8BPO: Rabbit 80S ribosome translating beta-tubulin

Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER). Determined by electron microscopy at 2.8 Å resolution. Released 5 Jul 2023.

Method
Electron microscopy
Resolution
2.8 Å
Organisms
Oryctolagus cuniculus, Homo sapiens
Chains
51
Atoms
143,326
Mol. weight
2627.75 kDa
Ligands
ZN, MG
Released
5 Jul 2023

Explore 8BPO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8BPO contains 385 α-helices and 324 β-strands across 48 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a2: 6 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix12-165
α-helix22-243
α-helix37-4812
α-helix54-7522
α-helix91-999
α-helix106-1138
Chain A2: 11 helices, 17 β-strands
ElementResiduesLengthSheet
α-helix3-53
α-helix6-94
α-helix29-324
α-helix34-385
β-strand41-50109
α-helix511
β-strand57-6489
β-strand71-7779
α-helix781
β-strand79110
β-strand83111
β-strand87-9049
β-strand101-10339
β-strand112-11439
β-strand116112
β-strand126112
β-strand134-14079
β-strand145-14959
β-strand155-15959
β-strand163-16649
α-helix1681
β-strand169110
α-helix174-1763
α-helix182-1909
α-helix201-2033
β-strand224-225213
α-helix229-2302
β-strand237-238213
Chain b2: 4 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix11-2414
β-strand26-29420
α-helix32-409
β-strand45-48420
α-helix56-6712
β-strand70-73420
α-helix78-847
β-strand93-98620
Chain B2: 14 helices, 20 β-strands
ElementResiduesLengthSheet
α-helix9-102
α-helix32-354
α-helix40-412
β-strand42-43214
β-strand45-591515
β-strand71-801015
α-helix82-832
β-strand84-951216
β-strand98-106916
α-helix112-1165
α-helix134-1363
α-helix140-15617
β-strand159-165716
α-helix168-1703
β-strand180-184516
β-strand185-186214
α-helix190-1978
β-strand204-205216
β-strand216-222715
α-helix223-2253
β-strand228-229217
α-helix231-2344
α-helix237-2415
β-strand270-271217
β-strand276-2871215
β-strand292-294318
β-strand297-299318
β-strand320119
β-strand324119
β-strand330-334515
β-strand344-349615
α-helix361-3633
β-strand365-368415
α-helix382-3898
Chain c2: 4 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand21-28824
α-helix29-335
α-helix38-403
α-helix41-5616
β-strand61-64424
α-helix66-727
β-strand83-921024
β-strand102-108724
β-strand120124
Chain C2: 23 helices, 10 β-strands
ElementResiduesLengthSheet
β-strand7-11521
β-strand17-23721
α-helix24-252
α-helix26-294
α-helix34-4411
α-helix45-484
α-helix49-513
β-strand64-66322
β-strand77-79322
α-helix117-12913
α-helix130-1323
α-helix134-1385
β-strand152-154321
α-helix164-17310
α-helix177-1859
β-strand188-189223
α-helix193-1975
β-strand201-202223
β-strand208-211421
α-helix217-2215
β-strand228-231421
α-helix237-2404
α-helix242-2443
β-strand250-253421
α-helix254-2574
α-helix260-2634
α-helix279-2824
α-helix289-2935
α-helix296-2994
α-helix303-3053
α-helix322-3287
α-helix332-3376
α-helix341-36020
Chain D1: 1 helix, 1 β-strand
ElementResiduesLengthSheet
α-helix4-1411
β-strand26-2726
Chain d2: 7 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix10-123
α-helix21-222
α-helix58-603
α-helix61-633
β-strand69128
β-strand75-79528
α-helix82-854
α-helix89-913
β-strand95-99528
α-helix105-11713
β-strand122128

40 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
28S ribosomal RNAA1RNA4380Oryctolagus cuniculus
5S ribosomal RNAB1RNA120Oryctolagus cuniculus
5.8S ribosomal RNAC1RNA156Oryctolagus cuniculus
Nascent polypeptide-associated complex subunit alpha N-terminal regionD1protein29Oryctolagus cuniculus
60S ribosomal protein L8A2protein257Oryctolagus cuniculus
Ribosomal protein L3B2protein403Oryctolagus cuniculusG1TL06 (AlphaFold model)
60S ribosomal protein L4C2protein425Oryctolagus cuniculusA0A5F9C3C5 (AlphaFold model)
Ribosomal_L18_c domain-containing proteinD2protein297Oryctolagus cuniculusP19949 (AlphaFold model)
60S ribosomal protein L6E2protein291Oryctolagus cuniculusG1SKF7 (AlphaFold model)
60S ribosomal protein L7F2protein247Oryctolagus cuniculus
60S ribosomal protein L7aG2protein319Oryctolagus cuniculusG1STW0
60S ribosomal protein L9H2protein192Oryctolagus cuniculusG1SWI6

39 more molecules are not listed.

