7VBA: DNA-directed RNA polymerase I subunit RPA1

Structure of the pre state human RNA Polymerase I Elongation Complex. Determined by electron microscopy at 2.89 Å resolution. Released 16 Feb 2022.

Method: Electron microscopy
Resolution: 2.89 Å
Organism: Homo sapiens
Chains: 16
Atoms: 33,079
Mol. weight: 616.63 kDa
Ligands: ZN, MG, 2TM
Released: 16 Feb 2022

Explore 7VBA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7VBA contains 160 α-helices and 229 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 74 helices, 58 β-strands

Element	Residues	Length	Sheet
β-strand	10	1	1
β-strand	12-19	8	2
β-strand	32	1	3
β-strand	39	1	4
β-strand	45	1	4
α-helix	46	1
β-strand	63	1	5
β-strand	70	1	5
β-strand	79-88	10	3
α-helix	93-101	9
α-helix	114-127	14
α-helix	133-143	11
α-helix	158-171	14
α-helix	177-179	3
α-helix	185-198	14
β-strand	216-217	2	6
β-strand	223-225	3	6
β-strand	254-255	2	6
α-helix	258-279	22
α-helix	294-297	4
β-strand	298-304	7	3
α-helix	305-306	2
α-helix	307-309	3
β-strand	315	1	7
β-strand	318	1	7
α-helix	323-347	25
α-helix	382-400	19
α-helix	404-406	3
α-helix	417-421	5
β-strand	436-437	2	8
β-strand	440-443	4	9
β-strand	445-447	3	10
β-strand	456-458	3	10
β-strand	467-471	5	11
α-helix	472	1
α-helix	477-486	10
β-strand	494-498	5	11
β-strand	505-506	2	11
α-helix	514-519	6
α-helix	534-536	3
β-strand	537-541	5	11
β-strand	548-551	4	9
α-helix	558-560	3
β-strand	561-564	4	9
β-strand	567-568	2	10
β-strand	575-577	3	10
α-helix	579-581	3
α-helix	582-585	4
β-strand	594-597	4	9
α-helix	604-610	7
β-strand	613	1	9
β-strand	619	1	12
β-strand	626	1	12
α-helix	632-634	3
α-helix	635-641	7
α-helix	650-653	4
α-helix	658-661	4
β-strand	675	1	13
β-strand	681	1	13
α-helix	685-695	11
α-helix	702-704	3
β-strand	705-708	4	14
β-strand	717	1	15
α-helix	729-732	4
β-strand	736-739	4	14
β-strand	744	1	14
α-helix	761-769	9
α-helix	771-791	21
β-strand	795	1	16
β-strand	804	1	17
α-helix	809-819	11
α-helix	823-830	8
α-helix	841-850	10
α-helix	858-880	23
β-strand	885	1	17
α-helix	906-909	4
β-strand	910	1	18
β-strand	913	1	18
β-strand	917-918	2	19
α-helix	925-928	4
α-helix	945-948	4
β-strand	950-951	2	19
α-helix	961-995	35
β-strand	1000-1001	2	20
β-strand	1007-1008	2	20
β-strand	1014-1016	3	20
α-helix	1026-1029	4
α-helix	1037-1042	6
α-helix	1044-1047	4
α-helix	1048-1052	5
α-helix	1053-1058	6
α-helix	1063-1078	16
α-helix	1088-1091	4
α-helix	1096-1098	3
α-helix	1099-1103	5
α-helix	1115-1125	11
α-helix	1137-1139	3
α-helix	1141-1145	5
α-helix	1146-1149	4
α-helix	1161-1178	18
α-helix	1189-1201	13
α-helix	1211-1225	15
α-helix	1245-1248	4
α-helix	1249-1254	6
β-strand	1264-1267	4	21
α-helix	1272-1285	14
β-strand	1288-1289	2	22
α-helix	1290-1292	3
β-strand	1298-1300	3	23
β-strand	1316-1318	3	23
α-helix	1321-1323	3
α-helix	1324-1326	3
α-helix	1328-1330	3
α-helix	1335-1341	7
α-helix	1342-1346	5
α-helix	1347-1358	12
α-helix	1497-1508	12
β-strand	1526-1528	3	23
α-helix	1541-1546	6
β-strand	1552-1554	3	22
β-strand	1562-1565	4	21
β-strand	1577-1580	4	21
α-helix	1586-1591	6
β-strand	1601-1602	2	21
α-helix	1608-1611	4
α-helix	1614-1630	17
α-helix	1638-1648	11
β-strand	1651	1	24
α-helix	1677-1686	10
β-strand	1690-1691	2	2
α-helix	1696-1701	6
β-strand	1713-1714	2	25

