7Q3L: Human 17S U2 snRNP 5' domain
Human 17S U2 snRNP 5' domain. Determined by electron microscopy at 2.21 Å resolution. Released 30 Mar 2022.
- Method
- Electron microscopy
- Resolution
- 2.21 Å
- Organism
- Homo sapiens
- Chains
- 9
- Atoms
- 20,470
- Mol. weight
- 732.55 kDa
- Ligands
- ZN
- Released
- 30 Mar 2022
Explore 7Q3L in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7Q3L contains 121 α-helices and 120 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 9: 7 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 395-398 | 4 | |
| β-strand | 407-408 | 2 | 32 |
| β-strand | 414-415 | 2 | 32 |
| α-helix | 419-422 | 4 | |
| α-helix | 425-427 | 3 | |
| α-helix | 429-437 | 9 | |
| α-helix | 444-446 | 3 | |
| α-helix | 452-468 | 17 | |
| α-helix | 473-475 | 3 | |
| β-strand | 478 | 1 | 33 |
| β-strand | 487 | 1 | 33 |
Chain A: 61 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 492-505 | 14 | |
| α-helix | 509-526 | 18 | |
| α-helix | 528-540 | 13 | |
| α-helix | 546-563 | 18 | |
| α-helix | 564-567 | 4 | |
| α-helix | 571-578 | 8 | |
| α-helix | 579-583 | 5 | |
| α-helix | 587-603 | 17 | |
| α-helix | 606-617 | 12 | |
| α-helix | 622-638 | 17 | |
| α-helix | 641-651 | 11 | |
| α-helix | 658-675 | 18 | |
| α-helix | 676-682 | 7 | |
| α-helix | 683-690 | 8 | |
| α-helix | 693-695 | 3 | |
| α-helix | 699-716 | 18 | |
| α-helix | 721-735 | 15 | |
| α-helix | 741-753 | 13 | |
| α-helix | 754-756 | 3 | |
| α-helix | 759-776 | 18 | |
| α-helix | 782-797 | 16 | |
| α-helix | 803-805 | 3 | |
| α-helix | 806-810 | 5 | |
| α-helix | 811-818 | 8 | |
| α-helix | 821-825 | 5 | |
| α-helix | 827-844 | 18 | |
| α-helix | 846-853 | 8 | |
| α-helix | 854-856 | 3 | |
| α-helix | 862-879 | 18 | |
| α-helix | 886-902 | 17 | |
| α-helix | 908-921 | 14 | |
| α-helix | 922-928 | 7 | |
| α-helix | 929-940 | 12 | |
| α-helix | 945-962 | 18 | |
| α-helix | 967-981 | 15 | |
| α-helix | 987-1001 | 15 | |
| α-helix | 1006-1008 | 3 | |
| α-helix | 1013-1020 | 8 | |
| α-helix | 1023-1025 | 3 | |
| α-helix | 1029-1045 | 17 | |
| α-helix | 1047-1049 | 3 | |
| α-helix | 1052-1062 | 11 | |
| α-helix | 1063-1067 | 5 | |
| α-helix | 1071-1088 | 18 | |
| α-helix | 1090-1100 | 11 | |
| α-helix | 1106-1121 | 16 | |
| α-helix | 1125-1127 | 3 | |
| α-helix | 1129-1136 | 8 | |
| α-helix | 1141-1158 | 18 | |
| α-helix | 1159-1164 | 6 | |
| α-helix | 1166-1178 | 13 | |
| α-helix | 1182-1199 | 18 | |
| α-helix | 1205-1215 | 11 | |
| α-helix | 1216-1220 | 5 | |
| α-helix | 1224-1240 | 17 | |
| α-helix | 1243-1250 | 8 | |
| α-helix | 1251-1253 | 3 | |
| α-helix | 1259-1276 | 18 | |
| α-helix | 1280-1283 | 4 | |
| α-helix | 1284-1286 | 3 | |
| α-helix | 1298-1301 | 4 | |
Chain B: 10 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 454-457 | 4 | |
| α-helix | 462-468 | 7 | |
| α-helix | 472-474 | 3 | |
| α-helix | 477-481 | 5 | |
| α-helix | 485-492 | 8 | |
| α-helix | 499-501 | 3 | |
| α-helix | 502-505 | 4 | |
| α-helix | 526-529 | 4 | |
| α-helix | 569-576 | 8 | |
| α-helix | 706-707 | 2 | |
Chain C: 27 helices, 100 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-9 | 7 | 1 |
| β-strand | 16-20 | 5 | 2 |
| β-strand | 29-33 | 5 | 2 |
| β-strand | 37-43 | 7 | 2 |
| β-strand | 50-57 | 8 | 2 |
| β-strand | 62-68 | 7 | 3 |
| α-helix | 76 | 1 | |
| β-strand | 77-82 | 6 | 3 |
| β-strand | 86-93 | 8 | 3 |
| β-strand | 98-106 | 9 | 3 |
| β-strand | 120-123 | 4 | 4 |
| β-strand | 129-133 | 5 | 4 |
| β-strand | 136 | 1 | 5 |
| β-strand | 139-143 | 5 | 4 |
| β-strand | 144-146 | 3 | 6 |
| β-strand | 152-154 | 3 | 6 |
| α-helix | 155-157 | 3 | |
| β-strand | 158-159 | 2 | 4 |
| β-strand | 165-173 | 9 | 5 |
| β-strand | 181-188 | 8 | 5 |
| α-helix | 190-193 | 4 | |
| α-helix | 199-202 | 4 | |
| β-strand | 207-214 | 8 | 5 |
| β-strand | 219-227 | 9 | 5 |
| β-strand | 232-237 | 6 | 7 |
| α-helix | 238-239 | 2 | |
| β-strand | 248-252 | 5 | 7 |
| β-strand | 255-259 | 5 | 7 |
| α-helix | 264-266 | 3 | |
| β-strand | 267-270 | 4 | 7 |
