7SYZ: Hendra virus G protein head domain

Hendra virus G protein head domain in complex with cross-neutralizing murine antibody hAH1.3. Determined by X-ray diffraction at 2.86 Å resolution. Released 8 Jun 2022.

Method: X-ray diffraction
Resolution: 2.86 Å
Organisms: Hendra henipavirus, Mus musculus
Chains: 3
Atoms: 7,012
Mol. weight: 121.2 kDa
Released: 8 Jun 2022

Explore 7SYZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7SYZ contains 24 α-helices and 79 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 35 β-strands

Element	Residues	Length	Sheet
β-strand	178-180	3	1
α-helix	185-187	3
β-strand	200-202	3	1
β-strand	216-225	10	1
β-strand	228-236	9	1
β-strand	245-257	13	1
β-strand	263-271	9	1
β-strand	279-287	9	2
β-strand	290-297	8	2
α-helix	310-312	3
β-strand	314-320	7	2
β-strand	332-336	5	2
β-strand	339-341	3	3
β-strand	347-350	4	3
β-strand	354	1	2
β-strand	356-358	3	3
β-strand	361-371	11	3
α-helix	372-374	3
α-helix	379-381	3
α-helix	394-397	4
β-strand	407-417	11	3
α-helix	418-420	3
β-strand	425-430	6	3
β-strand	431	1	4
α-helix	432	1
β-strand	442-447	6	5
β-strand	450-455	6	5
β-strand	463	1	6
β-strand	465-471	7	5
β-strand	475	1	4
β-strand	476-479	4	5
β-strand	486	1	6
β-strand	509	1	1
β-strand	511-515	5	7
β-strand	520-526	7	7
β-strand	533	1	8
β-strand	535-540	6	7
β-strand	545-550	6	7
β-strand	557	1	8
β-strand	558-568	11	1
β-strand	571-581	11	1
β-strand	588-596	9	1
α-helix	597-598	2

Chain H: 10 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	9
α-helix	7-9	3
β-strand	10-12	3	10
β-strand	18-25	8	9
α-helix	29-31	3
β-strand	33-39	7	10
β-strand	45-51	7	10
β-strand	57-59	3	10
α-helix	61-63	3
β-strand	67-72	6	9
β-strand	77-82	6	9
α-helix	84-86	3
β-strand	88-95	8	10
β-strand	100D-103	4	10
β-strand	107-111	5	10
β-strand	117	1	11
α-helix	118-119	2
β-strand	120-124	5	12
α-helix	132-134	3
β-strand	135-145	11	12
β-strand	146	1	11
β-strand	151-154	4	13
α-helix	155-157	3
β-strand	163-165	3	12
α-helix	166-168	3
β-strand	169-171	3	12
β-strand	174-184	11	12
α-helix	187-190	4
β-strand	194-199	6	13
α-helix	200-202	3
β-strand	204-209	6	13

Chain L: 6 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	14
β-strand	10-13	4	15
β-strand	19-25	7	14
β-strand	27C	1	16
β-strand	31	1	16
β-strand	33-38	6	15
β-strand	44-49	6	15
β-strand	53-54	2	15
α-helix	55	1
β-strand	62-67	6	14
β-strand	70-75	6	14
α-helix	80-82	3
β-strand	84-90	7	15
α-helix	96	1
β-strand	97-98	2	15
β-strand	102-106	5	15
β-strand	111	1	17
β-strand	114-118	5	18
α-helix	119-121	3
α-helix	122-127	6
β-strand	129-139	11	18
β-strand	140	1	17
β-strand	145-150	6	19
β-strand	153-155	3	19
β-strand	159-163	5	18
β-strand	173-182	10	18
α-helix	183-187	5
β-strand	191-198	8	19
β-strand	201-210	10	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Attachment glycoprotein	A	protein	604	Hendra henipavirus	O89343 (AlphaFold model)
Antibody hAH1.3 Heavy Chain	H	protein	223	Mus musculus
Antibody hAH1.3 light chain	L	protein	221	Mus musculus

Sequence of entity 1 (A), FASTA

>7SYZ_1 Attachment glycoprotein (chains A)
MMADSKLVSLNNNLSGKIKDQGKVIKNYYGTMDIKKINDGLLDSKILGAFNTVIALLGSI
IIIVMNIMIIQNYTRTTDNQALIKESLQSVQQQIKALTDKIGTEIGPKVSLIDTSSTITI
PANIGLLGSKISQSTSSINENVNDKCKFTLPPLKIHECNISCPNPLPFREYRPISQGVSD
LVGLPNQICLQKTTSTILKPRLISYTLPINTREGVCITDPLLAVDNGFFAYSHLEKIGSC
TRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHV
GDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMPYGPSGIKQGD
TLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSL
GGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWR
NNSVISRPGQSQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVF
KDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQ
CSES

Sequence of entity 2 (H), FASTA

>7SYZ_2 Antibody hAH1.3 Heavy Chain (chains H)
QIQLVQSGPELKKPGETVKISCTTSGYTFTNYGLNWVKQAPGKGFKWMAWINTYTGEPTY
ADDFKGRFAFSLETSASTTYLQINNLKNEDMSTYFCARSGYYDGLKAMDYWGQGTSVTVS
SAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQS
DLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC

Sequence of entity 3 (L), FASTA

>7SYZ_3 Antibody hAH1.3 light chain (chains L)
DVLMIQTPLSLPVSLGDQASISCRSSQSLIHINGNTYLEWYLQKPGQSPKLLIYKVSNRF
SGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPFTFGAGTKLELKRADAAPTV
SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSM
SSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNECVY

Primary citation

Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant. Wang, Z., Dang, H.V., Amaya, M. et al. Proc Natl Acad Sci U S A (2022) 119:e2122769119-e2122769119. DOI 10.1073/pnas.2122769119 · PubMed

Other PDB entries of the same protein (UniProt O89343 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6VY4 2.0 Å, Crystal structure of Hendra receptor binding protein head domain in complex with human…
6PD4 2.2 Å, Crystal Structure of Hendra Virus Attachment G Glycoprotein
6VY6 2.6 Å, Crystal structure of Hendra receptor binding protein head domain in complex with human…
6CMG 2.7 Å, Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent…
6PDL 2.7 Å, Crystal Structure of Hendra Virus Attachment G Glycoprotein in Complex with Receptor…
6CMI 2.72 Å, Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent…
7SYY 2.74 Å, Hendra virus G protein head domain in complex with cross-neutralizing murine antibody…
2X9M 2.9 Å, Hendra virus attachment glycoprotein
8VF1 3.0 Å, Crystal Structure of the Hendra Virus Attachment G glycoprotein (HeV-G)
8JR3 3.22 Å, Crystal structure of Hendra Virus attachment(G) glycoprotein mutant S586N in complex…
2VSK 3.3 Å, Hendra virus attachment glycoprotein in complex with human cell surface receptor ephrinB2
8JR5 3.3 Å, Crystal structure of Hendra Virus attachment(G) glycoprotein mutant S586N

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