8ADL: SEA complex

Cryo-EM structure of the SEA complex. Determined by electron microscopy at 2.95 Å resolution. Released 2 Nov 2022.

Method: Electron microscopy
Resolution: 2.95 Å
Organism: Saccharomyces cerevisiae
Chains: 22
Atoms: 98,972
Mol. weight: 2099.96 kDa
Ligands: ZN
Released: 2 Nov 2022

Explore 8ADL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8ADL contains 460 α-helices and 788 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and I: 18 helices, 44 β-strands

Element	Residues	Length	Sheet
β-strand	131	1	44
β-strand	144-146	3	45
β-strand	154-157	4	45
β-strand	164-169	6	45
β-strand	174-180	7	45
β-strand	216-217	2	46
β-strand	225-228	4	46
β-strand	235	1	47
β-strand	236-239	4	46
β-strand	254	1	47
β-strand	261-266	6	48
β-strand	274-278	5	48
β-strand	282-285	4	48
β-strand	301-304	4	48
β-strand	310-315	6	49
α-helix	316-317	2
β-strand	341-345	5	49
β-strand	349-352	4	49
β-strand	363-366	4	49
β-strand	372-377	6	50
β-strand	383-388	6	50
β-strand	392-394	3	51
β-strand	395-397	3	50
β-strand	437-439	3	51
β-strand	444-449	6	52
β-strand	461-466	6	52
β-strand	473-477	5	52
β-strand	486-488	3	52
β-strand	494-499	6	44
β-strand	504-509	6	44
β-strand	515-518	4	44
α-helix	519-521	3
α-helix	525-528	4
β-strand	536	1	53
β-strand	544	1	53
β-strand	547-548	2	54
α-helix	656-658	3
β-strand	659-660	2	54
β-strand	663	1	53
α-helix	665-677	13
α-helix	696-705	10
α-helix	837-863	27
α-helix	867-889	23
α-helix	1161-1175	15
α-helix	1178-1187	10
α-helix	1197-1213	17
α-helix	1218-1225	8
β-strand	1241	1	55
β-strand	1244	1	56
β-strand	1245	1	57
β-strand	1252	1	57
α-helix	1256-1268	13
α-helix	1275-1277	3
α-helix	1291	1
β-strand	1292	1	58
α-helix	1293	1
β-strand	1299	1	58
β-strand	1306	1	59
β-strand	1307	1	60
β-strand	1312	1	60
α-helix	1316-1320	5
α-helix	1321-1325	5

Chains B and J: 34 helices, 52 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	61
β-strand	16-21	6	61
β-strand	28-33	6	61
α-helix	40-42	3
β-strand	43-49	7	61
β-strand	55-60	6	62
β-strand	67-72	6	62
β-strand	76-81	6	62
β-strand	141-145	5	62
β-strand	152-157	6	63
β-strand	162-167	6	63
β-strand	174-180	7	63
α-helix	181-183	3
β-strand	190	1	62
β-strand	195-199	5	63
β-strand	205-208	4	64
β-strand	213-217	5	64
β-strand	222-226	5	64
β-strand	234-236	3	64
β-strand	242	1	65
β-strand	247	1	66
β-strand	250	1	66
β-strand	253-256	4	67
β-strand	257	1	65
β-strand	263-267	5	67
α-helix	268-272	5
β-strand	287-289	3	67
β-strand	303	1	68
β-strand	307-309	3	69
β-strand	316-321	6	69
β-strand	325-334	10	69
α-helix	351-352	2
β-strand	353-363	11	69
β-strand	369-376	8	70
β-strand	382-388	7	70
β-strand	393-397	5	70
β-strand	402-406	5	71
β-strand	413-417	5	71
β-strand	423-426	4	71
α-helix	499-504	6
α-helix	507-517	11
α-helix	523-531	9
α-helix	541-557	17
β-strand	571	1	72
α-helix	573-577	5
α-helix	597-608	12
α-helix	631-639	9
α-helix	646-658	13
α-helix	662-671	10
α-helix	675-682	8
α-helix	688-698	11
α-helix	711-722	12
α-helix	726-735	10
α-helix	740-742	3
α-helix	751-758	8
α-helix	764-781	18
α-helix	784-786	3
α-helix	787-790	4
β-strand	791	1	72
α-helix	794-807	14
α-helix	810-817	8
α-helix	821-824	4
α-helix	828-843	16
α-helix	847-859	13
β-strand	862	1	73
β-strand	868	1	73
α-helix	872-875	4
β-strand	879	1	56
β-strand	880	1	74
α-helix	881	1
β-strand	887	1	74
β-strand	940	1	75
β-strand	942	1	76
β-strand	949	1	76
α-helix	950-951	2
β-strand	952	1	77
α-helix	953	1
α-helix	958	1
β-strand	959	1	77
β-strand	962	1	75
α-helix	989-998	10
β-strand	1002	1	59
β-strand	1003-1004	2	78
β-strand	1010	1	55
β-strand	1011-1012	2	78
α-helix	1014-1020	7