| α-helix | 271-272 | 2 | |
| β-strand | 273-274 | 2 | 8 |
| β-strand | 287-295 | 9 | 9 |
| β-strand | 298-305 | 8 | 9 |
| β-strand | 309-318 | 10 | 9 |
| β-strand | 321-332 | 12 | 9 |
| β-strand | 336-342 | 7 | 10 |
| β-strand | 346-351 | 6 | 10 |
| β-strand | 356-361 | 6 | 10 |
| α-helix | 371 | 1 | |
| β-strand | 372-374 | 3 | 9 |
| β-strand | 386-387 | 2 | 8 |
| β-strand | 395-401 | 7 | 10 |
| α-helix | 405 | 1 | |
| β-strand | 407-413 | 7 | 11 |
| α-helix | 421 | 1 | |
| β-strand | 422-427 | 6 | 11 |
| α-helix | 430-432 | 3 | |
| β-strand | 434-440 | 7 | 11 |
| β-strand | 442 | 1 | 12 |
| β-strand | 445-450 | 6 | 13 |
| β-strand | 458-462 | 5 | 14 |
| β-strand | 473-477 | 5 | 14 |
| β-strand | 482-486 | 5 | 14 |
| β-strand | 492-494 | 3 | 14 |
| β-strand | 507-510 | 4 | 15 |
| β-strand | 516-520 | 5 | 15 |
| β-strand | 523-527 | 5 | 15 |
| β-strand | 534-537 | 4 | 15 |
| α-helix | 538 | 1 | |
| β-strand | 544-549 | 6 | 16 |
| β-strand | 553-558 | 6 | 16 |
| β-strand | 562-568 | 7 | 16 |
| β-strand | 574-576 | 3 | 16 |
| β-strand | 581-582 | 2 | 16 |
| α-helix | 583 | 1 | |
| β-strand | 587-592 | 6 | 17 |
| α-helix | 593-596 | 4 | |
| β-strand | 604-609 | 6 | 17 |
| β-strand | 613-618 | 6 | 17 |
| β-strand | 626-632 | 7 | 17 |
| β-strand | 637-644 | 8 | 18 |
| β-strand | 663-669 | 7 | 18 |
| β-strand | 673-678 | 6 | 18 |
| β-strand | 686-690 | 5 | 18 |
| β-strand | 700-706 | 7 | 19 |
| β-strand | 709-715 | 7 | 19 |
| β-strand | 719-724 | 6 | 19 |
| β-strand | 729-733 | 5 | 19 |
| β-strand | 734 | 1 | 12 |
| β-strand | 741-745 | 5 | 13 |
| β-strand | 753-758 | 6 | 13 |
| β-strand | 761-766 | 6 | 13 |
| β-strand | 774-780 | 7 | 11 |
| β-strand | 785-790 | 6 | 20 |
| β-strand | 797-804 | 8 | 20 |
| α-helix | 809-824 | 16 | |
| α-helix | 832-844 | 13 | |
| α-helix | 849-852 | 4 | |
| β-strand | 862-869 | 8 | 20 |
| β-strand | 876-881 | 6 | 20 |
| α-helix | 882-883 | 2 | |
| β-strand | 886-895 | 10 | 21 |
| β-strand | 903-911 | 9 | 21 |
| β-strand | 914-915 | 2 | 22 |
| β-strand | 918-919 | 2 | 22 |
| β-strand | 923-931 | 9 | 21 |
| β-strand | 936-945 | 10 | 21 |
| β-strand | 949-955 | 7 | 23 |
| β-strand | 958-963 | 6 | 23 |
| β-strand | 966-971 | 6 | 23 |
| β-strand | 978-983 | 6 | 23 |
| β-strand | 990-996 | 7 | 24 |
| β-strand | 999-1004 | 6 | 24 |
| β-strand | 1007 | 1 | 25 |
| β-strand | 1009-1015 | 7 | 24 |
| β-strand | 1020-1026 | 7 | 24 |
| β-strand | 1031 | 1 | 25 |
| β-strand | 1033-1040 | 8 | 26 |
| β-strand | 1043-1048 | 6 | 26 |
| β-strand | 1052-1057 | 6 | 26 |
| α-helix | 1058-1059 | 2 | |
| α-helix | 1073-1075 | 3 | |
| β-strand | 1087-1088 | 2 | 24 |
| β-strand | 1090-1096 | 7 | 26 |
| β-strand | 1101-1107 | 7 | 1 |
| α-helix | 1113-1115 | 3 | |
| β-strand | 1116-1121 | 6 | 1 |
| β-strand | 1126-1131 | 6 | 1 |
| α-helix | 1135-1151 | 17 | |
| α-helix | 1160-1164 | 5 | |
| β-strand | 1171 | 1 | 26 |
| β-strand | 1173-1175 | 3 | 1 |
| α-helix | 1176-1179 | 4 | |
| α-helix | 1180-1184 | 5 | |
| α-helix | 1187-1195 | 9 | |
| α-helix | 1201-1215 | 15 | |
Chain E: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 13-17 | 5 | |
| α-helix | 28-45 | 18 | |
| α-helix | 47-57 | 11 | |
| α-helix | 61-71 | 11 | |
Chain G: 8 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10 | 1 | 27 |
| α-helix | 14-15 | 2 | |
| α-helix | 18 | 1 | |
| β-strand | 19 | 1 | 28 |
| α-helix | 20 | 1 | |
| β-strand | 21-22 | 2 | 29 |
| β-strand | 39-42 | 4 | 30 |
| β-strand | 44 | 1 | 28 |
| α-helix | 48-50 | 3 | |
| α-helix | 52-54 | 3 | |
| β-strand | 57 | 1 | 31 |
| β-strand | 58 | 1 | 29 |
| β-strand | 64 | 1 | 31 |
| α-helix | 65 | 1 | |
| β-strand | 67-68 | 2 | 29 |
| β-strand | 70-72 | 3 | 30 |
| α-helix | 73-77 | 5 | |
| α-helix | 80-82 | 3 | |
| β-strand | 88 | 1 | 27 |
Chain p: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 159-173 | 15 | |
Chain q: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 134-138 | 5 | 34 |
| α-helix | 146-154 | 9 | |
| β-strand | 159 | 1 | 35 |
