8F3A: HIV-1 gp41 coiled-coil pocket IQN17
HIV-1 gp41 coiled-coil pocket IQN17. Determined by X-ray diffraction at 1.2 Å resolution. Released 8 Mar 2023.
- Method
- X-ray diffraction
- Resolution
- 1.2 Å
- Organism
- HIV-1 M:B_HXB2R
- Chains
- 3
- Atoms
- 1,425
- Mol. weight
- 16.54 kDa
- Released
- 8 Mar 2023
Explore 8F3A in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8F3A contains 3 α-helices and 0 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A, B and C: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-44 | 43 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| IQN17 | A, B, C | protein | 46 | HIV-1 M:B_HXB2R | P04578 (AlphaFold model) |
Sequence of entity 1 (A, B, C), FASTA
>8F3A_1 IQN17 (chains A, B, C)
RMKQIEDKIEEIESKQKKIENEIARIKKLLQLTVWGIKQLQARILX
Primary citation
Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies. Bruun, T.U.J., Tang, S., Erwin, G. et al. J Biol Chem (2023) 299:103062-103062. DOI 10.1016/j.jbc.2023.103062 · PubMed
Other PDB entries of the same protein (UniProt P04578 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6UCF 1.29 Å, N123-VRC34_pI4 HIV neutralizing antibody in complex with HIV fusion peptide residue…
- 6PSA 1.3 Å, PIE12 D-peptide against HIV entry (in complex with IQN17 Q577R resistance mutant)
- 6UCE 1.38 Å, N123-VRC34_pI3 HIV neutralizing antibody in complex with HIV fusion peptide residue…
- 9ARN 1.41 Å, Structure and interactions of HIV-1 gp41 CHR-NHR reverse hairpin constructs reveal…
- 1DF4 1.45 Å, Interactions between HIV-1 GP41 core and detergents and their implications for membrane…
- 6BXP 1.45 Å, Crystal Structure of HLA-B*57:01 with a modified HIV peptide RKV-Kyn
- 7EKB 1.45 Å, Crystal structure of 4E10 modified with pyrene acetamide
- 5X08 1.49 Å, Crystal structure of broadly neutralizing anti-HIV-1 antibody 4E10, mutant Npro, with…
- 6JQK 1.5 Å, Structure of C34M/N36
- 5TKK 1.55 Å, Structure of mouse vaccination-elicited HIV neutralizing antibody vFP5.01 in complex…
- 6PDR 1.55 Å, Vaccine-elicited murine FP-targeting antibody vFP25.18 in complex with HIV fusion…
- 6BXQ 1.58 Å, Crystal Structure of HLA-B*57:01 with an HIV peptide RKV
Browse structure collections
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