Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated. Determined by electron microscopy at 3.25 Å resolution. Released 1 Nov 2023.
Explore 8FHI in 3D Show helices and sheets RCSB PDB PDBe
8FHI contains 152 α-helices and 32 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 30-46 | 17 | |
| α-helix | 48-55 | 8 | |
| α-helix | 58-66 | 9 | |
| α-helix | 82-88 | 7 | |
| α-helix | 92-100 | 9 | |
| α-helix | 103-107 | 5 | |
| α-helix | 113-115 | 3 | |
| α-helix | 120-126 | 7 | |
| α-helix | 130-138 | 9 | |
| α-helix | 166-173 | 8 | |
| α-helix | 176-184 | 9 | |
| α-helix | 199-204 | 6 | |
| α-helix | 210-221 | 12 | |
| α-helix | 232-234 | 3 | |
| α-helix | 243-249 | 7 | |
| α-helix | 253-261 | 9 | |
| β-strand | 264-270 | 7 | 1 |
| β-strand | 273-279 | 7 | 1 |
| α-helix | 292-297 | 6 | |
| α-helix | 302-309 | 8 | |
| α-helix | 311-320 | 10 | |
| α-helix | 321-325 | 5 | |
| α-helix | 326-348 | 23 | |
| β-strand | 352-354 | 3 | 2 |
| β-strand | 364 | 1 | 3 |
| β-strand | 368-370 | 3 | 2 |
| α-helix | 371-372 | 2 | |
| α-helix | 380-409 | 30 | |
| α-helix | 412-416 | 5 | |
| α-helix | 424-444 | 21 | |
| α-helix | 451-463 | 13 | |
| α-helix | 464-471 | 8 | |
| α-helix | 476-485 | 10 | |
| α-helix | 486-490 | 5 | |
| α-helix | 491-511 | 21 | |
| α-helix | 521-523 | 3 | |
| α-helix | 526-537 | 12 | |
| β-strand | 550 | 1 | 4 |
| α-helix | 553-562 | 10 | |
| α-helix | 563-570 | 8 | |
| α-helix | 571-586 | 16 | |
| α-helix | 589-607 | 19 | |
| α-helix | 610-612 | 3 | |
| α-helix | 614-616 | 3 | |
| β-strand | 618 | 1 | 1 |
| β-strand | 630-636 | 7 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 5 | A, B, C, D | protein | 739 | Oryctolagus cuniculus | Q9XSM3 (AlphaFold model) |
>8FHI_1 Transient receptor potential cation channel subfamily V member 5 (chains A, B, C, D) MGACPPKAKGPWAQLQKLLISWPVGEQDWEQYRDRVNMLQQERIRDSPLLQAAKENDLRL LKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTA LHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEIVR LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVPNHQG LTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEELSFLELVVSSK KREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMICFTTCCIYRPLKLRDDNRT DPRDITILQQKLLQEAYVTHQDNIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTI LGGPFHVIIITYASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTI MIQKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFSTFELFLTI IDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT TVMLERKMPRFLWPRSGICGYEYGLGDRWFLRVENHHDQNPLRVLRYVEAFKCSDKEDGQ EQLSEKRPSTVESGMLSRASVAFQTPSLSRTTSQSSNSHRGWEILRRNTLGHLNLGLDLG EGDGEEVYHFTETSQVAPA
| ID | Name | Formula | Copies |
|---|---|---|---|
| POV | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl… | C42 H82 N O8 P | 4 |
| 3VV | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphono… | C39 H68 N7 O17 P3 S | 4 |
| ERG | Ergosterol | C28 H44 O | 8 |
Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A. Lee, B.H., De Jesus Perez, J.J., Moiseenkova-Bell, V. et al. Nat Commun (2023) 14:5883-5883. DOI 10.1038/s41467-023-41577-z · PubMed
Other PDB entries of the same protein (UniProt Q9XSM3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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