7XJ0: Human TRPV3

Structure of human TRPV3 in complex with Trpvicin. Determined by electron microscopy at 2.53 Å resolution. Released 9 Nov 2022.

Method

Electron microscopy

Resolution

2.53 Å

Organism

Homo sapiens

Chains

4

Atoms

18,791

Mol. weight

499.62 kDa

Ligands

EQK, 6OU

Released

9 Nov 2022

Explore 7XJ0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7XJ0 contains 138 α-helices and 32 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 34 helices, 9 β-strands

Molecules and chains

>7XJ0_1 Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP (chains A, B, C, D)
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTADFNKIQDSSRNNSKTTLNAF
EEVEEFPETSVLEVLFQGPSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKL
TLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKD
DGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNSHNVYITADKQKNGIK
ANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLE
FVTAAGITHGMDEWSHPQFEKGGGSGGGSGGSAWSHPQFEK

Ligands and cofactors

Primary citation

Structural basis of TRPV3 inhibition by an antagonist. Fan, J., Hu, L., Yue, Z. et al. Nat Chem Biol (2023) 19:81-90. DOI 10.1038/s41589-022-01166-5 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q8NET8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6H9J 1.83 Å, Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255)
• 6HA6 1.98 Å, Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (220-246)
• 7QQN 2.45 Å, The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3
• 8V6K 2.46 Å, Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs
• 13LU 2.49 Å, Structure of human TRPV3-W521S Olmsted syndrome mutant in the closed state
• 8GKA 2.55 Å, Human TRPV3 tetramer structure, closed conformation
• 8V6N 2.59 Å, Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs
• 9PJ5 2.76 Å, Closed-state structure of wild-type human TRPV3 purified in GDN detergent
• 8V6O 2.83 Å, Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs
• 13LJ 2.86 Å, Structure of human TRPV3-G568C Olmsted syndrome mutant in the closed state
• 7XJ1 2.93 Å, Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry
• 13LL 2.96 Å, Structure of human TRPV3-Q580P Olmsted syndrome mutant in the closed state

Browse structure collections

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