7TOQ: Mammalian 80S ribosome

Name: PDB 7TOQ: Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR
Published: 2022-05-25
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ribosome

Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR. Determined by electron microscopy at 3.1 Å resolution. Released 25 May 2022.

Method: Electron microscopy
Resolution: 3.1 Å
Organisms: Oryctolagus cuniculus, Saccharomyces cerevisiae, Homo sapiens
Chains: 84
Atoms: 213,639
Mol. weight: 3177.73 kDa
Ligands: ZN
Released: 25 May 2022

Explore 7TOQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7TOQ contains 504 α-helices and 563 β-strands across 78 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AL02: 10 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	4-5	2
α-helix	9-11	3
β-strand	28	1	31
α-helix	30-32	3
α-helix	34-38	5
β-strand	40-50	11	31
β-strand	57-64	8	31
β-strand	71-77	7	31
α-helix	78	1
β-strand	79	1	32
β-strand	83	1	33
β-strand	87-91	5	31
β-strand	101-103	3	31
α-helix	108	1
β-strand	112-114	3	31
β-strand	116	1	34
β-strand	126	1	34
β-strand	134-140	7	31
α-helix	142-144	3
β-strand	145-149	5	31
β-strand	155-159	5	31
β-strand	163-166	4	31
α-helix	168	1
β-strand	169	1	32
α-helix	182-190	9
β-strand	224-225	2	35
α-helix	229-230	2
β-strand	237-238	2	35

Chain AL03: 13 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	9-10	2
α-helix	20-22	3
α-helix	32-35	4
α-helix	40-41	2
β-strand	42	1	42
β-strand	45-60	16	43
β-strand	70-80	11	43
α-helix	82-83	2
β-strand	84-95	12	44
β-strand	98-106	9	44
α-helix	112-115	4
α-helix	133-136	4
α-helix	140-156	17
β-strand	159-165	7	44
β-strand	180-184	5	44
β-strand	186	1	42
α-helix	190-199	10
β-strand	204-205	2	44
β-strand	216-222	7	43
α-helix	223-225	3
β-strand	228-229	2	45
α-helix	231-234	4
α-helix	237-240	4
β-strand	270-271	2	45
β-strand	276-287	12	43
β-strand	293	1	46
β-strand	297	1	46
β-strand	320	1	47
β-strand	324	1	47
β-strand	330-334	5	43
β-strand	344-349	6	43
β-strand	365-368	4	43
α-helix	382-389	8

Chain AL04: 27 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	7-9	3	50
β-strand	11	1	51
β-strand	12-13	2	52
β-strand	15	1	52
β-strand	21-23	3	50
α-helix	24-25	2
α-helix	26-29	4
α-helix	31-32	2
α-helix	34-44	11
α-helix	45-48	4
α-helix	49-51	3
β-strand	64-66	3	53
β-strand	69	1	54
β-strand	71	1	54
β-strand	77-79	3	53
α-helix	100-101	2
α-helix	104-106	3
α-helix	117-129	13
α-helix	134-140	7
β-strand	152-154	3	51
α-helix	156-160	5
α-helix	164-173	10
α-helix	177-184	8
β-strand	188-189	2	55
α-helix	190	1
α-helix	193-197	5
β-strand	201-202	2	55
β-strand	208-211	4	51
α-helix	217-220	4
β-strand	229-231	3	51
α-helix	237-240	4
α-helix	242-244	3
β-strand	250-253	4	51
α-helix	254-258	5
α-helix	260-263	4
α-helix	279-282	4
α-helix	289-293	5
α-helix	296-299	4
α-helix	312-314	3
α-helix	322-328	7
α-helix	331-337	7
α-helix	341-362	22

Chain AL05: 19 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	10-15	6
α-helix	21-25	5
α-helix	30-37	8
α-helix	38-40	3
α-helix	41-43	3
β-strand	50-55	6	58
β-strand	60-66	7	58
β-strand	73-79	7	58
α-helix	80-82	3
α-helix	83-86	4
α-helix	95-113	19
α-helix	132-135	4
α-helix	139-142	4
β-strand	143	1	59
β-strand	145-147	3	58
α-helix	158-169	12
β-strand	172	1	59
β-strand	183-184	2	60
β-strand	189-190	2	60
α-helix	192-200	9
α-helix	202-214	13
α-helix	216-222	7
α-helix	224-228	5
α-helix	236-249	14
α-helix	254-261	8
α-helix	268-271	4
α-helix	273-294	22

