8AV6: RuvB-like helicase
CryoEM structure of INO80 core nucleosome complex in closed grappler conformation. Determined by electron microscopy at 4.68 Å resolution. Released 14 Dec 2022.
- Method
- Electron microscopy
- Resolution
- 4.68 Å
- Organisms
- Thermochaetoides thermophila, DNA molecule, Homo sapiens
- Chains
- 20
- Atoms
- 45,567
- Mol. weight
- 937.64 kDa
- Ligands
- ADP, ATP
- Released
- 14 Dec 2022
Explore 8AV6 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8AV6 contains 253 α-helices and 228 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 24 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16 | 1 | 1 |
| β-strand | 27 | 1 | 2 |
| α-helix | 32 | 1 | |
| β-strand | 33 | 1 | 2 |
| α-helix | 34 | 1 | |
| β-strand | 37 | 1 | 3 |
| β-strand | 40 | 1 | 3 |
| α-helix | 44-57 | 14 | |
| β-strand | 66-69 | 4 | 4 |
| α-helix | 77-88 | 12 | |
| β-strand | 94-97 | 4 | 4 |
| α-helix | 109-119 | 11 | |
| β-strand | 121-129 | 9 | 5 |
| β-strand | 131-135 | 5 | 6 |
| β-strand | 136 | 1 | 7 |
| β-strand | 141-143 | 3 | 8 |
| β-strand | 155-158 | 4 | 8 |
| β-strand | 161-162 | 2 | 7 |
| β-strand | 169-170 | 2 | 7 |
| β-strand | 172 | 1 | 9 |
| α-helix | 175-182 | 8 | |
| β-strand | 190-195 | 6 | 6 |
| β-strand | 201-206 | 6 | 6 |
| β-strand | 207 | 1 | 10 |
| α-helix | 208-210 | 3 | |
| β-strand | 222 | 1 | 10 |
| α-helix | 224-226 | 3 | |
| β-strand | 230 | 1 | 6 |
| β-strand | 233-240 | 8 | 5 |
| α-helix | 241-249 | 9 | |
| α-helix | 258-261 | 4 | |
| α-helix | 266-267 | 2 | |
| α-helix | 274-289 | 16 | |
| β-strand | 294-297 | 4 | 5 |
| β-strand | 299-302 | 4 | 4 |
| α-helix | 305-307 | 3 | |
| α-helix | 310-320 | 11 | |
| α-helix | 326 | 1 | |
| β-strand | 327-331 | 5 | 4 |
| β-strand | 334 | 1 | 11 |
| β-strand | 336-338 | 3 | 12 |
| β-strand | 346-348 | 3 | 12 |
| α-helix | 355-358 | 4 | |
| β-strand | 359-362 | 4 | 4 |
| α-helix | 363 | 1 | |
| α-helix | 371-383 | 13 | |
| β-strand | 387 | 1 | 13 |
| α-helix | 389-401 | 13 | |
| α-helix | 404-407 | 4 | |
| α-helix | 408-410 | 3 | |
| α-helix | 412-420 | 9 | |
| β-strand | 426 | 1 | 13 |
| α-helix | 428-437 | 10 | |
| β-strand | 439 | 1 | 14 |
| α-helix | 441-451 | 11 | |
| β-strand | 461 | 1 | 15 |
Chain B: 24 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 27 | 1 | 16 |
| β-strand | 33 | 1 | 16 |
| β-strand | 37 | 1 | 17 |
| β-strand | 40 | 1 | 17 |
| α-helix | 44-59 | 16 | |
| β-strand | 66-69 | 4 | 18 |
| α-helix | 77-88 | 12 | |
| β-strand | 94-98 | 5 | 18 |
| α-helix | 99-102 | 4 | |
