7Z8I: The barbed end complex of dynactin

The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2). Determined by electron microscopy at 3.3 Å resolution. Released 17 Aug 2022.

Method: Electron microscopy
Resolution: 3.3 Å
Organisms: Sus scrofa, Mus musculus, Homo sapiens
Chains: 17
Atoms: 43,425
Mol. weight: 2303.91 kDa
Ligands: ADP, MG
Released: 17 Aug 2022

Explore 7Z8I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Z8I contains 261 α-helices and 224 β-strands across 17 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	10-11	2
β-strand	12-16	5	1
β-strand	20-25	6	1
β-strand	35-36	2	1
β-strand	39-42	4	2
β-strand	45-46	2	3
β-strand	57	1	2
α-helix	60-64	5
α-helix	66-68	3
β-strand	69-72	4	2
β-strand	75-76	2	4
β-strand	79-80	2	4
α-helix	83-93	11
β-strand	108-111	4	1
α-helix	118-126	9
α-helix	127-131	5
β-strand	136-140	5	1
α-helix	143-149	7
β-strand	154-160	7	5
β-strand	165-171	7	5
β-strand	174-175	2	5
α-helix	177-179	3
β-strand	181-183	3	5
α-helix	187-199	13
α-helix	208-220	13
β-strand	223	1	6
α-helix	228-233	6
α-helix	235-237	3
β-strand	240-242	3	7
β-strand	248-250	3	7
α-helix	254-257	4
α-helix	259-262	4
α-helix	265-268	4
α-helix	275-284	10
α-helix	288-296	9
β-strand	298-301	4	5
α-helix	303-306	4
β-strand	308	1	6
α-helix	310-321	12
α-helix	323	1
β-strand	330-331	2	5
α-helix	339-349	11
α-helix	351-355	5
β-strand	358-359	2	1
α-helix	360-365	6
α-helix	368-374	7

Chain B: 22 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	12-16	5	8
β-strand	20-25	6	8
β-strand	33-36	4	8
β-strand	39-42	4	9
β-strand	45-46	2	10
β-strand	57	1	9
α-helix	60-64	5
α-helix	66-68	3
β-strand	69-72	4	9
β-strand	75-76	2	11
β-strand	79-80	2	11
α-helix	83-93	11
β-strand	108-110	3	8
β-strand	111-112	2	12
α-helix	118-126	9
α-helix	127-131	5
β-strand	136-137	2	8
β-strand	140-141	2	12
α-helix	142-150	9
β-strand	155-160	6	13
β-strand	165-171	7	13
β-strand	174-175	2	13
α-helix	176	1
β-strand	181-183	3	13
α-helix	187-200	14
α-helix	208-220	13
β-strand	223	1	14
α-helix	228-233	6
α-helix	235-236	2
β-strand	240-242	3	15
β-strand	248-250	3	15
α-helix	254-257	4
α-helix	259-262	4
α-helix	265-268	4
α-helix	275-284	10
α-helix	291-295	5
β-strand	298-301	4	13
α-helix	303-306	4
β-strand	308	1	14
α-helix	310-321	12
β-strand	330-331	2	13
α-helix	339-349	11
α-helix	351-355	5
β-strand	358-359	2	8
α-helix	360-365	6
α-helix	368-375	8

Chain C: 24 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	6-8	3
α-helix	10-11	2
β-strand	12-16	5	16
β-strand	20-25	6	16
β-strand	33-36	4	16
β-strand	39-42	4	17
β-strand	45-46	2	18
β-strand	57	1	17
α-helix	60-64	5
α-helix	66-68	3
β-strand	69-72	4	17
β-strand	75-76	2	19
β-strand	79-80	2	19
α-helix	83-93	11
β-strand	108-112	5	16
α-helix	118-126	9
α-helix	127-131	5
β-strand	136-141	6	16
α-helix	142-150	9
β-strand	155-160	6	3
β-strand	165-171	7	3
β-strand	174-175	2	3
α-helix	177-179	3
β-strand	181-183	3	3
α-helix	187-200	14
α-helix	211-220	10
β-strand	223	1	20
α-helix	228-233	6
β-strand	240-242	3	21
β-strand	248-250	3	21
α-helix	254-257	4
α-helix	259-262	4
α-helix	265-268	4
α-helix	275-284	10
α-helix	288-296	9
β-strand	298-301	4	3
α-helix	303-306	4
β-strand	308	1	20
α-helix	310-321	12
α-helix	323	1
β-strand	330-331	2	3
α-helix	339-349	11
α-helix	351-355	5
β-strand	358-359	2	16
α-helix	360-366	7
α-helix	368-372	5

