7T6J: TRPV5 at pH8 in nanodiscs

Cryo-EM structure of TRPV5 at pH8 in nanodiscs. Determined by electron microscopy at 3.2 Å resolution. Released 4 May 2022.

Method
Electron microscopy
Resolution
3.2 Å
Organism
Oryctolagus cuniculus
Chains
4
Atoms
19,412
Mol. weight
335.14 kDa
Released
4 May 2022

Explore 7T6J in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7T6J contains 144 α-helices and 24 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B and C: 36 helices, 6 β-strands

ElementResiduesLengthSheet
α-helix30-4617
α-helix48-558
α-helix58-669
α-helix82-887
α-helix92-10110
α-helix103-1053
α-helix120-1267
α-helix130-1389
α-helix166-1738
α-helix176-1849
α-helix194-1963
α-helix199-2046
α-helix211-22111
α-helix243-2508
α-helix254-2618
β-strand264-26851
β-strand273-27971
α-helix281-2844
α-helix292-2976
α-helix303-3075
α-helix313-3197
α-helix320-3256
α-helix326-34823
β-strand352-35432
β-strand368-37032
α-helix371-3722
α-helix380-40122
α-helix405-4084
α-helix412-4176
α-helix423-44422
α-helix451-46313
α-helix464-4718
α-helix476-48611
α-helix489-51123
α-helix526-53510
α-helix542-5432
α-helix553-56513
α-helix570-60435
α-helix610-6123
α-helix614-6163
β-strand618-61921
β-strand629-63681
Chain D: 36 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix30-4617
α-helix48-558
α-helix58-669
α-helix82-887
α-helix92-10110
α-helix103-1053
α-helix120-1267
α-helix130-1389
α-helix166-1738
α-helix176-1849
α-helix194-1963
α-helix199-2046
α-helix211-22111
α-helix243-2508
α-helix254-2618
β-strand264-26857
β-strand273-27977
α-helix281-2844
α-helix292-2976
α-helix303-3097
α-helix313-3197
α-helix320-3256
α-helix326-34823
β-strand352-35438
β-strand368-37038
α-helix371-3722
α-helix380-40122
α-helix405-4084
α-helix412-4176
α-helix423-44422
α-helix451-46313
α-helix464-4718
α-helix476-48611
α-helix489-51123
α-helix526-53510
α-helix542-5432
α-helix553-56513
α-helix570-60435
α-helix610-6123
α-helix614-6163
β-strand618-61927
β-strand629-63687

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transient receptor potential cation channel subfamily V member 5A, B, C, Dprotein739Oryctolagus cuniculusQ9XSM3 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>7T6J_1 Transient receptor potential cation channel subfamily V member 5 (chains A, B, C, D)
MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL
LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA
LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK
KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT
DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI
LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI
IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ
EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG
EGDGEEVYHFTETSQVAPA

Primary citation

Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Fluck, E.C., Yazici, A.T., Rohacs, T. et al. Cell Rep (2022) 39:110737-110737. DOI 10.1016/j.celrep.2022.110737 · PubMed

Other PDB entries of the same protein (UniProt Q9XSM3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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