7WOT: Nucleoporin NIC96
Cryo-EM structure of the inner ring monomer of the Saccharomyces cerevisiae nuclear pore complex. Determined by electron microscopy at 3.73 Å resolution. Released 13 Apr 2022.
- Method
- Electron microscopy
- Resolution
- 3.73 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 24
- Atoms
- 133,827
- Mol. weight
- 2572.4 kDa
- Released
- 13 Apr 2022
Explore 7WOT in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7WOT contains 853 α-helices and 251 β-strands across 24 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 50 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-31 | 18 | |
| α-helix | 45-55 | 11 | |
| α-helix | 80-91 | 12 | |
| α-helix | 113-139 | 27 | |
| α-helix | 192-194 | 3 | |
| α-helix | 202-204 | 3 | |
| α-helix | 206-227 | 22 | |
| α-helix | 234-242 | 9 | |
| α-helix | 249-262 | 14 | |
| α-helix | 270-293 | 24 | |
| α-helix | 301-308 | 8 | |
| α-helix | 309-313 | 5 | |
| β-strand | 314 | 1 | 1 |
| β-strand | 320 | 1 | 1 |
| β-strand | 327-328 | 2 | 2 |
| β-strand | 331-332 | 2 | 2 |
| α-helix | 333-342 | 10 | |
| α-helix | 346-355 | 10 | |
| α-helix | 362-364 | 3 | |
| α-helix | 365-376 | 12 | |
| α-helix | 384-393 | 10 | |
| α-helix | 394-398 | 5 | |
| α-helix | 406-416 | 11 | |
| α-helix | 432-441 | 10 | |
| α-helix | 453-455 | 3 | |
| α-helix | 459-469 | 11 | |
| α-helix | 478-484 | 7 | |
| α-helix | 488-496 | 9 | |
| α-helix | 500-512 | 13 | |
| α-helix | 534-542 | 9 | |
| α-helix | 550-558 | 9 | |
| α-helix | 559-563 | 5 | |
| α-helix | 566-583 | 18 | |
| α-helix | 586-589 | 4 | |
| β-strand | 593 | 1 | 3 |
| α-helix | 598 | 1 | |
| β-strand | 599 | 1 | 3 |
| α-helix | 600-601 | 2 | |
| α-helix | 603-606 | 4 | |
| α-helix | 609-611 | 3 | |
| α-helix | 616-619 | 4 | |
| α-helix | 620-625 | 6 | |
| α-helix | 626-634 | 9 | |
| α-helix | 637-646 | 10 | |
| α-helix | 650-667 | 18 | |
| α-helix | 685-692 | 8 | |
| α-helix | 693-697 | 5 | |
| α-helix | 700-704 | 5 | |
| α-helix | 708-728 | 21 | |
| α-helix | 732-741 | 10 | |
| α-helix | 750-762 | 13 | |
| α-helix | 765-768 | 4 | |
| α-helix | 771-791 | 21 | |
| α-helix | 797-819 | 23 | |
| α-helix | 821-823 | 3 | |
| α-helix | 826-837 | 12 | |
Chains C and O: 69 helices, 42 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 69-71 | 3 | |
| α-helix | 90-106 | 17 | |
| α-helix | 108-110 | 3 | |
| α-helix | 114-117 | 4 | |
| β-strand | 122-126 | 5 | 4 |
| α-helix | 133-135 | 3 | |
| β-strand | 138-145 | 8 | 5 |
| α-helix | 146-147 | 2 | |
| α-helix | 148-154 | 7 | |
| β-strand | 161-166 | 6 | 6 |
| β-strand | 171-176 | 6 | 6 |
| β-strand | 179-184 | 6 | 6 |
| β-strand | 191-194 | 4 | 6 |
| β-strand | 201-207 | 7 | 7 |
| α-helix | 208-210 | 3 | |
| β-strand | 220-226 | 7 | 7 |
| β-strand | 229-237 | 9 | 7 |
| α-helix | 243 | 1 | |
| β-strand | 244-254 | 11 | 7 |
| β-strand | 260-266 | 7 | 8 |
| β-strand | 271-276 | 6 | 8 |
| β-strand | 284-288 | 5 | 8 |
| β-strand | 293 | 1 | 9 |
| β-strand | 296 | 1 | 9 |
| β-strand | 299-303 | 5 | 8 |
| α-helix | 324-326 | 3 | |
| α-helix | 337-340 | 4 | |
| β-strand | 342-348 | 7 | 10 |
| β-strand | 353-358 | 6 | 10 |
| β-strand | 363-369 | 7 | 10 |
| β-strand | 372-379 | 8 | 10 |
| α-helix | 381-390 | 10 | |
| α-helix | 397-399 | 3 | |
| β-strand | 406-411 | 6 | 11 |
| β-strand | 420-426 | 7 | 11 |
| β-strand | 431-435 | 5 | 11 |
| β-strand | 438-439 | 2 | 12 |
| β-strand | 442-443 | 2 | 12 |
| α-helix | 444-446 | 3 | |
| β-strand | 447-452 | 6 | 11 |