Chain D: 24 helices, 22 β-strands

Element	Residues	Length	Sheet
α-helix	10-11	2
β-strand	12-16	5	22
β-strand	20-25	6	22
β-strand	33-36	4	22
β-strand	39-42	4	23
β-strand	45-46	2	24
β-strand	57	1	23
α-helix	60-64	5
α-helix	66-68	3
β-strand	69-72	4	23
β-strand	75-76	2	25
β-strand	79-80	2	25
α-helix	83-93	11
α-helix	103-105	3
β-strand	108-112	5	22
α-helix	118-126	9
α-helix	127-131	5
β-strand	136-141	6	22
α-helix	142-150	9
β-strand	155-160	6	10
β-strand	165-171	7	10
β-strand	174-175	2	10
β-strand	181-183	3	10
α-helix	187-201	15
α-helix	208-220	13
β-strand	223	1	26
α-helix	228-234	7
α-helix	236-238	3
β-strand	240-242	3	27
β-strand	248-250	3	27
α-helix	254-257	4
α-helix	259-262	4
α-helix	265-268	4
α-helix	275-284	10
α-helix	290-296	7
β-strand	298-301	4	10
α-helix	303-306	4
β-strand	308	1	26
α-helix	310-321	12
α-helix	323	1
β-strand	330-331	2	10
α-helix	339-348	10
α-helix	351-355	5
β-strand	358-359	2	22
α-helix	360-366	7
α-helix	368-375	8

Chain E: 25 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	10-11	2
β-strand	12-16	5	28
β-strand	20-25	6	28
β-strand	33-36	4	28
β-strand	39-42	4	29
β-strand	57	1	29
α-helix	60-64	5
α-helix	66-68	3
β-strand	69-72	4	29
β-strand	75-76	2	30
β-strand	79-80	2	30
α-helix	83-93	11
β-strand	108-111	4	28
α-helix	118-126	9
α-helix	127-131	5
β-strand	136-140	5	28
α-helix	143-150	8
β-strand	155-160	6	18
β-strand	165-171	7	18
β-strand	174-175	2	18
α-helix	177-179	3
β-strand	181-183	3	18
α-helix	187-200	14
α-helix	208-220	13
β-strand	223	1	31
α-helix	228-233	6
α-helix	235-238	4
β-strand	240-242	3	32
β-strand	248-250	3	32
α-helix	254-257	4
α-helix	259-262	4
α-helix	265-268	4
α-helix	275-285	11
α-helix	288-290	3
α-helix	291-295	5
β-strand	298-301	4	18
α-helix	303-306	4
β-strand	308	1	31
α-helix	310-321	12
α-helix	323	1
β-strand	330-331	2	18
α-helix	339-349	11
α-helix	351-355	5
β-strand	358-359	2	28
α-helix	360-366	7
α-helix	369-373	5