| α-helix | 112-120 | 9 | |
| β-strand | 122-141 | 20 | 19 |
| β-strand | 158-163 | 6 | 19 |
| β-strand | 168 | 1 | 20 |
| β-strand | 172-173 | 2 | 19 |
| α-helix | 178-181 | 4 | |
| β-strand | 190-195 | 6 | 19 |
| β-strand | 201-207 | 7 | 19 |
| α-helix | 208-210 | 3 | |
| β-strand | 221-222 | 2 | 19 |
| α-helix | 223-225 | 3 | |
| β-strand | 230-240 | 11 | 19 |
| α-helix | 241-249 | 9 | |
| α-helix | 257-260 | 4 | |
| α-helix | 274-289 | 16 | |
| β-strand | 293-296 | 4 | 19 |
| β-strand | 299-303 | 5 | 18 |
| α-helix | 305-307 | 3 | |
| α-helix | 310-319 | 10 | |
| α-helix | 325-326 | 2 | |
| β-strand | 327-331 | 5 | 18 |
| β-strand | 334 | 1 | 21 |
| β-strand | 337-338 | 2 | 22 |
| α-helix | 339 | 1 | |
| β-strand | 346-347 | 2 | 22 |
| α-helix | 348-350 | 3 | |
| α-helix | 353-356 | 4 | |
| β-strand | 360-362 | 3 | 18 |
| α-helix | 369-371 | 3 | |
| α-helix | 373-383 | 11 | |
| β-strand | 387 | 1 | 23 |
| α-helix | 389-401 | 13 | |
| α-helix | 404-407 | 4 | |
| α-helix | 411-419 | 9 | |
| β-strand | 426 | 1 | 23 |
| α-helix | 428-437 | 10 | |
| β-strand | 439 | 1 | 24 |
| α-helix | 441-446 | 6 | |
| α-helix | 447-451 | 5 | |
Chain C: 20 helices, 29 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5 | 1 | |
| β-strand | 6 | 1 | 25 |
| α-helix | 7-8 | 2 | |
| β-strand | 16 | 1 | 26 |
| β-strand | 27 | 1 | 27 |
| β-strand | 33 | 1 | 27 |
| β-strand | 37 | 1 | 28 |
| β-strand | 40 | 1 | 28 |
| α-helix | 44-58 | 15 | |
| β-strand | 66-69 | 4 | 29 |
| α-helix | 77-88 | 12 | |
| β-strand | 94 | 1 | 29 |
| β-strand | 98 | 1 | 29 |
| α-helix | 99-101 | 3 | |
| α-helix | 109-120 | 12 | |
| β-strand | 121-140 | 20 | 30 |
| β-strand | 143 | 1 | 31 |
| α-helix | 147-148 | 2 | |
| β-strand | 154-155 | 2 | 31 |
| β-strand | 158-163 | 6 | 30 |
| β-strand | 168-173 | 6 | 30 |
| α-helix | 178-184 | 7 | |
| β-strand | 190-194 | 5 | 30 |
| β-strand | 202-206 | 5 | 30 |
| β-strand | 221 | 1 | 30 |
| β-strand | 230-240 | 11 | 30 |
| α-helix | 241-249 | 9 | |
| α-helix | 259-262 | 4 | |
| α-helix | 274-290 | 17 | |
| β-strand | 293-297 | 5 | 30 |
| β-strand | 299-303 | 5 | 29 |
| α-helix | 310-320 | 11 | |
| β-strand | 327-331 | 5 | 29 |
| β-strand | 334 | 1 | 32 |
| β-strand | 336-338 | 3 | 33 |
| β-strand | 346-348 | 3 | 33 |
| α-helix | 353-356 | 4 | |
| β-strand | 360-362 | 3 | 29 |
| α-helix | 365-368 | 4 | |
| α-helix | 372-383 | 12 | |
| β-strand | 387 | 1 | 34 |
| α-helix | 389-401 | 13 | |
| α-helix | 404-407 | 4 | |
| α-helix | 412-421 | 10 | |
| β-strand | 426 | 1 | 34 |