| α-helix | 453-455 | 3 | |
| α-helix | 457-461 | 5 | |
| α-helix | 483-486 | 4 | |
| β-strand | 495 | 1 | 4 |
| β-strand | 500-502 | 3 | 4 |
| β-strand | 506-513 | 8 | 4 |
| α-helix | 515-517 | 3 | |
| α-helix | 534 | 1 | |
| β-strand | 535-543 | 9 | 4 |
| α-helix | 545-551 | 7 | |
| β-strand | 555-561 | 7 | 4 |
| α-helix | 566 | 1 | |
| β-strand | 567-572 | 6 | 5 |
| α-helix | 589-592 | 4 | |
| α-helix | 597-599 | 3 | |
| β-strand | 600-605 | 6 | 5 |
| β-strand | 608-614 | 7 | 5 |
| α-helix | 617-623 | 7 | |
| α-helix | 629-635 | 7 | |
| α-helix | 637-649 | 13 | |
| α-helix | 655-667 | 13 | |
| β-strand | 669 | 1 | 13 |
| β-strand | 673 | 1 | 13 |
| β-strand | 678-679 | 2 | 14 |
| α-helix | 686-689 | 4 | |
| β-strand | 703-704 | 2 | 14 |
| α-helix | 707-719 | 13 | |
| β-strand | 727 | 1 | 15 |
| β-strand | 729-732 | 4 | 16 |
| α-helix | 733-735 | 3 | |
| β-strand | 742-745 | 4 | 16 |
| α-helix | 749-773 | 25 | |
| α-helix | 785-786 | 2 | |
| α-helix | 787-815 | 29 | |
| α-helix | 819-830 | 12 | |
| α-helix | 838-846 | 9 | |
| β-strand | 848 | 1 | 15 |
| α-helix | 849-853 | 5 | |
| α-helix | 857-876 | 20 | |
| α-helix | 881-891 | 11 | |
| α-helix | 898-916 | 19 | |
| α-helix | 921-937 | 17 | |
| α-helix | 944-956 | 13 | |
| α-helix | 960-974 | 15 | |
| α-helix | 979-985 | 7 | |
| α-helix | 995-1022 | 28 | |
| α-helix | 1035-1048 | 14 | |
| α-helix | 1053-1065 | 13 | |
| α-helix | 1069-1072 | 4 | |
| α-helix | 1080-1088 | 9 | |
| α-helix | 1092-1104 | 13 | |
| α-helix | 1108-1120 | 13 | |
| α-helix | 1127-1141 | 15 | |
| α-helix | 1147-1149 | 3 | |
| α-helix | 1150-1178 | 29 | |
| α-helix | 1185-1195 | 11 | |
| α-helix | 1199-1201 | 3 | |
| α-helix | 1202-1205 | 4 | |
| α-helix | 1206-1210 | 5 | |
| α-helix | 1216-1225 | 10 | |
| α-helix | 1231-1247 | 17 | |
| α-helix | 1257-1276 | 20 | |
| α-helix | 1285-1295 | 11 | |
| α-helix | 1302-1303 | 2 | |
| α-helix | 1306-1313 | 8 | |
| α-helix | 1318-1331 | 14 | |
| α-helix | 1336-1353 | 18 | |
| α-helix | 1355-1360 | 6 | |
| α-helix | 1363-1367 | 5 | |
| α-helix | 1374-1376 | 3 | |
| α-helix | 1380-1387 | 8 | |
Chain D: 62 helices, 40 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 100-116 | 17 | |
| α-helix | 118-120 | 3 | |
| β-strand | 133-139 | 7 | 17 |
| α-helix | 143-145 | 3 | |
| β-strand | 148-155 | 8 | 18 |
| α-helix | 156-157 | 2 | |
| α-helix | 158-163 | 6 | |
| β-strand | 172-176 | 5 | 19 |
| β-strand | 181-185 | 5 | 19 |
| β-strand | 190-194 | 5 | 19 |
| β-strand | 201-204 | 4 | 19 |
| β-strand | 211-217 | 7 | 20 |
| α-helix | 218-220 | 3 | |
| β-strand | 230-236 | 7 | 20 |
| β-strand | 239-247 | 9 | 20 |
| α-helix | 253 | 1 | |
| β-strand | 254-258 | 5 | 20 |
| β-strand | 263-264 | 2 | 20 |
| β-strand | 270-276 | 7 | 21 |
| β-strand | 281-286 | 6 | 21 |
| β-strand | 294-296 | 3 | 21 |
| α-helix | 301-303 | 3 | |
| β-strand | 313-314 | 2 | 21 |
| α-helix | 331-333 | 3 | |
| α-helix | 334-338 | 5 | |
| β-strand | 342-343 | 2 | 22 |
| β-strand | 349-350 | 2 | 22 |
| β-strand | 356-362 | 7 | 23 |
| β-strand | 367-372 | 6 | 23 |
| β-strand | 377-381 | 5 | 23 |
| β-strand | 393 | 1 | 23 |
| α-helix | 395-402 | 8 | |
| β-strand | 420-425 | 6 | 24 |
| β-strand | 434-440 | 7 | 24 |
| β-strand | 445-449 | 5 | 24 |
| β-strand | 452-453 | 2 | 25 |
| β-strand | 456-457 | 2 | 25 |
| β-strand | 461-466 | 6 | 24 |
| α-helix | 473-481 | 9 | |
| α-helix | 496-498 | 3 | |
| β-strand | 524-526 | 3 | 17 |
| β-strand | 530-536 | 7 | 17 |
