1202	14
β-strand	1204	1	18
α-helix	1205-1206	2
α-helix	1211-1217	7
α-helix	1245-1248	4
α-helix	1249-1253	5
β-strand	1264-1265	2	19
β-strand	1267	1	20
β-strand	1268	1	21
α-helix	1272-1284	13
β-strand	1289	1	22
α-helix	1290-1292	3
β-strand	1294-1301	8	23
β-strand	1304-1305	2	24
β-strand	1311-1313	3	24
β-strand	1315-1321	7	23
α-helix	1322-1323	2
α-helix	1324-1326	3
α-helix	1335-1341	7
α-helix	1342-1346	5
α-helix	1347-1358	12
β-strand	1371	1	25
α-helix	1502-1506	5
β-strand	1512-1517	6	23
β-strand	1524-1529	6	23
β-strand	1531-1532	2	24
α-helix	1537-1538	2
α-helix	1540-1547	8
β-strand	1551	1	22
β-strand	1566	1	20
β-strand	1577	1	20
β-strand	1595	1	21
α-helix	1597-1599	3
β-strand	1601-1602	2	19
α-helix	1605-1611	7
α-helix	1621-1631	11
α-helix	1638-1648	11
α-helix	1659-1664	6
α-helix	1668-1674	7
α-helix	1677-1685	9
β-strand	1690	1	1
β-strand	1713-1718	6	26

Chain B: 45 helices, 70 β-strands

Element	Residues	Length	Sheet
α-helix	27-28	2
α-helix	37-39	3
α-helix	40-47	8
α-helix	48-52	5
α-helix	53-57	5
β-strand	64-68	5	27
β-strand	71-75	5	27
β-strand	77-82	6	28
α-helix	83-85	3
β-strand	86	1	29
α-helix	87-88	2
β-strand	97	1	29
α-helix	100-105	6
β-strand	111-118	8	28
β-strand	121-122	2	27
β-strand	125-126	2	27
β-strand	130-138	9	28
β-strand	140	1	30
α-helix	153-157	5
β-strand	170-172	3	30
β-strand	175-179	5	30
α-helix	180	1
β-strand	181-185	5	31
α-helix	186	1
β-strand	187	1	32
β-strand	191-194	4	32
α-helix	196-201	6
β-strand	205	1	33
β-strand	208-216	9	32
β-strand	220-226	7	32
β-strand	227-228	2	25
β-strand	229	1	33
β-strand	234-239	6	25
β-strand	244-248	5	25
α-helix	249-256	8
α-helix	261-268	8
α-helix	276-290	15
α-helix	297-307	11
α-helix	339-357	19
α-helix	362-365	4
α-helix	369-371	3
β-strand	372-375	4	31
α-helix	377-404	28
α-helix	428-436	9
β-strand	454-456	3	30
α-helix	462-467	6
β-strand	471-473	3	31
α-helix	485-487	3
α-helix	491-493	3
β-strand	494	1	34
β-strand	497	1	34
β-strand	511-513	3	31
β-strand	519-520	2	35
α-helix	530-536	7
β-strand	540-541	2	36
α-helix	549	1
β-strand	553-558	6	36
β-strand	561-567	7	36
α-helix	568-570	3
α-helix	572-583	12
β-strand	594-598	5	36
β-strand	609-613	5	36
β-strand	619-625	7	35
β-strand	630-635	6	35
β-strand	658-659	2	35
α-helix	670-672	3
α-helix	682-691	10
β-strand	695-696	2	37
β-strand	712-714	3	38
β-strand	722-723	2	39
α-helix	726-729	4
α-helix	732-734	3
β-strand	738-745	8	37
β-strand	756-760	5	37
α-helix	761-766	6
β-strand	771-780	10	38
β-strand	792-794	3	40
α-helix	801-803	3
β-strand	807	1	41
β-strand	813	1	41
α-helix	814	1
β-strand	818-819	2	38
β-strand	824-826	3	42
β-strand	828-830	3	40
β-strand	836	1	40
β-strand	839-840	2	42
β-strand	847-853	7	38
β-strand	854-855	2	43
β-strand	866-873	8	38
β-strand	882-884	3	37
β-strand	891-897	7	37
α-helix	899-901	3
β-strand	913-915	3	37
α-helix	926-939	14
β-strand	945-946	2	39
α-helix	958-968	11
β-strand	976-977	2	37
β-strand	992-1002	11	37
β-strand	1012-1013	2	7
α-helix	1017	1
β-strand	1018	1	44
α-helix	1019	1
β-strand	1025	1	44
β-strand	1035-1036	2	6
α-helix	1039-1048	10
α-helix	1051-1055	5
α-helix	1056-1060	5
β-strand	1064-1070	7	45
β-strand	1079-1081	3	46
α-helix	1082-1085	4
β-strand	1096-1098	3	46
β-strand	1103	1	46
β-strand	1107-1113	7	45
α-helix	1114-1123	10
β-strand	1128-1133	6	1

