7PEQ: Nuclear pore complex protein Nup133
Model of the outer rings of the human nuclear pore complex. Determined by electron microscopy at 35.0 Å resolution. Released 20 Oct 2021.
- Method
- Electron microscopy
- Resolution
- 35.0 Å
- Organism
- Homo sapiens
- Chains
- 36
- Atoms
- 91,352
- Mol. weight
- 2933.05 kDa
- Released
- 20 Oct 2021
Explore 7PEQ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7PEQ contains 702 α-helices and 717 β-strands across 36 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains AC and BC: 32 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 519-530 | 12 | |
| α-helix | 531-533 | 3 | |
| α-helix | 537-549 | 13 | |
| α-helix | 558-571 | 14 | |
| α-helix | 597-618 | 22 | |
| α-helix | 639-656 | 18 | |
| α-helix | 660-673 | 14 | |
| α-helix | 687-690 | 4 | |
| α-helix | 693-707 | 15 | |
| α-helix | 722-741 | 20 | |
| α-helix | 743-745 | 3 | |
| α-helix | 776-789 | 14 | |
| α-helix | 791-794 | 4 | |
| α-helix | 797-822 | 26 | |
| α-helix | 830-851 | 22 | |
| α-helix | 857-865 | 9 | |
| α-helix | 870-879 | 10 | |
| α-helix | 883-891 | 9 | |
| α-helix | 897-905 | 9 | |
| α-helix | 922-930 | 9 | |
| α-helix | 937-942 | 6 | |
| α-helix | 946-959 | 14 | |
| α-helix | 964-980 | 17 | |
| α-helix | 985-1006 | 22 | |
| α-helix | 1010-1015 | 6 | |
| α-helix | 1028-1035 | 8 | |
| α-helix | 1045-1052 | 8 | |
| α-helix | 1053-1057 | 5 | |
| α-helix | 1066-1079 | 14 | |
| α-helix | 1096-1104 | 9 | |
| α-helix | 1125-1128 | 4 | |
| α-helix | 1142-1154 | 13 | |
Chain AD: 37 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 154-164 | 11 | |
| α-helix | 167-169 | 3 | |
| α-helix | 170-194 | 25 | |
| α-helix | 196 | 1 | |
| α-helix | 200-202 | 3 | |
| α-helix | 203-235 | 33 | |
| α-helix | 249-259 | 11 | |
| α-helix | 261-281 | 21 | |
| α-helix | 284-286 | 3 | |
| α-helix | 298-302 | 5 | |
| α-helix | 327-330 | 4 | |
| α-helix | 337-356 | 20 | |
| α-helix | 359-369 | 11 | |
| α-helix | 372-379 | 8 | |
| α-helix | 383-384 | 2 | |
| β-strand | 385 | 1 | 12 |
| β-strand | 399 | 1 | 12 |
| α-helix | 404-416 | 13 | |
| α-helix | 422-432 | 11 | |
| β-strand | 435 | 1 | 13 |
| α-helix | 445-467 | 23 | |
| α-helix | 489-499 | 11 | |
| α-helix | 505-509 | 5 | |
| α-helix | 511-521 | 11 | |
| α-helix | 524-534 | 11 | |
| α-helix | 546-560 | 15 | |
| α-helix | 566-583 | 18 | |
| α-helix | 586-588 | 3 | |
| α-helix | 590-593 | 4 | |
| α-helix | 668-680 | 13 | |
| α-helix | 685-701 | 17 | |
| α-helix | 705-714 | 10 | |
| α-helix | 720-723 | 4 | |
| α-helix | 738-767 | 30 | |
| α-helix | 770-772 | 3 | |
| α-helix | 782-821 | 40 | |
| α-helix | 840-867 | 28 | |
| α-helix | 871-875 | 5 | |
| α-helix | 877-880 | 4 | |
| α-helix | 894-914 | 21 | |
Chain AE: 32 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 336-343 | 8 | |
| β-strand | 346-350 | 5 | 14 |
| β-strand | 355-360 | 6 | 14 |
| α-helix | 387-399 | 13 | |
| α-helix | 417-438 | 22 | |
| α-helix | 441-445 | 5 | |
| α-helix | 452-457 | 6 | |
| α-helix | 458-460 | 3 | |
| α-helix | 463-472 | 10 | |
| α-helix | 477-482 | 6 | |
| α-helix | 491-503 | 13 | |
| α-helix | 513-521 | 9 | |
| α-helix | 531-533 | 3 | |
| α-helix | 536-538 | 3 | |
| α-helix | 544-552 | 9 | |
| α-helix | 562-571 | 10 | |
| α-helix | 611-618 | 8 | |
| α-helix | 626-634 | 9 | |
| α-helix | 642-653 | 12 | |