| β-strand | 560 | 1 | 26 |
| β-strand | 562 | 1 | 26 |
| β-strand | 574-581 | 8 | 17 |
| α-helix | 583-587 | 5 | |
| β-strand | 594-598 | 5 | 17 |
| β-strand | 605-610 | 6 | 18 |
| β-strand | 638-643 | 6 | 18 |
| β-strand | 646-652 | 7 | 18 |
| α-helix | 653-654 | 2 | |
| α-helix | 655-661 | 7 | |
| α-helix | 670-687 | 18 | |
| α-helix | 693-704 | 12 | |
| α-helix | 768-780 | 13 | |
| α-helix | 782-785 | 4 | |
| β-strand | 788 | 1 | 27 |
| β-strand | 790 | 1 | 28 |
| β-strand | 832 | 1 | 28 |
| α-helix | 836-855 | 20 | |
| α-helix | 857-859 | 3 | |
| α-helix | 865-867 | 3 | |
| α-helix | 881-883 | 3 | |
| α-helix | 885-914 | 30 | |
| α-helix | 930-933 | 4 | |
| α-helix | 941-944 | 4 | |
| β-strand | 948 | 1 | 27 |
| α-helix | 949-953 | 5 | |
| α-helix | 957-971 | 15 | |
| α-helix | 980-989 | 10 | |
| α-helix | 1001-1016 | 16 | |
| α-helix | 1017-1019 | 3 | |
| α-helix | 1021-1037 | 17 | |
| α-helix | 1039-1041 | 3 | |
| α-helix | 1044-1055 | 12 | |
| α-helix | 1060-1074 | 15 | |
| α-helix | 1079-1085 | 7 | |
| α-helix | 1095-1120 | 26 | |
| α-helix | 1135-1151 | 17 | |
| α-helix | 1155-1167 | 13 | |
| α-helix | 1171-1175 | 5 | |
| α-helix | 1182-1190 | 9 | |
| α-helix | 1194-1206 | 13 | |
| α-helix | 1210-1222 | 13 | |
| α-helix | 1229-1243 | 15 | |
| α-helix | 1249-1251 | 3 | |
| α-helix | 1252-1281 | 30 | |
| α-helix | 1287-1297 | 11 | |
| α-helix | 1304-1306 | 3 | |
| α-helix | 1307-1312 | 6 | |
| α-helix | 1318-1327 | 10 | |
| α-helix | 1333-1350 | 18 | |
| α-helix | 1357-1378 | 22 | |
| α-helix | 1387-1401 | 15 | |
| α-helix | 1407-1408 | 2 | |
| α-helix | 1413-1419 | 7 | |
| α-helix | 1423-1436 | 14 | |
| α-helix | 1442-1458 | 17 | |
| α-helix | 1460-1465 | 6 | |
| α-helix | 1468-1472 | 5 | |
| α-helix | 1479-1481 | 3 | |
| α-helix | 1483-1491 | 9 | |
Chains E and Q: 85 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-24 | 5 | |
| α-helix | 34-46 | 13 | |
| α-helix | 70-77 | 8 | |
| α-helix | 87-91 | 5 | |
| α-helix | 97-118 | 22 | |
| α-helix | 124-130 | 7 | |
| α-helix | 134-150 | 17 | |
| α-helix | 154-161 | 8 | |
| α-helix | 167-198 | 32 | |
| α-helix | 207-215 | 9 | |
| α-helix | 216-220 | 5 | |
| α-helix | 221-228 | 8 | |
| α-helix | 254-272 | 19 | |
| β-strand | 275-276 | 2 | 29 |
| β-strand | 281-282 | 2 | 29 |
| α-helix | 287-289 | 3 | |
| α-helix | 295-307 | 13 | |
| α-helix | 319-335 | 17 | |
| α-helix | 348-355 | 8 | |
| α-helix | 358-368 | 11 | |
| α-helix | 373-386 | 14 | |
| α-helix | 394-404 | 11 | |
| α-helix | 409-413 | 5 | |
| α-helix | 419-425 | 7 | |
| α-helix | 440-443 | 4 | |
| α-helix | 450-455 | 6 | |
| β-strand | 460 | 1 | 30 |
| β-strand | 463-466 | 4 | 31 |
| β-strand | 475-476 | 2 | 31 |
| β-strand | 496-501 | 4 | 31 |
| β-strand | 505-507 | 3 | 32 |
| α-helix | 508-509 | 2 | |
| β-strand | 520-522 | 3 | 32 |
| β-strand | 527-531 | 5 | 31 |
| β-strand | 552-555 | 4 | 31 |
| β-strand | 559 | 1 | 30 |
| α-helix | 561-579 | 19 | |
| α-helix | 585-602 | 18 | |
| α-helix | 609-617 | 9 | |
| α-helix | 634-647 | 14 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-678 | 10 | |
| α-helix | 708-722 | 15 | |
| α-helix | 732-750 | 19 | |
| α-helix | 762-769 | 8 | |
| β-strand | 785 | 1 | 33 |
| α-helix | 796-805 | 10 | |
| α-helix | 815-825 | 11 | |
| α-helix | 826-828 | 3 | |
| α-helix | 830-835 | 6 | |
| α-helix | 843-862 | 20 | |
| α-helix | 868-870 | 3 | |
| α-helix | 873-879 | 7 | |
| α-helix | 881-889 | 9 | |
| α-helix | 898-909 | 12 | |
| α-helix | 927-939 | 13 | |