Chains C and Q: 26 helices, 46 β-strands

Element	Residues	Length	Sheet
β-strand	19-22	4	1
β-strand	29-32	4	2
β-strand	38-43	6	2
β-strand	46-51	6	2
α-helix	58-59	2
β-strand	60-63	4	2
α-helix	69-70	2
β-strand	73-75	3	3
β-strand	84-89	6	3
β-strand	92-97	6	3
β-strand	106-111	6	3
β-strand	117-122	6	4
β-strand	129-134	6	4
β-strand	139-143	5	4
β-strand	152-154	3	4
β-strand	161-166	6	5
β-strand	173-178	6	5
β-strand	181-186	6	5
β-strand	193-197	5	5
β-strand	204-209	6	6
β-strand	217-221	5	6
β-strand	225-229	5	6
β-strand	240-243	4	6
β-strand	248-253	6	7
β-strand	259-264	6	7
α-helix	268-270	3
β-strand	272-276	5	7
β-strand	288-290	3	6
β-strand	295-297	3	7
β-strand	304-312	9	1
β-strand	319	1	8
β-strand	323-330	8	1
β-strand	334-339	6	1
α-helix	342-347	6
β-strand	355	1	8
α-helix	359-361	3
α-helix	371-372	2
β-strand	391	1	9
α-helix	401-406	6
β-strand	411	1	1
α-helix	430-440	11
β-strand	445-450	6	10
β-strand	455-462	8	10
β-strand	473-480	8	10
α-helix	491-492	2
β-strand	493-496	4	10
α-helix	504-523	20
α-helix	530-536	7
α-helix	617-621	5
β-strand	624-626	3	11
β-strand	632-637	6	11
β-strand	774-779	6	11
α-helix	781-783	3
α-helix	788-791	4
α-helix	801-814	14
α-helix	818-830	13
α-helix	839-845	7
α-helix	848-852	5
α-helix	853-864	12
α-helix	868-880	13
β-strand	998-1001	4	12
α-helix	1005-1010	6
α-helix	1026-1039	14
α-helix	1043-1060	18
β-strand	1080-1082	3	13
α-helix	1091-1095	5
β-strand	1097	1	14
β-strand	1104	1	14
β-strand	1109-1111	3	15
β-strand	1118-1120	3	15
α-helix	1121-1127	7
α-helix	1142-1145	4

Chains D and L: 6 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	71
β-strand	12-17	6	79
β-strand	23-28	6	79
β-strand	32-38	7	79
β-strand	45-52	8	79
β-strand	58-63	6	80
α-helix	64-65	2
β-strand	71-76	6	80
β-strand	81-86	6	80
α-helix	87	1
β-strand	98-104	7	80
β-strand	111-116	6	81
α-helix	117-118	2
α-helix	119-121	3
β-strand	125-129	5	81
β-strand	134-138	5	81
β-strand	149-153	5	81
α-helix	160-162	3
β-strand	170-173	4	82
β-strand	182-186	5	82
β-strand	191-196	6	82
β-strand	202-208	7	82
β-strand	215-220	6	83
α-helix	221-222	2
β-strand	228-235	8	83
β-strand	240-247	8	83
β-strand	292-300	9	83
β-strand	309-311	3	84
β-strand	319-322	4	84
β-strand	327-333	7	84
β-strand	339-346	8	84

