7TOR: Mammalian 80S ribosome
Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20. Determined by electron microscopy at 2.9 Å resolution. Released 25 May 2022.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organisms
- Oryctolagus cuniculus, Escherichia coli K-12, Homo sapiens
- Chains
- 86
- Atoms
- 213,154
- Mol. weight
- 3184.55 kDa
- Ligands
- ZN
- Released
- 25 May 2022
Explore 7TOR in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7TOR contains 527 α-helices and 555 β-strands across 77 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain AL02: 11 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 6-9 | 4 | |
| α-helix | 30-32 | 3 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 28 |
| β-strand | 58-64 | 7 | 28 |
| β-strand | 71-77 | 7 | 28 |
| α-helix | 78 | 1 | |
| β-strand | 79 | 1 | 29 |
| β-strand | 83 | 1 | 30 |
| β-strand | 87-91 | 5 | 28 |
| β-strand | 101-103 | 3 | 28 |
| α-helix | 104-106 | 3 | |
| β-strand | 112-114 | 3 | 28 |
| β-strand | 116 | 1 | 31 |
| β-strand | 126 | 1 | 31 |
| β-strand | 134-140 | 7 | 28 |
| α-helix | 142-144 | 3 | |
| β-strand | 145-149 | 5 | 28 |
| β-strand | 155-159 | 5 | 28 |
| β-strand | 163-166 | 4 | 28 |
| α-helix | 168 | 1 | |
| β-strand | 169 | 1 | 29 |
| α-helix | 174-176 | 3 | |
| α-helix | 178-179 | 2 | |
| α-helix | 182-190 | 9 | |
| β-strand | 224-225 | 2 | 32 |
| β-strand | 237-238 | 2 | 32 |
Chain AL03: 13 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-10 | 2 | |
| α-helix | 32-34 | 3 | |
| α-helix | 40-41 | 2 | |
| β-strand | 42-43 | 2 | 38 |
| β-strand | 45-54 | 10 | 39 |
| β-strand | 57-59 | 3 | 40 |
| β-strand | 71-73 | 3 | 40 |
| β-strand | 76-80 | 5 | 39 |
| α-helix | 82-83 | 2 | |
| β-strand | 84-95 | 12 | 41 |
| β-strand | 98-106 | 9 | 41 |
| α-helix | 112-115 | 4 | |
| α-helix | 133-137 | 5 | |
| α-helix | 140-156 | 17 | |
| β-strand | 159-165 | 7 | 41 |
| β-strand | 180-184 | 5 | 41 |
| β-strand | 185-186 | 2 | 38 |
| α-helix | 190-199 | 10 | |
| β-strand | 204-205 | 2 | 41 |
| α-helix | 207-210 | 4 | |
| β-strand | 216-222 | 7 | 39 |
| α-helix | 223-224 | 2 | |
| β-strand | 225-229 | 5 | 42 |
| α-helix | 231-234 | 4 | |
| α-helix | 237-241 | 5 | |
| β-strand | 270-273 | 4 | 42 |
| β-strand | 276-287 | 12 | 39 |
| β-strand | 292-294 | 3 | 43 |
| β-strand | 297-299 | 3 | 43 |
| β-strand | 320 | 1 | 44 |
| β-strand | 324 | 1 | 44 |
| β-strand | 330-334 | 5 | 39 |
| β-strand | 344-349 | 6 | 39 |
| β-strand | 365-367 | 3 | 40 |
| α-helix | 382-389 | 8 | |
Chain AL04: 24 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-11 | 5 | 50 |
| α-helix | 16 | 1 | |
| β-strand | 17-23 | 7 | 50 |
| α-helix | 24-25 | 2 | |
| α-helix | 26-29 | 4 | |