| α-helix | 428-434 | 7 | |
| β-strand | 439 | 1 | 35 |
| α-helix | 441-450 | 10 | |
| β-strand | 461 | 1 | 36 |
Chain D: 15 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 32 | 1 | 37 |
| β-strand | 39 | 1 | 37 |
| α-helix | 51-65 | 15 | |
| β-strand | 68 | 1 | 1 |
| β-strand | 72-76 | 5 | 14 |
| α-helix | 83-94 | 12 | |
| β-strand | 100-104 | 5 | 14 |
| α-helix | 115-124 | 10 | |
| β-strand | 127-137 | 11 | 38 |
| β-strand | 140-149 | 10 | 31 |
| β-strand | 156-163 | 8 | 31 |
| β-strand | 168-173 | 6 | 31 |
| α-helix | 175-184 | 10 | |
| β-strand | 190-194 | 5 | 31 |
| β-strand | 195 | 1 | 38 |
| β-strand | 201-206 | 6 | 31 |
| β-strand | 223 | 1 | 31 |
| β-strand | 233-242 | 10 | 38 |
| α-helix | 243-251 | 9 | |
| α-helix | 269-284 | 16 | |
| β-strand | 288-292 | 5 | 38 |
| β-strand | 294-298 | 5 | 14 |
| α-helix | 300-302 | 3 | |
| α-helix | 305-314 | 10 | |
| β-strand | 322-326 | 5 | 14 |
| β-strand | 329 | 1 | 15 |
| β-strand | 331-333 | 3 | 39 |
| α-helix | 334 | 1 | |
| β-strand | 340-342 | 3 | 39 |
| β-strand | 354-357 | 4 | 14 |
| α-helix | 363-376 | 14 | |
| α-helix | 383-396 | 14 | |
| α-helix | 398-414 | 17 | |
| α-helix | 422-431 | 10 | |
| β-strand | 433 | 1 | 29 |
| α-helix | 434 | 1 | |
| α-helix | 435-444 | 10 | |
| β-strand | 450 | 1 | 32 |
Chain E: 19 helices, 27 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 42-43 | 2 | 40 |
| β-strand | 46-47 | 2 | 40 |
| α-helix | 51-63 | 13 | |
| β-strand | 72-76 | 5 | 24 |
| α-helix | 84-92 | 9 | |
| β-strand | 100-104 | 5 | 24 |
| α-helix | 116-124 | 9 | |
| β-strand | 127-137 | 11 | 41 |
| β-strand | 141-147 | 7 | 42 |
| β-strand | 158-163 | 6 | 42 |
| β-strand | 168-172 | 5 | 42 |
| α-helix | 175-184 | 10 | |
| β-strand | 190-191 | 2 | 42 |
| β-strand | 194 | 1 | 43 |
| β-strand | 201 | 1 | 43 |
| β-strand | 205-206 | 2 | 42 |
| β-strand | 207 | 1 | 44 |
| α-helix | 208-213 | 6 | |
| β-strand | 224 | 1 | 44 |
| α-helix | 226-228 | 3 | |
| β-strand | 233-242 | 10 | 41 |
| α-helix | 243-249 | 7 | |
| α-helix | 258-261 | 4 | |
| α-helix | 269-284 | 16 | |
| β-strand | 290-292 | 3 | 41 |
| β-strand | 294-298 | 5 | 24 |
| α-helix | 300-302 | 3 | |
| β-strand | 304 | 1 | 45 |
| α-helix | 305-314 | 10 | |
| α-helix | 321 | 1 | |
| β-strand | 322-327 | 6 | 24 |
| β-strand | 331-333 | 3 | 46 |
| α-helix | 334 | 1 | |
| β-strand | 335 | 1 | 45 |
| β-strand | 340-342 | 3 | 46 |
| α-helix | 347-350 | 4 | |
| β-strand | 354-357 | 4 | 24 |
| α-helix | 360-362 | 3 | |
| α-helix | 363-377 | 15 | |
