8G7D: Full length Neuroligin-2 from Mouse

Cryo-EM structure of full length Neuroligin-2 from Mouse. Determined by electron microscopy at 3.28 Å resolution. Released 14 May 2025.

Method
Electron microscopy
Resolution
3.28 Å
Organism
Mus musculus
Chains
2
Atoms
8,346
Mol. weight
191.34 kDa
Ligands
NAG
Released
14 May 2025

Explore 8G7D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8G7D contains 54 α-helices and 33 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 26 helices, 17 β-strands

ElementResiduesLengthSheet
β-strand43-4531
β-strand50-5231
β-strand5412
α-helix56-583
β-strand66-7382
α-helix89-924
β-strand96-9831
α-helix102-1076
α-helix121-1255
α-helix127-1304
β-strand143-14972
α-helix1761
β-strand177-18372
α-helix199-2057
β-strand208-21252
α-helix218-2214
α-helix233-25220
β-strand254-264112
α-helix266-27510
β-strand288-29032
β-strand30113
α-helix304-31512
α-helix322-33110
α-helix334-3385
β-strand35413
α-helix364-3696
β-strand378-38362
α-helix387-3893
α-helix406-41510
α-helix425-43410
α-helix438-4403
α-helix447-45610
α-helix457-4615
α-helix462-47312
β-strand478-48362
α-helix504-5074
α-helix525-54420
β-strand57314
β-strand57814
β-strand581-58332
α-helix595-5995
α-helix600-6045
α-helix605-6073
Chain B: 28 helices, 16 β-strands
ElementResiduesLengthSheet
β-strand43-4535
β-strand50-5235
β-strand5416
β-strand66-7056
α-helix89-924
β-strand96-9835
α-helix102-1076
α-helix121-1255
α-helix127-1337
β-strand144-14966
α-helix1761
β-strand177-18376
α-helix193-1953
α-helix199-2057
β-strand208-21256
α-helix218-2214
α-helix233-25220
β-strand254-264116
α-helix266-27510
β-strand286-29056
β-strand30117
α-helix304-31512
α-helix322-33110
α-helix334-3385
β-strand35417
α-helix364-3696
β-strand378-38366
α-helix387-3893
α-helix393-3953
α-helix403-41513
α-helix425-43410
α-helix438-4403
α-helix447-45610
α-helix457-4615
α-helix462-47312
β-strand478-48366
α-helix504-5074
α-helix525-54319
α-helix570-5723
β-strand580-58346
β-strand589-59026
α-helix595-5995
α-helix600-6045
α-helix605-6073

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Neuroligin-1,Neuroligin-2A, Bprotein870Mus musculusQ69ZK9 (AlphaFold model), Q99K10 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8G7D_1 Neuroligin-1,Neuroligin-2 (chains A, B)
MALPRCMWPNYVWRAMMACVVHRGSGAPLTLCLLGCLLQTFHVLSQKYPYDVPDYAQRGG
GGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPP
LGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQS
EDCLYLNLYVPTEDDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYR
LGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLI
LSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSR
ELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSA
ESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALF
TDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGA
TDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNS
KEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTPG
PGTSGTRRPPPPATLPPESDIDLGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAF
AALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPTAGRELPPEEELVSLQLKRGGGVG
ADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPP
PPPTATSHNNTLPHPHSTTRVSNSLEVLFQ

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O64

Primary citation

Weaker neuroligin 2-neurexin beta 1 interaction tethers membranes and recruits gephyrin at membrane junctions through clustering. Boyd, R., Jaqaman, K., Wang, W. Sci Adv (2026) 12:eads9732-eads9732. DOI 10.1126/sciadv.ads9732 · PubMed

Other PDB entries of the same protein (UniProt Q69ZK9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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