7Z2Z: DNA-directed RNA polymerase III subunit RPC1

Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A. Determined by electron microscopy at 3.07 Å resolution. Released 5 Apr 2023.

Method: Electron microscopy
Resolution: 3.07 Å
Organism: Saccharomyces cerevisiae S288C
Chains: 22
Atoms: 41,670
Mol. weight: 797.62 kDa
Ligands: 4QM, MG, ZN
Released: 5 Apr 2023

Explore 7Z2Z in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Z2Z contains 231 α-helices and 282 β-strands across 19 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 78 helices, 63 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	1
β-strand	11-17	7	2
α-helix	25-28	4
β-strand	30-33	4	3
β-strand	36	1	4
β-strand	40	1	5
α-helix	47	1
β-strand	48	1	5
α-helix	49	1
α-helix	56-58	3
β-strand	81-91	11	3
α-helix	93-95	3
α-helix	96-103	8
β-strand	106	1	6
β-strand	113	1	6
α-helix	117-127	11
α-helix	134-150	17
β-strand	163	1	7
β-strand	166	1	8
β-strand	178-180	3	8
β-strand	181	1	7
α-helix	182-184	3
α-helix	192-207	16
α-helix	213-215	3
β-strand	220-222	3	8
α-helix	224-231	8
α-helix	240-242	3
α-helix	253-256	4
β-strand	257-263	7	3
α-helix	264-265	2
α-helix	270-271	2
β-strand	272	1	9
β-strand	281	1	9
α-helix	284-305	22
α-helix	309-327	19
α-helix	334-336	3
α-helix	354-356	3
α-helix	363	1
α-helix	364-368	5
β-strand	371-373	3	10
β-strand	376-380	5	11
β-strand	381-383	3	12
α-helix	388	1
β-strand	391	1	11
β-strand	392-393	2	12
β-strand	394-395	2	13
α-helix	396-399	4
β-strand	404-407	4	14
α-helix	408	1
α-helix	413-422	10
β-strand	430-434	5	14
β-strand	441	1	15
β-strand	442-443	2	14
α-helix	449-455	7
β-strand	461-464	4	14
β-strand	471-475	5	11
α-helix	482-484	3
β-strand	485-489	5	11
β-strand	492-493	2	13
β-strand	498-500	3	12
α-helix	502-504	3
α-helix	505-508	4
β-strand	516-520	5	11
α-helix	525-535	11
β-strand	536	1	11
α-helix	537-540	4
β-strand	542	1	16
β-strand	549	1	16
α-helix	555-565	11
β-strand	570-571	2	17
α-helix	573-583	11
α-helix	592-595	4
β-strand	597-599	3	18
β-strand	603	1	18
β-strand	604-605	2	17
α-helix	606-614	9
β-strand	626-629	4	19
α-helix	643-645	3
β-strand	651-655	5	19
β-strand	658-661	4	19
α-helix	666-669	4
α-helix	677-685	9
α-helix	687-708	22
α-helix	714-716	3
α-helix	718-720	3
α-helix	721-747	27
α-helix	750-753	4
α-helix	758-784	27
α-helix	785-786	2
α-helix	790-797	8
α-helix	803-810	8
β-strand	815	1	20
β-strand	817-818	2	21
β-strand	821-822	2	21
α-helix	823-825	3
β-strand	827	1	22
β-strand	830	1	22
β-strand	847	1	20
α-helix	858-893	36
β-strand	897-898	2	23
β-strand	904-905	2	23
β-strand	911-913	3	23
α-helix	916-918	3
α-helix	935-945	11
α-helix	952-955	4
α-helix	956-966	11
α-helix	969-972	4
β-strand	977	1	24
β-strand	983	1	24
α-helix	999-1024	26
α-helix	1052-1059	8
α-helix	1064-1080	17
α-helix	1083-1084	2
α-helix	1089-1101	13
α-helix	1123-1131	9
β-strand	1140-1145	6	25
α-helix	1150-1154	5
α-helix	1155-1158	4
α-helix	1166-1170	5
β-strand	1172-1177	6	26
β-strand	1182-1187	6	26
α-helix	1191-1195	5
α-helix	1203-1216	14
β-strand	1222-1223	2	26
β-strand	1229-1233	5	26
α-helix	1255-1266	12
α-helix	1267-1269	3
β-strand	1278-1285	8	25
β-strand	1291-1297	7	25
α-helix	1300-1305	6
β-strand	1309-1316	8	25
α-helix	1319-1325	7
α-helix	1328-1344	17
α-helix	1352-1362	11
α-helix	1383-1389	7
α-helix	1392-1402	11
α-helix	1411-1416	6
α-helix	1424-1426	3
β-strand	1428-1432	5	1
α-helix	1439-1441	3
α-helix	1453-1456	4

