7W59: Human pre-C*-I complex
The cryo-EM structure of human pre-C*-I complex. Determined by electron microscopy at 3.6 Å resolution. Released 22 Jun 2022.
- Method
- Electron microscopy
- Resolution
- 3.6 Å
- Organisms
- Homo sapiens, unidentified adenovirus
- Chains
- 50
- Atoms
- 92,315
- Mol. weight
- 2672.89 kDa
- Ligands
- IHP, GTP, MG, ZN
- Released
- 22 Jun 2022
Explore 7W59 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7W59 contains 556 α-helices and 434 β-strands across 45 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains a and h: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-12 | 8 | |
| β-strand | 17-22 | 6 | 17 |
| β-strand | 27-35 | 9 | 17 |
| β-strand | 41-49 | 9 | 17 |
| β-strand | 55-63 | 9 | 17 |
| α-helix | 65-67 | 3 | |
| β-strand | 68-73 | 6 | 17 |
Chain A: 97 helices, 46 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-44 | 18 | |
| α-helix | 47-49 | 3 | |
| α-helix | 63-73 | 11 | |
| α-helix | 82-84 | 3 | |
| α-helix | 85-90 | 6 | |
| α-helix | 96-103 | 8 | |
| α-helix | 106-108 | 3 | |
| β-strand | 115-121 | 7 | 1 |
| β-strand | 127-129 | 3 | 1 |
| β-strand | 134-135 | 2 | 2 |
| α-helix | 137-157 | 21 | |
| α-helix | 163-165 | 3 | |
| α-helix | 174-177 | 4 | |
| α-helix | 178-182 | 5 | |
| α-helix | 193-196 | 4 | |
| β-strand | 228-229 | 2 | 3 |
| α-helix | 232-241 | 10 | |
| α-helix | 253-255 | 3 | |
| α-helix | 260-268 | 9 | |
| α-helix | 310-315 | 6 | |
| α-helix | 357-358 | 2 | |
| α-helix | 396-403 | 8 | |
| β-strand | 415-416 | 2 | 3 |
| β-strand | 419-420 | 2 | 2 |
| α-helix | 428-431 | 4 | |
| α-helix | 441-459 | 19 | |
| α-helix | 473-477 | 5 | |
| β-strand | 482-488 | 7 | 1 |
| α-helix | 489-510 | 22 | |
| β-strand | 516-518 | 3 | 4 |
| β-strand | 524-526 | 3 | 4 |
| α-helix | 532-536 | 5 | |
| α-helix | 542-551 | 10 | |
| α-helix | 553-565 | 13 | |
| α-helix | 572-583 | 12 | |
| α-helix | 585-588 | 4 | |
| α-helix | 596-598 | 3 | |
| α-helix | 599-616 | 18 | |
| α-helix | 631-639 | 9 | |
| α-helix | 641-661 | 21 | |
| α-helix | 677-689 | 13 | |
| α-helix | 706-716 | 11 | |
| α-helix | 718-721 | 4 | |
| α-helix | 733-752 | 20 | |
| α-helix | 754-762 | 9 | |
| α-helix | 769-796 | 28 | |
| α-helix | 806-820 | 15 | |
| α-helix | 822-825 | 4 | |
| α-helix | 835-847 | 13 | |
| α-helix | 858-872 | 15 | |
| α-helix | 874-887 | 14 | |
| β-strand | 894-900 | 7 | 5 |
| β-strand | 905-910 | 6 | 5 |
| α-helix | 913-932 | 20 | |
| β-strand | 940 | 1 | 6 |
| α-helix | 948-960 | 13 | |
| β-strand | 973-980 | 8 | 6 |
| α-helix | 985-987 | 3 | |
| α-helix | 990-998 | 9 | |
| α-helix | 1003-1012 | 10 | |
| β-strand | 1016-1019 | 4 | 5 |
| β-strand | 1022-1025 | 4 | 5 |
| α-helix | 1037-1050 | 14 | |
| α-helix | 1055-1062 | 8 | |
| α-helix | 1077-1080 | 4 | |
| β-strand | 1085-1091 | 7 | 6 |
| β-strand | 1094-1101 | 8 | 6 |
| α-helix | 1103-1116 | 14 | |
| α-helix | 1140-1141 | 2 | |
| α-helix | 1146-1158 | 13 | |
| β-strand | 1174-1178 | 5 | 6 |
| β-strand | 1185-1188 | 4 | 7 |
| β-strand | 1192 | 1 | 8 |
| β-strand | 1193-1198 | 6 | 7 |
| β-strand | 1213-1217 | 5 | 7 |
| β-strand | 1224-1229 | 6 | 7 |
| β-strand | 1232 | 1 | 8 |
| α-helix | 1234-1249 | 16 | |
| α-helix | 1256-1264 | 9 | |
| α-helix | 1271-1274 | 4 | |
| α-helix | 1282-1300 | 19 | |
| α-helix | 1308-1310 | 3 | |
| α-helix | 1313-1315 | 3 | |
| α-helix | 1320-1322 | 3 | |
| β-strand | 1334-1337 | 4 | 9 |
| α-helix | 1340-1346 | 7 | |
| β-strand | 1352-1355 | 4 | 9 |
| α-helix | 1368-1371 | 4 | |
| α-helix | 1375-1398 | 24 | |
| α-helix | 1409-1411 | 3 | |
| α-helix | 1419-1423 | 5 | |
| α-helix | 1430-1432 | 3 | |
| α-helix | 1437-1442 | 6 | |
| α-helix | 1443-1445 | 3 | |
| α-helix | 1458-1461 | 4 | |
| α-helix | 1467-1469 | 3 | |
| α-helix | 1472-1475 | 4 | |
| α-helix | 1481-1484 | 4 | |
| α-helix | 1485-1487 | 3 | |
| α-helix | 1491-1493 | 3 | |
| β-strand | 1502 | 1 | 10 |
| α-helix | 1509-1514 | 6 | |
| α-helix | 1520-1527 | 8 | |