| α-helix | 662-679 | 18 | |
| α-helix | 683-690 | 8 | |
| α-helix | 695-708 | 14 | |
| α-helix | 727-729 | 3 | |
| α-helix | 733-747 | 15 | |
| α-helix | 750-753 | 4 | |
| α-helix | 755-758 | 4 | |
| α-helix | 767-774 | 8 | |
| α-helix | 775-777 | 3 | |
| α-helix | 784-800 | 17 | |
| α-helix | 809-825 | 17 | |
| α-helix | 835-847 | 13 | |
| α-helix | 849-852 | 4 | |
| α-helix | 859-869 | 11 | |
| α-helix | 916-920 | 5 | |
Chain AF: 4 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16 | 1 | 17 |
| β-strand | 20-21 | 2 | 18 |
| β-strand | 27-31 | 5 | 18 |
| β-strand | 32 | 1 | 17 |
| β-strand | 37-43 | 7 | 18 |
| β-strand | 46-53 | 8 | 18 |
| β-strand | 60-65 | 6 | 19 |
| α-helix | 68-70 | 3 | |
| β-strand | 74-78 | 5 | 19 |
| β-strand | 83-86 | 4 | 19 |
| β-strand | 89 | 1 | 20 |
| β-strand | 92 | 1 | 20 |
| β-strand | 95-99 | 5 | 19 |
| β-strand | 106-111 | 6 | 21 |
| β-strand | 119-124 | 6 | 21 |
| β-strand | 129-134 | 6 | 21 |
| β-strand | 140-142 | 3 | 21 |
| β-strand | 145 | 1 | 21 |
| β-strand | 153-158 | 6 | 22 |
| α-helix | 175-177 | 3 | |
| β-strand | 181-186 | 6 | 22 |
| β-strand | 193-196 | 4 | 22 |
| β-strand | 202-206 | 5 | 22 |
| β-strand | 215 | 1 | 23 |
| α-helix | 219 | 1 | |
| β-strand | 220 | 1 | 24 |
| α-helix | 221-223 | 3 | |
| β-strand | 230-234 | 5 | 24 |
| β-strand | 235 | 1 | 23 |
| β-strand | 239-245 | 7 | 24 |
| β-strand | 253-254 | 2 | 24 |
| β-strand | 257-260 | 4 | 24 |
| β-strand | 265-270 | 6 | 25 |
| β-strand | 277-281 | 5 | 25 |
| β-strand | 286-291 | 6 | 25 |
| β-strand | 297-302 | 6 | 25 |
Chain AG: 4 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 6-8 | 3 | 27 |
| β-strand | 15-17 | 3 | 28 |
| β-strand | 20 | 1 | 28 |
| β-strand | 26-31 | 6 | 28 |
| β-strand | 36-41 | 6 | 28 |
| β-strand | 47-53 | 7 | 28 |
| β-strand | 60-65 | 6 | 29 |
| β-strand | 73-78 | 6 | 29 |
| β-strand | 83-88 | 6 | 29 |
| β-strand | 100-105 | 6 | 29 |
| α-helix | 111-113 | 3 | |
| β-strand | 116-121 | 6 | 30 |
| α-helix | 124-126 | 3 | |
| β-strand | 129-134 | 6 | 30 |
| β-strand | 138-143 | 6 | 30 |
| β-strand | 154-160 | 7 | 30 |
| β-strand | 168-172 | 5 | 31 |
| β-strand | 181-186 | 6 | 31 |
| β-strand | 189 | 1 | 31 |
| β-strand | 191-194 | 4 | 31 |
| α-helix | 199-202 | 4 | |
| β-strand | 213-214 | 2 | 31 |
| β-strand | 222-228 | 7 | 32 |
| α-helix | 229 | 1 | |
| β-strand | 237-242 | 6 | 32 |
| β-strand | 247-250 | 4 | 32 |
| β-strand | 270-274 | 5 | 32 |
| β-strand | 283 | 1 | 33 |
| β-strand | 292-296 | 5 | 33 |
| β-strand | 302-307 | 6 | 33 |
| β-strand | 313-319 | 7 | 33 |
Chain AH: 33 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 23-26 | 4 | 44 |
| β-strand | 36 | 1 | 45 |
| β-strand | 37-40 | 4 | 44 |
| β-strand | 47-49 | 3 | 27 |
| β-strand | 51 | 1 | 45 |
| α-helix | 62-75 | 14 | |
| α-helix | 80-83 | 4 | |
| α-helix | 96-123 | 28 | |
| α-helix | 130-148 | 19 | |
| α-helix | 159-173 | 15 | |
| α-helix | 181-184 | 4 | |
| α-helix | 194-205 | 12 | |
| α-helix | 209-216 | 8 | |
| α-helix | 226-238 | 13 | |
| α-helix | 249-270 | 22 | |
| α-helix | 278-287 | 10 | |
| α-helix | 304-314 | 11 | |
| α-helix | 322-326 | 5 | |
| α-helix | 330-339 | 10 | |
| α-helix | 346-353 | 8 | |
| α-helix | 359-364 | 6 | |
| α-helix | 372-383 | 12 | |
| α-helix | 398-409 | 12 | |
| α-helix | 417-423 | 7 | |