| β-strand | 185-187 | 3 | 34 |
| β-strand | 188 | 1 | 35 |
| α-helix | 192-200 | 9 | |
| β-strand | 212-214 | 3 | 34 |
| α-helix | 241-244 | 4 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Splicing factor 3B subunit 2 | B | protein | 895 | Homo sapiens | Q13435 (AlphaFold model) |
| Splicing factor 3B subunit 3 | C | protein | 1217 | Homo sapiens | Q15393 (AlphaFold model) |
| Splicing factor 3B subunit 5 | E | protein | 86 | Homo sapiens | Q9BWJ5 (AlphaFold model) |
| PHD finger-like domain-containing protein 5A | G | protein | 110 | Homo sapiens | Q7RTV0 (AlphaFold model) |
| U2 snRNA | 2 | RNA | 188 | Homo sapiens | |
| Splicing factor 3A subunit 3 | 9 | protein | 501 | Homo sapiens | Q12874 |
| HIV Tat-specific factor 1 | q | protein | 803 | Homo sapiens | O43719 |
| Splicing factor 3B subunit 1 | A | protein | 1304 | Homo sapiens | O75533 |
| Probable ATP-dependent RNA helicase DDX46 | p | protein | 1031 | Homo sapiens | Q7L014 |
Sequence of entity 1 (B), FASTA
>7Q3L_1 Splicing factor 3B subunit 2 (chains B)
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Sequence of entity 2 (C), FASTA
>7Q3L_2 Splicing factor 3B subunit 3 (chains C)
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFG
VIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQF
LAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPG
GSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFF
FLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDT
PQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVN
ATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQ
RSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSI
GFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFP
LQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAA
AFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTG
EDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVL
IGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQ
LIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRG
LLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDF
FQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRT
PPEVSKKLEDIRTRYAF
Sequence of entity 3 (E), FASTA
>7Q3L_3 Splicing factor 3B subunit 5 (chains E)
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN
Sequence of entity 4 (G), FASTA
>7Q3L_4 PHD finger-like domain-containing protein 5A (chains G)
MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVI
CGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR
Sequence of entity 5 (2), FASTA
>7Q3L_5 U2 snRNA (chains 2)
AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAU
CUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGA
AUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACG
GUGCACCC
Sequence of entity 6 (9), FASTA
>7Q3L_6 Splicing factor 3A subunit 3 (chains 9)
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDL
YDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENP
SEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNA
EYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQAEFEKKWENGTFPGWPKETSSALTHA
GAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSL
FAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEE
EEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPK
AFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYE
DSSGNVVNKKTYEDLKRQGLL
Sequence of entity 7 (q), FASTA
>7Q3L_7 HIV Tat-specific factor 1 (chains q)
GPGSSGMDEKTTGWRGGHVVEGLAGELEQLRARLEHHPQGQREPGGGGSSGTNLDGNDEF
DEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWFPKITEDFIATYQ
ANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKAESGWFHVEEDRN
TNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRE
SVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKLSMQQKQLDWRPE
RRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPD
GVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAF
LNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFE
KTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVR
GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDC
SEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLD
EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL
FEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGS
VEEGPLSTGSSFILSSDDDDDDI
Sequence of entity 8 (A), FASTA
>7Q3L_8 Splicing factor 3B subunit 1 (chains A)
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAA
TELEDDDDDYSSSTSLLGQKKPGYHAPVALLNDIPQSTEQYDPFAEHRPPKIADREDEYK
KHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKAKAGE
LKVVNGAAASQPPSKRKRRWDQTADQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAK
GSETPGATPGSKIWDPTPSHTPAGAATPGRGDTPGHATPGHGGATSSARKNRWDETPKTE
RDTPGHGSGWAETPRTDRGGDSIGETPTPGASKRKSRWDETPASQMGGSTPVLTPGKTPI
GTPAMNMATPTPGHIMSMTPEQLQAWRWEREIDERNRPLSDEELDAMFPEGYKVLPPPAG
YVPIRTPARKLTATPTPLGGMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLV
DVDESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLM
SPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNL
AKAAGLATMISTMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQA
RHTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYG
IESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSP
DEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLVDTTVEL
ANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAF
QEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAV
VMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRL
TPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNT
FGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPE
LNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVY
GFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARK
VRDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Sequence of entity 9 (p), FASTA
>7Q3L_9 Probable ATP-dependent RNA helicase DDX46 (chains p)
MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRS
RSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRS
KEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAME
NIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVK
KFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEE
VDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGI
TVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGS
GKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVY
GGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFE
PQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVI
EEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDS
IINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAY
TFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKF
DETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPA
PTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQL
AEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISE
YSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSY
QPTNKGRYKVL
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 4 |
Primary citation
Structural basis of branch site recognition by the human spliceosome. Tholen, J., Razew, M., Weis, F. et al. Science (2022) 375:50-57. DOI 10.1126/science.abm4245 · PubMed
Other PDB entries of the same protein (UniProt Q13435 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7Q4O 2.1 Å, Substrate-bound A-like U2 snRNP
- 7Q4P 2.15 Å, U2 snRNP after ATP-dependent remodelling
- 7EVO 2.5 Å, The cryo-EM structure of the human 17S U2 snRNP
- 8H6L 2.6 Å, Cryo-EM structure of human exon-defined spliceosome in the early B state.
- 8H6K 2.7 Å, Cryo-EM structure of human exon-defined spliceosome in the mature B state.
- 8HK1 2.7 Å, The cryo-EM structure of human pre-17S U2 snRNP
- 7DVQ 2.89 Å, Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
- 7VPX 3.0 Å, The cryo-EM structure of the human pre-A complex
- 8I0R 3.0 Å, The cryo-EM structure of human Bact-I complex
- 8I0T 3.0 Å, The cryo-EM structure of human Bact-III complex
- 8I0V 3.0 Å, The cryo-EM structure of human post-Bact complex
- 7ONB 3.1 Å, Structure of the U2 5' module of the A3'-SSA complex
Browse structure collections
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