Chain B: 39 helices, 74 β-strands

Element	Residues	Length	Sheet
α-helix	27-28	2
α-helix	40-47	8
α-helix	48-52	5
α-helix	53-60	8
β-strand	64-68	5	26
β-strand	71-82	12	26
β-strand	86	1	27
β-strand	97	1	27
β-strand	111-122	12	26
β-strand	126-138	13	26
β-strand	140	1	28
α-helix	155-158	4
β-strand	170	1	28
β-strand	177	1	28
β-strand	181-184	4	29
β-strand	190-193	4	30
α-helix	196-201	6
β-strand	205-216	12	30
β-strand	220-229	10	30
β-strand	234-240	7	30
β-strand	243-248	6	30
α-helix	251-256	6
α-helix	261-268	8
α-helix	276-286	11
α-helix	297-308	12
α-helix	320-331	12
α-helix	340-357	18
α-helix	362-365	4
α-helix	369-371	3
β-strand	373-375	3	29
α-helix	377-403	27
α-helix	408-411	4
α-helix	415-422	8
α-helix	427-435	9
β-strand	456	1	28
α-helix	462-465	4
β-strand	471-473	3	29
α-helix	477-479	3
β-strand	497	1	31
β-strand	511-513	3	29
β-strand	514	1	31
β-strand	515	1	32
β-strand	519-520	2	33
α-helix	530-537	8
β-strand	539	1	34
β-strand	553-554	2	34
β-strand	558	1	35
β-strand	561	1	35
β-strand	566-567	2	34
α-helix	571-584	14
β-strand	594-598	5	36
α-helix	607-608	2
β-strand	609-613	5	36
β-strand	619-625	7	33
β-strand	632-635	4	33
α-helix	638-641	4
β-strand	644-645	2	33
β-strand	658-660	3	33
β-strand	668	1	32
α-helix	677-679	3
α-helix	682-691	10
β-strand	695-696	2	37
β-strand	712-714	3	38
β-strand	718	1	37
β-strand	722	1	39
α-helix	726-729	4
β-strand	738-745	8	37
β-strand	747	1	16
β-strand	757-760	4	37
α-helix	761-765	5
β-strand	771-780	10	38
β-strand	794	1	40
α-helix	801-803	3
β-strand	807	1	41
β-strand	813	1	41
α-helix	814	1
β-strand	818-819	2	38
β-strand	828-830	3	40
β-strand	835-837	3	40
β-strand	847-855	9	38
β-strand	866-874	9	38
β-strand	882-884	3	37
β-strand	891-897	7	37
β-strand	905	1	42
β-strand	913-915	3	37
α-helix	920-923	4
α-helix	926-941	16
β-strand	945	1	39
α-helix	958-967	10
β-strand	976-977	2	37
β-strand	979	1	42
β-strand	980	1	43
β-strand	987	1	43
α-helix	991	1
β-strand	992-1002	11	37
β-strand	1011-1013	3	9
β-strand	1019	1	44
β-strand	1024	1	44
α-helix	1034	1
β-strand	1035-1036	2	8
α-helix	1039-1045	7
α-helix	1051-1055	5
α-helix	1056-1062	7
β-strand	1065	1	45
β-strand	1068-1070	3	46
β-strand	1075	1	46
β-strand	1079-1080	2	47
β-strand	1097-1098	2	47
β-strand	1107-1109	3	46
β-strand	1110	1	1
β-strand	1112	1	45
α-helix	1114-1124	11
β-strand	1128-1134	7	2

Chain C: 12 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	13-14	2	48
β-strand	16	1	49
β-strand	21	1	49
α-helix	42-48	7
β-strand	50	1	50
β-strand	53	1	51
β-strand	61	1	52
β-strand	63	1	51
β-strand	66	1	50
α-helix	70-82	13
β-strand	86-97	12	53
α-helix	103-111	9
α-helix	114	1
β-strand	115	1	54
α-helix	119-121	3
α-helix	124-126	3
β-strand	138-145	8	53
β-strand	167-168	2	55
α-helix	170-172	3
β-strand	173-176	4	53
β-strand	192	1	54
β-strand	200-201	2	55
β-strand	207-217	11	53
α-helix	223-225	3
β-strand	228	1	56
β-strand	233-241	9	48
β-strand	246	1	57
α-helix	249-255	7
β-strand	262-265	4	57
β-strand	272-275	4	57
α-helix	278-280	3
α-helix	287-289	3
β-strand	297-308	12	48
β-strand	310	1	52
β-strand	312	1	56
α-helix	318-340	23

