7TAB: G-925

G-925 bound to the SMARCA4 (BRG1) Bromodomain. Determined by X-ray diffraction at 1.16 Å resolution. Released 17 Aug 2022.

Method: X-ray diffraction
Resolution: 1.16 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,170
Mol. weight: 15.37 kDa
Ligands: GGU
Released: 17 Aug 2022

Explore 7TAB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7TAB contains 9 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	1449-1455	7
α-helix	1456-1471	16
β-strand	1473	1	1
β-strand	1480	1	1
α-helix	1481-1485	5
α-helix	1488-1490	3
α-helix	1495-1500	6
α-helix	1507-1515	9
α-helix	1522-1539	18
α-helix	1541	1
α-helix	1545-1568	24

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Isoform 4 of Transcription activator BRG1	A	protein	130	Homo sapiens	P51532 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7TAB_1 Isoform 4 of Transcription activator BRG1 (chains A)
GSAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPV
DFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIE
KEDDSEGEES

Ligands and cofactors

ID	Name	Formula	Copies
GGU	2-(6-amino-5-phenylpyridazin-3-yl)phenol	C16 H13 N3 O	1

Primary citation

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. Taylor, A.M., Bailey, C., Belmont, L.D. et al. J Med Chem (2022) 65:11177-11186. DOI 10.1021/acs.jmedchem.2c00662 · PubMed

Other PDB entries of the same protein (UniProt P51532 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2GRC 1.5 Å, 1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF…
6ZS2 1.57 Å, Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in…
7TD9 1.61 Å, G-059 bound to the SMARCA4 (BRG1) Bromodomain
6HR2 1.76 Å, Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and…
3UVD 1.85 Å, Crystal Structure of the bromodomain of human Transcription activator BRG1 (SMARCA4) in…
5DKD 2.0 Å, Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3…
5EA1 2.0 Å, Crystal Structure of SMARCA4 bromodomain in complex with MPD
9DTX 2.11 Å, Crystal structure of PRT3789 in complex with the bromodomain of human BRG1 (SMARCA4) and…
7VRB 2.39 Å, Structure of the Human BRG1/SS18 complex
9UXC 2.74 Å, The ADP-bound structure of BCL7B-containing ARP module of the human SWI/SNF complex
7VDT 2.8 Å, The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex
9WBZ 2.9 Å, The structure of NCP-motor-ARP module of ncBAF-nucleosome complex

Browse structure collections

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