Beta-lactoglobulin (LGB) is a 178-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02754.
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The mean pLDDT of this model is 91.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule
Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms (PubMed:10595563, PubMed:8601463, PubMed:9115437, PubMed:9760236). Interaction with LMBR1L which mediates the endocytosis of LGB has been observed in PubMed:17991420, but not in PubMed:23964685 (PubMed:17991420, PubMed:23964685)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Q19 | X-ray | 1.55 Å | AAA=17-178 |
| 4GNY | X-ray | 1.64 Å | A=17-178 |
| 7Q2P | X-ray | 1.69 Å | AAA/BBB=17-178 |
| 5NUK | X-ray | 1.7 Å | A=17-178 |
| 7Q2N | X-ray | 1.7 Å | AAA/BBB=17-178 |
| 7KOT | X-ray | 1.74 Å | A=17-178 |
| 1BEB | X-ray | 1.8 Å | A/B=17-178 |
| 7BF8 | X-ray | 1.8 Å | AAA/BBB=17-178 |
| 7BF9 | X-ray | 1.8 Å | AAA=17-178 |
| 7Q17 | X-ray | 1.8 Å | AAA=17-178 |
| 7Q18 | X-ray | 1.8 Å | AAA/BBB=17-178 |
| 7Q2O | X-ray | 1.8 Å | AAA/BBB=17-178 |
| 4KII | X-ray | 1.85 Å | A=17-178 |
| 3NQ3 | X-ray | 1.9 Å | A=17-178 |
| 3NQ9 | X-ray | 1.9 Å | A=17-178 |
| 3UEV | X-ray | 1.9 Å | A=17-178 |
| 4DQ4 | X-ray | 1.9 Å | A=17-178 |
| 6GHH | X-ray | 1.9 Å | A=17-178 |
| 7BGA | X-ray | 1.9 Å | AAA=17-178 |
| 1B8E | X-ray | 1.95 Å | A=17-178 |
Showing 20 of 105 experimental structures (best resolution first).
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