| α-helix | 424-426 | 3 | |
| α-helix | 431-439 | 9 | |
| α-helix | 447-457 | 11 | |
| α-helix | 463-478 | 16 | |
| α-helix | 485-491 | 7 | |
| α-helix | 497-510 | 14 | |
| α-helix | 533-535 | 3 | |
| α-helix | 536-546 | 11 | |
| α-helix | 552-564 | 13 | |
| α-helix | 574-581 | 8 | |
| α-helix | 582-584 | 3 | |
| α-helix | 597-608 | 12 | |
| α-helix | 620-623 | 4 | |
| α-helix | 629-646 | 18 | |
Chain AI: 2 helices, 36 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-8 | 4 | 53 |
| β-strand | 12-18 | 7 | 54 |
| α-helix | 19-20 | 2 | |
| β-strand | 31-37 | 7 | 54 |
| β-strand | 42-43 | 2 | 55 |
| β-strand | 46-48 | 3 | 54 |
| β-strand | 66-69 | 4 | 54 |
| β-strand | 72-73 | 2 | 55 |
| β-strand | 79-82 | 4 | 56 |
| β-strand | 88-91 | 4 | 56 |
| β-strand | 97-99 | 3 | 56 |
| β-strand | 102-103 | 2 | 57 |
| β-strand | 108-109 | 2 | 57 |
| β-strand | 113-115 | 3 | 56 |
| α-helix | 132-133 | 2 | |
| β-strand | 134-137 | 4 | 58 |
| β-strand | 140 | 1 | 59 |
| β-strand | 143-145 | 3 | 59 |
| β-strand | 146-148 | 3 | 58 |
| β-strand | 152-157 | 6 | 59 |
| β-strand | 165-168 | 4 | 59 |
| β-strand | 177-182 | 6 | 60 |
| β-strand | 185-189 | 5 | 60 |
| β-strand | 195-197 | 3 | 60 |
| β-strand | 209-211 | 3 | 60 |
| β-strand | 222-225 | 4 | 61 |
| β-strand | 232-236 | 5 | 61 |
| β-strand | 241-246 | 6 | 61 |
| β-strand | 249 | 1 | 62 |
| β-strand | 251 | 1 | 62 |
| β-strand | 253-258 | 6 | 61 |
| β-strand | 264-269 | 6 | 63 |
| β-strand | 276-281 | 6 | 63 |
| β-strand | 286-290 | 5 | 63 |
| β-strand | 341-344 | 4 | 63 |
| β-strand | 353-359 | 7 | 53 |
| β-strand | 362-367 | 6 | 53 |
| β-strand | 371-375 | 5 | 53 |
Chain AJ: 35 helices, 36 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 88-94 | 7 | 66 |
| β-strand | 101-107 | 7 | 66 |
| β-strand | 112-115 | 4 | 66 |
| β-strand | 128-130 | 3 | 66 |
| β-strand | 145-146 | 2 | 67 |
| β-strand | 152-156 | 5 | 67 |
| β-strand | 161-165 | 5 | 67 |
| β-strand | 199 | 1 | 67 |
| β-strand | 202 | 1 | 67 |
| β-strand | 214 | 1 | 68 |
| β-strand | 218 | 1 | 69 |
| α-helix | 219-221 | 3 | |
| β-strand | 230-232 | 3 | 69 |
| β-strand | 233 | 1 | 68 |
| β-strand | 238-242 | 5 | 69 |
| β-strand | 245 | 1 | 70 |
| β-strand | 252 | 1 | 70 |
| β-strand | 255-257 | 3 | 69 |
| α-helix | 281-283 | 3 | |
| β-strand | 285-292 | 8 | 71 |
| β-strand | 297-303 | 7 | 71 |
| β-strand | 307-312 | 6 | 71 |
| β-strand | 318-323 | 6 | 71 |
| β-strand | 330-331 | 2 | 72 |
| β-strand | 336-337 | 2 | 72 |
| β-strand | 351 | 1 | 73 |
| β-strand | 356-358 | 3 | 73 |
| β-strand | 371-374 | 4 | 73 |
| β-strand | 384-385 | 2 | 73 |
| α-helix | 393-394 | 2 | |
| β-strand | 398-402 | 5 | 74 |
| β-strand | 405-411 | 7 | 74 |
| β-strand | 417-423 | 7 | 74 |
| β-strand | 430 | 1 | 74 |
| α-helix | 454-461 | 8 | |
| α-helix | 469-478 | 10 | |
| α-helix | 494-503 | 10 | |
| α-helix | 507-509 | 3 | |
| β-strand | 510 | 1 | 75 |
| β-strand | 515 | 1 | 75 |
| α-helix | 517-540 | 24 | |
| β-strand | 547 | 1 | 76 |
| β-strand | 558-560 | 3 | 76 |
| β-strand | 565-567 | 3 | 76 |
| α-helix | 573-577 | 5 | |
| α-helix | 605-615 | 11 | |
| α-helix | 619-630 | 12 | |
| α-helix | 655-662 | 8 | |
| α-helix | 669-678 | 10 | |
| α-helix | 711-741 | 31 | |
| α-helix | 763-781 | 19 | |
| α-helix | 823-827 | 5 | |
| α-helix | 860-869 | 10 | |
| α-helix | 878-887 | 10 | |