| α-helix | 34-44 | 11 | |
| β-strand | 64-66 | 3 | 51 |
| β-strand | 77-79 | 3 | 51 |
| α-helix | 100-101 | 2 | |
| α-helix | 117-130 | 14 | |
| α-helix | 134-138 | 5 | |
| β-strand | 152-154 | 3 | 50 |
| α-helix | 156-160 | 5 | |
| α-helix | 164-173 | 10 | |
| α-helix | 177-185 | 9 | |
| β-strand | 188-189 | 2 | 52 |
| α-helix | 190 | 1 | |
| α-helix | 193-196 | 4 | |
| β-strand | 201-202 | 2 | 52 |
| β-strand | 208-211 | 4 | 50 |
| α-helix | 217-221 | 5 | |
| β-strand | 228-231 | 4 | 50 |
| α-helix | 237-240 | 4 | |
| α-helix | 242-244 | 3 | |
| β-strand | 250-253 | 4 | 50 |
| α-helix | 254-258 | 5 | |
| α-helix | 260-263 | 4 | |
| α-helix | 279-282 | 4 | |
| α-helix | 289-293 | 5 | |
| α-helix | 296-300 | 5 | |
| α-helix | 303-305 | 3 | |
| α-helix | 322-328 | 7 | |
| α-helix | 332-337 | 6 | |
| α-helix | 341-362 | 22 | |
Chain AL05: 17 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-14 | 5 | |
| α-helix | 21-25 | 5 | |
| α-helix | 30-35 | 6 | |
| β-strand | 49-55 | 7 | 56 |
| β-strand | 60-66 | 7 | 56 |
| β-strand | 73-79 | 7 | 56 |
| α-helix | 80-82 | 3 | |
| α-helix | 95-112 | 18 | |
| α-helix | 134-135 | 2 | |
| α-helix | 139-142 | 4 | |
| β-strand | 143 | 1 | 57 |
| β-strand | 145-147 | 3 | 56 |
| α-helix | 158-168 | 11 | |
| β-strand | 172 | 1 | 57 |
| β-strand | 183-184 | 2 | 58 |
| β-strand | 189-190 | 2 | 58 |
| α-helix | 192-199 | 8 | |
| α-helix | 202-214 | 13 | |
| α-helix | 216-222 | 7 | |
| α-helix | 225-228 | 4 | |
| α-helix | 236-249 | 14 | |
| α-helix | 255-257 | 3 | |
| α-helix | 259-261 | 3 | |
| α-helix | 268-272 | 5 | |
| α-helix | 273-294 | 22 | |
Chain AL06: 9 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 43-47 | 5 | |
| α-helix | 50 | 1 | |
| β-strand | 51-53 | 3 | 63 |
| β-strand | 56-57 | 2 | 63 |
| α-helix | 61-68 | 8 | |
| α-helix | 70-72 | 3 | |
| β-strand | 94-99 | 6 | 64 |
| β-strand | 106-111 | 6 | 64 |
| α-helix | 114-116 | 3 | |
| α-helix | 124-129 | 6 | |
| α-helix | 136-138 | 3 | |
| β-strand | 151-155 | 5 | 65 |
| β-strand | 163 | 1 | 66 |
| β-strand | 164-166 | 3 | 65 |
| β-strand | 167-170 | 4 | 67 |
| β-strand | 176-178 | 3 | 67 |
| β-strand | 190-192 | 3 | 67 |
| β-strand | 197-203 | 7 | 65 |
| α-helix | 247-264 | 18 | |
| α-helix | 270-275 | 6 | |
| β-strand | 277 | 1 | 66 |
| β-strand | 280 | 1 | 68 |
Chain AL07: 12 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 25-77 | 53 | |
| β-strand | 80-82 | 3 | 75 |
| α-helix | 83-86 | 4 | |
| β-strand | 88-93 | 6 | 76 |
| α-helix | 102-110 | 9 | |
| β-strand | 118-123 | 6 | 76 |
| α-helix | 126-133 | 8 | |
| β-strand | 139-142 | 4 | 76 |
| α-helix | 146-155 | 10 | |
| β-strand | 158-161 | 4 | 77 |
| β-strand | 164-167 | 4 | 77 |