| β-strand | 381 | 1 | 47 |
| α-helix | 383-414 | 32 | |
| β-strand | 420 | 1 | 47 |
| α-helix | 422-431 | 10 | |
| β-strand | 433 | 1 | 4 |
| α-helix | 435-443 | 9 | |
| β-strand | 450 | 1 | 11 |
Chain F: 23 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 42-43 | 2 | 48 |
| β-strand | 46-47 | 2 | 48 |
| α-helix | 50-65 | 16 | |
| β-strand | 68 | 1 | 26 |
| β-strand | 72-75 | 4 | 35 |
| α-helix | 83-92 | 10 | |
| β-strand | 100-104 | 5 | 35 |
| α-helix | 105-107 | 3 | |
| α-helix | 115-125 | 11 | |
| β-strand | 127-148 | 22 | 25 |
| β-strand | 157-163 | 7 | 25 |
| β-strand | 168-173 | 6 | 25 |
| α-helix | 176-184 | 9 | |
| β-strand | 190-195 | 6 | 25 |
| β-strand | 201-207 | 7 | 25 |
| α-helix | 208-210 | 3 | |
| β-strand | 216 | 1 | 19 |
| β-strand | 223-224 | 2 | 25 |
| α-helix | 225-227 | 3 | |
| β-strand | 232-242 | 11 | 25 |
| α-helix | 243-249 | 7 | |
| α-helix | 255-257 | 3 | |
| α-helix | 258-261 | 4 | |
| α-helix | 269-284 | 16 | |
| β-strand | 289-292 | 4 | 25 |
| β-strand | 294-298 | 5 | 35 |
| α-helix | 300-302 | 3 | |
| α-helix | 305-314 | 10 | |
| β-strand | 322-326 | 5 | 35 |
| β-strand | 329 | 1 | 36 |
| β-strand | 331-333 | 3 | 49 |
| α-helix | 334 | 1 | |
| β-strand | 340-342 | 3 | 49 |
| α-helix | 347-350 | 4 | |
| β-strand | 354-356 | 3 | 35 |
| α-helix | 360-362 | 3 | |
| α-helix | 363-376 | 14 | |
| β-strand | 381 | 1 | 50 |
| α-helix | 383-396 | 14 | |
| α-helix | 398-401 | 4 | |
| α-helix | 403-414 | 12 | |
| β-strand | 420 | 1 | 50 |
| α-helix | 422-431 | 10 | |
| β-strand | 433 | 1 | 18 |
| α-helix | 434 | 1 | |
| α-helix | 435-444 | 10 | |
| β-strand | 450 | 1 | 21 |
Chain G: 46 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 974-988 | 15 | |
| β-strand | 993-995 | 3 | 51 |
| α-helix | 997-998 | 2 | |
| α-helix | 1003-1013 | 11 | |
| α-helix | 1014-1018 | 5 | |
| β-strand | 1024-1028 | 5 | 51 |
| α-helix | 1030-1032 | 3 | |
| α-helix | 1033-1043 | 11 | |
| β-strand | 1049-1052 | 4 | 51 |
| α-helix | 1056-1063 | 8 | |
| β-strand | 1081-1085 | 5 | 51 |
| α-helix | 1086-1091 | 6 | |
| α-helix | 1093-1096 | 4 | |
| β-strand | 1101 | 1 | 52 |
| β-strand | 1103-1106 | 4 | 51 |
| α-helix | 1109-1112 | 4 | |
| α-helix | 1118-1124 | 7 | |
| β-strand | 1128 | 1 | 52 |
| β-strand | 1131-1134 | 4 | 51 |
| α-helix | 1144-1153 | 10 | |
| α-helix | 1161-1164 | 4 | |
| α-helix | 1165-1169 | 5 | |
| α-helix | 1170-1178 | 9 | |
| α-helix | 1184-1194 | 11 | |
| α-helix | 1195-1197 | 3 | |
| β-strand | 1198-1199 | 2 | 51 |
| α-helix | 1203-1206 | 4 | |