Chains E and M: 4 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	3-4	2	16
β-strand	12-17	6	17
β-strand	23-28	6	17
β-strand	32-38	7	17
β-strand	45-52	8	17
β-strand	58-63	6	18
α-helix	64-65	2
α-helix	66-68	3
β-strand	71-76	6	18
β-strand	81-86	6	18
β-strand	98-103	6	18
β-strand	111-116	6	19
β-strand	125-129	5	19
β-strand	133-139	7	19
β-strand	148-155	8	19
α-helix	160-162	3
β-strand	169-173	5	20
β-strand	182-187	6	20
β-strand	190-196	7	20
β-strand	202-208	7	20
β-strand	215-220	6	21
α-helix	221-222	2
β-strand	229-235	7	21
β-strand	240-247	8	21
β-strand	292-300	9	21
β-strand	307-311	5	22
β-strand	319-323	5	22
β-strand	328-333	6	22
β-strand	339-345	7	22

Chains F and N: 5 helices, 25 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	54
β-strand	12-17	6	85
β-strand	23-28	6	85
β-strand	32-38	7	85
β-strand	45-51	7	85
β-strand	58-63	6	86
α-helix	66-68	3
β-strand	71-76	6	86
β-strand	81-86	6	86
α-helix	91	1
β-strand	98-103	6	86
β-strand	111-116	6	87
α-helix	117-118	2
α-helix	119-121	3
β-strand	124-129	6	87
β-strand	133-138	6	87
β-strand	149-155	7	87
β-strand	170-173	4	88
α-helix	180-181	2
β-strand	182-186	5	88
β-strand	192-196	5	88
β-strand	202-207	6	88
β-strand	215-220	6	89
β-strand	229-235	7	89
β-strand	240-248	9	89
β-strand	291-300	10	89
β-strand	307-312	6	12
β-strand	318-323	6	12
β-strand	327-333	7	12
β-strand	339-346	8	12

Chains G and O: 32 helices, 42 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	23
β-strand	16-21	6	23
β-strand	28-33	6	23
α-helix	40-42	3
β-strand	44-49	6	23
β-strand	58-60	3	24
β-strand	67-70	4	24
β-strand	77-81	5	24
β-strand	141-144	4	24
β-strand	145	1	25
β-strand	154-157	4	26
β-strand	162-166	5	26
β-strand	174-178	5	27
β-strand	179-180	2	26
α-helix	181-183	3
β-strand	190	1	25
β-strand	195-199	5	27
β-strand	205-207	3	28
β-strand	214-217	4	28
β-strand	221-225	5	28
β-strand	235-237	3	28
β-strand	242-246	5	29
β-strand	253-257	5	29
β-strand	263-267	5	29
α-helix	268-272	5
β-strand	287-289	3	29
β-strand	307-309	3	30
β-strand	316-321	6	30
β-strand	325-334	10	30
β-strand	353-363	11	30
β-strand	369-376	8	31
α-helix	378-380	3
β-strand	382-388	7	31
β-strand	393-397	5	31
α-helix	398-399	2
β-strand	402-406	5	16
β-strand	413-417	5	16
β-strand	423-426	4	16
α-helix	499-505	7
α-helix	507-517	11
α-helix	523-531	9
α-helix	541-557	17
β-strand	571	1	32
α-helix	573-578	6
α-helix	597-608	12
α-helix	630-639	10
α-helix	646-659	14
α-helix	662-672	11
α-helix	675-682	8
α-helix	688-698	11
α-helix	711-722	12
α-helix	726-736	11
α-helix	741-744	4
α-helix	751-760	10
α-helix	764-781	18
α-helix	784-786	3
α-helix	787-790	4
β-strand	791	1	32
α-helix	794-807	14
α-helix	810-817	8
α-helix	821-824	4
α-helix	828-843	16
α-helix	847-860	14
β-strand	862	1	33
β-strand	868	1	33
α-helix	873-875	3
β-strand	877-879	3	13
β-strand	942	1	34
α-helix	948	1
β-strand	949	1	34
α-helix	950-953	4
β-strand	1002	1	35
β-strand	1013	1	35
α-helix	1014-1021	8

Chains H and P: 5 helices, 29 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	11
β-strand	14-17	4	36
β-strand	23-27	5	36
β-strand	33-37	5	36
β-strand	44-49	6	36
β-strand	56-61	6	37
α-helix	62-63	2
β-strand	69-74	6	37
β-strand	79-85	7	37
β-strand	88-95	8	37
β-strand	102-107	6	38
α-helix	108-109	2
α-helix	110-112	3
β-strand	115-120	6	38
β-strand	124-129	6	38
α-helix	135-138	4
β-strand	139-142	4	38
β-strand	148-153	6	39
α-helix	154-155	2
β-strand	172-177	6	39
β-strand	182-188	7	39
β-strand	193-200	8	39
β-strand	207-212	6	40
β-strand	220	1	41
β-strand	222-226	5	40
β-strand	230-232	3	40
β-strand	235	1	42
β-strand	236	1	41
β-strand	244	1	42
β-strand	247	1	40
β-strand	257-262	6	43
β-strand	268-273	6	43
β-strand	277-283	7	43
β-strand	289-296	8	43

