7XLP: MEK1

MEK1 bound to DS03090629. Determined by X-ray diffraction at 2.1 Å resolution. Released 1 Mar 2023.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,458
Mol. weight: 39.58 kDa
Ligands: CA, FZC
Released: 1 Mar 2023

Explore 7XLP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7XLP contains 21 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 21 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	38-40	3
α-helix	44-58	15
α-helix	65-67	3
β-strand	68-77	10	1
β-strand	80-87	8	1
β-strand	93-100	8	1
α-helix	105-114	10
α-helix	115-120	6
β-strand	123	1	2
β-strand	126	1	2
β-strand	129-135	7	1
β-strand	138-143	6	1
β-strand	150	1	2
α-helix	151-158	8
α-helix	163-184	22
α-helix	193-195	3
β-strand	196-198	3	2
β-strand	204-206	3	2
α-helix	213-219	7
α-helix	232-235	4
α-helix	238-240	3
α-helix	242-258	17
α-helix	265-267	3
α-helix	268-274	7
α-helix	310-319	10
α-helix	321-323	3
α-helix	325-326	2
α-helix	332-341	10
α-helix	352-356	5
α-helix	359-366	8
α-helix	371-379	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Dual specificity mitogen-activated protein kinase kinase 1	A	protein	348	Homo sapiens	Q02750 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7XLP_1 Dual specificity mitogen-activated protein kinase kinase 1 (chains A)
GLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMA
RKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL
KKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL
IDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF
GCQVEGDAAETPPRPRTPGRPLNKKGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQ
DFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQ

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	3
FZC	(1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl…	C25 H26 Cl N5 O2	1

Water and common crystallization additives (DMS) are not listed.

Primary citation

Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma. Takano, K., Munehira, Y., Hatanaka, M. et al. Mol Cancer Ther (2023) 22:317-332. DOI 10.1158/1535-7163.MCT-22-0306 · PubMed

Other PDB entries of the same protein (UniProt Q02750 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7B7R 1.7 Å, MEK1 in complex with compound 4
7B9L 1.7 Å, MEK1 in complex with compound 23
3EQC 1.8 Å, X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a…
3EQI 1.9 Å, X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a…
3EQH 2.0 Å, X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a…
3VVH 2.0 Å, X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex…
7B94 2.0 Å, MEK1 in complex with compound 6
7F2X 2.01 Å, Crystal structure of MEK1 C121S mutant
9AXX 2.07 Å, Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer
3EQD 2.1 Å, X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a…
4AN3 2.1 Å, Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518…
7XNC 2.1 Å, MEK1 bound to DS94070624

Browse structure collections

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