| α-helix | 1530-1537 | 8 | |
| α-helix | 1539-1542 | 4 | |
| β-strand | 1552-1554 | 3 | 11 |
| β-strand | 1561-1563 | 3 | 11 |
| α-helix | 1567-1576 | 10 | |
| α-helix | 1581-1597 | 17 | |
| α-helix | 1598-1600 | 3 | |
| β-strand | 1606-1611 | 6 | 12 |
| β-strand | 1629-1637 | 9 | 12 |
| β-strand | 1643 | 1 | 12 |
| β-strand | 1657-1667 | 11 | 12 |
| α-helix | 1677-1687 | 11 | |
| β-strand | 1700-1706 | 7 | 12 |
| β-strand | 1711-1716 | 6 | 12 |
| α-helix | 1723-1736 | 14 | |
| α-helix | 1738-1751 | 14 | |
| β-strand | 1754 | 1 | 10 |
| α-helix | 1768-1772 | 5 | |
| β-strand | 1777-1780 | 4 | 13 |
| β-strand | 1788-1792 | 5 | 14 |
| β-strand | 1798-1802 | 5 | 14 |
| β-strand | 1805-1806 | 2 | 15 |
| β-strand | 1810 | 1 | 16 |
| β-strand | 1817 | 1 | 16 |
| β-strand | 1819-1822 | 4 | 15 |
| α-helix | 1824-1827 | 4 | |
| α-helix | 1833-1851 | 19 | |
| β-strand | 1860-1863 | 4 | 13 |
| α-helix | 1866-1868 | 3 | |
| α-helix | 1869-1875 | 7 | |
| β-strand | 1883-1885 | 3 | 13 |
| α-helix | 1894-1898 | 5 | |
| α-helix | 1900-1908 | 9 | |
| β-strand | 1913-1915 | 3 | 15 |
| α-helix | 1923-1925 | 3 | |
| α-helix | 1929-1945 | 17 | |
| α-helix | 1949-1954 | 6 | |
| α-helix | 1973-1995 | 23 | |
| α-helix | 1999-2001 | 3 | |
| α-helix | 2004-2011 | 8 | |
Chain b: 3 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-10 | 4 | |
| β-strand | 16-21 | 6 | 17 |
| β-strand | 26-33 | 8 | 17 |
| β-strand | 40-48 | 9 | 17 |
| β-strand | 64-72 | 9 | 17 |
| α-helix | 74-76 | 3 | |
| β-strand | 77-84 | 8 | 17 |
| α-helix | 85-87 | 3 | |
| β-strand | 107 | 1 | 29 |
| β-strand | 112 | 1 | 78 |
Chains c and j: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-8 | 6 | |
| β-strand | 14-19 | 6 | 17 |
| β-strand | 24-32 | 9 | 17 |
| β-strand | 38-46 | 9 | 17 |
| β-strand | 53-60 | 8 | 17 |
| α-helix | 62-64 | 3 | |
| β-strand | 65-69 | 5 | 17 |
| α-helix | 70-71 | 2 | |
| α-helix | 76-79 | 4 | |
Chain C: 44 helices, 43 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 69-73 | 5 | |
| β-strand | 78-81 | 4 | 18 |
| α-helix | 115-125 | 11 | |
| β-strand | 129-136 | 8 | 19 |
| α-helix | 142-153 | 12 | |
| α-helix | 174-177 | 4 | |
| β-strand | 184-191 | 8 | 19 |
| β-strand | 197-204 | 8 | 19 |
| α-helix | 209-211 | 3 | |
| α-helix | 215-221 | 7 | |
| β-strand | 224-230 | 7 | 19 |
| β-strand | 234 | 1 | 19 |
| α-helix | 237-248 | 12 | |
| β-strand | 252-258 | 7 | 19 |
| α-helix | 260-263 | 4 | |
| α-helix | 271-292 | 22 | |
| α-helix | 302-304 | 3 | |
| β-strand | 307-311 | 5 | 19 |
| β-strand | 316-318 | 3 | 19 |
| α-helix | 321-330 | 10 | |
| α-helix | 336-340 | 5 | |
| β-strand | 348-350 | 3 | 20 |
| β-strand | 355-357 | 3 | 20 |
| α-helix | 365-367 | 3 | |
| α-helix | 368-369 | 2 | |
| α-helix | 370-374 | 5 | |
| α-helix | 375-387 | 13 | |
| α-helix | 392-398 | 7 | |
| α-helix | 407-409 | 3 | |
| α-helix | 412-423 | 12 | |
| α-helix | 428-436 | 9 | |
| α-helix | 441-452 | 12 | |
| β-strand | 453 | 1 | 21 |
| α-helix | 461-465 | 5 | |
| β-strand | 475 | 1 | 22 |
| β-strand | 476-482 | 7 | 23 |
| β-strand | 491-496 | 6 | 23 |
| β-strand | 498 | 1 | 22 |
| β-strand | 501-502 | 2 | 24 |
| β-strand | 506-510 | 5 | 23 |
| α-helix | 511 | 1 | |
| β-strand | 515 | 1 | 25 |
| β-strand | 518 | 1 | 25 |
| β-strand | 524-526 | 3 | 23 |
| β-strand | 530-534 | 5 | 23 |
| β-strand | 537-541 | 5 | 23 |
| β-strand | 543-544 | 2 | 24 |
| β-strand | 548-552 | 5 | 23 |
| β-strand | 563-566 | 4 | 23 |
| β-strand | 577 | 1 | 21 |
| α-helix | 578-579 | 2 | |
| β-strand | 588-594 | 7 | 26 |
| α-helix | 597-599 | 3 | |
| α-helix | 600-613 | 14 | |
| β-strand | 618-621 | 4 | 26 |
| β-strand | 627-631 | 5 | 26 |
| α-helix | 634-643 | 10 | |
| α-helix | 644-648 | 5 | |
| β-strand | 653-655 | 3 | 26 |
| α-helix | 656-658 | 3 | |
| β-strand | 659-660 | 2 | 26 |
| β-strand | 663-666 | 4 | 27 |
| β-strand | 674-677 | 4 | 28 |
| β-strand | 684-691 | 8 | 28 |
| α-helix | 694-701 | 8 | |