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Maintenance of telomere capping protein 5	C, Q	protein	1148	Saccharomyces cerevisiae	Q03897 (AlphaFold model)
Nucleoporin SEH1	D, E, F, L, M, N	protein	349	Saccharomyces cerevisiae	P53011 (AlphaFold model)
SEH-associated protein 4	B, G, J, O	protein	1038	Saccharomyces cerevisiae	P38164 (AlphaFold model)
Protein transport protein SEC13	H, P	protein	297	Saccharomyces cerevisiae	Q04491 (AlphaFold model)
Restriction of telomere capping protein 1	A, I	protein	1341	Saccharomyces cerevisiae	Q08281
Nitrogen permease regulator 3	U, V	protein	1146	Saccharomyces cerevisiae	P38742
Vacuolar membrane-associated protein IML1	W, X	protein	1584	Saccharomyces cerevisiae	P47170
Nitrogen permease regulator 2	S, T	protein	615	Saccharomyces cerevisiae	P39923

Sequence of entity 1 (C, Q), FASTA

>8ADL_1 Maintenance of telomere capping protein 5 (chains C, Q)
MCSSINEGPYNSPTFGKSLSLKVDGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPR
WLHHITPWQVADVQWSPHPAKPYWIVSTSNQKAIIWNLAKSSSNAIEFVLHGHSRAITDI
NFNPQHPDVLATCSVDTYVHAWDMRSPHRPFYSTSSWRSAASQVKWNYKDPNVLASSHGN
DIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYSEIMSSSNDGTVKFWDYSKSTTESKR
TVTTNFPIWRGRYLPFGEGYCIMPMVGGNNAVYLINLCDDDDSEQNKKTKLQPIYAFKGH
SDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISDSIYGKVNFDRGKRLEEKL
PDYDYCSYNKEPENRENVQKNEFRRLRENFVTTSGLKKNKTNHITWLSGIRMNSATSQED
LFNETKIQNLGEEVSAIGHKFPKVVFEKISVSTRELCLTLNGPWSEENPDDYIFLRISIN
FPLNYPNKGDPPKFTIEENSNLTMSKRQEILSNLATIGQKYTDSNLYCLEPCIRFVLGEK
VSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYSDSQNPENLSSQSDIESYKEALVFPD
TSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANEKKPEKKQNAIIKLSQKEAGV
EKHPFKIEPQVLYDKEVDSSVITAADELKARPKRYVDTLGLGGGTNGDSRTYFDDETSSD
DSFDSVADDWDDILRNDIIVRTKIPILRGNFKAFSSVHSESGKTVESTKKNKNLVISKNF
SSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDLDEISHCWQILSDMLIDQSDYDPY
TTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSARRKKIPARYYGQELENMEG
TIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGGDNSSIRSDDHHAR
LRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMPDIKVELLHDDIIEAYEQEDLLHLEV
SDIPKFQTYIYQYSKLLFRWGLPLERVKILKVSTDFRSSYSSQGIPPNNNKKSPYNGVLT
HWIENNEFGEEKFLARNCNYCDLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGC
NCPEMFDA

Sequence of entity 2 (D, E, F, L, M, N), FASTA

>8ADL_2 Nucleoporin SEH1 (chains D, E, F, L, M, N)
MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA
IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH
LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP
EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI
RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH
DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ

Sequence of entity 3 (B, G, J, O), FASTA

>8ADL_3 SEH-associated protein 4 (chains B, G, J, O)
MGLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKDFGSITCLDY
SESEIGMIGVGEKNGYLRIFNISGQNSSSPASHAPVGLNANNETSMTNASGGKAAQAENI
VGSVSNLKDTQGYPVSETNYDIRVRAKKQRCINSLGINTNGLIAMGLDRNKHDSSLQIWD
MNYHDDSHETINPMFSYCTNESIVSLKFLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRL
TYDIKLNPFNDWQFSTYGDDGTLAIWDRRKLSDQASLGDLNVASPLLTFEKLVGSGAASR
KYMNSCFRWSCVRNNEFATLHRGDTIKRWRLGYYCDSNRDIAADDDNEMNIENLFVSSVH
DTNTMYDRVATFDYIPRSNNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFEN
TEIDEIRVNNEHEKSNLENVKTILKNLSFEDLDVSEDYFPSGHDEPNNEIEYSELSEEEN
EGSNDVLDSKRGFELFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKNLQNNA
YIRNTWRWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGINGISNQDRYRQETILSDKQL
NKEMEKIIKLRRKNRDRNSPIANAAGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNG
HYEKAAAWAVFFGDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMS
SELDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLDRTSSTVIE
NGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSPRYFRDQRVDEWIQTYRDM
LKSWELFSMRARFDVLRSKLSRTKTGVLTADIKPRQIYIQCQNCKQNINTPRTSSPSSAV
STSAGNYKNGEAYRRNNADYKKFNTGSSEAQAADEKPRHKYCCPHCGSSFPRCAICLMPL
GTSNLPFVINGTQSRDPMQTEDSQDGANRELVSRKLKLNEWFSFCLSCNHGMHAGHAEEW
FDRHNVCPTPGCTCQCNK

Sequence of entity 4 (H, P), FASTA

>8ADL_4 Protein transport protein SEC13 (chains H, P)
MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD
WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVAS
SDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN
LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ
GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ

Sequence of entity 5 (A, I), FASTA

>8ADL_5 Restriction of telomere capping protein 1 (chains A, I)
MSLSPHVENASIPKGSTPIPKNRNVSSIGKGEFLGSSSSNNSSFRMNHYSNSGQPSVLDS
IRRPNLTPTFSYSNGVYMPESHRTSSFNDSYLPYDKNPYAKTTGSMSNKSNMKIKTKKNA
INTNTRKSSGLIYTTKVDKELSSIDKVNDPNINGLVCAGKTHLGLYKFSPSDRSIKCVHD
FITPNSNTSTRGTTSLLPKLSKRTRQNKFSTIADVKTGFNNYKNCIAVCNNSTAISIYDL
NKSSSIDNPLITSLCEHTRSINSFDFNMVESNLIISGGQDSCVKIWDLRSNKSKSSNRSD
ISINTASDSIRDVKWMPGYNFASKNDQGSSTYGNLKSGYKFASIHDSGYLLKFDLRQPAQ
YEKKLNAHTGPGLCLNWHPNQEYIATGGRDGKCCLWFVGDNANAAENTVLNYGNSPSLHA
PNTSLNNSGSLAFPKLTINTGYPVTKLKFKPAYSSNIYNSLLGISSMGDEAEVRIYSLAR
KYIPKHVLLSETPSLGLVWWDENLIFNIDKGTRINGWDINKEPTVLENLSKNTTTWRDLD
GNGLLSVDQEIGSYEVVEPELQPTSSTTCKKHPGTIKNPKNGNPENQGIIGGIKKGFSHT
GLTSFTPERPPTLKAGPTFSTKSLTLASGASSFNSSSASLTSLTPQTENREEIAIEPPCI
ITLDIPQIFNNIRLTKIAHSRKKNVISESSSMKNSPVEKFKYLARQLKFSYIREHNVSDS
ADTAYKNDIENIDVVKNATETHGDNTTTTNNNDDGDDDDDDDDDDKIIESHLLKKYNFPE
NNTWATLMNEKVNNKKSKRNSSSSREFDEKDVRSSISSISASRQSHDRARKIDKNVEAEL
QEKIQTLVDLISIATHNASVYLSIDDLTNFKIWILIRDSLLWDLKWMTSSQISSDNASNM
DANESSDFEAGENLKTGKEFPEEDGAGTSGAESLVEERPQAFRANSDEPSDAEKKPVSKL
KEQLKNTEIIPYAQPNEDSDEVLTKLKELQNQRLESRTKMGETVSDDVIIEEDEHEHQEE
EQPHDSPTKSAQFHASPIAKSIPILQKREHRKSFIDTFMLHSPNGYNGDTDIGNEDDNIS
PRFTYNSVSPRSKVSSLQSYATTTSQLETFKKLSSHTAPIIGSPRHAPSRPDSIGREQLS
SSLTKKLAKCKKIIADPPWDTKKLIKQLYNQATETGNVVLTVNILFLFQTIYQITEIDIA
KDAIAHFLLLLHRYELFGIAADVLKYCPFEDIMGSEGDQSSIRLFCERCGELITNESSKE
KLRAEAQQTGNKKIMDKFGYWYCDSCKKKNTSCVLCERPLKKLTMVILPCGHEGHFQCIQ
EWFLDENEQECPGGCPGVAFI

