Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B. Determined by X-ray diffraction at 2.56 Å resolution. Released 13 Apr 2022.
Explore 7UJP in 3D Show helices and sheets RCSB PDB PDBe
7UJP contains 31 α-helices and 30 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 9-12 | 4 | |
| β-strand | 13-21 | 9 | 1 |
| β-strand | 25-32 | 8 | 1 |
| β-strand | 37-45 | 9 | 1 |
| α-helix | 51-66 | 16 | |
| β-strand | 72 | 1 | 2 |
| α-helix | 73-74 | 2 | |
| β-strand | 75-81 | 7 | 1 |
| β-strand | 84-90 | 7 | 1 |
| β-strand | 96 | 1 | 2 |
| α-helix | 97-104 | 8 | |
| α-helix | 109-128 | 20 | |
| β-strand | 131-132 | 2 | 3 |
| α-helix | 138-140 | 3 | |
| β-strand | 141-143 | 3 | 2 |
| α-helix | 150-151 | 2 | |
| β-strand | 152-154 | 3 | 2 |
| β-strand | 161-162 | 2 | 3 |
| β-strand | 169 | 1 | 4 |
| β-strand | 175 | 1 | 5 |
| α-helix | 177-179 | 3 | |
| α-helix | 182-185 | 4 | |
| β-strand | 190 | 1 | 4 |
| α-helix | 193-208 | 16 | |
| α-helix | 218-226 | 9 | |
| α-helix | 242-251 | 10 | |
| α-helix | 260-261 | 2 | |
| α-helix | 262-265 | 4 | |
| α-helix | 269-272 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 9-12 | 4 | |
| β-strand | 13-21 | 9 | 6 |
| β-strand | 25-32 | 8 | 6 |
| α-helix | 33-35 | 3 | |
| β-strand | 37-45 | 9 | 6 |
| α-helix | 51-66 | 16 | |
| β-strand | 72 | 1 | 7 |
| α-helix | 73-74 | 2 | |
| β-strand | 75-81 | 7 | 6 |
| β-strand | 84-90 | 7 | 6 |
| β-strand | 96 | 1 | 7 |
| α-helix | 97-104 | 8 | |
| α-helix | 109-128 | 20 | |
| β-strand | 131-132 | 2 | 8 |
| α-helix | 138-140 | 3 | |
| β-strand | 141-143 | 3 | 7 |
| α-helix | 150-151 | 2 | |
| β-strand | 152-154 | 3 | 7 |
| β-strand | 161-162 | 2 | 8 |
| β-strand | 169 | 1 | 9 |
| β-strand | 175 | 1 | 10 |
| α-helix | 177-179 | 3 | |
| α-helix | 182-185 | 4 | |
| β-strand | 190 | 1 | 9 |
| α-helix | 193-208 | 16 | |
| α-helix | 218-226 | 9 | |
| α-helix | 242-251 | 10 | |
| α-helix | 260-261 | 2 | |
| α-helix | 262-265 | 4 | |
| α-helix | 269-272 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1304 | 1 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | A, B | protein | 268 | Homo sapiens | Q9UQM7 (AlphaFold model) |
| Glutamate receptor ionotropic, NMDA 2B | C, D | protein | 22 | Homo sapiens | Q13224 (AlphaFold model) |
>7UJP_1 Calcium/calmodulin-dependent protein kinase type II subunit alpha (chains A, B) TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC HQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKD LINKMLTINPSKRITAAEALKHPWISHR
>7UJP_2 Glutamate receptor ionotropic, NMDA 2B (chains C, D) KAQKKNRNKLRRQHSYDTFVDL
| ID | Name | Formula | Copies |
|---|---|---|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
| MG | Magnesium ion | Mg | 3 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
Water and common crystallization additives (GOL) are not listed.
CaMKII binds both substrates and activators at the active site. Ozden, C., Sloutsky, R., Mitsugi, T. et al. Cell Rep (2022) 40:111064-111064. DOI 10.1016/j.celrep.2022.111064 · PubMed
Other PDB entries of the same protein (UniProt Q9UQM7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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