8A43: Human RNA polymerase I

Human RNA polymerase I. Determined by electron microscopy at 4.09 Å resolution. Released 31 Aug 2022.

Method: Electron microscopy
Resolution: 4.09 Å
Organism: Homo sapiens
Chains: 12
Atoms: 31,109
Mol. weight: 565.23 kDa
Released: 31 Aug 2022

Explore 8A43 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8A43 contains 165 α-helices and 199 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 79 helices, 52 β-strands

Element	Residues	Length	Sheet
α-helix	22-27	6
β-strand	32	1	1
β-strand	35	1	2
β-strand	49	1	2
α-helix	53-55	3
β-strand	80	1	1
β-strand	81	1	3
β-strand	87-88	2	4
α-helix	93-101	9
β-strand	103	1	5
β-strand	110	1	5
α-helix	114-127	14
α-helix	133-137	5
α-helix	160-170	11
α-helix	182-200	19
β-strand	215-218	4	6
β-strand	222-225	4	6
α-helix	230-235	6
β-strand	254-255	2	6
α-helix	256-257	2
α-helix	258-279	22
α-helix	294-296	3
β-strand	298-299	2	4
β-strand	302	1	3
α-helix	303-305	3
α-helix	311-313	3
β-strand	315	1	7
β-strand	318	1	7
α-helix	324-345	22
α-helix	384-402	19
α-helix	413-415	3
α-helix	427-430	4
β-strand	440-444	5	8
β-strand	445-447	3	9
β-strand	455-458	4	8
α-helix	459	1
α-helix	460-465	6
β-strand	467-468	2	10
β-strand	471	1	11
α-helix	477-486	10
β-strand	496-498	3	11
β-strand	504-506	3	11
α-helix	512-522	11
β-strand	537-539	3	11
β-strand	540-541	2	10
α-helix	542	1
β-strand	547-549	3	8
α-helix	555	1
α-helix	558-560	3
β-strand	563-568	6	8
β-strand	575-577	3	9
α-helix	580-584	5
β-strand	593-597	5	8
α-helix	602-606	5
α-helix	607-611	5
β-strand	619-620	2	12
β-strand	625-626	2	12
α-helix	632-634	3
α-helix	636-641	6
α-helix	650-659	10
α-helix	684-695	12
α-helix	751-754	4
α-helix	761-769	9
α-helix	772-787	16
α-helix	803	1
β-strand	804	1	13
α-helix	805	1
α-helix	808-816	9
α-helix	820-822	3
α-helix	823-831	9
α-helix	842-851	10
α-helix	856-869	14
α-helix	873-876	4
β-strand	885	1	13
α-helix	895-898	4
α-helix	910-913	4
β-strand	917-918	2	14
β-strand	921	1	15
β-strand	924	1	15
α-helix	925	1
α-helix	927	1
α-helix	945-947	3
β-strand	950-951	2	14
α-helix	963-992	30
β-strand	1000	1	16
β-strand	1001	1	17
β-strand	1007	1	17
β-strand	1008	1	18
β-strand	1014	1	18
α-helix	1029-1032	4
α-helix	1037-1040	4
α-helix	1044-1049	6
α-helix	1064-1078	15
α-helix	1090-1102	13
α-helix	1115-1126	12
α-helix	1129-1137	9
α-helix	1141	1
α-helix	1143-1145	3
α-helix	1146-1149	4
α-helix	1161-1179	19
α-helix	1191-1203	13
α-helix	1205-1206	2
β-strand	1210	1	16
α-helix	1211-1225	15
α-helix	1244-1248	5
α-helix	1249-1254	6
β-strand	1265-1267	3	19
α-helix	1268-1269	2
α-helix	1275-1284	10
β-strand	1287-1289	3	20
β-strand	1294-1300	7	21
β-strand	1314-1321	8	21
α-helix	1324-1331	8
α-helix	1337-1361	25
α-helix	1496-1508	13
β-strand	1514-1516	3	21
β-strand	1524-1530	7	21
α-helix	1536-1537	2
α-helix	1540-1548	9
β-strand	1552-1555	4	20
β-strand	1563-1564	2	19
β-strand	1577-1579	3	19
α-helix	1585-1588	4
α-helix	1607-1612	6
α-helix	1615-1630	16
α-helix	1641-1648	8
α-helix	1662-1664	3
α-helix	1668-1672	5
α-helix	1677-1687	11
α-helix	1696-1702	7
β-strand	1710	1	22