Chain C: 14 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	42-48	7
β-strand	50	1	47
β-strand	53-55	3	48
β-strand	61	1	49
β-strand	62-63	2	48
β-strand	64-66	3	47
α-helix	70-82	13
β-strand	86-94	9	50
β-strand	95-97	3	51
α-helix	103-111	9
α-helix	114	1
β-strand	115	1	52
α-helix	119-121	3
α-helix	124-126	3
β-strand	138-140	3	50
β-strand	142	1	53
β-strand	143-145	3	51
β-strand	147-148	2	54
α-helix	159-162	4
β-strand	163-164	2	54
α-helix	170-172	3
β-strand	173	1	53
α-helix	181-184	4
β-strand	192	1	52
β-strand	207-209	3	51
β-strand	212-217	6	50
α-helix	223-225	3
β-strand	228-232	5	49
β-strand	235-238	4	47
β-strand	241	1	55
α-helix	247-254	8
β-strand	262-267	6	56
β-strand	270-275	6	56
α-helix	278-280	3
β-strand	297	1	55
β-strand	300-307	8	47
β-strand	309-312	4	49
α-helix	318-321	4
α-helix	323-343	21

Chain E: 9 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	4-18	15
α-helix	22-24	3
β-strand	26	1	57
α-helix	31-33	3
α-helix	38-42	5
β-strand	60-63	4	58
β-strand	64	1	57
β-strand	71-75	5	58
β-strand	81-82	2	59
α-helix	84-96	13
β-strand	101-105	5	58
β-strand	109-110	2	59
α-helix	112-119	8
β-strand	122	1	60
β-strand	125	1	60
β-strand	126-130	5	58
α-helix	139-141	3
β-strand	147-150	4	61
α-helix	153-161	9
β-strand	172-173	2	61
α-helix	178-182	5
β-strand	190-195	6	61
β-strand	203-209	7	61

Chain F: 2 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	62
α-helix	59-71	13
α-helix	89-99	11
β-strand	105-109	5	26
β-strand	115-119	5	26
β-strand	124	1	62

Chain G: 3 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	35-38	4
β-strand	49	1	63
β-strand	52	1	63
β-strand	57-58	2	26
α-helix	61-63	3
α-helix	68-76	9
β-strand	89-98	10	63
β-strand	102-105	4	26
β-strand	113-114	2	26
β-strand	116-123	8	63
β-strand	134-138	5	64
β-strand	142-147	6	64
β-strand	151-156	6	64
β-strand	183-186	4	65
β-strand	192-195	4	65

Chain H: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	12
β-strand	20	1	13
β-strand	26-32	7	12
β-strand	38-43	6	12
β-strand	55-61	7	12
α-helix	85-87	3
β-strand	90-99	10	12
β-strand	102	1	66
β-strand	111	1	66
β-strand	112-118	7	12
β-strand	121-127	7	12
β-strand	141-147	7	12

Chain I: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	12-14	3	67
β-strand	19	1	68
α-helix	25	1
β-strand	26	1	68
α-helix	27-30	4
β-strand	35-37	3	69
β-strand	44-46	3	69
α-helix	47-52	6
β-strand	55-60	6	23
β-strand	82-83	2	70
β-strand	95-100	6	70
β-strand	110-115	6	70
β-strand	123-124	2	70

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA1	A	protein	1720	Homo sapiens	O95602 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA2	B	protein	1135	Homo sapiens	Q9H9Y6 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase I subunit RPA43	G	protein	338	Homo sapiens	Q3B726
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase I subunit RPA12	I	protein	126	Homo sapiens	Q9P1U0
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803
DNA-directed RNA polymerase I subunit RPA49	M	protein	419	Homo sapiens	Q9GZS1

3 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7OBB_1 DNA-directed RNA polymerase I subunit RPA1 (chains A)
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR

Sequence of entity 2 (B), FASTA

>7OBB_2 DNA-directed RNA polymerase I subunit RPA2 (chains B)
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

Sequence of entity 3 (C), FASTA

>7OBB_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (E), FASTA

>7OBB_4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 5 (F), FASTA

>7OBB_5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 6 (G), FASTA

>7OBB_6 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALS
PRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADF
VIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFE
VFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEV
DSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSS
GYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL

Sequence of entity 7 (H), FASTA

>7OBB_7 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 8 (I), FASTA

>7OBB_8 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVV
FHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKF
QEKEDS

Sequence of entity 9 (J), FASTA

>7OBB_9 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 10 (K), FASTA

>7OBB_10 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 11 (L), FASTA

>7OBB_11 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 12 (M), FASTA

>7OBB_12 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRIL
AAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVES
ELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKG
VTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTS
EEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGP
GVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRD
LKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7

Primary citation

Cryo-EM structures of human RNA polymerase I. Misiaszek, A.D., Girbig, M., Grotsch, H. et al. Nat Struct Mol Biol (2021) 28:997-1008. DOI 10.1038/s41594-021-00693-4 · PubMed

Other PDB entries of the same protein (UniProt O95602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7OB9 2.7 Å, Cryo-EM structure of human RNA Polymerase I in elongation state
7VBB 2.81 Å, Structure of the post state human RNA Polymerase I Elongation Complex
7VBA 2.89 Å, Structure of the pre state human RNA Polymerase I Elongation Complex
7VBC 3.01 Å, Back track state of human RNA Polymerase I Elongation Complex
7OBA 3.1 Å, Cryo-EM structure of human RNA Polymerase I in complex with RRN3
8A43 4.09 Å, Human RNA polymerase I

Browse structure collections

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