| α-helix | 946-961 | 16 | |
| α-helix | 966-972 | 7 | |
| α-helix | 994-1003 | 10 | |
| α-helix | 1010-1025 | 16 | |
| α-helix | 1033-1035 | 3 | |
| α-helix | 1037-1048 | 12 | |
| α-helix | 1051-1054 | 4 | |
| α-helix | 1063-1087 | 25 | |
| α-helix | 1094-1099 | 6 | |
| α-helix | 1106-1113 | 8 | |
| α-helix | 1120-1131 | 12 | |
| α-helix | 1139-1141 | 3 | |
| β-strand | 1143 | 1 | 34 |
| β-strand | 1144 | 1 | 33 |
| α-helix | 1145-1146 | 2 | |
| α-helix | 1149-1151 | 3 | |
| β-strand | 1158 | 1 | 34 |
| α-helix | 1160-1166 | 7 | |
| α-helix | 1171-1174 | 4 | |
| α-helix | 1184-1214 | 31 | |
| α-helix | 1221-1222 | 2 | |
| α-helix | 1224-1238 | 15 | |
| α-helix | 1249-1266 | 18 | |
| α-helix | 1274-1288 | 15 | |
| α-helix | 1305-1307 | 3 | |
| α-helix | 1309-1319 | 11 | |
| α-helix | 1329-1357 | 29 | |
| α-helix | 1383 | 1 | |
| α-helix | 1384-1388 | 5 | |
| α-helix | 1389-1397 | 9 | |
| α-helix | 1402-1415 | 14 | |
| α-helix | 1419-1430 | 12 | |
| β-strand | 1433 | 1 | 35 |
| β-strand | 1436 | 1 | 35 |
| α-helix | 1440-1451 | 12 | |
| α-helix | 1455-1460 | 6 | |
| α-helix | 1466-1470 | 5 | |
| α-helix | 1473-1479 | 7 | |
| α-helix | 1490-1508 | 19 | |
| α-helix | 1515-1537 | 23 | |
| α-helix | 1545-1557 | 13 | |
| α-helix | 1560-1563 | 4 | |
| α-helix | 1592-1606 | 15 | |
| α-helix | 1609-1615 | 7 | |
| α-helix | 1621-1628 | 8 | |
| α-helix | 1633-1654 | 22 | |
Chains F and R: 81 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-13 | 8 | |
| α-helix | 22-27 | 6 | |
| α-helix | 29-33 | 5 | |
| β-strand | 42 | 1 | 36 |
| α-helix | 46-50 | 5 | |
| α-helix | 51-53 | 3 | |
| β-strand | 55-57 | 3 | 37 |
| β-strand | 63-65 | 3 | 37 |
| α-helix | 68-80 | 13 | |
| β-strand | 83 | 1 | 36 |
| α-helix | 86-93 | 8 | |
| α-helix | 102-121 | 20 | |
| α-helix | 129-134 | 6 | |
| α-helix | 140-168 | 29 | |
| α-helix | 176-199 | 24 | |
| α-helix | 210-219 | 10 | |
| α-helix | 228-231 | 4 | |
| α-helix | 234-240 | 7 | |
| α-helix | 249-258 | 10 | |
| α-helix | 271-286 | 16 | |
| α-helix | 299-305 | 7 | |
| α-helix | 308-316 | 9 | |
| α-helix | 319-326 | 8 | |
| β-strand | 390 | 1 | 38 |
| β-strand | 393 | 1 | 38 |
| α-helix | 425-442 | 18 | |
| α-helix | 449-458 | 10 | |
| α-helix | 478-488 | 11 | |
| α-helix | 494-498 | 5 | |
| α-helix | 499-501 | 3 | |
| α-helix | 506-513 | 8 | |
| α-helix | 520-533 | 14 | |
| α-helix | 537-548 | 12 | |
| α-helix | 563-566 | 4 | |
| α-helix | 567-571 | 5 | |
| α-helix | 579-581 | 3 | |
| α-helix | 603-620 | 18 | |
| α-helix | 626-632 | 7 | |
| α-helix | 635-642 | 8 | |
| α-helix | 652-656 | 5 | |
| α-helix | 666-678 | 13 | |
| α-helix | 688-695 | 8 | |
| α-helix | 704-717 | 14 | |
| α-helix | 751-757 | 7 | |
| α-helix | 772-775 | 4 | |
| α-helix | 786-789 | 4 | |
| α-helix | 836-840 | 5 | |
| α-helix | 850-852 | 3 | |
| α-helix | 861-871 | 11 | |
| α-helix | 872-874 | 3 | |
| α-helix | 894-896 | 3 | |
| α-helix | 912-914 | 3 | |
| β-strand | 920 | 1 | 39 |
| β-strand | 923 | 1 | 39 |
| α-helix | 927-929 | 3 | |
| α-helix | 937-949 | 13 | |
| α-helix | 966-968 | 3 | |
| α-helix | 975-986 | 12 | |
| α-helix | 999-1010 | 12 | |
| α-helix | 1021-1024 | 4 | |
| β-strand | 1028 | 1 | 40 |
| β-strand | 1034 | 1 | 40 |
| α-helix | 1049-1052 | 4 | |
| α-helix | 1070-1087 | 18 | |
| α-helix | 1094-1102 | 9 | |
| α-helix | 1106-1110 | 5 | |
| α-helix | 1138-1140 | 3 | |
| α-helix | 1144-1168 | 25 | |
| α-helix | 1177-1179 | 3 | |
| α-helix | 1213-1216 | 4 | |
