8FJ2: Evasin P1243

Crystal Structure of the Tick Evasin EVA-AAM1001(C8) Complexed to Human Chemokine CCL17. Determined by X-ray diffraction at 2.07 Å resolution. Released 29 Mar 2023.

Method: X-ray diffraction
Resolution: 2.07 Å
Organisms: Amblyomma americanum, Homo sapiens
Chains: 2
Atoms: 1,096
Mol. weight: 19.37 kDa
Released: 29 Mar 2023

Explore 8FJ2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8FJ2 contains 4 α-helices and 14 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	28-29	2	1
β-strand	31-33	3	2
β-strand	40	1	2
β-strand	41-42	2	3
β-strand	45-48	4	4
β-strand	51-54	4	4
α-helix	55-56	2
β-strand	60-63	4	3
α-helix	66-71	6
β-strand	79-86	8	3
β-strand	89-98	10	3
β-strand	99-101	3	2

Chain B: 2 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	9-10	2	1
α-helix	21-23	3
β-strand	24-29	6	5
β-strand	39-43	5	5
β-strand	48-51	4	5
α-helix	56-66	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Evasin P1243	A	protein	103	Amblyomma americanum	A0A0C9S461 (AlphaFold model)
C-C motif chemokine 17	B	protein	71	Homo sapiens	Q92583 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8FJ2_1 Evasin P1243 (chains A)
GSTSARNHTEDNSTEYYDYEEARSACPARHLNNTNGTVLKLLGCHYFCNGTLSTAPDGYP
CYNLTAQQVRTLTTYPNTSCAVGVCMKGTCVKNGTMEQCFKTP

Sequence of entity 2 (B), FASTA

>8FJ2_2 C-C motif chemokine 17 (chains B)
ARGTNVGRECCLEYFKGAIPLRKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKN
AVKYLQSLERS

Primary citation

Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Devkota, S.R., Aryal, P., Pokhrel, R. et al. Nat Commun (2023) 14:4204-4204. DOI 10.1038/s41467-023-39879-3 · PubMed

Other PDB entries of the same protein (UniProt A0A0C9S461 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SCS 1.51 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL11
8FK6 1.74 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL7
7SCT 1.84 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL16
7SCU 1.86 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7
8FK8 1.96 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL7
7SCV 2.01 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL17
8FJ3 2.07 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7(Y13A)
8SKK 2.1 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17
8FJ0 2.91 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2

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