Sequence of entity 6 (U, V), FASTA

>8ADL_6 Nitrogen permease regulator 3 (chains U, V)
MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTST
NKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSS
IPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLS
SSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTN
NKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNA
FTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQ
YDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRF
EFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENT
LKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMN
PHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIR
GAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMP
NFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGH
CGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLV
RNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPL
SSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRS
KFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRV
DKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGM
QSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERAT
AIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYL
IEIHHW

Sequence of entity 7 (W, X), FASTA

>8ADL_7 Vacuolar membrane-associated protein IML1 (chains W, X)
MFAKLHGKKQRPISSINSQTPRTSNTTHANSISLSSGNLIVGSNRNLRQKKEQFGSQQRA
SGRKLISNKENDDNVNNGGDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVML
NLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQ
TLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLA
FLDSIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLF
QKMVNSFFPKIFKKWKDVDTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVD
QVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTIL
TDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIV
PLFRYRDFENKLHHCVPLWLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVD
VEYLQLNKKVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARK
IPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKIST
PTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTS
KNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNL
SIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQL
KHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITIS
DFPSKDDFDRNFIFRNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIE
LSRESGESETVVNKYLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFD
QVPSYIPLVKTRYESSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHGFRAKY
VVLPTDIPPNTYSMVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREE
IQPEVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGED
RITLVNRKWHWKKHEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKH
NFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVV
PAISASNASVADAKEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIR
LEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWE
DPEFKDRELFAKSKFYYHVYLLKASGFLLDNRASKFLQNQDIEFDIMYSWGKPQFKYVQY
IHHTGAYVAELRENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCL
DYQKLRSIFLDAKEMWITGKIVED

Sequence of entity 8 (S, T), FASTA

>8ADL_8 Nitrogen permease regulator 2 (chains S, T)
MLSYFQGFVPIHTIFYSVFHPTEGSKIKYEFPPNNLKNHGINFNTFKNYIIPKPILCHKL
ITFKYGTYRIVCYPVTINSPIYARNFFSFNFVFVFPYDCETSPYEPAITRLGKMFKVLEE
QNQLLSKSERDPVFFDLKVLENSTTTPSTAGPSSTPNPSSNTTPTHPTSEKDTKDMRSSR
YSDLIKDLGLPQSAFSIQDLLMRIFQDLNNYSECLIPIDEGNAVDIKIFPLLRPPTTCVS
LEDVPLSSVNLKKIIDVNWDPTMMSIVPYIDGLNSIAKISKLSNSDPGLVIECIRHLIYY
KCVTLSDIFQFSNIYAPSSLIRNFLTDPLMASDCQSYVTFPEVSKISNLPLNKSLGSGDQ
DSPSFSVRRKSKSSSIPSNPDSRTTSFSSTSRVSQNSSLNSSFSSIYKDWRQSQTSCSSS
NIHVINNRNRFLPTRSCLFDLYRSLSQGQTLKTWYESKYMILKENNIDIRRFITFGLEKR
IIYRCYSFPVMINAGSREPKEMTPIITKDLVNNDKLLEKRNHNHLLSATGSRNTAQSGNL
KPERPSKVSFEMQRVSSLATGKSTMPKLSDEEEGILEESIRNAETFDKICVLLSKPKLEV
ESYLNELGEFKVINS

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	28

Primary citation

Cryo-EM structure of the SEA complex. Tafur, L., Hinterndorfer, K., Gabus, C. et al. Nature (2022) 611:399-404. DOI 10.1038/s41586-022-05370-0 · PubMed

Other PDB entries of the same protein (UniProt Q03897 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8AE6 2.7 Å, Cryo-EM structure of the SEA complex wing (SEACIT)
9H4Q 3.1 Å, Cryo-EM structure of the SEAC wing - EGOC
9H5K 3.2 Å, Cryo-EM structure of the SEAC-EGOC supercomplex

Browse structure collections

About this viewer

MolViewer shows 8ADL directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.