7Q18: Beta-lactoglobulin

Beta-lactoglobulin mutant FAF (I56F/L39A/M107F), unliganded form. Determined by X-ray diffraction at 1.8 Å resolution. Released 11 May 2022.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Bos taurus
Chains: 2
Atoms: 2,446
Mol. weight: 36.58 kDa
Released: 11 May 2022

Explore 7Q18 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Q18 contains 8 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 5 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	6-7	2
α-helix	12-14	3
β-strand	17-18	2	1
β-strand	20-26	7	2
α-helix	29-31	3
β-strand	42-48	7	1
β-strand	54-61	8	1
β-strand	66-73	8	1
β-strand	74-75	2	2
β-strand	81-84	4	2
β-strand	90-97	8	2
β-strand	102-108	7	2
β-strand	117-123	7	2
α-helix	130-140	11
β-strand	147-150	4	2
α-helix	153-157	5

Chain BBB: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	17-18	2	3
β-strand	20-26	7	2
α-helix	29-31	3
β-strand	42-48	7	3
β-strand	54-60	7	3
β-strand	67-73	7	3
β-strand	74-75	2	2
β-strand	81-83	3	2
β-strand	91-97	7	2
β-strand	102-108	7	2
β-strand	117-123	7	2
α-helix	130-140	11
β-strand	147-150	4	2
α-helix	153-156	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Beta-lactoglobulin	AAA, BBB	protein	162	Bos taurus	P02754 (AlphaFold model)

Sequence of entity 1 (AAA, BBB), FASTA

>7Q18_1 Beta-lactoglobulin (chains AAA, BBB)
ASVTQTMKGLDIQKVAGTWYSLAMAASDISLLDAQSAPARVYVEELKPTPEGDLEFLLQK
WENGECAQKKIIAEKTKIPAVFKIDALNENKVLVLDTDYKKYLLFCFENSAEPEQSLACQ
CLVRTPEVDDEALEKFDKALKALPMHIRLSFNPTQLEEQCHI

Primary citation

New ligand-binding sites identified in the crystal structures of [beta]-lactoglobulin complexes with desipramine. Loch, J.I., Barciszewski, J., Sliwiak, J. et al. IUCrJ (2022) 9:386-398. DOI 10.1107/S2052252522004183

Other PDB entries of the same protein (UniProt P02754 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Q19 1.55 Å, Beta-lactoglobulin mutant FAW (I56F/L39A/M107W) in complex with desipramine (FAW-DSM#3)
4GNY 1.64 Å, Bovine beta-lactoglobulin complex with dodecyl sulfate
7Q2P 1.69 Å, Beta-lactoglobulin mutant FAW (I56F/L39A/M107W) in complex with desipramine (FAW-DSM#2)
5NUK 1.7 Å, Engineered beta-lactoglobulin: variant I56F-L39A-M107F in complex with chlorpromazine…
7Q2N 1.7 Å, Beta-lactoglobulin mutant FAF (I56F/L39A/M107F) in complex with desipramine (FAF-DSM)
7KOT 1.74 Å, Energetic and structural effects of the Tanford transition on the ligand recognition of…
1BEB 1.8 Å, Bovine beta-lactoglobulin, lattice X
7BF8 1.8 Å, Mutant I56F of recombinant bovine beta-lactoglobulin in complex with tetracaine
7BF9 1.8 Å, Mutant M107L of recombinant bovine beta-lactoglobulin in complex with tetracaine
7Q17 1.8 Å, Beta-lactoglobulin mutant FAW (I56F/L39A/M107W), unliganded form
7Q2O 1.8 Å, Beta-lactoglobulin mutant FAW (I56F/L39A/M107W) in complex with desipramine (FAW-DSM#1)
4KII 1.85 Å, Beta-lactoglobulin in complex with Cp*Rh(III)Cl N,N-di(pyridin-2-yl)dodecanamide

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