Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1. Determined by X-ray diffraction at 3.11 Å resolution. Released 6 Apr 2022.
Explore 7UIQ in 3D Show helices and sheets RCSB PDB PDBe
7UIQ contains 30 α-helices and 36 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8-12 | 5 | |
| β-strand | 13 | 1 | 1 |
| β-strand | 18-20 | 3 | 2 |
| β-strand | 22 | 1 | 3 |
| β-strand | 24 | 1 | 3 |
| β-strand | 25-31 | 7 | 2 |
| β-strand | 32 | 1 | 1 |
| β-strand | 38-45 | 8 | 2 |
| α-helix | 52-64 | 13 | |
| β-strand | 69 | 1 | 4 |
| β-strand | 72 | 1 | 4 |
| β-strand | 75-81 | 7 | 2 |
| β-strand | 84-89 | 6 | 2 |
| α-helix | 90-91 | 2 | |
| β-strand | 96 | 1 | 4 |
| α-helix | 97-104 | 8 | |
| α-helix | 109-128 | 20 | |
| β-strand | 131-132 | 2 | 5 |
| α-helix | 138-140 | 3 | |
| β-strand | 141-143 | 3 | 4 |
| β-strand | 152-154 | 3 | 4 |
| α-helix | 157-159 | 3 | |
| β-strand | 161-162 | 2 | 5 |
| β-strand | 169 | 1 | 6 |
| α-helix | 177-179 | 3 | |
| α-helix | 182-186 | 5 | |
| β-strand | 190 | 1 | 6 |
| α-helix | 194-208 | 15 | |
| α-helix | 218-227 | 10 | |
| α-helix | 237-239 | 3 | |
| α-helix | 242-251 | 10 | |
| α-helix | 260-261 | 2 | |
| α-helix | 262-267 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 9-12 | 4 | |
| β-strand | 13-20 | 8 | 7 |
| β-strand | 22 | 1 | 8 |
| β-strand | 24 | 1 | 8 |
| β-strand | 25-32 | 8 | 7 |
| β-strand | 38-45 | 8 | 7 |
| α-helix | 53-65 | 13 | |
| β-strand | 69 | 1 | 9 |
| β-strand | 72 | 1 | 9 |
| β-strand | 75-81 | 7 | 7 |
| β-strand | 84-89 | 6 | 7 |
| β-strand | 96 | 1 | 9 |
| α-helix | 97-104 | 8 | |
| α-helix | 109-128 | 20 | |
| β-strand | 131-132 | 2 | 10 |
| α-helix | 138-140 | 3 | |
| β-strand | 141-143 | 3 | 9 |
| β-strand | 152-154 | 3 | 9 |
| α-helix | 157-159 | 3 | |
| β-strand | 161-162 | 2 | 10 |
| β-strand | 169 | 1 | 11 |
| α-helix | 177-179 | 3 | |
| α-helix | 182-186 | 5 | |
| β-strand | 190 | 1 | 11 |
| α-helix | 194-208 | 15 | |
| β-strand | 217 | 1 | 12 |
| α-helix | 218-227 | 10 | |
| α-helix | 242-251 | 10 | |
| α-helix | 260-261 | 2 | |
| α-helix | 262-267 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1542 | 1 | 12 |
| α-helix | 1546-1549 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1546-1549 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | A, B | protein | 268 | Homo sapiens | Q9UQM7 (AlphaFold model) |
| T-lymphoma invasion and metastasis-inducing protein 1 | C, D | protein | 19 | Mus musculus | Q60610 (AlphaFold model) |
>7UIQ_1 Calcium/calmodulin-dependent protein kinase type II subunit alpha (chains A, B) TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC HQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKD LINKMLTINPSKRITAAEALKHPWISHR
>7UIQ_2 T-lymphoma invasion and metastasis-inducing protein 1 (chains C, D) RTLDSHASRMTQLKKQAAL
CaMKII binds both substrates and activators at the active site. Ozden, C., Sloutsky, R., Mitsugi, T. et al. Cell Rep (2022) 40:111064-111064. DOI 10.1016/j.celrep.2022.111064 · PubMed
Other PDB entries of the same protein (UniProt Q9UQM7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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