| α-helix | 171-178 | 8 | |
| α-helix | 179-181 | 3 | |
| α-helix | 186-194 | 9 | |
| α-helix | 200-206 | 7 | |
| β-strand | 207 | 1 | 77 |
| α-helix | 208-209 | 2 | |
| β-strand | 210-211 | 2 | 76 |
| α-helix | 214-215 | 2 | |
| β-strand | 225 | 1 | 78 |
| β-strand | 232 | 1 | 78 |
| β-strand | 233-234 | 2 | 76 |
| α-helix | 239-246 | 8 | |
Chain AL08: 16 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 98-100 | 3 | |
| α-helix | 105-107 | 3 | |
| α-helix | 112-126 | 15 | |
| β-strand | 129 | 1 | 81 |
| α-helix | 131-134 | 4 | |
| α-helix | 142-154 | 13 | |
| α-helix | 156-159 | 4 | |
| α-helix | 160-175 | 16 | |
| α-helix | 185-187 | 3 | |
| β-strand | 189-191 | 3 | 82 |
| α-helix | 193-201 | 9 | |
| β-strand | 207-211 | 5 | 82 |
| α-helix | 217-219 | 3 | |
| α-helix | 222-229 | 8 | |
| β-strand | 234-237 | 4 | 82 |
| α-helix | 240-243 | 4 | |
| β-strand | 254-257 | 4 | 82 |
| α-helix | 266-275 | 10 | |
| α-helix | 276-280 | 5 | |
| α-helix | 283-287 | 5 | |
| β-strand | 291 | 1 | 81 |
| α-helix | 297-318 | 22 | |
Chain AL09: 5 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-11 | 9 | 86 |
| β-strand | 17-21 | 5 | 87 |
| β-strand | 24-28 | 5 | 87 |
| β-strand | 33-37 | 5 | 87 |
| β-strand | 44-46 | 3 | 86 |
| α-helix | 50-52 | 3 | |
| β-strand | 54-62 | 9 | 86 |
| α-helix | 64-85 | 22 | |
| β-strand | 88-95 | 8 | 88 |
| β-strand | 102-106 | 5 | 89 |
| β-strand | 111-115 | 5 | 89 |
| α-helix | 117-119 | 3 | |
| β-strand | 124-127 | 4 | 89 |
| α-helix | 128-129 | 2 | |
| β-strand | 133-135 | 3 | 88 |
| β-strand | 144-148 | 5 | 88 |
| α-helix | 151-164 | 14 | |
| β-strand | 178-185 | 8 | 88 |
69 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 18S rRNA | A18S | RNA | 1698 | Oryctolagus cuniculus | |
| 28S rRNA | A28S | RNA | 3552 | Oryctolagus cuniculus | |
| 5.8S rRNA | A58S | RNA | 151 | Oryctolagus cuniculus | |
| 5S rRNA | A5S | RNA | 120 | Oryctolagus cuniculus | |
| 60S ribosomal protein L8 | AL02 | protein | 248 | Oryctolagus cuniculus | G1TT27 (AlphaFold model) |
| 60S ribosomal protein L3 | AL03 | protein | 394 | Oryctolagus cuniculus | G1TL06 (AlphaFold model) |
| 60S ribosomal protein L4 | AL04 | protein | 362 | Oryctolagus cuniculus | A0A5F9DCT1 (AlphaFold model) |
| 60S ribosomal protein L5 | AL05 | protein | 293 | Oryctolagus cuniculus | P19949 (AlphaFold model) |
| 60S ribosomal protein L6 | AL06 | protein | 251 | Oryctolagus cuniculus | G1SKF7 |
| 60S ribosomal protein L7 | AL07 | protein | 225 | Oryctolagus cuniculus | G1SV32 |
| eL8 | AL08 | protein | 233 | Oryctolagus cuniculus | |
| 60S ribosomal protein L9 | AL09 | protein | 190 | Oryctolagus cuniculus | G1SWI6 |
72 more molecules are not listed.
