8FK6: Evasin P1243

Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL7. Determined by X-ray diffraction at 1.74 Å resolution. Released 29 Mar 2023.

Method: X-ray diffraction
Resolution: 1.74 Å
Organisms: Amblyomma americanum, Homo sapiens
Chains: 2
Atoms: 1,226
Mol. weight: 20.19 kDa
Released: 29 Mar 2023

Explore 8FK6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8FK6 contains 6 α-helices and 15 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	28-29	2	1
β-strand	31	1	2
β-strand	32-33	2	3
β-strand	40	1	2
β-strand	41-42	2	4
β-strand	45-48	4	5
β-strand	51-54	4	5
α-helix	55-56	2
β-strand	60-63	4	4
α-helix	66-71	6
α-helix	79	1
β-strand	80-86	7	4
β-strand	89-97	9	4
β-strand	99-100	2	3

Chain B: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	10-11	2	1
α-helix	22-24	3
β-strand	25-31	7	6
α-helix	32-33	2
β-strand	41-45	5	6
β-strand	50-53	4	6
α-helix	58-68	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Evasin P1243	A	protein	103	Amblyomma americanum	A0A0C9S461 (AlphaFold model)
C-C motif chemokine 7	B	protein	76	Homo sapiens	P80098 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8FK6_1 Evasin P1243 (chains A)
GSTSARNHTEDNSTEYYDYEEARCACPARHLNNTNGTVLKLLGCHAFCNGTLCTAPDGYP
CYNLTAQQVRTLTTYPNTSCAVGVCMKGTCVKNGTMEQCFKTP

Sequence of entity 2 (B), FASTA

>8FK6_2 C-C motif chemokine 7 (chains B)
QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWV
QDFMKHLDKKTQTPKL

Primary citation

Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Devkota, S.R., Aryal, P., Pokhrel, R. et al. Nat Commun (2023) 14:4204-4204. DOI 10.1038/s41467-023-39879-3 · PubMed

Other PDB entries of the same protein (UniProt A0A0C9S461 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SCS 1.51 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL11
7SCT 1.84 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL16
7SCU 1.86 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7
8FK8 1.96 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL7
7SCV 2.01 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL17
8FJ2 2.07 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(C8) Complexed to Human Chemokine CCL17
8FJ3 2.07 Å, Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7(Y13A)
8SKK 2.1 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17
8FJ0 2.91 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2

Browse structure collections

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