Chain B: 47 helices, 67 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
α-helix	34-37	4
α-helix	40-48	9
α-helix	49-53	5
α-helix	54-56	3
α-helix	62-63	2
β-strand	76-83	8	23
α-helix	100-105	6
β-strand	113-119	7	23
β-strand	129-133	5	23
α-helix	153-158	6
β-strand	170-172	3	24
β-strand	175-179	5	24
α-helix	180-181	2
β-strand	182-185	4	25
β-strand	191-192	2	26
α-helix	197-199	3
β-strand	205	1	27
β-strand	210-211	2	26
β-strand	213-215	3	28
β-strand	221-223	3	28
β-strand	226	1	26
β-strand	229	1	27
β-strand	235-239	5	29
β-strand	244-248	5	29
α-helix	249-255	7
α-helix	262-267	6
α-helix	278-288	11
α-helix	297-312	16
α-helix	320-331	12
α-helix	334-336	3
α-helix	340-357	18
β-strand	372-375	4	25
α-helix	377-405	29
α-helix	416-419	4
α-helix	427-435	9
β-strand	454-456	3	24
α-helix	457-458	2
α-helix	463-468	6
α-helix	476-478	3
α-helix	484-486	3
β-strand	494	1	30
β-strand	497	1	30
α-helix	530-535	6
α-helix	539	1
β-strand	540	1	31
α-helix	541	1
β-strand	554-557	4	31
β-strand	562-566	5	31
α-helix	571-583	13
β-strand	594-598	5	32
α-helix	607-608	2
β-strand	609-613	5	32
β-strand	620-625	6	33
β-strand	631-635	5	33
α-helix	636-639	4
α-helix	648-650	3
β-strand	658-659	2	33
α-helix	663-666	4
α-helix	670-672	3
α-helix	682-691	10
α-helix	692-694	3
β-strand	695	1	34
β-strand	710-714	5	35
β-strand	723	1	36
α-helix	725-727	3
α-helix	732-734	3
β-strand	739	1	37
β-strand	742-744	3	38
β-strand	757-760	4	38
α-helix	762-765	4
β-strand	771-775	5	35
β-strand	779	1	39
β-strand	791	1	40
α-helix	813-814	2
β-strand	818-819	2	41
β-strand	824-826	3	42
β-strand	829	1	40
β-strand	836	1	40
β-strand	839-840	2	42
β-strand	847-849	3	41
β-strand	854	1	39
β-strand	867	1	39
β-strand	871-872	2	41
β-strand	873-875	3	35
β-strand	883-884	2	43
β-strand	893-897	5	38
β-strand	904	1	44
β-strand	913-914	2	38
α-helix	917-919	3
α-helix	927-941	15
α-helix	944-945	2
β-strand	946	1	36
α-helix	958-969	12
β-strand	976-977	2	45
β-strand	980	1	44
β-strand	987	1	44
β-strand	992-993	2	45
β-strand	994-996	3	38
β-strand	999	1	37
β-strand	1000-1001	2	43
β-strand	1002	1	34
β-strand	1011-1013	3	8
β-strand	1018	1	46
β-strand	1025	1	46
α-helix	1039-1048	10
β-strand	1050	1	22
α-helix	1052-1054	3
α-helix	1055-1062	8
β-strand	1066-1070	5	47
β-strand	1080	1	48
β-strand	1097	1	48
β-strand	1107-1111	5	47
α-helix	1114-1125	12

Chain C: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	42-46	5
β-strand	52-55	4	49
β-strand	61	1	50
β-strand	62-64	3	49
α-helix	70-83	14
β-strand	86-89	4	51
β-strand	91-94	4	52
α-helix	103-111	9
α-helix	113-114	2
β-strand	115	1	53
α-helix	119-121	3
α-helix	124-126	3
β-strand	140-143	4	52
β-strand	147	1	54
α-helix	159-162	4
β-strand	164	1	54
β-strand	173-175	3	52
α-helix	181-184	4
β-strand	192	1	53
β-strand	209-211	3	52
β-strand	214-217	4	51
β-strand	228-231	4	50
α-helix	235-236	2
β-strand	237	1	55
α-helix	250-256	7
β-strand	262-266	5	56
β-strand	271-275	5	56
β-strand	301	1	55
β-strand	307	1	49
β-strand	310-312	3	50
α-helix	318-343	26

Chain E: 8 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	3-24	22
α-helix	30-33	4
α-helix	37-43	7
β-strand	61-62	2	57
β-strand	71-72	2	57
β-strand	73-74	2	58
β-strand	81-82	2	59
α-helix	84-97	14
β-strand	101-103	3	58
β-strand	106	1	60
β-strand	109-110	2	59
α-helix	112-121	10
β-strand	126-128	3	58
β-strand	131	1	60
β-strand	148-150	3	61
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	61
α-helix	178-183	6
β-strand	190-193	4	61
β-strand	205-209	5	61