Chain AL06: 8 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	51-53	3	64
β-strand	56-57	2	64
α-helix	61-68	8
α-helix	70-72	3
β-strand	94-99	6	65
β-strand	106-111	6	65
α-helix	114-116	3
α-helix	124-128	5
α-helix	136-138	3
β-strand	152-155	4	66
β-strand	163-166	4	66
β-strand	167-170	4	67
β-strand	176-178	3	67
β-strand	190-192	3	67
β-strand	197-199	3	66
α-helix	217-220	4
α-helix	247-266	20
α-helix	270-275	6
β-strand	277	1	66
β-strand	280	1	68

Chain AL07: 12 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	27-79	53
β-strand	82-85	4	73
α-helix	86-89	4
β-strand	91-96	6	74
α-helix	105-113	9
β-strand	121-126	6	74
α-helix	129-135	7
β-strand	142-145	4	74
α-helix	149-156	8
β-strand	161-164	4	75
β-strand	167-170	4	75
α-helix	174-177	4
α-helix	182-184	3
α-helix	189-197	9
α-helix	203-209	7
β-strand	210	1	75
α-helix	211-212	2
β-strand	213-214	2	74
β-strand	228	1	76
α-helix	229-231	3
β-strand	235	1	76
β-strand	236-237	2	74
α-helix	242-249	8

Chain AL08: 16 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	45-46	2
α-helix	52-54	3
β-strand	56	1	78
α-helix	59-73	15
β-strand	76	1	79
α-helix	78-81	4
α-helix	89-100	12
α-helix	103-106	4
α-helix	109-119	11
α-helix	120-122	3
β-strand	137	1	80
α-helix	140-148	9
β-strand	154-158	5	80
α-helix	164-166	3
α-helix	169-177	9
β-strand	181-184	4	80
α-helix	187-193	7
β-strand	201-204	4	80
α-helix	212-222	11
α-helix	223-227	5
α-helix	230-233	4
β-strand	238	1	79
α-helix	244-260	17

Chain AL09: 3 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	83
β-strand	6-11	6	84
β-strand	17-21	5	85
β-strand	24-28	5	85
β-strand	33-37	5	85
β-strand	44-48	5	84
β-strand	54-59	6	84
β-strand	62	1	83
α-helix	64-85	22
β-strand	88-95	8	86
β-strand	102-105	4	87
β-strand	111-115	5	87
β-strand	124-127	4	87
α-helix	128-129	2
β-strand	133-136	4	86
β-strand	143-148	6	86
α-helix	151-164	14
β-strand	178-185	8	86

70 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
18S rRNA	A18S	RNA	1698	Oryctolagus cuniculus
28S rRNA	A25S	RNA	3649	Oryctolagus cuniculus
5.8S rRNA	A58S	RNA	156	Oryctolagus cuniculus
5S rRNA	A5S	RNA	120	Oryctolagus cuniculus
uL2	AL02	protein	244	Oryctolagus cuniculus
60S ribosomal protein L3	AL03	protein	394	Oryctolagus cuniculus	G1TL06 (AlphaFold model)
60S ribosomal protein L4	AL04	protein	362	Oryctolagus cuniculus	A0A5F9DCT1 (AlphaFold model)
60S ribosomal protein L5	AL05	protein	293	Oryctolagus cuniculus	P19949 (AlphaFold model)
60S ribosomal protein L6	AL06	protein	251	Oryctolagus cuniculus	G1SKF7 (AlphaFold model)
uL30	AL07	protein	225	Oryctolagus cuniculus
eL8	AL08	protein	241	Oryctolagus cuniculus
60S ribosomal protein L9	AL09	protein	190	Oryctolagus cuniculus	G1SWI6

72 more molecules are not listed.