Chain f: 39 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	211-222	12
α-helix	229-237	9
α-helix	239-260	22
α-helix	271-292	22
α-helix	295-306	12
α-helix	310-314	5
α-helix	315-319	5
α-helix	322-332	11
α-helix	333-335	3
α-helix	341-345	5
α-helix	350-364	15
α-helix	365-368	4
α-helix	374-399	26
α-helix	401-403	3
α-helix	406-440	35
α-helix	456-484	29
α-helix	514-532	19
α-helix	540-574	35
α-helix	578-587	10
α-helix	590-592	3
α-helix	597-603	7
α-helix	605-624	20
α-helix	631-638	8
α-helix	643-669	27
α-helix	673-675	3
α-helix	677-692	16
α-helix	696-709	14
β-strand	716	1	43
β-strand	718-723	6	44
α-helix	731	1
β-strand	732-737	6	44
α-helix	741-753	13
α-helix	754-756	3
α-helix	762-797	36
α-helix	799-805	7
α-helix	806-820	15
β-strand	823	1	43
α-helix	829-865	37
α-helix	871-890	20
α-helix	896-913	18
β-strand	997	1	45
α-helix	998	1
α-helix	1014-1017	4
β-strand	1018	1	45
α-helix	1020-1024	5

Chain F: 17 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	11	1
β-strand	12-15	4	33
β-strand	20-25	6	33
β-strand	33-36	4	33
β-strand	75-76	2	34
β-strand	79-80	2	34
α-helix	83-92	10
β-strand	108-112	5	33
α-helix	118-126	9
α-helix	127-132	6
β-strand	136-141	6	33
α-helix	142-150	9
β-strand	155-160	6	24
β-strand	165-171	7	24
β-strand	174-175	2	24
β-strand	181-183	3	24
α-helix	187-193	7
α-helix	216-220	5
β-strand	223	1	35
α-helix	260-263	4
α-helix	275-284	10
α-helix	288-296	9
β-strand	298-301	4	24
α-helix	303-306	4
β-strand	308	1	35
α-helix	310-321	12
α-helix	323	1
β-strand	330-331	2	24
α-helix	339-349	11
α-helix	351-355	5
β-strand	358-359	2	33
α-helix	360-366	7
α-helix	368-373	6

Chain h: 4 helices, 32 β-strands

Element	Residues	Length	Sheet
β-strand	265-271	7	46
β-strand	282-287	6	47
β-strand	294-299	6	47
β-strand	311-317	7	47
β-strand	327-331	5	47
α-helix	334	1
β-strand	335-340	6	48
β-strand	347-352	6	48
β-strand	357-361	5	48
β-strand	371	1	48
β-strand	384-392	9	49
β-strand	395-402	8	49
β-strand	406-410	5	49
β-strand	411	1	50
β-strand	414	1	50
β-strand	420-423	4	49
β-strand	425	1	51
β-strand	431	1	51
β-strand	434-438	5	52
β-strand	446-451	6	52
β-strand	456-460	5	52
β-strand	467-468	2	52
β-strand	479-484	6	53
β-strand	496-501	6	53
β-strand	506-510	5	53
β-strand	518-520	3	53
β-strand	527-532	6	54
β-strand	539-544	6	54
β-strand	548-553	6	54
β-strand	563-566	4	54
β-strand	573-578	6	46
β-strand	584-589	6	46
β-strand	594-599	6	46
α-helix	600	1
α-helix	601-604	4
α-helix	610-620	11

8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ARP1 actin related protein 1 homolog A	A, B, C, D, E, F	protein	376	Sus scrofa	F2Z5G5 (AlphaFold model)
Capping protein (Actin filament) muscle Z-line, alpha 1	K	protein	286	Sus scrofa	A0A4X1T8I3 (AlphaFold model)
F-actin capping protein beta subunit	L	protein	272	Sus scrofa	A0PFK7 (AlphaFold model)
BICD family-like cargo adapter 1	X, x	protein	577	Mus musculus	A0JNT9 (AlphaFold model)
Cytoplasmic dynein 1 heavy chain 1	f, m, n	protein	4646	Homo sapiens	Q14204
Cytoplasmic dynein 1 intermediate chain 2	h, o	protein	638	Homo sapiens	Q13409
Cytoplasmic dynein 1 light intermediate chain 2	j, r	protein	492	Homo sapiens	O43237

