7X70: TRIM7

TRIM7 in complex with C-terminal peptide of NSP8. Determined by X-ray diffraction at 1.25 Å resolution. Released 10 Aug 2022.

Method: X-ray diffraction
Resolution: 1.25 Å
Organisms: Homo sapiens, Severe acute respiratory syndrome coronavirus 2
Chains: 2
Atoms: 1,650
Mol. weight: 20.25 kDa
Released: 10 Aug 2022

Explore 7X70 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7X70 contains 2 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 16 β-strands

Element	Residues	Length	Sheet
β-strand	9	1	1
β-strand	18-20	3	2
β-strand	26-29	4	2
β-strand	48-50	3	3
β-strand	51	1	1
β-strand	55	1	3
β-strand	59-66	8	2
β-strand	72-78	7	3
α-helix	91-93	3
β-strand	95-101	7	3
β-strand	104-107	4	3
β-strand	114-116	3	3
β-strand	123-129	7	2
β-strand	134-139	6	2
β-strand	144-150	7	2
β-strand	157-163	7	3
β-strand	170-173	4	2

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	90-92	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase TRIM7	A	protein	174	Homo sapiens	Q9C029 (AlphaFold model)
peptide	B	protein	5	Severe acute respiratory syndrome coronavirus 2	P0DTD1 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7X70_1 E3 ubiquitin-protein ligase TRIM7 (chains A)
KEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLPNHPCRFDTNTRVLASCGFSSGRH
HWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWALQLNGGQYWAVTSPERSPLSCGH
LSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLRIWP

Sequence of entity 2 (B), FASTA

>7X70_2 peptide (chains B)
AVKLQ

Primary citation

A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Liang, X., Xiao, J., Li, X. et al. Nat Chem Biol (2022) 18:1214-1223. DOI 10.1038/s41589-022-01128-x · PubMed

Other PDB entries of the same protein (UniProt Q9C029 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W0Q 1.1 Å, TRIM7 in complex with C-terminal peptide of 2C
7X6Y 1.39 Å, TRIM7 in complex with C-terminal peptide of NSP5
7W0S 1.4 Å, TRIM7 in complex with C-terminal peptide of 2C
7X6Z 1.43 Å, TRIM7 in complex with C-terminal peptide of NSP12
9HIN 1.55 Å, Crystal structure of human TRIM7 PRYSPRY domain bound to…
7W0T 1.57 Å, TRIM7 in complex with C-terminal peptide of 2C
6UMA 1.6 Å, Crystal structure of the TRIM7 B30.2 domain at 1.6 angstrom resolution
8R5B 1.6 Å, Crystal structure of human TRIM7 PRYSPRY domain bound to (3-phenoxybenzoyl)-L-glutamine
8R5C 1.6 Å, Crystal structure of human TRIM7 PRYSPRY domain bound to…
8A5L 1.62 Å, TRIM7 PRYSPRY in complex with a 2BC peptide TIEALFQ
7OVX 1.7 Å, E3 RING ligase binding domain
7Y3A 1.7 Å, Crystal structure of TRIM7 bound to 2C

Browse structure collections

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