Sequence of entity 1 (A18S), FASTA

>7TOQ_1 18S rRNA (chains A18S)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUA
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCGACGGGCGCU
GACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGUGGUGACUCUAGAUAACCUCGGGC
CGAUCGCACGCCCGGCGGCGACGACCCAUUCGAACGUCUGCCCUAUCAACUUUCGAUGGU
AGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUCGAUUCCGGAGA
GGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCGCGCAAAUUACCCACU
CCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCUUUCGAGGCCCUGUAA
UUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAGGGCAAGUCUGGUGCC
AGCAGCCGCGAUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCU
CGUAGUUGGAUCUUGGGAGCGGCCGUCCCCUGCUCGGCGCCGGCCCGAAGCGUUUACUUU
GAAAAAAUUAGAGUGUUCAAAGCAGGCCGCCUGGAUACCGCAGCUAGGAAUAAUGGAAUA
GGACCGCGGUUCUAUUUUGUUGGUUUUCGGAACUGAGGCCAUGAUUAAGAGGGACGGCCG
GGGGCAUUCGUAUUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACCAGA
GCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGAAGA
CGAUCAGAUACCGUCGUAGUUCCGACCAUAAACGAUGCCGACUGGCGAUGCGGCGGCGUU
AUUCCCAUGACCCGCCGGGCAGCUUCCGGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGU
AUGGUUGCAAAGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCU
GCGGCUUAAUUUGACUCAACACGGGAAACCUCACCCGGCCCGGACACGGACAGGAUUGAC
AGAUUGAUAGCUCUUUCUCGAUUCCGUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGG
AGCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCUGGCAUGCUAACUAGUUACGC
GACCCCGGUCGGCGUAACUUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGC
AAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGC
UCAGCGUGUGCCUACCCUACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAU
GGGGAUCGGGGAUUGCAAUUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAU
AAGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUG
GAUGGUUUAGUGAGGCCCUCGGAUCGGCCCCGCCGGGGUGCCCUGGCGGAGCGCUGAGAA
GACGGUCGAACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAA
CCUGCGGAAGGAUCAUUA

Sequence of entity 2 (A25S), FASTA

>7TOQ_2 28S rRNA (chains A25S)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GCGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUCCCGCUCCCGUCGGCGGGGGACCGUCC
CCCGACCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGG
CUCCGGGACGGCUGGGAAGGCCCCGGCGGGGAAGGUGGCCCGGGGGCCCCGGGUGUUACA
GCCCCGCCCCGGCAGCAGCAGCUCGCCGAAUCCCGGGGCCGAGGGAGCGAGACCCGUGCG
CCGCGCUCUCCCCCCUCGGGGGGGCCGGGCCACCCCUCCCACGGCGCGACCGCUGGGGCG
GACUGUCCAGUGCGCCCCGGGCGGGUCGCGCCGUCGGGCCCGGGGGGCCACGCGUCCCCC
GCGAGCGCACGGGGUCGGCGGCGAUGUCGGCUACCCACCCGACCCGUCUUGAAACACGGA
CCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCGUGGCGCAAUG
AAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCAGUCCGCCGAGGGC
GCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCACGAGCGCACGUGUUAG
GACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGAGGAAACUCUGGUGGAG
GUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACU
AAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGCUCUC
CGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCU
AUUCUCAAACUUUAAAUGGGUAAGAAGCCCGGCUCGCUGGUGUGGAGCCGGGCGUGGAAU
GCGAGUGCCUAGUGGGCCACUUUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACG
CCGGGUUAAGGCGCCCGAUGCCGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAU
AGACAGCAGGAUGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACC
UGCCGAAUCAACUAGCCCUGAAAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCG
UCGCCGGCAGUCGGCAGAGCGAGAAAGAGAGUGGCGCGGACGCUACGCCGCGACGAGUAG
GAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGCAGG
UGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGGAGA
AGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGAGCG
CCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUCGGG
UUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGUAAC
GCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUGAAG
GGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCGUCG
CGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGGUGU
AAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUCUGG
CAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAUAAG
GAUUGGCUCUAAGGGCUGGGUCGGUCGCGGCCGGCGCCUAGCAGCCGACUUAGAACUGGU
GCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGGCGGG
UGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAAUGA
AGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAU
CUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCCCUACCUACUAUCCA
GCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCUGUUG
AGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGAAUAAGUGGGAGGCC
GGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCCGGUGAGGCGGGGGG
GCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGCGCGCCGGCCGGGCG
CGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCAAA
CGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUGGAGCAGAA
GGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAAGCGGGGCCU
CACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUACCACAGGGA
UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUCGAUGUCG
GCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCACUAAUAG
GGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAUGU
GUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGACAUUUGGUGU
AUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAUGACUGAACG
CCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGGAGCCUCGGUUGGC
CUCGGAUAGCCGGUCCCCCGCGGGGUCCGGUGCGGAGAGCCCUUCGUCCCGGGAAACGGG
GCGGCCGGAAAGGGGGCCGCCCUCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUG
GCGCUAAACCAUUCGUAGACGACCUGCUUCUGGGUCGGGGUUUCGUACGUAGCAGAGCAG
CUCCCUCGCUGCGAUCUAUUGAAAGUCAGCCCUCGACACAAGGGUUUGU