Sequence of entity 1 (A1), FASTA
>8BPO_1 28S ribosomal RNA (chains A1)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAA
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGAAAUGUGGCGUACGGAAGACCCACUCCCCGGCGC
CGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCGGUAGCG
GCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCAGCCCAA
AGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAACAAGUA
CCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAACCGUUA
AGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGCGCGGUC
CGGCCGUGCCGGCGGGGCGGAUCUCCCGCUCCCGUCGGCGGGGGACCGCCCCCCGGCCGG
CGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGGAC
GGCUGGGAAGGCCCCGGCGGGGAAGGUGGCCCGGGGGCCCCGGGUGUUACAGCCCCGCCC
CGGCAGCAGCAGCUCGCCGAAUCCCGGGGCCGAGGGAGCGAGACCCGUGCGCCGCGCUCU
CCCCCCUCGGGGGGGCCGGGCCACCCCUCCCACGGCGCGACCGCUGGGGCGGACUGUCCA
GUGCGCCCCGGGCGGGUCGCGCCGUCGGGCCCGGGGGGCCACGCGUCCCCCGCGAGCGCA
CGGGGUCGGCGGCGAUGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAAGGAGU
CUAACACGUGCGCGAGUCGGGGGCUACGAAAGCCGCCGUGGCGCAAUGAAGGUGAAGGCC
GGCGGCGCGCCGCCGGCCGAGGUGGGAUCCCGAGGCCUUCCAGUCCGCCGAGGGCGCACC
ACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCACGAGCGCACGUGUUAGGACCC
GAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGAGGAAACUCUGGUGGAGGUCCG
UAGCGGUCCUGACGUGCGAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCG
AACCAUCUAGUAGCUGGUUCCCUCCAAAGUUUCCCUCAGGAUAGCUGGCGCUCUCGCAAC
CCCGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAAC
CUAUUCUCAAACUUUAAAUGGGUAAGAAGCCCGGCUCGCUGGUGUGGAGCCGGGCGUGGA
AUGCGAGUGCCUAGUGGGCCACUUUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAA
CGCCGGGUUAAGGCGCCCGAUGCCGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAU
AUAGACAGCAGGAUGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCA
CCUGCCGAAUCAACUAGCCCUGAAAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGC
CGUCGCUGGCAGUCGGCAGAGCGAGAAAGAGAGUGGAGCGCGCCGCGGGACUCCCCCGCG
GGGGUCCCGGCCACCCCCCCCGCGGACGCUACGCCGCGACGAGUAGGAGGGCCGCUGCGG
UGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGCAGGUGCAGAUCUUGGUG
GUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGGAGAAGGGUUCCAUGUGA
ACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGAGCGCCGUUCCGAAGGGA
CGGGCGAUGGCCUCCGUUGCCCUCAGCCGAUCGAAAGGGAGUCGGGUUCAGAUCCCCGAA
UCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGUAACGCGACCGAUCCCGG
AGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUGAAGGGCAGGGCGCCCUG
GAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCGUCGCGGUUCCGGCGGCG
UCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGGUGUAAAUCUCGCGCCGG
GCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUCUGGCAUGUUGGAACAAU
GUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAUAAGGAUUGGCUCUAAGG
GCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGCGCCGCGGCUGGACGAGG
CGCCGCCGCCCCCCCCACGCCCGGGCGCCCUCCCCCGGCCGGGUCCGCUCCUCGCGCGCG
CACGUGCGCCGUGGCGCGCGCCGCGCGCGCGGCCGAGCCCCGUCUCCCCCCCUCUCCCCU
CCCGGGGCGGGGUGCGGGGAGGGGCGGGCGGGGCCGUCGCUCGCCGCGCGUGCGCGUCGC
UGCGCGUGCGCCGCGCGGGGGUCCGGCGGGCCUCCGGACGGGGGCUCCGGGCACCCGGGC
ACCCGGGGGGCCGGCGGCGGCGGCGACUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCG
CCCCAGCUGCGGCGGGCGUCGCGGCCGCCCGGGGAGCCCGGCGGGCGCCGCGUGCGCGCG
CGUGCGCGCCCGGGGUCGGGGGGGUGCGAGGCAGGGGAGCCCUCUCCUCCUCCCCCACCC
CGGCGCCGCGGCGCCGCGCGUGCGCGCGCGGUCUCCCCCCGCCGGGUCCGCCCCCGGGGC
CGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAGCCGACUUAGAACUGGUGC
GGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGGCGGGUG
UUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAAUGAAG
CGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCU
AAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCCCUACCUACUAUCCAGC
GAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCUGUUGAG
CUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGAAUAAGUGGGAGGCCCC
CGCGCCCUCCCGCCCCCGCGAGGGGCGGGGCGGGGGUGCCGGCCUUGCGGGCCGCCGGUG
AAAUACCACUACUCUUAUCGUUUUUUCACUGACCCGGUGAGGCGGGGGGGCGAGCCCCGA
GGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCCCGUCGGUCCGCGCGGGCGGCGGCCGG
GCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUC
AAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUGGAGCA
GAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAAGCGGGG
CCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUACCACAG
GGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUCGAUG
UCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCACUAA
UAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGA
UGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGACAUUUGG
UGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAUGACUGA
ACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUAGCGCCGGAGCCUCGGUUGGCCU
CGGAUAGCCGGUCCCCCGCCGUCCCCGCCGGCGGCCCGCGUCGUGCGUCCGCCUCGGCGG
CGAGCGGCCCGCCCCCCGCCGCGCGUUGGGACGGGGUCCGGUGCGGAGAGCCCUUCGUCC
CGGGAAACGGGGCGGCCGGAAAGGGGGCCGCCCUCUCGCCCGUCACGCACCGCACGUUCG
UGGGGAACCUGGCGCUAAACCAUUCGUAGACGACCUGCUUCUGGGUCGGGGUUUCGUACG
UAGCAGAGCAGCUCCCUCGCUGCGAUCUAUUGAAAGUCAGCCCUCGACACAAGGGUUUGU
Sequence of entity 2 (B1), FASTA
>8BPO_2 5S ribosomal RNA (chains B1)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 3 (C1), FASTA
>8BPO_3 5.8S ribosomal RNA (chains C1)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU
Sequence of entity 4 (D1), FASTA
>8BPO_4 Nascent polypeptide-associated complex subunit alpha N-terminal region (chains D1)
XXXXXXXXXXLXXXXXPXXXXXXXXXXXX
Sequence of entity 5 (A2), FASTA
>8BPO_5 60S ribosomal protein L8 (chains A2)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN
Sequence of entity 6 (B2), FASTA
>8BPO_6 Ribosomal protein L3 (chains B2)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 7 (C2), FASTA
>8BPO_7 60S ribosomal protein L4 (chains C2)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKL
APGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAA
KSDPKEAPAKKKPVVGKKVKKPRAVGIKQKKKPVVGRKAAAAKKPAADKKAADKRAGPED
KKPAA
Sequence of entity 8 (D2), FASTA
>8BPO_8 Ribosomal_L18_c domain-containing protein (chains D2)
MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMY
KKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Sequence of entity 9 (E2), FASTA
>8BPO_9 60S ribosomal protein L6 (chains E2)
MAGEKAPAAKPDATKKSPAKKADHARGKAKKKTLAEKKPKKGKPHCSRNPVLVRGIGRYS
RSAMYSRKALYKRKYAAPKSRIERKKKREKVLATVTKPVGGDKNGGTRVVKLRKMPRYYP
TEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLSSGLLLVTG
PLSLNRVPLRRTHQKFVIATSTKIDISGVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEK
EKYEITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNGVYPHKLVF
Sequence of entity 10 (F2), FASTA
>8BPO_10 60S ribosomal protein L7 (chains F2)
MEGAEEKKKVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEY
RQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGT
FVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNTLIARSLGK
YNIICMEDLIHEIYTVGKHFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQIN
RLIRRMN
Sequence of entity 11 (G2), FASTA
>8BPO_11 60S ribosomal protein L7a (chains G2)
MSSYRLGYCMKEERHNLVLCLWSQSPGILNSKCLWPFTNIHLLVGALPREGAGGAWGGGR
SEQLPTCSTTHHDFTWDKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQR
AILYKRLKVPPAINQFTQVLDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGD
VPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCILKGK
ARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSV
ARIAKLEKAKAKELATKLG
Sequence of entity 12 (H2), FASTA
>8BPO_12 60S ribosomal protein L9 (chains H2)
MKTILSNQTVDIPENVDISLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELVLEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn5
MGMagnesium ionMg214

Primary citation

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Hopfler, M., Absmeier, E., Peak-Chew, S.Y. et al. Mol Cell (2023) 83:2290. DOI 10.1016/j.molcel.2023.05.020 · PubMed

Other PDB entries of the same protein (UniProt G1TL06 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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