Sequence of entity 1 (A, B, C, D, E, F), FASTA

>7Z8I_1 ARP1 actin related protein 1 homolog A (chains A, B, C, D, E, F)
MESYDVIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDIFIGP
KAEEHRGLLSIRYPMEHGIVKDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPRKN
RERAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSI
MRIDIAGRDVSRFLRLYLRKEGYDFHSSSEFEIVKAIKERACYLSINPQKDETLETEKAQ
YYLPDGSTIEIGPSRFRAPELLFRPDLIGEESEGIHEVLVFAIQKSDMDLRRTLFSNIVL
SGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPQERLYSTWIGGSILASLDTFKKMWVSK
KEYEEDGARSIHRKTF

Sequence of entity 2 (K), FASTA

>7Z8I_2 Capping protein (Actin filament) muscle Z-line, alpha 1 (chains K)
MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMD
QFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEVDGSLKSW
RESCDSALRAYVKDHYSNGFCTVYAKNIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFT
ITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEAQTAKEFIKIIEHAENEYQ
TAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Sequence of entity 3 (L), FASTA

>7Z8I_3 F-actin capping protein beta subunit (chains L)
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYL
LCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVY
LWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTN
KSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIV
NGLRSVQTFADKSKQEALKNDLVEALKRKQQC

Sequence of entity 4 (X, x), FASTA

>7Z8I_4 BICD family-like cargo adapter 1 (chains X, x)
MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPATAAALVSFPGGPGELELALEEE
LALLAAGERSSEPGEHPQAEPESPVEGHGPPLPPPPTQDPELLSVIRQKEKDLVLAARLG
KALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELETDVKQL
QDELERQQLHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALKEDFREK
NSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQG
HDKDLQLHQSQLELQEVRLSYRQLQGKVEELTEERSLQSSAATSTSLLSEIEQSMEAEEL
EQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRT
ALNDLKRLIQSIVDGVEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEA
IAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLK
EQSRPAAAAFPRGHGVGRGQEPSTADGKRLFSFFRKI

Sequence of entity 5 (f, m, n), FASTA

>7Z8I_5 Cytoplasmic dynein 1 heavy chain 1 (chains f, m, n)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE

Sequence of entity 6 (h, o), FASTA

>7Z8I_6 Cytoplasmic dynein 1 intermediate chain 2 (chains h, o)
MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEKKRREA
EALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDP
SVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVMAQPKEDEEEDDDVVA
PKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQ
INIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYN
NNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLW
DNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQD
SMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT
GIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPALF
ACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG
EQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA

Sequence of entity 7 (j, r), FASTA

>7Z8I_7 Cytoplasmic dynein 1 light intermediate chain 2 (chains j, r)
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVF
GEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK
FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKD
FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVL
EKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPA
LVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQ
VFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIK
NNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPD
SMVTNSSTENEA

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	6
MG	Magnesium ion	Mg	6

Primary citation

Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Chaaban, S., Carter, A.P. Nature (2022) 610:212-216. DOI 10.1038/s41586-022-05186-y · PubMed

Other PDB entries of the same protein (UniProt F2Z5G5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6F1U 3.4 Å, N terminal region of dynein tail domains in complex with dynactin filament and BICDR-1
6F1T 3.5 Å, Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1
6ZNL 3.8 Å, Cryo-EM structure of the dynactin complex
5ADX 4.0 Å, CryoEM structure of dynactin complex at 4.0 angstrom resolution
6ZNM 4.1 Å, The pointed end complex of dynactin bound to BICDR1
7Z8K 4.37 Å, Cytoplasmic dynein (A1) bound to BICDR1
6ZNN 4.5 Å, The pointed end complex of dynactin bound to Hook3
9HHL 6.53 Å, Structure of Dynein-Dynactin-NuMA-LIS1
6F38 6.7 Å, Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3
6ZNO 6.8 Å, The pointed end complex of dynactin with the p150 projection docked
5AFU 8.2 Å, Cryo-EM structure of dynein tail-dynactin-BICD2N complex
6F3A 8.2 Å, Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N

Browse structure collections

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