| α-helix | 1211-1213 | 3 | |
| β-strand | 1214-1220 | 7 | 53 |
| α-helix | 1221-1223 | 3 | |
| α-helix | 1224-1235 | 12 | |
| α-helix | 1260-1269 | 10 | |
| α-helix | 1271-1273 | 3 | |
| β-strand | 1283-1284 | 2 | 54 |
| β-strand | 1287 | 1 | 55 |
| β-strand | 1302 | 1 | 9 |
| β-strand | 1308 | 1 | 55 |
| β-strand | 1312-1314 | 3 | 56 |
| α-helix | 1318-1322 | 5 | |
| α-helix | 1335-1344 | 10 | |
| α-helix | 1353-1356 | 4 | |
| α-helix | 1366-1369 | 4 | |
| α-helix | 1375-1381 | 7 | |
| α-helix | 1386-1393 | 8 | |
| α-helix | 1403-1406 | 4 | |
| α-helix | 1418-1420 | 3 | |
| α-helix | 1430-1434 | 5 | |
| α-helix | 1443-1446 | 4 | |
| α-helix | 1448-1455 | 8 | |
| β-strand | 1469-1470 | 2 | 54 |
| α-helix | 1472-1474 | 3 | |
| β-strand | 1475-1477 | 3 | 56 |
| α-helix | 1481-1490 | 10 | |
| α-helix | 1494-1501 | 8 | |
| α-helix | 1505-1512 | 8 | |
| α-helix | 1528-1530 | 3 | |
| α-helix | 1545-1551 | 7 | |
| α-helix | 1553-1568 | 16 | |
| β-strand | 1572-1576 | 5 | 53 |
| α-helix | 1579-1591 | 13 | |
| β-strand | 1596-1599 | 4 | 53 |
| α-helix | 1605-1617 | 13 | |
| β-strand | 1623-1627 | 5 | 53 |
| β-strand | 1642-1645 | 4 | 53 |
| α-helix | 1652-1659 | 8 | |
| α-helix | 1670-1671 | 2 | |
| β-strand | 1672-1678 | 7 | 53 |
| α-helix | 1682-1701 | 20 | |
Chain H: 4 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 382-415 | 34 | |
| α-helix | 424-437 | 14 | |
| β-strand | 448-452 | 5 | 31 |
| β-strand | 457-460 | 4 | 31 |
| α-helix | 463-465 | 3 | |
| α-helix | 471-474 | 4 | |
10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| RuvB-like helicase | A, B, C | protein | 462 | Thermochaetoides thermophila | G0RYI5 (AlphaFold model) |
| RuvB-like helicase | D, E, F | protein | 488 | Thermochaetoides thermophila | G0RYC2 (AlphaFold model) |
| Ino80 | G | protein | 1856 | Thermochaetoides thermophila | |
| PAPA-1 domain-containing protein | H | protein | 492 | Thermochaetoides thermophila | G0RY01 (AlphaFold model) |
| YL1_C domain-containing protein | I | protein | 219 | Thermochaetoides thermophila | G0S590 (AlphaFold model) |
| DASH complex subunit DAD4 | J | protein | 769 | Thermochaetoides thermophila | G0S589 |
| DNA | K | DNA | 227 | DNA molecule | |
| DNA (208-mer) | L | DNA | 227 | DNA molecule | |
| Histone H3.2 | M, Q | protein | 135 | Homo sapiens | Q71DI3 |
| Histone H4 | N, R | protein | 102 | Homo sapiens | P62805 |
| Histone H2A | O, S | protein | 129 | Homo sapiens | P0C0S8 |
| Histone H2B type 1-C/E/F/G/I | P, T | protein | 125 | Homo sapiens | P62807 |