Chain E: 8 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-23	19
β-strand	26	1	58
α-helix	30-33	4
α-helix	37-43	7
β-strand	60-63	4	59
β-strand	64	1	58
β-strand	71-75	5	59
β-strand	81-82	2	60
α-helix	84-97	14
β-strand	101	1	61
β-strand	103-106	4	59
β-strand	109-110	2	60
α-helix	112-120	9
α-helix	123-125	3
β-strand	126	1	61
β-strand	129-131	3	59
α-helix	139-141	3
β-strand	147-150	4	24
α-helix	153-163	11
β-strand	172-173	2	24
β-strand	190-197	8	24
β-strand	201-209	9	24

Chain F: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	62
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-99	11
β-strand	105-109	5	25
α-helix	110	1
β-strand	115-119	5	25
β-strand	124	1	62

Chain G: 3 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	48-59	12	69
α-helix	61-63	3
α-helix	67-73	7
β-strand	94-98	5	69
β-strand	104-105	2	69
β-strand	112-123	12	69
β-strand	131	1	70
β-strand	138	1	71
β-strand	143	1	71
β-strand	154	1	72
α-helix	157-159	3
β-strand	166	1	73
β-strand	171	1	73
β-strand	185	1	70
β-strand	189	1	72
β-strand	200	1	72

Chain H: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	4-11	8	63
β-strand	12-14	3	64
β-strand	20	1	15
β-strand	25-31	7	64
β-strand	38-44	7	64
β-strand	55-61	7	63
α-helix	69-71	3
β-strand	90-91	2	63
β-strand	92	1	13
β-strand	94-101	8	64
β-strand	111-117	7	64
β-strand	122-128	7	64
α-helix	129-131	3
β-strand	140-141	2	64
β-strand	142-147	6	63

Chain I: 0 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	13	1	65
β-strand	20	1	65
β-strand	51-52	2	23

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA1	A	protein	1719	Homo sapiens	O95602 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA2	B	protein	1135	Homo sapiens	Q9H9Y6 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase I subunit RPA12	I	protein	126	Homo sapiens	Q9P1U0
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803
DNA-directed RNA polymerase I subunit RPA34	N	protein	510	Homo sapiens	O15446
DNA-directed RNA polymerase I subunit RPA43	G	protein	338	Homo sapiens	Q3B726

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7VBA_1 DNA-directed RNA polymerase I subunit RPA1 (chains A)
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPL

Sequence of entity 2 (B), FASTA

>7VBA_2 DNA-directed RNA polymerase I subunit RPA2 (chains B)
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

Sequence of entity 3 (C), FASTA

>7VBA_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (E), FASTA

>7VBA_4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 5 (F), FASTA

>7VBA_5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 6 (H), FASTA

>7VBA_6 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 7 (I), FASTA

>7VBA_7 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVV
FHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKF
QEKEDS

Sequence of entity 8 (J), FASTA

>7VBA_8 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 9 (K), FASTA

>7VBA_9 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 10 (L), FASTA

>7VBA_10 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 11 (N), FASTA

>7VBA_11 DNA-directed RNA polymerase I subunit RPA34 (chains N)
MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRH
VPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEG
PQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQ
VTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLE
PLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGME
PEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESP
GGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTS
TKKKKKKKERGHTVTEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEE
MPGPPLNSESGEEAPTGRDKKRKQQQQQPV

Sequence of entity 12 (G), FASTA

>7VBA_12 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALS
PRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADF
VIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFE
VFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEV
DSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSS
GYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	5
MG	Magnesium ion	Mg	1
2TM	5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidi…	C10 H18 N3 O13 P3	1

Primary citation

Structure of the human RNA polymerase I elongation complex. Zhao, D., Liu, W., Chen, K. et al. Cell Discov (2021) 7:97-97. DOI 10.1038/s41421-021-00335-5 · PubMed

Other PDB entries of the same protein (UniProt O95602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7OB9 2.7 Å, Cryo-EM structure of human RNA Polymerase I in elongation state
7VBB 2.81 Å, Structure of the post state human RNA Polymerase I Elongation Complex
7VBC 3.01 Å, Back track state of human RNA Polymerase I Elongation Complex
7OBA 3.1 Å, Cryo-EM structure of human RNA Polymerase I in complex with RRN3
7OBB 3.3 Å, Cryo-EM structure of human RNA Polymerase I Open Complex
8A43 4.09 Å, Human RNA polymerase I

Browse structure collections

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