Chain B: 52 helices, 84 β-strands

Element	Residues	Length	Sheet
α-helix	40-43	4
α-helix	44-46	3
α-helix	47-54	8
α-helix	60-67	8
α-helix	68-72	5
α-helix	73-79	7
β-strand	82-83	2	27
β-strand	93-100	8	27
α-helix	112-114	3
α-helix	115-121	7
β-strand	126-134	9	27
β-strand	135	1	28
β-strand	143	1	28
β-strand	147-153	7	27
α-helix	154-155	2
α-helix	168-173	6
β-strand	185-187	3	29
β-strand	190-194	5	29
β-strand	196-200	5	30
α-helix	201	1
β-strand	206-210	5	31
β-strand	214-218	5	31
β-strand	220-222	3	32
β-strand	227-229	3	32
β-strand	232	1	31
β-strand	234	1	33
β-strand	240	1	33
β-strand	241-242	2	34
β-strand	251-252	2	34
α-helix	253-259	7
α-helix	267-272	6
β-strand	276	1	35
α-helix	277-283	7
α-helix	289-292	4
α-helix	298-306	9
α-helix	317-319	3
α-helix	322-324	3
α-helix	325-328	4
α-helix	330-332	3
α-helix	343-361	19
α-helix	372-374	3
β-strand	375-378	4	30
α-helix	380-407	28
α-helix	418-425	8
α-helix	427-439	13
β-strand	442-443	2	36
β-strand	450-451	2	36
β-strand	455-457	3	29
α-helix	458-459	2
α-helix	463-469	7
β-strand	472-474	3	30
α-helix	485-487	3
α-helix	491-493	3
β-strand	497	1	37
β-strand	512-513	2	30
β-strand	514	1	37
β-strand	519-520	2	38
α-helix	528-536	9
α-helix	538	1
β-strand	539-540	2	39
β-strand	553	1	40
β-strand	554-557	4	41
β-strand	560-561	2	41
β-strand	563-564	2	39
β-strand	565	1	40
α-helix	568-580	13
β-strand	589-593	5	41
β-strand	598-602	5	41
β-strand	608-609	2	38
β-strand	611-614	4	42
β-strand	615-616	2	43
β-strand	619-620	2	43
α-helix	625-632	8
α-helix	638-642	5
β-strand	646-648	3	42
α-helix	653-656	4
β-strand	659-660	2	42
α-helix	663-665	3
β-strand	672-673	2	42
α-helix	684-687	4
α-helix	691-693	3
β-strand	694	1	44
α-helix	696-705	10
β-strand	709	1	45
β-strand	724-728	5	46
β-strand	732	1	47
β-strand	736-737	2	48
α-helix	739-743	5
β-strand	753-759	7	49
β-strand	770-774	5	49
β-strand	785-794	10	46
β-strand	805	1	50
β-strand	811	1	51
β-strand	817	1	51
α-helix	819-821	3
β-strand	829	1	52
β-strand	832	1	53
β-strand	835-836	2	46
β-strand	841-843	3	52
β-strand	846-847	2	50
β-strand	867-868	2	50
β-strand	871-872	2	52
β-strand	879-888	10	46
β-strand	894-904	11	46
β-strand	911-913	3	49
β-strand	920-926	7	49
α-helix	928-930	3
β-strand	933	1	54
β-strand	942-944	3	49
α-helix	946-948	3
β-strand	954	1	44
α-helix	956-970	15
β-strand	974-975	2	48
α-helix	984-992	9
β-strand	1001-1002	2	49
β-strand	1005	1	54
β-strand	1012	1	54
α-helix	1013	1
β-strand	1017-1026	10	49
β-strand	1027	1	45
α-helix	1031-1033	3
β-strand	1036-1038	3	11
β-strand	1043-1044	2	55
β-strand	1050	1	55
α-helix	1059	1
β-strand	1060-1062	3	10
α-helix	1064-1072	9
α-helix	1076-1080	5
α-helix	1081-1085	5
β-strand	1089-1095	7	56
β-strand	1101	1	56
β-strand	1103	1	57
β-strand	1106	1	57
β-strand	1116-1122	7	56
α-helix	1123-1134	12
β-strand	1140-1145	6	2

