7RG5: Importin alpha3

Importin alpha3 in complex with p50 NLS. Determined by X-ray diffraction at 2.15 Å resolution. Released 25 Aug 2021.

Method: X-ray diffraction
Resolution: 2.15 Å
Organism: Homo sapiens
Chains: 2
Atoms: 3,357
Mol. weight: 55.3 kDa
Released: 25 Aug 2021

Explore 7RG5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7RG5 contains 33 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 33 helices, 0 β-strands

Element	Residues	Length
α-helix	73-80	8
α-helix	85-100	16
α-helix	107-112	6
α-helix	116-122	7
α-helix	129-142	14
α-helix	147-155	9
α-helix	158-165	8
α-helix	171-185	15
α-helix	189-197	9
α-helix	201-206	6
α-helix	214-228	15
α-helix	234-236	3
α-helix	237-250	14
α-helix	256-270	15
α-helix	274-282	9
α-helix	286-289	4
α-helix	290-294	5
α-helix	298-312	15
α-helix	316-324	9
α-helix	328-330	3
α-helix	331-335	5
α-helix	340-354	15
α-helix	358-366	9
α-helix	370-379	10
α-helix	382-398	17
α-helix	401-409	9
α-helix	413-417	5
α-helix	418-421	4
α-helix	425-441	17
α-helix	446-455	10
α-helix	458-464	7
α-helix	465-467	3
α-helix	471-484	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Importin subunit alpha-3	A	protein	459	Homo sapiens	O00629 (AlphaFold model)
Isoform 3 of Nuclear factor NF-kappa-B p105 subunit	B	protein	40	Homo sapiens	P19838 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7RG5_1 Importin subunit alpha-3 (chains A)
SGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHC
LERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALG
NIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQE
ILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQT
AALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQ
AVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTV
KDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIID
QFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF

Sequence of entity 2 (B), FASTA

>7RG5_2 Isoform 3 of Nuclear factor NF-kappa-B p105 subunit (chains B)
VQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNF

Primary citation

MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Munasinghe, T.S., Edwards, M.R., Tsimbalyuk, S. et al. Nat Commun (2022) 13:1604-1604. DOI 10.1038/s41467-022-28851-2 · PubMed

Other PDB entries of the same protein (UniProt O00629 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6BW9 1.6 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1
8HKW 1.9 Å, Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
7LFC 2.1 Å, Structure of importin a3 bound to p50 NLS
6BWA 2.2 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2
6BVV 2.3 Å, Nipah virus W protein C-terminus in complex with Importin alpha 3
6BVZ 2.3 Å, Importin alpha 3 in cargo free state
6BWB 2.3 Å, Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 3
6WX8 2.3 Å, SOX2 bound to Importin-alpha 3
7RFY 2.5 Å, Importin alpha3 in complex with MERS ORF4B
7JJL 2.6 Å, Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
4UAE 2.7 Å, Importin alpha 3 delta IBB in complex with Influenza PB2 Nuclear Localization Domain
8FUB 2.75 Å, Crystal structure of human Importin alpha 3 in complex with Hendra virus matrix protein…

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