7VQG: Human neuroglobin A15C mutant

The X-ray structure of human neuroglobin A15C mutant. Determined by X-ray diffraction at 1.35 Å resolution. Released 26 Oct 2022.

Method: X-ray diffraction
Resolution: 1.35 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,437
Mol. weight: 17.93 kDa
Ligands: HEM, DIO
Released: 26 Oct 2022

Explore 7VQG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7VQG contains 11 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	6-17	12
α-helix	20-34	15
α-helix	36-38	3
α-helix	39-45	7
α-helix	52-56	5
α-helix	59-77	19
α-helix	82-85	4
α-helix	86-98	13
α-helix	105-121	17
α-helix	122-124	3
α-helix	127-145	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neuroglobin	A	protein	148	Homo sapiens	Q9NPG2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7VQG_1 Neuroglobin (chains A)
ERPEPELIRQSWRCVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPEF
LDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKCL
GPAFTPATRAAWSQLYGAVVQAMSRGWD

Ligands and cofactors

ID	Name	Formula	Copies
HEM	Protoporphyrin IX containing FE	C34 H32 Fe N4 O4	1
DIO	1,4-diethylene dioxide	C4 H8 O2	3

Water and common crystallization additives (MES, SO4) are not listed.

Primary citation

The X-ray structure of human neuroglobin A15C mutant. Lin, Y.W. To be published.

Other PDB entries of the same protein (UniProt Q9NPG2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8WUB 1.5 Å, The X-ray structure of human neuroglobin C120S mutant
4MPM 1.74 Å, Wild-type human neuroglobin
1OJ6 1.95 Å, Human brain neuroglobin three-dimensional structure
8GRZ 2.0 Å, X-ray crystal structure of V71C human neuroglobin mutant

Browse structure collections

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