| α-helix | 892-898 | 7 | |
| α-helix | 907-920 | 14 | |
| α-helix | 923-933 | 11 | |
| α-helix | 940-942 | 3 | |
| α-helix | 944-952 | 9 | |
| α-helix | 961-973 | 13 | |
| α-helix | 977-988 | 12 | |
| α-helix | 998-1011 | 14 | |
| α-helix | 1017-1027 | 11 | |
| α-helix | 1031-1043 | 13 | |
| α-helix | 1047-1050 | 4 | |
| α-helix | 1054-1056 | 3 | |
| α-helix | 1059-1070 | 12 | |
| α-helix | 1079-1091 | 13 | |
| α-helix | 1098-1108 | 11 | |
| α-helix | 1116-1133 | 18 | |
| α-helix | 1177-1194 | 18 | |
23 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Nuclear pore complex protein Nup133 | AC, BC, CC, DC | protein | 1156 | Homo sapiens | Q8WUM0 (AlphaFold model) |
| Nuclear pore complex protein Nup107 | AD, BD, CD, DD | protein | 925 | Homo sapiens | P57740 (AlphaFold model) |
| Nuclear pore complex protein Nup96 | AE, BE, CE, DE | protein | 937 | Homo sapiens | P52948 (AlphaFold model) |
| Protein SEC13 homolog | AF, BF, CF, DF | protein | 322 | Homo sapiens | P55735 (AlphaFold model) |
| Nucleoporin SEH1 | AG, BG, CG, DG | protein | 360 | Homo sapiens | Q96EE3 |
| Nuclear pore complex protein Nup85 | AH, BH, CH, DH | protein | 656 | Homo sapiens | Q9BW27 |
| Nucleoporin Nup43 | AI, BI, CI, DI | protein | 380 | Homo sapiens | Q8NFH3 |
| Nuclear pore complex protein Nup160 | AJ, BJ, CJ, DJ | protein | 1436 | Homo sapiens | Q12769 |
| Nucleoporin Nup37 | AK, BK, CK, DK | protein | 326 | Homo sapiens | Q8NFH4 |
Sequence of entity 1 (AC, BC, CC, DC), FASTA
>7PEQ_1 Nuclear pore complex protein Nup133 (chains AC, BC, CC, DC)
MFPAAPSPRTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGRRSSLSS
RGTPTRMFPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVDDQLTINIDEGGWACLVCK
EKLIIWKIALSPITKLSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATR
EGSIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGKI
HQHILPQGQGMLSGIGRKVSSLFGILSPSSDLTLSSVLWDRERSSFYSLTSSNISKWELD
DSSEKHAYSWDINRALKENITDAIWGSESNYEAIKEGVNIRYLDLKQNCDGLVILAAAWH
SADNPCLIYYSLITIEDNGCQMSDAVTVEVTQYNPPFQSEDLILCQLTVPNFSNQTAYLY
NESAVYVCSTGTGKFSLPQEKIVFNAQGDSVLGAGACGGVPIIFSRNSGLVSITSRENVS
ILAEDLEGSLASSVAGPNSESMIFETTTKNETIAQEDKIKLLKAAFLQYCRKDLGHAQMV
VDELFSSHSDLDSDSELDRAVTQISVDLMDDYPASDPRWAESVPEEAPGFSNTSLIILHQ
LEDKMKAHSFLMDFIHQVGLFGRLGSFPVRGTPMATRLLLCEHAEKLSAAIVLKNHHSRL
SDLVNTAILIALNKREYEIPSNLTPADVFFREVSQVDTICECLLEHEEQVLRDAPMDSIE
WAEVVINVNNILKDMLQAASHYRQNRNSLYRREESLEKEPEYVPWTATSGPGGIRTVIIR
QHEIVLKVAYPQADSNLRNIVTEQLVALIDCFLDGYVSQLKSVDKSSNRERYDNLEMEYL
QKRSDLLSPLLSLGQYLWAASLAEKYCDFDILVQMCEQTDNQSRLQRYMTQFADQNFSDF
LFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHATLLGLANME
TRYFAKKKTLLGLSKLAALASDFSEDMLQEKIEEMAEQERFLLHQETLPEQLLAEKQLNL
SAMPVLTAPQLIGLYICEENRRANEYDFKKALDLLEYIDEEEDININDLKLEILCKALQR
DNWSSSDGKDDPIEVSKDSIFVKILQKLLKDGIQLSEYLPEVKDLLQADQLGSLKSNPYF
EFVLKANYEYYVQGQI
Sequence of entity 2 (AD, BD, CD, DD), FASTA
>7PEQ_2 Nuclear pore complex protein Nup107 (chains AD, BD, CD, DD)
MDRSGFGEISSPVIREAEVTRTARKQSAQKRVLLQASQDENFGNTTPRNQVIPRTPSSFR
QPFTPTSRSLLRQPDISCILGTGGKSPRLTQSSGFFGNLSMVTNLDDSNWAAAFSSQRSG
LFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSDFLQSFLKHSSSTVFDLVEEYENI
CGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLASLYRDRIQSALEEESVF
AVTAVNASEKTVVEALFQRDSLVRQSQLVVDWLESIAKDEIGEFSDNIEFYAKSVYWENT
LHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDREDEVRLLKYLFTLIRAGMTE
EAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELF
NRYERAIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPR
EYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLILGDIDGLMDEFSKWLSKSRN
NLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDL
AVAQYALFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPAL
DTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLASKKHEAAKEVFVKIPQDSI
AEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQP
TFTEKVAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDH
ERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKL
LQKLRESSLMLLDQGLDPLGYEIQL
Sequence of entity 3 (AE, BE, CE, DE), FASTA
>7PEQ_3 Nuclear pore complex protein Nup96 (chains AE, BE, CE, DE)
SKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQL
GRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLT
DEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLS
PSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPR
EKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFL
PNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPN
LGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQIL
ERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLAL
LLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCS
QLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAE
EQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHL
SAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWA
KETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAII
NENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLH
IKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPL
RLLAPHIGRLPMPEDYAMDELRSLTQSYLRELAVGSL
Sequence of entity 4 (AF, BF, CF, DF), FASTA
>7PEQ_4 Protein SEC13 homolog (chains AF, BF, CF, DF)
MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPV
WQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLIL
ACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK
RFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRV
FIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI
SDVNKGQGSVSASVTEGQQNEQ
Sequence of entity 5 (AG, BG, CG, DG), FASTA
>7PEQ_5 Nucleoporin SEH1 (chains AG, BG, CG, DG)
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV
WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP
MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRKHS
Sequence of entity 6 (AH, BH, CH, DH), FASTA
>7PEQ_6 Nuclear pore complex protein Nup85 (chains AH, BH, CH, DH)
MEELDGEPTVTLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKD
VDVYSQILRKLFNESHGIFLGLQRIDEELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVA
IAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSL
SADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTM
PILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKEL
LSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQV
IKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLG
VDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRN
NRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGK
YREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYEL
MRCLEDLTSRRPVHGESDTEQLQDDDIETTKVEMLRLSLARNLARAIIREGSLEGS
Sequence of entity 7 (AI, BI, CI, DI), FASTA
>7PEQ_7 Nucleoporin Nup43 (chains AI, BI, CI, DI)
MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGG
FEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHY
HTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTF
LRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDG
MLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSS
LFHQGGRSSTFLSHSISNQANVHQSVISSWLSTDPAKDRIEITSLLPSRSLSVNTLDVLG
PCLVCGTDAEAIYVTRHLFS
Sequence of entity 8 (AJ, BJ, CJ, DJ), FASTA
>7PEQ_8 Nuclear pore complex protein Nup160 (chains AJ, BJ, CJ, DJ)
MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFR
EFTVCSIGTANAVAGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLD
INLLNNAIRLKFQNCSVLPGGVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVD
SQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTASTAWLSSDGEALFALPCASGGIFV
LKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIF
ALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYM
HAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVK
YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFC
RGTERNLDLSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQE
ALSHPLALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIA
RDVICLIKCLRLIEESVTVDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDICS
KLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGV
HKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGS
ECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLF
SQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHP
WCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPRL
QYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEA
LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNY
YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYA
WIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLAQHD
PSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAA
QAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVP
LPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP
MVWLPYSSIDQLLQALGENSANSHNIALSQKILDKLEDYQQKVDKATRDLLYRRTL
Sequence of entity 9 (AK, BK, CK, DK), FASTA
>7PEQ_9 Nucleoporin Nup37 (chains AK, BK, CK, DK)
MKQDASRNAAYTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEG
IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL
EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEETFK
LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRS
SYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGS
GLSWHRTLPLCVIGGDHKLLFWVTEV
Primary citation
The cellular environment shapes the nuclear pore complex architecture. Schuller, A.P., Wojtynek, M., Mankus, D. et al. Nature (2021) 598:667-671. DOI 10.1038/s41586-021-03985-3 · PubMed
Other PDB entries of the same protein (UniProt Q8WUM0 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1XKS 2.35 Å, The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold…
- 3CQC 2.53 Å, Nucleoporin Nup107/Nup133 interaction complex
- 3CQG 3.0 Å, Nucleoporin Nup107/Nup133 interaction complex, delta finger mutant
- 3I4R 3.53 Å, Nup107(aa658-925)/Nup133(aa517-1156) complex, H.sapiens
- 7R5K 12.0 Å, Human nuclear pore complex (constricted)
- 5A9Q 23.0 Å, Human nuclear pore complex
- 7R5J 50.0 Å, Human nuclear pore complex (dilated)
- 9A25 Molecular assembly pathway of the human Nuclear Pore Complex after cell division
- 9A8T Integrative spatiotemporal modeling of biomolecular processes: application to the…
Browse structure collections
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