Sequence of entity 1 (A18S), FASTA
>7TOR_1 18S rRNA (chains A18S)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUA
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCGACGGGCGCU
GACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGUGGUGACUCUAGAUAACCUCGGGC
CGAUCGCACGCCCGGCGGCGACGACCCAUUCGAACGUCUGCCCUAUCAACUUUCGAUGGU
AGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUCGAUUCCGGAGA
GGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCGCGCAAAUUACCCACU
CCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCUUUCGAGGCCCUGUAA
UUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAGGGCAAGUCUGGUGCC
AGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCU
CGUAGUUGGAUCUUGGGAGCGGCCGUCCCCUGCUCGGCGCCGGCCCGAAGCGUUUACUUU
GAAAAAAUUAGAGUGUUCAAAGCAGGCCGCCUGGAUACCGCAGCUAGGAAUAAUGGAAUA
GGACCGCGGUUCUAUUUUGUUGGUUUUCGGAACUGAGGCCAUGAUUAAGAGGGACGGCCG
GGGGCAUUCGUAUUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACCAGA
GCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGAAGA
CGAUCAGAUACCGUCGUAGUUCCGACCAUAAACGAUGCCGACUGGCGAUGCGGCGGCGUU
AUUCCCAUGACCCGCCGGGCAGCUUCCGGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGU
AUGGUUGCAAAGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCU
GCGGCUUAAUUUGACUCAACACGGGAAACCUCACCCGGCCCGGACACGGACAGGAUUGAC
AGAUUGAUAGCUCUUUCUCGAUUCCGUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGG
AGCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCUGGCAUGCUAACUAGUUACGC
GACCCCGGUCGGCGUAACUUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGC
AAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGC
UCAGCGUGUGCCUACCCUACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAU
GGGGAUCGGGGAUUGCAAUUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAU
AAGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUG
GAUGGUUUAGUGAGGCCCUCGGAUCGGCCCCGCCGGGGUGCCCUGGCGGAGCGCUGAGAA
GACGGUCGAACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAA
CCUGCGGAAGGAUCAUUA
Sequence of entity 2 (A28S), FASTA
>7TOR_2 28S rRNA (chains A28S)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAA
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGAAAUGUGGCGUACGGAAGACCCACUCCCCGGCGC
GGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCGGUAGCGGC
CCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCAGCCCAAAG
CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAACAAGUACC
GUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAACCGUUAAG
AGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGCGCGGUCCG
GCCGUGCCGGCGGGGCGGAUCCCCGCUCUCGGCGGGGGACCGCCCCCCGGCCGGCGACCG
GCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGGACGGCUGG
GAAGGCCCCGGCGGGGAAGGUGGCCCGGGGGCCCCGGGUGUUACAGCCCCGCCCCGGCAG
CAGCAGCUCGCCGAAUCCCGGGGCCGAGGGAGCGAGACCCGUGCGCCGCGCUCUCCCCCC
GGGGGGCCGGGCCACCCCUCCCACGGCGCGACCGCUGGGGCGGACUGUCCAGUGCGCCCC
GGGCGGGUCGCGCCGUCGGGCCCGGGGGGCCACGCGUCCAGCGCACGGGGUCGGCGGCGA
UGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAAGGAGUCUAACACGUGCGCGA
GUCGGGGGCUACGAAAGCCGCCGUGGCGCAAUGAAGGUGAAGGCCGGCCGGCCGAGGUGG
GAUCCCGAGGCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGA
GGUGGAGCACGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGC
GAAGCCAGAGGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCGAAUCGGUCGUCC
GACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCAAAGU
UUCCCUCAGGAUAGCUGGCGCUCUCCGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGU
CUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGUAAGAAGCCCGGCUC
GCUGGUGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACUUUUGGUAAGCAGAA
CUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGCCGACGCUCAUCAGA
CCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGAUGGUGGCCAUGGAAGUCGGAAUCC
GCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGAAAAUGGAUGGCGCU
GGAGCGUCGGGCCCAUACCCGGCCGUCGCUGGCAGUCGGCAGAGCGAGAAAGAGAGGGAC
GCUACGCCGCGACGAGUAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCC
CGGGUGGAGCCGCCGCAGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACU
UUGAAGGCCGAAGUGGAGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGU
CCUGAGAGAUGGGCGAGCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCAGC
CGAUCGAAAGGGAGUCGGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCG
AGGCGUCCAGUGCGGUAACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAG
UUCUCUUUUCUUUGUGAAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCC
CGUGCCUUGGAAAGCGUCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAA
AAUCCGGGGGAGAGGGUGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUC
CAAGGUGAACAGCCUCUGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGA
UCCGUAACUUCGGGAUAAGGAUUGGCUCUAAGGGCUCAGCCGACUUAGAACUGGUGCGGA
CCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGGCGGGUGUUG
ACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAAUGAAGCGC
GGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCUAAU
UAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCCCUACCUACUAUCCAGCGAA
ACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCUGUUGAGCUU
GACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGAAUAAGUGGGAGGCCGGCCG
CCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCCGGUGAGGCGGGGGGGCGAG
GGCUCUCGCUUCUGGCGCCAAGCGCCCGGCGCCGGGCGCGACCCGCUCCGGGGACAGUGC
CAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGG
CGAGCUCAGGGAGGACAGAAACCUCCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUU
GAUUUUCAGUACGAAUACAGACCGUGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGG
GUUUUAAGCAGGAGGUGUCAGAAAAGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAG
CGUUCAUAGCGACGUCGCUUUUUGAUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGC
AGAAUUCACCAAGCGUUGGAUUGUUCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGAC
CGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGC
UCAGUACGAGAGGAACCGCAGGUUCAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAA
UGGGGCGAAGCUACCAUCUGUGGGAUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCC
AGGCGGAACGAUAGCCGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGGGGGUCCGG
UGCGGAGAGCCCUUCGUCCCGGGAAACGGGGCGGCCGGAAAGGGGGCCGCCCUCUCGCCC
GUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGACGACCUGCUUC
UGGGUCGGGGUUUCGUACGUAGCAGAGCAGGCUGCGAUCUAUUGAAAGUCAGCCCUCGAC
ACAAGGGUUUGU
Sequence of entity 3 (A58S), FASTA
>7TOR_3 5.8S rRNA (chains A58S)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCGGGUUC
CUCCCGGGGCUACGCCUGUCUGAGCGUCGCU
Sequence of entity 4 (A5S), FASTA
>7TOR_4 5S rRNA (chains A5S)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 5 (AL02), FASTA
>7TOR_5 60S ribosomal protein L8 (chains AL02)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGRLRGT
Sequence of entity 6 (AL03), FASTA
>7TOR_6 60S ribosomal protein L3 (chains AL03)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKD
Sequence of entity 7 (AL04), FASTA
>7TOR_7 60S ribosomal protein L4 (chains AL04)
ACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQ
TSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKR
YAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIK
KVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKLA
PGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRA
LRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAAK
SD
Sequence of entity 8 (AL05), FASTA
>7TOR_8 60S ribosomal protein L5 (chains AL05)
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIIC
QIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQ
VEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPG
YDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKK
AHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA
Sequence of entity 9 (AL06), FASTA
>7TOR_9 60S ribosomal protein L6 (chains AL06)
KGKPHCSRNPVLVRGIGRYSRSAMYSRKALYKRKYAAPKSRIERKKKREKVLATVTKPVG
GDKNGGTRVVKLRKMPRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRH
RGKRVVFLKQLSSGLLLVTGPLSLNRVPLRRTHQKFVIATSTKIDISGVKIPKHLTDAYF
KKKKLRKPRHQEGEIFDTEKEKYEITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFAL
TNGVYPHKLVF
Sequence of entity 10 (AL07), FASTA
>7TOR_10 60S ribosomal protein L7 (chains AL07)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNTLIARSLGKYNIICMEDLIHEIYTVGKHFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
Sequence of entity 11 (AL08), FASTA
>7TOR_11 eL8 (chains AL08)
VVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQV
LDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAKRPPVLRAGVNTVTTLVENKKAQ
LVVIAHDVDPIELVVFLPALCRKMGVPYCILKGKARLGRLVHRKTCTTVAFTQVNSEDKG
ALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG
Sequence of entity 12 (AL09), FASTA
>7TOR_12 60S ribosomal protein L9 (chains AL09)
MKTILSNQTVDIPENVDISLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELVLEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 6 |
Primary citation
Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Loveland, A.B., Svidritskiy, E., Susorov, D. et al. Nat Commun (2022) 13:2776-2776. DOI 10.1038/s41467-022-30418-0 · PubMed
Other PDB entries of the same protein (UniProt G1TT27 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 11IQ 2.4 Å, Rabbit 80S with eEF2,eIF5A and SERBP1
- 8SCB 2.5 Å, Terminating ribosome with SRI-41315
- 9MR4 2.65 Å, NAC: Ribosome nascent chain complex(Oxa1L)
- 9RHU 2.65 Å, Rabbit 80S ribosome in complex with eRF1-AAQ, stalled at the Stop codon in mutated F2A…
- 8RJB 2.69 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
- 8VVQ 2.7 Å, Codon sampling state of elongation inhibitor-treated mammalian ribosomes obtained from…
- 8RJD 2.79 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
- 8B6C 2.79 Å, Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative…
- 6SGC 2.8 Å, Rabbit 80S ribosome stalled on a poly(A) tail
- 7UCK 2.8 Å, 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine
- 9BDL 2.8 Å, 80S ribosome with angiogenin
- 9QQA 2.8 Å, Ternary complex of translating ribosome, NAC and NMT1
Browse structure collections
About this viewer
MolViewer shows 7TOR directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.