| α-helix | 1239-1254 | 16 | |
| α-helix | 1271-1302 | 32 | |
| α-helix | 1310-1313 | 4 | |
| α-helix | 1347-1363 | 17 | |
| α-helix | 1381-1385 | 5 | |
| α-helix | 1386-1388 | 3 | |
| α-helix | 1401-1413 | 13 | |
| α-helix | 1422-1430 | 9 | |
| α-helix | 1435-1442 | 8 | |
| α-helix | 1453-1470 | 18 | |
| α-helix | 1475-1479 | 5 | |
| α-helix | 1485-1493 | 9 | |
| α-helix | 1510-1526 | 17 | |
| α-helix | 1534-1539 | 6 | |
| α-helix | 1544-1549 | 6 | |
| α-helix | 1551-1553 | 3 | |
| α-helix | 1595-1610 | 16 | |
| α-helix | 1621-1632 | 12 | |
| α-helix | 1634-1636 | 3 | |
| α-helix | 1638-1643 | 6 | |
| α-helix | 1657-1674 | 18 | |
Chains G and S: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 272-358 | 87 | |
| α-helix | 362-364 | 3 | |
| α-helix | 366-407 | 42 | |
| α-helix | 438-469 | 32 | |
Chains H and T: 9 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 289-298 | 10 | |
| β-strand | 312 | 1 | 41 |
| α-helix | 332-339 | 8 | |
| α-helix | 348-349 | 2 | |
| β-strand | 350 | 1 | 41 |
| α-helix | 355-389 | 35 | |
| α-helix | 390-394 | 5 | |
| α-helix | 395-422 | 28 | |
| α-helix | 431-447 | 17 | |
| α-helix | 450-475 | 26 | |
| α-helix | 511-535 | 25 | |
Chains I and U: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 639-725 | 87 | |
| α-helix | 742-775 | 34 | |
| α-helix | 794-819 | 26 | |
9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Nucleoporin NIC96 | A, M, N, Z | protein | 839 | Saccharomyces cerevisiae | P34077 (AlphaFold model) |
| Nucleoporin NUP157 | C, O | protein | 1391 | Saccharomyces cerevisiae | P40064 (AlphaFold model) |
| Nucleoporin NUP170 | D, P | protein | 1502 | Saccharomyces cerevisiae | P38181 (AlphaFold model) |
| Nucleoporin NUP188 | E, Q | protein | 1655 | Saccharomyces cerevisiae | P52593 (AlphaFold model) |
| Nucleoporin NUP192 | F, R | protein | 1683 | Saccharomyces cerevisiae | P47054 |
| Nucleoporin NUP49/NSP49 | G, J, S, V | protein | 472 | Saccharomyces cerevisiae | Q02199 |
| Nucleoporin NUP57 | H, K, T, W | protein | 541 | Saccharomyces cerevisiae | P48837 |
| Nucleoporin NSP1 | I, L, U, X | protein | 823 | Saccharomyces cerevisiae | P14907 |
Sequence of entity 1 (A, M, N, Z), FASTA
>7WOT_1 Nucleoporin NIC96 (chains A, M, N, Z)
MLETLRGNKLHSGTSKGANKKLNELLESSDNLPSASSELGSIQVSINELRRRVFQLRSKN
KASKDYTKAHYLLANSGLSFEDVDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEEN
ILMSIEQLLNGATKDFDNFINHNLNLDWAQHKNEVMKNFGILIQDKKTVDHKKSISSLDP
KLPSWGNKGNNILNSNESRLNVNENNILREKFENYARIVFQFNNSRQANGNFDIANEFIS
ILSSANGTRNAQLLESWKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLAT
NVNKIKSFIDTKLKKADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANI
KKVEQSFLTYFKAYASSKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDL
SRKNIPAVTLSIEDWLWMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQ
TLLLSGLYGLAIDYTYTFSEMDAVHLAIGLASLKLFKIDSSTRLTKKPKRDIRFANILAN
YTKSFRYSDPRVAVEYLVLITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARI
PGVIEERQPLLHVRDEKEFLHTITEQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSL
LSDTLSASDLDQPLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNI
SSIRELYFNKQWQETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLS
CISNMIHILNESKYQSSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL
Sequence of entity 2 (C, O), FASTA
>7WOT_2 Nucleoporin NUP157 (chains C, O)
MYSTPLKKRIDYDRETFTASASLGGNRLRNRPRDDQNNGKPNLSSRSFLSERKTRKDVLN
KYGEAGNTIESELRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKG
LDYNFSDEVGGLGAFTPFQRQQVTNIPDEVLSQVSNTEIKSDMGIFLELNYCWITSDNKL
ILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTISFNDR
THELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGVNVWELQYNCSENLFNSKSN
KICLTKSNLANLLPTKLIPSIPGGKLIQKVLEGDAGTEEETISQLEVDQSRGVLHTLSTK
SIVRSYLITSNGLVGPVLIDAAHIRRGMNALGVKNSPLLSNRAFKIAKIVSISMCENNDL
FLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNKSFIIGHHPLNTHDT
GPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYV
SAPDYGILKNYGKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSAEPLK
VAVLTSNALEIYCYRTPDEVFESLIENPLPFIHSYGLSEACSTALYLACKFNKSEHIKSS
ALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYGSALLITRLF
SQIWEERVFVFKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPK
GSNAITASDAESIAMNALILLINSIKDALSLINVFYEDIDAFKSLLNTLMGAGGVYDSKT
REYFFDLKFHDLFTPNAKTKQLIKEILIEVVNANIASGTSADYIVNVLKERFGSFCHSAD
ILCYRAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAENIELCELRRVVDIMVKLNYQ
PKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTS
IEQSPSIANISIFSPASSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFV
LPYLKERAEKSLEISNLLWFYLFKEEHFLEAADVLYALASSDFDLKLSERIECLARANGL
CDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQLTLKLNGRVL
PLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQES
FLSSISNTLIRIGKTTRDTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLK
LYYILSRIIENSEGNVELAKKEMVWLIKDWYQSDSDLRGSIAPEQIKKLEKYDPNTDPVQ
DYVKDRHHGLK
Sequence of entity 3 (D, P), FASTA
>7WOT_3 Nucleoporin NUP170 (chains D, P)
MFQSFFHNNGPAAAGETFSDSRSYPLTNHQEVPRNGLNELASSATKAQQQPTHILNSYPI
TGSNPLMRASAMGATSGSINPNMSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPV
LDERSYYNSGVDYNFSREKNGLGAFTPFEKQDVFNIPDEILHEFSTSQTKTDMGIFPELN
RCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMEL
FMFAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGQASGLNIWELHYSG
SDDWFNSKCSKVCLTKSALLSLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQETITQLT
IDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRIIGTTTARAAPILGPKYLKI
VKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEVIQQE
LLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQ
QTHQQEKKENSSVTGTTATAGSKTVKQQPVTLQHKLFVSVPDYGILKTHGKYVENATFLE
TAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVAVLTSTSIEIYKYRTPDEIFE
DLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRY
SVSTVSSLLSKPTLSTATTNLQQSITGFSKPSPANKEDFDLDDVILSPRFYGIALLITRL
LRDIWGRHVFMTFTDNRVTSHAFISSSDPITPSINNLKSDEISQNRNIISKVSISKDCIE
YYLSSINILNEFFITYGDSISQISAPYVLANNSNGRVIDKTEEVANQAESIAINAMIKMV
QSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNDKTK
SLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGLRN
YDSLNYHLKNATALLEQIVDDLSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLA
CQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEKKQSSKTQNQISISNDDEVK
LRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNIL
WVYYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLAS
RIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEI
ALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQD
SEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSD
NSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLGICFY
KE
Sequence of entity 4 (E, Q), FASTA
>7WOT_4 Nucleoporin NUP188 (chains E, Q)
MATPSFGNSSPQLTFTHVANFMNDAAADVSAVDAKQLAQIRQFLKANKTNLIESLNTIRQ
NVTSSGDHNKLRSTIANLLQINVDNDPFFAQSEDLSHAVEFFMSERSSRLHIVYSLLVNP
DIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSLAHDYNNDQDMFTIVSLVQLK
KFSDLKFILQILQILNLMILNTKVPVDIVNQWFLQYQNQFVEFCRNINSTDKSIDTSSLQ
LYKFQNFQDLSYLSETLISRISSLFTITTILILGLNTSIAQFDIQSPLYMDTETFDTVNS