| α-helix | 711-722 | 12 | |
| α-helix | 726-730 | 5 | |
| β-strand | 732-734 | 3 | 28 |
| β-strand | 744-747 | 4 | 28 |
| α-helix | 750-755 | 6 | |
| α-helix | 756-759 | 4 | |
| α-helix | 763-773 | 11 | |
| β-strand | 784 | 1 | 27 |
| β-strand | 787-795 | 9 | 28 |
| α-helix | 808-821 | 14 | |
| β-strand | 825-839 | 15 | 27 |
| α-helix | 840-842 | 3 | |
| α-helix | 844-852 | 9 | |
| β-strand | 857-862 | 6 | 27 |
| α-helix | 863 | 1 | |
| β-strand | 868-876 | 9 | 27 |
| α-helix | 883-890 | 8 | |
| β-strand | 896-906 | 11 | 27 |
| α-helix | 923-925 | 3 | |
| α-helix | 926-928 | 3 | |
| α-helix | 929-937 | 9 | |
| α-helix | 938-942 | 5 | |
Chain d: 3 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-26 | 6 | |
| α-helix | 30-38 | 9 | |
| β-strand | 41-46 | 6 | 17 |
| β-strand | 51-59 | 9 | 17 |
| β-strand | 65-76 | 12 | 17 |
| β-strand | 90-101 | 12 | 17 |
| α-helix | 103-105 | 3 | |
| β-strand | 106-111 | 6 | 17 |
Chains e and l: 2 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-27 | 11 | |
| β-strand | 30-35 | 6 | 17 |
| β-strand | 38-50 | 13 | 17 |
| β-strand | 56-65 | 10 | 17 |
| β-strand | 70-79 | 10 | 17 |
| α-helix | 81-83 | 3 | |
| β-strand | 84-90 | 7 | 17 |
Chain E: 1 helix, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 61-63 | 3 | 29 |
| β-strand | 69-74 | 6 | 30 |
| β-strand | 80 | 1 | 31 |
| β-strand | 81-85 | 5 | 30 |
| β-strand | 90-93 | 4 | 30 |
| β-strand | 94 | 1 | 31 |
| β-strand | 101-105 | 5 | 30 |
| β-strand | 112-117 | 6 | 32 |
| β-strand | 123-128 | 6 | 32 |
| β-strand | 133-137 | 5 | 32 |
| β-strand | 143-146 | 4 | 32 |
| β-strand | 154-159 | 6 | 33 |
| α-helix | 160-161 | 2 | |
| β-strand | 167-171 | 5 | 33 |
| β-strand | 176-180 | 5 | 33 |
| β-strand | 185-189 | 5 | 33 |
| β-strand | 196-201 | 6 | 34 |
| β-strand | 207-212 | 6 | 34 |
| β-strand | 217-221 | 5 | 34 |
| β-strand | 227-231 | 5 | 34 |
| β-strand | 240-243 | 4 | 35 |
| β-strand | 249-253 | 5 | 35 |
| β-strand | 259-263 | 5 | 35 |
| β-strand | 273-277 | 5 | 35 |
| β-strand | 291-293 | 3 | 36 |
| β-strand | 299-302 | 4 | 36 |
| β-strand | 304 | 1 | 29 |
| β-strand | 309-313 | 5 | 36 |
| β-strand | 319-323 | 5 | 36 |
| β-strand | 330-335 | 6 | 29 |
| β-strand | 341-346 | 6 | 29 |
| β-strand | 350-355 | 6 | 29 |
33 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Pre-mRNA-processing-splicing factor 8 | A | protein | 2335 | Homo sapiens | Q6P2Q9 (AlphaFold model) |
| 116 kDa U5 small nuclear ribonucleoprotein component | C | protein | 972 | Homo sapiens | Q15029 (AlphaFold model) |
| U5 small nuclear ribonucleoprotein 40 kDa protein | E | protein | 357 | Homo sapiens | Q96DI7 (AlphaFold model) |
| pre-mRNA | 4 | RNA | 46 | unidentified adenovirus | |
| pre-mRNA | G | RNA | 174 | unidentified adenovirus | |
| Crooked neck-like protein 1 | J | protein | 848 | Homo sapiens | Q9BZJ0 (AlphaFold model) |
| Cell division cycle 5-like protein | L | protein | 802 | Homo sapiens | Q99459 |
| Pre-mRNA-splicing factor SYF2 | M | protein | 243 | Homo sapiens | O95926 |
| Protein BUD31 homolog | N | protein | 144 | Homo sapiens | P41223 |
| Pre-mRNA-splicing factor RBM22 | O | protein | 420 | Homo sapiens | Q9NW64 |
| Spliceosome-associated protein CWC15 homolog | P | protein | 229 | Homo sapiens | Q9P013 |
| SNW domain-containing protein 1 | R | protein | 536 | Homo sapiens | Q13573 |
28 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>7W59_1 Pre-mRNA-processing-splicing factor 8 (chains A)
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKED
MPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLY
HITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYR
LANQLLTDLVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLVRDINLQDEDWNEFNDIN
KIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRR
ALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKATK
FFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMR
QIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLARQF
EGRHSKGVAKTVTKQRVESHFDLELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCW
KANIPWKVPGLPTPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLT
RLYLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSYKHDTKLLI
LALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMD
LYSHLVPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGIN
NLQDVWETSEGECNVMLESRFEKMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYK
DMNHTNSYGIIRGLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATE
AAHPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARM
RLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDNPNLLFNMCGFECRILPKC
RTSYEEFTHKDGVWNLQNEVTKERTAQCFLRVDDESMQRFHNRVRQILMASGSTTFTKIV
NKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPK
ELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHEEDQLIPNLYRYIQPWESEFI
DSQRVWAEYALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRT
DFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEG
LFWEKASGFEESMKWKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQKETIHPRKSY
KMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKYWIDIQLRWGDYDSHDIERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGSKPLIQQAMAKIMKANPAL
YVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTT
KPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQ
IIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLY
DDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWPTLTDEEWIKVE
VQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSQQRQQIAEIEKQTKEQSQLT
ATQTRTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISAANLHLRTNHIYVSSDDIKET
GYTYILPKNVLKKFICISDLRAQIAGYLYGVSPPDNPQVKEIRCIVMVPQWGTHQTVHLP
GQLPQHEYLKEMEPLGWIHTQPNESPQLSPQDVTTHAKIMADNPSWDGEKTIIITCSFTP
GSCTLTAYKLTPSGYEWGRQNTDKGNNPKGYLPSHYERVQMLLSDRFLGFFMVPAQSSWN
YNFMGVRHDPNMKYELQLANPKEFYHEVHRPSHFLNFALLQEGEVYSADREDLYA
Sequence of entity 2 (C), FASTA
>7W59_2 116 kDa U5 small nuclear ribonucleoprotein component (chains C)
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLH
EDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTE
RLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVC
KKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSEL
PKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT
KYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLC
DELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPA
DCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSV
FHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLE
LAKQDVVLNYPM
Sequence of entity 3 (E), FASTA
>7W59_3 U5 small nuclear ribonucleoprotein 40 kDa protein (chains E)
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Sequence of entity 4 (4), FASTA
>7W59_4 pre-mRNA (chains 4)
GAUCGGGCUCGCCACUCUUGGAUCGGAACCCGUCGGCCUCCGAACG
Sequence of entity 5 (G), FASTA
>7W59_5 pre-mRNA (chains G)
GUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCUGCACGUCUAGGGC
GCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAG
CUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCCGAUAUCCG
Sequence of entity 6 (J), FASTA
>7W59_6 Crooked neck-like protein 1 (chains J)
MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLVLAWSSQFRRLTWGCAL
DALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHGNGAASVTAQARGQRSVLQ
VPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAADMAASTAAGKQRIPKVAKVK
NKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRT
VISNWIKYAQWEESLKEIQRARSIYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWD
RAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVD
RARTIYERFVLVHPDVKNWIKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFA
KFEENQKEFERVRVIYKYALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQY
EEEVKANPHNYDAWFDYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINY
ALYEELEAKDPERTRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSI
GKCPKNKLFKVYIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRAR
AIYELAISQPRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFEL
SSGKEGSLTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPE
KVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPD
EDVDESES
Sequence of entity 7 (L), FASTA
>7W59_7 Cell division cycle 5-like protein (chains L)
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKK
TEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDP
RKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEAR
RLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFR
KLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAP
QISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQD
RILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGA
EGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGL
LGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKA
VQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKG
KTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQV
WEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKIL
LGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQER
EKELQHRYADLLLEKETLKSKF
Sequence of entity 8 (M), FASTA
>7W59_8 Pre-mRNA-splicing factor SYF2 (chains M)
MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK
RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP
DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID
RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG
TAV
Sequence of entity 9 (N), FASTA
>7W59_9 Protein BUD31 homolog (chains N)
MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYI
FDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICR
VPKSKLEVGRIIECTHCGCRGCSG
Sequence of entity 10 (O), FASTA
>7W59_10 Pre-mRNA-splicing factor RBM22 (chains O)
MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPG
VRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQN
MEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECP
YRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLG
DTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNV
KWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAV
VNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP
Sequence of entity 11 (P), FASTA
>7W59_11 Spliceosome-associated protein CWC15 homolog (chains P)
MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFR
RELEERERAAAREKNRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEEDEDFEEE
SDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPSQPQA
NFKVKRRWDDDVVFKNCAKGVDDQKKDKRFVNDTLRSEFHKKFMEKYIK
Sequence of entity 12 (R), FASTA
>7W59_12 SNW domain-containing protein 1 (chains R)
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| IHP | Inositol hexakisphosphate | C6 H18 O24 P6 | 1 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
| MG | Magnesium ion | Mg | 9 |
| ZN | Zinc ion | Zn | 6 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
Primary citation
Mechanism of exon ligation by human spliceosome. Zhan, X., Lu, Y., Zhang, X. et al. Mol Cell (2022) 82:2769-2778.e4. DOI 10.1016/j.molcel.2022.05.021 · PubMed
Other PDB entries of the same protein (UniProt Q6P2Q9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4JK8 1.15 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion
- 4JKB 1.3 Å, Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion
- 4JKA 1.32 Å, Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion
- 4JK7 1.4 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion
- 4JK9 1.5 Å, Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion
- 4JKC 1.5 Å, Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion
- 4JKD 1.55 Å, Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion
- 4JKE 1.65 Å, Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion
- 4JKG 1.8 Å, Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain…
- 4JKH 1.8 Å, Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion
- 3ENB 1.85 Å, Crystal Structure of PRP8 core domain IV
- 3LRU 1.85 Å, hPRP8 Non-Native Subdomain
Browse structure collections
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