Sequence of entity 3 (A58S), FASTA

>7TOQ_3 5.8S rRNA (chains A58S)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU

Sequence of entity 4 (A5S), FASTA

>7TOQ_4 5S rRNA (chains A5S)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU

Sequence of entity 5 (AL02), FASTA

>7TOQ_5 uL2 (chains AL02)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGR

Sequence of entity 6 (AL03), FASTA

>7TOQ_6 60S ribosomal protein L3 (chains AL03)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKD

Sequence of entity 7 (AL04), FASTA

>7TOQ_7 60S ribosomal protein L4 (chains AL04)
ACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQ
TSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKR
YAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIK
KVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKLA
PGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRA
LRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAAK
SD

Sequence of entity 8 (AL05), FASTA

>7TOQ_8 60S ribosomal protein L5 (chains AL05)
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIIC
QIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQ
VEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPG
YDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKK
AHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA

Sequence of entity 9 (AL06), FASTA

>7TOQ_9 60S ribosomal protein L6 (chains AL06)
KGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYAAPKSRIERKKKREKVLATVTKPVG
GDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRH
RGKRVVFLKQLSSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPKHLTDAYF
KKKKLRKPRHQEGEIFDTEKEKYEITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFAL
TNGVYPHKLVF

Sequence of entity 10 (AL07), FASTA

>7TOQ_10 uL30 (chains AL07)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGEDAGNREDQINRLIRRMN

Sequence of entity 11 (AL08), FASTA

>7TOQ_11 eL8 (chains AL08)
KVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQ
VLDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTT
LVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCILKGKARLGRLVHRKTCTTVAFT
QVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKL
G

Sequence of entity 12 (AL09), FASTA

>7TOQ_12 60S ribosomal protein L9 (chains AL09)
MKTILSNQTVDIPENVDISLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELVLEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQA

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Primary citation

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Loveland, A.B., Svidritskiy, E., Susorov, D. et al. Nat Commun (2022) 13:2776-2776. DOI 10.1038/s41467-022-30418-0 · PubMed

Other PDB entries of the same protein (UniProt G1TL06 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7O7Y 2.2 Å, Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a…
7OYD 2.3 Å, Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b
11IQ 2.4 Å, Rabbit 80S with eEF2,eIF5A and SERBP1
7O7Z 2.4 Å, Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a…
8SCB 2.5 Å, Terminating ribosome with SRI-41315
9MR4 2.65 Å, NAC: Ribosome nascent chain complex(Oxa1L)
9RHU 2.65 Å, Rabbit 80S ribosome in complex with eRF1-AAQ, stalled at the Stop codon in mutated F2A…
8RJB 2.69 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
8VVQ 2.7 Å, Codon sampling state of elongation inhibitor-treated mammalian ribosomes obtained from…
8RJD 2.79 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
8B6C 2.79 Å, Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative…
6SGC 2.8 Å, Rabbit 80S ribosome stalled on a poly(A) tail

Browse structure collections

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