Chain C: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	58
β-strand	12-13	2	58
α-helix	36-39	4
β-strand	41-48	8	58
β-strand	51-57	7	58
α-helix	61-73	13
β-strand	77-88	12	59
α-helix	94-103	10
β-strand	106	1	60
α-helix	115-117	3
α-helix	122-125	4
β-strand	132-139	8	59
β-strand	141-142	2	61
β-strand	157-158	2	61
β-strand	161-162	2	62
β-strand	168-169	2	59
α-helix	175-178	4
β-strand	186	1	60
β-strand	194-195	2	62
β-strand	201-211	11	59
α-helix	217-219	3
β-strand	222-235	14	58
α-helix	242-248	7
β-strand	257-258	2	63
β-strand	265-266	2	63
α-helix	279-281	3
β-strand	289-304	16	58
α-helix	310-330	21
β-strand	334	1	64

Chain D: 10 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	3-5	3	1
α-helix	15-26	12
α-helix	33-35	3
α-helix	53-67	15
α-helix	69-70	2
α-helix	100-105	6
α-helix	107-112	6
α-helix	120-123	4
α-helix	131-137	7
α-helix	141-144	4
α-helix	151-157	7

Chain E: 11 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	2-27	26
β-strand	28	1	65
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	66
β-strand	53	1	66
α-helix	55-57	3
β-strand	60-62	3	67
β-strand	64	1	65
α-helix	66-71	6
β-strand	78-80	3	67
β-strand	81-82	2	68
β-strand	87-88	2	69
α-helix	90-102	13
β-strand	107-111	5	68
β-strand	115-116	2	69
α-helix	120-123	4
β-strand	131-135	5	68
β-strand	140	1	70
β-strand	142	1	70
α-helix	144-146	3
β-strand	152-155	4	71
α-helix	158-168	11
β-strand	177-178	2	71
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-202	8	71
β-strand	206-214	9	71

Chain F: 6 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	72	1
β-strand	73	1	1
α-helix	74-75	2
β-strand	84	1	72
α-helix	85-86	2
α-helix	87-102	16
α-helix	117-126	10
β-strand	133-137	5	1
α-helix	138	1
β-strand	143-147	5	1
β-strand	152	1	72

Chain G: 5 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-4	2	1
β-strand	6-13	8	1
α-helix	15-19	5
α-helix	22-33	12
β-strand	38-39	2	1
β-strand	43-54	12	1
β-strand	57-58	2	1
α-helix	65	1
β-strand	66-77	12	1
β-strand	85-94	10	73
β-strand	96-100	5	73
β-strand	108	1	74
β-strand	110	1	73
β-strand	115	1	75
β-strand	120	1	76
β-strand	129	1	76
β-strand	145-148	4	73
β-strand	152-155	4	74
α-helix	163-172	10
β-strand	194-197	4	74
β-strand	200	1	75
β-strand	203	1	77
β-strand	205	1	77
α-helix	208-210	3

Chain H: 0 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	18
β-strand	24-30	7	18
β-strand	37-42	6	18
β-strand	54-60	7	18
β-strand	95-108	14	18
β-strand	111-118	8	18
β-strand	121-127	7	18
β-strand	140-145	6	18

11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase III subunit RPC1	A	protein	1460	Saccharomyces cerevisiae S288C	P04051 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC2	B	protein	1149	Saccharomyces cerevisiae S288C	P22276 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae S288C	P07703 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC9	D	protein	161	Saccharomyces cerevisiae S288C	P47076 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae S288C	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae S288C	P20435
DNA-directed RNA polymerase III subunit RPC8	G	protein	212	Saccharomyces cerevisiae S288C	P35718
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae S288C	P20436
DNA-directed RNA polymerase III subunit RPC10	I	protein	110	Saccharomyces cerevisiae S288C	Q04307
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae S288C	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae S288C	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae S288C	P40422

10 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>7Z2Z_1 DNA-directed RNA polymerase III subunit RPC1 (chains A)
MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGV
SSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDK
RQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIH
DTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCE
LLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIK
AGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGK
QGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELI
VNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSL
HRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNN
LLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKP
YYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQIL
SGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPA
DDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDV
CINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSK
TPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQY
DNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIM
ETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALA
NLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRK
ARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPI
INAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLEL
TIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRM
QQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVL
EVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMR
DSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKD
LVPKRCLFESLSNEAALKAN

