9PJ5: PDB entry 9PJ5

Closed-state structure of wild-type human TRPV3 purified in GDN detergent. Determined by electron microscopy at 2.76 Å resolution. Released 1 Jul 2026.

Method: Electron microscopy
Resolution: 2.76 Å
Organism: Homo sapiens
Chains: 4
Atoms: 22,278
Mol. weight: 395.09 kDa
Ligands: POV
Released: 1 Jul 2026

Explore 9PJ5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9PJ5 contains 140 α-helices and 40 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 35 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	120-129	10
α-helix	132-146	15
α-helix	155-158	4
β-strand	163	1	1
β-strand	170	1	1
α-helix	171-177	7
α-helix	183-196	14
α-helix	200-203	4
β-strand	208	1	2
β-strand	214	1	2
α-helix	218-224	7
α-helix	228-237	10
α-helix	265-271	7
α-helix	275-282	8
α-helix	299-305	7
α-helix	316-328	13
α-helix	332-335	4
α-helix	344-350	7
α-helix	354-361	8
α-helix	371-373	3
β-strand	376-382	7	3
β-strand	385-391	7	3
α-helix	403-408	6
α-helix	416-419	4
α-helix	423-432	10
α-helix	433-437	5
α-helix	438-460	23
α-helix	482-506	25
α-helix	521-541	21
α-helix	547-560	14
α-helix	561-568	8
α-helix	570-582	13
α-helix	583-587	5
α-helix	588-607	20
β-strand	609	1	4
α-helix	610-612	3
α-helix	625-637	13
β-strand	648	1	4
α-helix	651-662	12
α-helix	663-669	7
α-helix	670-684	15
α-helix	688-706	19
α-helix	709-712	4
β-strand	719-724	6	3
β-strand	727-737	11	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transient receptor potential cation channel subfamily V member 3	A, B, C, D	protein	808	Homo sapiens	Q8NET8 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>9PJ5_1 Transient receptor potential cation channel subfamily V member 3 (chains A, B, C, D)
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTADFNKIQDSSRNNSKTTLNAF
EEVEEFPETSVLVPRGSAAAWSHPQFEK

Ligands and cofactors

ID	Name	Formula	Copies
POV	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl…	C42 H82 N O8 P	32

Water and common crystallization additives (NA) are not listed.

Primary citation

Structural diversity of heat-sensing channel TRPV3 with Olmsted syndrome mutations. Khau, J., Purohit, R., Nadezhdin, K.D. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-74687-5 · PubMed

Other PDB entries of the same protein (UniProt Q8NET8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6H9J 1.83 Å, Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255)
6HA6 1.98 Å, Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (220-246)
7QQN 2.45 Å, The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3
8V6K 2.46 Å, Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs
13LU 2.49 Å, Structure of human TRPV3-W521S Olmsted syndrome mutant in the closed state
7XJ0 2.53 Å, Structure of human TRPV3 in complex with Trpvicin
8GKA 2.55 Å, Human TRPV3 tetramer structure, closed conformation
8V6N 2.59 Å, Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs
8V6O 2.83 Å, Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs
13LJ 2.86 Å, Structure of human TRPV3-G568C Olmsted syndrome mutant in the closed state
7XJ1 2.93 Å, Structure of human TRPV3_G573S in complex with Trpvicin in C2 symmetry
13LL 2.96 Å, Structure of human TRPV3-Q580P Olmsted syndrome mutant in the closed state

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