Chain F: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	59-74	16
α-helix	93-99	7
β-strand	106	1	62
β-strand	109	1	63
β-strand	115	1	63
β-strand	118	1	62
α-helix	120-122	3

Chain H: 1 helix, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	64
β-strand	26-32	7	64
β-strand	38-43	6	64
β-strand	55-61	7	64
β-strand	65	1	65
β-strand	83	1	65
α-helix	84-87	4
β-strand	90-92	3	64
β-strand	96-98	3	64
β-strand	112-118	7	64
β-strand	121-127	7	64
β-strand	139	1	64
β-strand	142-148	7	64

Chain I: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
α-helix	26-29	4
β-strand	36	1	66
β-strand	45	1	66

Chain J: 5 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3
β-strand	6	1	67
β-strand	13	1	67
α-helix	17-26	10
α-helix	31-37	7
α-helix	43-46	4
α-helix	60-62	3

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA1	A	protein	1720	Homo sapiens	O95602 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA2	B	protein	1135	Homo sapiens	Q9H9Y6 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase I subunit RPA12	I	protein	126	Homo sapiens	Q9P1U0
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803
DNA-directed RNA polymerase I subunit RPA49	N	protein	419	Homo sapiens	Q9GZS1
DNA-directed RNA polymerase I subunit RPA34	M	protein	510	Homo sapiens	O15446

Sequence of entity 1 (A), FASTA

>8A43_1 DNA-directed RNA polymerase I subunit RPA1 (chains A)
MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADS
KEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLL
LCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAH
VKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDS
EPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTT
DEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQI
LEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL
RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQ
SELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRG
LTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKET
PRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTC
LARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQS
GAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIK
PPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYG
EDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHP
NTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKW
QRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIK
TPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQ
FLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNA
GELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEEN
DDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMER
RVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGIT
RCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRV
IEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQF
LKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR

Sequence of entity 2 (B), FASTA

>8A43_2 DNA-directed RNA polymerase I subunit RPA2 (chains B)
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

Sequence of entity 3 (C), FASTA

>8A43_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (E), FASTA

>8A43_4 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 5 (F), FASTA

>8A43_5 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 6 (H), FASTA

>8A43_6 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 7 (I), FASTA

>8A43_7 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVV
FHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKF
QEKEDS

Sequence of entity 8 (J), FASTA

>8A43_8 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 9 (K), FASTA

>8A43_9 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 10 (L), FASTA

>8A43_10 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 11 (N), FASTA

>8A43_11 DNA-directed RNA polymerase I subunit RPA49 (chains N)
MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRIL
AAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVES
ELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKG
VTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTS
EEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGP
GVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRD
LKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT

Sequence of entity 12 (M), FASTA

>8A43_12 DNA-directed RNA polymerase I subunit RPA34 (chains M)
MEEPQAGDAARFSCPPNFTAKPPASESPRFSLEALTGPDTELWLIQAPADFAPECFNGRH
VPLSGSQIVKGKLAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEG
PQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPRSALAPNLLTSGKKKKEMQ
VTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLE
PLGVLFPSTTKKRKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGME
PEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEPGTEAMEPVEPEMKPLESP
GGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTS
TKKKKKKKERGHTVTEPIQPLEPELPGEGQPEARATPGSTKKRKKQSQESRMPETVPQEE
MPGPPLNSESGEEAPTGRDKKRKQQQQQPV

Primary citation

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. Daiss, J.L., Pilsl, M., Straub, K. et al. Life Sci Alliance (2022) 5. DOI 10.26508/lsa.202201568 · PubMed

Other PDB entries of the same protein (UniProt O95602 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7OB9 2.7 Å, Cryo-EM structure of human RNA Polymerase I in elongation state
7VBB 2.81 Å, Structure of the post state human RNA Polymerase I Elongation Complex
7VBA 2.89 Å, Structure of the pre state human RNA Polymerase I Elongation Complex
7VBC 3.01 Å, Back track state of human RNA Polymerase I Elongation Complex
7OBA 3.1 Å, Cryo-EM structure of human RNA Polymerase I in complex with RRN3
7OBB 3.3 Å, Cryo-EM structure of human RNA Polymerase I Open Complex

Browse structure collections

About this viewer

MolViewer shows 8A43 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.