7PY2: Pathological TDP-43 filaments from ALS with FTLD

Structure of pathological TDP-43 filaments from ALS with FTLD. Determined by electron microscopy at 2.59 Å resolution. Released 15 Dec 2021.

Method: Electron microscopy
Resolution: 2.59 Å
Organism: Homo sapiens
Chains: 4
Atoms: 2,152
Mol. weight: 179.14 kDa
Released: 15 Dec 2021

Explore 7PY2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7PY2 contains 0 α-helices and 44 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 0 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	283-285	3	1
β-strand	289	1	2
β-strand	298-299	2	3
β-strand	302-303	2	4
β-strand	311-313	3	5
β-strand	318	1	6
β-strand	327-329	3	7
β-strand	333-343	11	8
β-strand	346-347	2	9
β-strand	354-356	3	10
β-strand	359	1	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
TAR DNA-binding protein 43	A, B, C, D	protein	414	Homo sapiens	Q13148 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>7PY2_1 TAR DNA-binding protein 43 (chains A, B, C, D)
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGI
LHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDL
KEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNS
KQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIA
QSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLG
NNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQ
REPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM

Primary citation

Structure of pathological TDP-43 filaments from ALS with FTLD. Arseni, D., Hasegawa, M., Murzin, A.G. et al. Nature (2022) 601:139-143. DOI 10.1038/s41586-021-04199-3 · PubMed

Other PDB entries of the same protein (UniProt Q13148 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6CF4 0.75 Å, Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low…
5WHP 1.0 Å, Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low…
5WKB 1.0 Å, MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low…
5WIA 1.0 Å, Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43,…
5WHN 1.1 Å, Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43,…
5WIQ 1.25 Å, Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43,…
5W50 1.4 Å, Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253
5W52 1.4 Å, MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257
6CFH 1.5 Å, SWGMMGMLASQ segment from the low complexity domain of TDP-43
5WKD 1.8 Å, Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43,…
5MDI 2.1 Å, Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution
7N9H 2.2 Å, Structure of the mammalian importin a1 bound to the TDP-43 NLS

Browse structure collections

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