9ARN: Transmembrane protein gp41

Structure and interactions of HIV-1 gp41 CHR-NHR reverse hairpin constructs reveal molecular determinants of antiviral activity. Determined by X-ray diffraction at 1.41 Å resolution. Released 5 Mar 2025.

Method: X-ray diffraction
Resolution: 1.41 Å
Organism: Human immunodeficiency virus 1
Chains: 1
Atoms: 654
Mol. weight: 9.65 kDa
Released: 5 Mar 2025

Explore 9ARN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9ARN contains 2 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-21	20
α-helix	32-79	48

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transmembrane protein gp41	A	protein	81	Human immunodeficiency virus 1	P04578 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9ARN_1 Transmembrane protein gp41 (chains A)
PLIEELIRRSEEQQRRNEEALRREDSGGGRQLLSGIVQQQNNLLRAIEAQQHLLQLTVWG
IKQLQARILAVERYLRDQQED

Primary citation

Structure and Interactions of HIV-1 gp41 CHR-NHR Reverse Hairpin Constructs Reveal Molecular Determinants of Antiviral Activity. He, L., McAndrew, R., Barbu, R. et al. J Mol Biol (2024) 436:168650-168650. DOI 10.1016/j.jmb.2024.168650 · PubMed

Other PDB entries of the same protein (UniProt P04578 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8F3A 1.2 Å, HIV-1 gp41 coiled-coil pocket IQN17
6UCF 1.29 Å, N123-VRC34_pI4 HIV neutralizing antibody in complex with HIV fusion peptide residue…
6PSA 1.3 Å, PIE12 D-peptide against HIV entry (in complex with IQN17 Q577R resistance mutant)
6UCE 1.38 Å, N123-VRC34_pI3 HIV neutralizing antibody in complex with HIV fusion peptide residue…
1DF4 1.45 Å, Interactions between HIV-1 GP41 core and detergents and their implications for membrane…
6BXP 1.45 Å, Crystal Structure of HLA-B*57:01 with a modified HIV peptide RKV-Kyn
7EKB 1.45 Å, Crystal structure of 4E10 modified with pyrene acetamide
5X08 1.49 Å, Crystal structure of broadly neutralizing anti-HIV-1 antibody 4E10, mutant Npro, with…
6JQK 1.5 Å, Structure of C34M/N36
5TKK 1.55 Å, Structure of mouse vaccination-elicited HIV neutralizing antibody vFP5.01 in complex…
6PDR 1.55 Å, Vaccine-elicited murine FP-targeting antibody vFP25.18 in complex with HIV fusion…
6BXQ 1.58 Å, Crystal Structure of HLA-B*57:01 with an HIV peptide RKV

Browse structure collections

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