Sequence of entity 1 (A, B, C), FASTA
>8AV6_1 RuvB-like helicase (chains A, B, C)
MVQISEVRGNTRDHRTAAHTHIKGLGLNSSGIAEKQAAGFVGQCAAREACGVVVDLIKAH
KMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPITGSEIYSTEVKKTEVLMENFRRA
IGLRVRETKDVYEGEVTEMTPEEAENPLGGYGKTISTLLIGLKSARGQKKLRLDPSIYEA
IQKERVQVGDVIYIETNTGACKRVGRSDAYATEFDLEAEEYVPIPKGEVHKKKEIVQDVT
LHDLDVANARPQGGQDIISMMGQLMKPKMTEITDKLRMEINKVVQKYINQGVAELIPGVL
FIDEAHMLDIECFTYLNKALESPIAPIVVLASNRGIATIRGADDLKAAHGIPPDFLQRLL
IIPTHPYEPDEIRRIVRIRAQTEGVQLTDAAVDRVAEHGVRISLRYCLQLLAPASILARV
NGRTQVDVQDIAEAEELFLDARRSANILTSTGESGGLHGFIS
Sequence of entity 2 (D, E, F), FASTA
>8AV6_2 RuvB-like helicase (chains D, E, F)
MAAPLVTSVTETKELRGLNLIAAHSHIRGLGVDADTLEPRPSSQGLVGQEKARKAAAVVL
EMIKQGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGQDVPFTTLAASEIFSLEMSKTEALT
QAFRKSIGVRIKEESEIMEGEVVEIQIDRSVTGGAKQGKLTIKTTDMEAIYDMGSKMIDA
MTKERVMAGDIISIDKSSGKITKLGRSYARSRDYDAMGVDTKFLQCPEGELQKRKEVVHT
VSLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVAEWKEEGKAEIVPGVLFIDEV
HMLDIECFSYINRALESDLAPIVIMASNRGVSRIRGTDYKSPHGLPLDFLDRVVIINTHP
YTPDELRQILSIRAQEEEVDLTPDALALLTKIGQEAGLRYASNLITTSQLIAAKRRAKQV
GVEDVQRSFKLFYDPARSVRFVQESEKRLIGNDGVVDFSYQGAAEAAAPTLPAAAPVDPV
GGEKMDMS
Sequence of entity 3 (G), FASTA
>8AV6_3 Ino80 (chains G)
MDHFPTVLQRPPHFDEDGSAGTGRMRSNVVGNGSSNGARDDRGLRGGLRDILNPVGSASQ
TMPSASHGGTHSTPGTPGAPAPPRPHSSFSLRSPTQTGNHHASPYSAPTSSAAATSSQQP
AGACSMLNNPFVTASTPFPPPPLQAPPSLASSRTSPSGLQHPPRSPLHAPPVYYPSDVRD
RDLVRDQQTSLSFYDPTTDSKRDRDRERDRERERTGSDPESGAWSTSTQNSPPKIRDSYN
YSRSPSFNNSGNYPSATGSYPPRSPVVRPHPAPPAGSMSPSAGSRTVTSPSLRHLAMPST
HSSQSASTVLPPLARTETPAPSARATPASNTPSRASGVMSFSNILSSSEPISKPRPTSPI
SLDNNPAMVARTEPAERPDKGEKDKKQSRKIIKTRVSDIKSAESTPKMTRKSAVKPETPT
MLRIPTKRTANGSMKHKAFSADKEKTIRDIMDQFDYESIDETEFEDELLAWKERARRRRQ
EMNRRDFIHRQSRRSDFAETEALKLQIHANLGKARYSDLHYDEALQEVREQELWAEKERK
KDMQRKRRREKSMAATLEQQAAALQKASQAEDEAERLKYIREAERANKKVQQTKYILQKG
IKGPARNLPPIEPNLEGGTMATFSAENMEPGKVKGKGRGGRLKKSKEQKQAEKEQAELAQ
AAIDAGEEPPSKEETKIRIKLSKAKASAKEEAEKDKENKEPKQPKEPEKPVEEPKDPLEL
KFQSKGYNQIYDQIWRDLARKDVSKVFRLATDSYATKASNLKKTAILASKEAKRWQLRTN
KGTKDLQARAKRVMRDMMGFWKRNEREERDLRKAAERLELENARKEEADREAARQRRKLN
FLISQTELYSHFISKKIKTHEVERSTDHPDVATDEKDKIPEPTLNINVPEPTGPIAPKVT
DFNSLDFDNEDESALQAAAMANAQNAIAEAQKKAREFNKDETKLDEDGEMNFQHPELTEF
EVAQPKLLNCQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAERYDI
WGPFLVVAPASTLHNWQQEVSKFVPDFKVLPYWGTAADRKVLRKFWDRKHTTYKKDSPFH
VMITSYQLVVSDVAYFQKMKWQYMILDEAQAIKSSQSSRWKCLLGFHCRNRLLLTGTPIQ
NNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLR
RVKKHVQKELGDKIEIDVFCELSYRQRAMYQSLRNQISIMDLIEKATVGDNEDSATLMNL
VMQFRKVCNHPDLFERADTSSPFFCGHFAETGSFLREGTNVALGYSTRSLVEYRLPRLIW
CDGGRLDKPGPGNLVAGFRSKYLNHMMNIWTPENIRSSLEGIENFTWLRFVDTSLQEAYR
ASHTDVFARAVDLASKQNRLGHMQIVYDEPEDKKWTPVHALFQICERENPKAVAEITTEG
VLRDLMNIARVKYRELGLCRLEKAARPRASAPPIEVVCDSRSAVIERENIMFHPAMRKAL
FGPTPSEIKEASFGPRPVTLYPPRALLPAPDHDKQRFTNITVPSMARFVTDSGKLAKLDE
LLRELKEGGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQTRPE
IFIFLLSTRAGGLGINLTTADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRLITRG
TIEERIRKRALQKEEVQRVVITGTGSVDFSGRRPPENRNRDIAMWLADDEQAEMIERREK
ELIESGEYDKIMQQRRKGGKRKRGAANGDTVPSLEDMYHEGEGHFDDNKGSGAATPVDAD
SLGRGGKRKKAGGSKKAKTTKQRLAIADGEIDDGEIDIDYKDDDDKGTDYKDDDDK
Sequence of entity 4 (H), FASTA
>8AV6_4 PAPA-1 domain-containing protein (chains H)
MSTRPRRHAAQRASQAITDLADRDRESDHSHGPISSRMSSFNSSSRSRLPGKGIASVSRS
EAGGASDPEHIHLTVKLPSSKLRQATSSSGIKKAGSVGSSSSSSGGGKAAVKRARGGKRS
RVLESSEEEEEENEVEVLGDEDEEEEEEEDEIEVREGEGYDEDEEDVEDEDEEMQDLGEE
DADGEDDEMDVDAEGEEDADGDVNMDAGVVGARATTVRAVPPAIKVTKPPKESPSNGKAA
TASKANDNAVPVKRPAPDSDDESLSSLESEPEEEVNVAGGEDAEGEDDDAEGEVDAEGEE
EEEEEEIEVADEDAEGEDVEQDEDEDEEEEDDDDEMISRAQTPDMSRLTARQRARLGEAS
GEYLKLSDEVQSKKHFTAEELSMRRAEMARRRRNLSEKRNEEIKMETVNKLLKKQAPRTT
RRAAQAAAAAEEAEEAAKQPKRPDPMMIRWVNNKMGSVVAVPEELLGTHAGVVFGAGPGK
GLPAGKMVEEVS
Sequence of entity 5 (I), FASTA
>8AV6_5 YL1_C domain-containing protein (chains I)
MSNPDAQSAQAAHQALVEQLDLHSIHKTFRNPNWRPNQRRNKTIKAILGESQRKEASSTS
AVATPRADDNGGGSGADTPANNDNNDGLSTSGTSTPANGNGSGAGTPASNGQPNLAQASR
SLQKLVLEKSLASAQAPDKKAANGFASSAPTATYTNIESAPSLAPMKHYCDVTGLPAPYL
DPKTRLRYHNKEIFAMIRNLPQGMGEQFLEARGAHTVLK
Sequence of entity 6 (J), FASTA
>8AV6_6 DASH complex subunit DAD4 (chains J)
MAPSAVAEPPPIPQRDEPWKRLPPPTVYPVKEARFEKYIPPQLDGRERALAQPPGQVAIV
IDNGSHSVRAGWNFEDKPRLAIPPIMSKYRDRKMGKTFSFAGSDCYADTTARSHIRNAFE
AGTGIVSNWDVMEHVLDYVFVKLGMNECDGAIDMPIVMTEAVANLPYSRKSMSEIIFECY
GAPSLVYGIDSLFSFRHNQGQTGLVVSSSYSATHVIPVYNRKALLSQAIRLNWGGWHMAE
YMLKLLKLKYYTGFPGKLNSSQTEHMVRDFCYVSLDYDRELAGYLDWTGLEDRERIVQYP
YTEEVVVQKTEEELARIAERKKESGRRLQEQAAKMRLERLMKKEQELEYYKDIQRRMQGE
SKKEIKRLLDEAELKDEAALERVIRDLERSIKRARQKDLGEPEEEEVPDFSLLDVPDDQL
DEAGLRQKRQQRLLKSNWEARQRAKAEKEAEKARLAEEARLDEERRKNDLEGWLEEKRQL
RLAKLNQLKERERLKADLGNRKSLASQIRMKNIANLASDNPTGSGSRKRRRGGAGADQDD
DFGADDADWGVYRSVAIGANKGDDSDDEEGEEDLEAAIRSLENDLLRYDKTFSYDMTLDA
QRDWSKSLLHAFRYGPRPFDPSSQAETHRVHLNVERIRVPEVLFQPAAIAGVDQAGLVEI
AGDILCQRLPSLPGIQDAPDAFLRDVFLTGGNTLFQNFDERLRQGLMALLPVGAPLRVRR
AQDAILDAWRGAAGWACTEEAKAAWITREEYLEKGGEYIKEHDLGNAFA
Sequence of entity 7 (K), FASTA
>8AV6_7 DNA (chains K)
CTGGAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGACAGCTCTAGCACCGCTTAA
ACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCA
GGCACGTGTCAGATATATACATCCTGTGCATGTATTGAACAGCGACCTTGCCGGTGCCAG
TCGGATAGTGTTCCGAGCTCCCACTCTAGAGGATCCCCGGGTACCGA
Sequence of entity 8 (L), FASTA
>8AV6_8 DNA (208-MER) (chains L)
TCGGTACCCGGGGATCCTCTAGAGTGGGAGCTCGGAACACTATCCGACTGGCACCGGCAA
GGTCGCTGTTCAATACATGCACAGGATGTATATATCTGACACGTGCCTGGAGACTAGGGA
GTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTA
GAGCTGTCTACGACCAATTGAGCGGCCTCGGCACCGGGATTCTCCAG
Sequence of entity 9 (M, Q), FASTA
>8AV6_9 Histone H3.2 (chains M, Q)
ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTEL
LIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIM
PKDIQLARRIRGERA
Sequence of entity 10 (N, R), FASTA
>8AV6_10 Histone H4 (chains N, R)
SGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKV
FLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Sequence of entity 11 (O, S), FASTA
>8AV6_11 Histone H2A (chains O, S)
SGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKT
ESHHKAKGK
Sequence of entity 12 (P, T), FASTA
>8AV6_12 Histone H2B type 1-C/E/F/G/I (chains P, T)
PEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMG
IMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTK
YTSSK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 6 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
Primary citation
Structural mechanism of extranucleosomal DNA readout by the INO80 complex. Kunert, F., Metzner, F.J., Jung, J. et al. Sci Adv (2022) 8:eadd3189-eadd3189. DOI 10.1126/sciadv.add3189 · PubMed
Other PDB entries of the same protein (UniProt G0RYI5 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8OOP 2.7 Å, CryoEM Structure INO80core Hexasome complex composite model state2
- 8OO7 2.8 Å, CryoEM Structure INO80core Hexasome complex composite model state1
- 8OOR 2.87 Å, CryoEM Structure INO80core Hexasome complex Rvb core refinement state2
- 5FM7 2.9 Å, Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(ADP)
- 8OOC 2.93 Å, CryoEM Structure INO80core Hexasome complex Rvb core refinement state1
- 4WW4 2.94 Å, Double-heterohexameric rings of full-length Rvb1(ADP)/Rvb2(ADP)
- 5FM6 3.0 Å, Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(apo)
- 4WVY 3.64 Å, Double-heterohexameric rings of full-length Rvb1(ATP)/Rvb2(apo)
- 6FHS 3.75 Å, CryoEM Structure of INO80core
- 6FML 4.34 Å, CryoEM Structure INO80core Nucleosome complex
Browse structure collections
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