ALENDVATNIVNEDPIFHPMIHYSWSFILYYRRALQSSESFDDSDITKFALFAESHDVLQ
KLNTLSEILSFDPVYTTVITVFLEFSLNFIPITASTSRVFAKIISKAPEQFIENFLTNDT
FEKKLSIIKAKLPLLNESLIPLINLALIDTEFANFELKDICSFAVTKSSLNDLDYDLIAD
TITNSSSSSDIIVPDLIELKSDLLVAPPLENENSNCLLSIPKSTKGKILTIKQQQQQQQQ
QNGQQPPTTSNLIIFLYKFNGWSLVGRILQNLLHSYMEKGTQLDDLQHELMISIIKLVTN
VVDPKTSIEKSSEILSYLSNSLDTSASTINGASIIQVIFEIFEISLQRKDYTSIVQCCEF
MTMLTPNYLHLVSSYLNKSDLLDKYGKTGLSNMILGSVELSTGDYTFTIQLLKLTKVFIR
ESLSLKNIHISKRSKIDIINKLILHAIHIFESYYNWKYNNFLQKFEIAFHLTLIFYDVLH
DVFTINPHQKDQLIISSSANKLLQLFLTPMDSIDLAPNTLTNILISPLNTTTKILGDKIL
GNLYSKVMNNSFKLCTLLIAIRGSNRDLKPSNLEKLLFINSSKLVDVYTLPSYVHFKVQI
IELLSYLVEAPWNDDYPFLLSFLGEAKSMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLL
ESKQDGLSILFLTGQFASNKKINDESSIDKKSSILTVLQKNSLLLDSTPEEVSCKLLETI
TYVLNTWTNSKIFIKDPKFVNSLLAKLKDSKKLFQKKENLTRDETVSLIKKYKLISRIVE
IFALCIYNSTDSNSEILNFLNQEDLFELVHHFFQIDGFNKTFHDELNLKFKEKWPSLELQ
SFQKIPLSRINENENFGYDIPLLDIVLKADRSWNEPSKSQTNFKEEITDASLNLQYVNYE
ISTAKAWGALITTFVKRSTVPLNDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFY
ILYSFKLSGKLLKEEKIIELMNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLE
LVSSGDRFIELISDQLLEFFELVFSKGVYLILSEILCQINKCSTRGLSTDHTTQIVNLED
NTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLYSSAHLIRINDEPILG
QITLTFISELCSIEPIAAKLINSGLYSVLLESPLSVAIQQGDIKPEFSPRLHNIWSNGLL
SIVLLLLSQFGIKVLPETCLFVSYFGKQIKSTIYNWGDNKLAVSSSLIKETNQLVLLQKM
LNLLNYQELFIQPKNSDDQQEAVELVIGLDSEHDKKRLSAALSKFLTHPKYLNSRIIPTT
LEEQQQLEDESSRLEFVKGISRDIKALQDSLFKDV
Sequence of entity 5 (F, R), FASTA
>7WOT_5 Nucleoporin NUP192 (chains F, R)
MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKNNASRSQLEKGEIELSD
GSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTTANNGKVQYFLRRQYILQIVSFI
VNCFHEDTELYQELIKNGALVSNILSAFKFIHTQLSEIKQQINKAQILENYNALFQQNIK
FRRDFLLREYDILSQILYGLVDKGAIMKNKDFILSLLHHVSELDSNDFFIIYYTPAFFHL
FASLRVLPDADVKLLHSQFMKDLKDDSIYTKPVKVALIFIFFAYFIGWCKEDPKRRADTM
DFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQDKSMELFYDIRSLLERHIPRLIPKQL
LDDEKIFSQTTNSTYNPASATDNMSGRGLWNPSYPGMMSTTGTARLNSMPNNVNEYSYTT
IVLSDQTQEFFLSSFDDVLQTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISLKADLER
FFLSIYFFYASRPEYSCTFWSDKESNAYGFIEWCSRCNDNLMRSCFYLMVSSLSFGPENA
LNVYHYFGENSSISWKNIAQCLSDYTKKISNFNSSLHKRQQFSESTHNDIDSTAVALEEG
LNEEAVIFLSSLLTLVGSVTYQVDEDVKSSLSKVFSDVLFEFTKINTPLVGAAFKVISNL
VPKLESSRTKFWSFLDSLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIH
SRENNSEYMVFGKLAFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLPI
LKIIYTGLCSFDYSVILNSIPAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSI
FNVVDVGVDQLSIELEGGKNQAELLQLAVKIINKVLDYQETYVEELFPIVKKHGKTDYFL
PKNYSLHGLRSFYDAIFFNIPLVAHLGLYVGVDDQILATNSLRILAKLSERSNGSVASLS
KRNKLLTIFDSVDESARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTIS
HLLLGFQVSNVISLGPNLATFISSGTSLLDSLISVLEASLNSITKDNIDYAPMRLATAAL
EIILKLCRNPLTSGLLYSYLIKENFFERIMILDPQVTRFTTWNGSPFDNSTEEKCKNFIE
SESVGAFLSFLAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLDP
LNYGNICEPKETLSIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSN
SFSLTVSKEQFLKDADVECIKAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLE
PSTRSNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFLFDIYNRDRKLITDKGTVDGR
LYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSEKVLQDLRLGSKKLVEI
IWNDVVYGEGTSRVTGILLLDSLIQLANRSKENFILDSLMKTTRLLLIIRSLKNTDALLN
STTEHINIDDLLYELTAFKATVFFLIRVAETRGGASALIENNLFRIIAELSFLKVDPDLG
LDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISAVLVSMGSSNK
AVVQTVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVKLIVMLCTLTGYQ
NND
Sequence of entity 6 (G, J, S, V), FASTA
>7WOT_6 Nucleoporin NUP49/NSP49 (chains G, J, S, V)
MFGLNKASSTPAGGLFGQASGASTGNANTGFSFGGTQTGQNTGPSTGGLFGAKPAGSTGG
LGASFGQQQQQSQTNAFGGSATTGGGLFGNKPNNTANTGGGLFGANSNSNSGSLFGSNNA
QTSRGLFGNNNTNNINNSSSGMNNASAGLFGSKPAGGTSLFGNTSTSSAPAQNQGMFGAK
PAGTSLFGNNAGNTTTGGGLFGSKPTGATSLFGSSNNNNNNNNSNNIMSASGGLFGNQQQ
QLQQQPQMQCALQNLSQLPITPMTRISELPPQIRQEIEQLDQYIQKQVQISHHLKADTID
HDELIDSIPRDVAYLLKSESATSQYLKQDLKKISSFKSLIDEDLLDTQTFSVLLQQLLTP
GSKISSNDLDKFFQKKIHLYEKKLEDYCRILSDIETAVNGIDTDLFGAPNNPNSTAITAD
LGSSEAENLLQLKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASLSI
Sequence of entity 7 (H, K, T, W), FASTA
>7WOT_7 Nucleoporin NUP57 (chains H, K, T, W)
MFGFSGSNNGFGNKPAGSTGFSFGQNNNNTNTQPSASGFGFGGSQPNSGTATTGGFGANQ
ATNTFGSNQQSSTGGGLFGNKPALGSLGSSSTTASGTTATGTGLFGQQTAQPQQSTIGGG
LFGNKPTTTTGGLFGNSAQNNSTTSGGLFGNKVGSTGSLMGGNSTQNTSNMNAGGLFGAK
PQNTTATTGGLFGSKPQGSTTNGGLFGSGTQNNNTLGGGGLFGQSQQPQTNTAPGLGNTV
STQPSFAWSKPSTGSNLQQQQQQQIQVPLQQTQAIAQQQQLSNYPQQIQEQVLKCKESWD
PNTTKTKLRAFVYNKVNETEAILYTKPGHVLQEEWDQAMEKKPSPQTIPIQIYGFEGLNQ
RNQVQTENVAQARIILNHILEKSTQLQQKHELDTASRILKAQSRNVEIEKRILKLGTQLA
TLKNRGLPLGIAEEKMWSQFQTLLQRSEDPAGLGKTNELWARLAILKERAKNISSQLDSK
LMVFNDDTKNQDSMSKGTGEESNDRINKIVEILTNQQRGITYLNEVLEKDAAIVKKYKNK
T
Sequence of entity 8 (I, L, U, X), FASTA
>7WOT_8 Nucleoporin NSP1 (chains I, L, U, X)
MNFNTPQQNKTPFSFGTANNNSNTTNQNSSTGAGAFGTGQSTFGFNNSAPNNTNNANSSI
TPAFGSNNTGNTAFGNSNPTSNVFGSNNSTTNTFGSNSAGTSLFGSSSAQQTKSNGTAGG
NTFGSSSLFNNSTNSNTTKPAFGGLNFGGGNNTTPSSTGNANTSNNLFGATANANKPAFS
FGATTNDDKKTEPDKPAFSFNSSVGNKTDAQAPTTGFSFGSQLGGNKTVNEAAKPSLSFG
SGSAGANPAGASQPEPTTNEPAKPALSFGTATSDNKTTNTTPSFSFGAKSDENKAGATSK
PAFSFGAKPEEKKDDNSSKPAFSFGAKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAF
SFGAKSDEKKDGDASKPAFSFGAKPDENKASATSKPAFSFGAKPEEKKDDNSSKPAFSFG
AKSNEDKQDGTAKPAFSFGAKPAEKNNNETSKPAFSFGAKSDEKKDGDASKPAFSFGAKS
DEKKDSDSSKPAFSFGTKSNEKKDSGSSKPAFSFGAKPDEKKNDEVSKPAFSFGAKANEK
KESDESKSAFSFGSKPTGKEEGDGAKAAISFGAKPEEQKSSDTSKPAFTFGAQKDNEKKT
EESSTGKSTADVKSSDSLKLNSKPVELKPVSLDNKTLDDLVTKWTNQLTESASHFEQYTK
KINSWDQVLVKGGEQISQLYSDAVMAEHSQNKIDQSLQYIERQQDELENFLDNFETKTEA
LLSDVVSTSSGAAANNNDQKRQQAYKTAQTLDENLNSLSSNLSSLIVEINNVSNTFNKTT
NIDINNEDENIQLIKILNSHFDALRSLDDNSTSLEKQINSIKK
Primary citation
Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Li, Z., Chen, S., Zhao, L. et al. Cell Res (2022) 32:437-450. DOI 10.1038/s41422-022-00632-y · PubMed
Other PDB entries of the same protein (UniProt P34077 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6X07 2.1 Å, Nic96 from S. cerevisiae bound by VHH-SAN12
- 2QX5 2.5 Å, Structure of nucleoporin Nic96
- 2RFO 2.6 Å, Crystral Structure of the nucleoporin Nic96
- 7WOO 3.71 Å, Cryo-EM structure of the inner ring protomer of the Saccharomyces cerevisiae nuclear…
- 8TJ5 6.6 Å, Inner spoke ring of the yeast NPC
- 7N85 7.6 Å, Inner ring spoke from the isolated yeast NPC
- 7N9F 37.0 Å, Structure of the in situ yeast NPC
- 8ZZA Integrative structure and functional anatomy of a single spoke of a nuclear pore complex
- 8ZZB Integrative structure and functional anatomy of three spokes of a nuclear pore complex
- 8ZZC Integrative structure and functional anatomy of eight spokes of a nuclear pore complex
- 9A0F Integrative model of the wild type yeast nuclear pore complex
- 9A0G Integrative model of Nup116 knockout (at 25C) yeast nuclear pore complex
Browse structure collections
About this viewer
MolViewer shows 7WOT directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.