Sequence of entity 2 (B), FASTA

>7Z2Z_2 DNA-directed RNA polymerase III subunit RPC2 (chains B)
MVAATKRRKTHIHKHVKDEAFDDLLKPVYKGKKLTDEINTAQDKWHLLPAFLKVKGLVKQ
HLDSFNYFVDTDLKKIIKANQLILSDVDPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRL
RDMTYSAPIYVDIEYTRGRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLD
PGGYFIVNGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKNGKI
YLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNLEESSKLDIYTQQQ
ALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTVEALDFREKALYIAMMTRRVVMAM
YNPKMIDDRDYVGNKRLELAGQLISLLFEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALL
SINVHSNNITSGLNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKS
RKVSGPRALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLGVED
ITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEFISIYSNSHQMAVH
IATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDFDDFLKLGLVEYLDVNEENDSYIA
LYEKDIVPSMTHLEIEPFTILGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKR
IDTLLYLMTYPQQPMVKTKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDR
GFGRCETRRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQSGQ
IYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMSVSDNDQALIKVLL
RQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQGIVPDIIMNPHGFPSRMTVGKMIE
LISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQGFNYSGKDMLYSGITGECLQAYIFFG
PIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLL
ERLMISSDAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNIAPR
LRLEDIFQQ

Sequence of entity 3 (C), FASTA

>7Z2Z_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>7Z2Z_4 DNA-directed RNA polymerase III subunit RPC9 (chains D)
MKVLEERNAFLSDYEVLKFLTDLEKKHLWDQKSLAALKKSRSKGKQNRPYNHPELQGITR
NVVNYLSINKNFINQEDEGEERESSGAKDAEKSGISKMSDESFAELMTKLNSFKLFKAEK
LQIVNQLPANMVHLYSIVEECDARFDEKTIEEMLEIISGYA

Sequence of entity 5 (E), FASTA

>7Z2Z_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>7Z2Z_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>7Z2Z_7 DNA-directed RNA polymerase III subunit RPC8 (chains G)
MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLK
PGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCY
YTPEESAWIWPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEG
KNEETPQNEKPPAYALLGSCQTDGMGLVSWWE

Sequence of entity 8 (H), FASTA

>7Z2Z_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>7Z2Z_9 DNA-directed RNA polymerase III subunit RPC10 (chains I)
MLSFCPSCNNMLLITSGDSGVYTLACRSCPYEFPIEGIEIYDRKKLPRKEVDDVLGGGWD
NVDQTKTQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCGHRWKEN

Sequence of entity 10 (J), FASTA

>7Z2Z_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>7Z2Z_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>7Z2Z_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
XXXXXXXXXXXXXXXXXXXXXXXXXXLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
4QM	(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4…	C24 H42 O3	1
MG	Magnesium ion	Mg	2
ZN	Zinc ion	Zn	7

Primary citation

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nguyen, P.Q., Huecas, S., Asif-Laidin, A. et al. Nat Commun (2023) 14:1729-1729. DOI 10.1038/s41467-023-37109-4 · PubMed

Other PDB entries of the same protein (UniProt P04051 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7Z0H 2.6 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.6 A (focus subunit AC40).
7Z1O 2.7 Å, Structure of yeast RNA Polymerase III PTC + NTPs
7Z31 2.76 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.7 A (focus subunit C11,…
7Z1L 2.8 Å, Structure of yeast RNA Polymerase III Pre-Termination Complex (PTC)
7Z30 2.9 Å, Structure of yeast RNA Polymerase III-Ty1 integrase complex at 2.9 A (focus subunit C11…
8BWS 3.2 Å, Structure of yeast RNA Polymerase III elongation complex at 3.3 A
6TUT 3.25 Å, Cryo-EM structure of the RNA Polymerase III-Maf1 complex
6EU3 3.3 Å, Apo RNA Polymerase III - closed conformation (cPOL3)
6EU1 3.4 Å, RNA Polymerase III - open DNA complex (OC-POL3).
6EU2 3.4 Å, Apo RNA Polymerase III - open conformation (oPOL3)
7Z1M 3.4 Å, Structure of yeast RNA Polymerase III Elongation Complex (EC)
6F40 3.7 Å, RNA Polymerase III open complex

Browse structure collections

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