8I9T: Brix domain-containing protein
Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-1. Determined by electron microscopy at 3.6 Å resolution. Released 17 May 2023.
- Method
- Electron microscopy
- Resolution
- 3.6 Å
- Organism
- Chaetomium thermophilum
- Chains
- 55
- Atoms
- 133,790
- Mol. weight
- 3133.1 kDa
- Ligands
- ZN, GTP
- Released
- 17 May 2023
Explore 8I9T in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8I9T contains 508 α-helices and 417 β-strands across 52 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain CA: 8 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 26 | 1 | 15 |
| β-strand | 36-41 | 6 | 16 |
| α-helix | 46-58 | 13 | |
| β-strand | 62-68 | 7 | 16 |
| α-helix | 74-83 | 10 | |
| β-strand | 88-95 | 8 | 16 |
| β-strand | 99-106 | 8 | 16 |
| β-strand | 112-121 | 10 | 16 |
| β-strand | 133 | 1 | 17 |
| α-helix | 136-137 | 2 | |
| β-strand | 138-142 | 5 | 16 |
| α-helix | 145-148 | 4 | |
| α-helix | 150-162 | 13 | |
| β-strand | 169 | 1 | 15 |
| β-strand | 178-184 | 7 | 16 |
| β-strand | 189-199 | 11 | 16 |
| α-helix | 200-202 | 3 | |
| β-strand | 228-233 | 6 | 16 |
| β-strand | 237-246 | 10 | 16 |
| β-strand | 254-257 | 4 | 16 |
| α-helix | 264-294 | 31 | |
| α-helix | 311-314 | 4 | |
Chain Cb: 35 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-22 | 6 | |
| α-helix | 92-95 | 4 | |
| α-helix | 99-108 | 10 | |
| α-helix | 115-125 | 11 | |
| β-strand | 130-133 | 4 | 118 |
| α-helix | 140-152 | 13 | |
| β-strand | 163-166 | 4 | 118 |
| α-helix | 170-183 | 14 | |
| β-strand | 191-194 | 4 | 118 |
| α-helix | 200-209 | 10 | |
| β-strand | 213-216 | 4 | 118 |
| α-helix | 218-228 | 11 | |
| β-strand | 237-241 | 5 | 118 |
| α-helix | 243-249 | 7 | |
| α-helix | 252-261 | 10 | |
| β-strand | 267-272 | 6 | 118 |
| α-helix | 277-286 | 10 | |
| β-strand | 291-294 | 4 | 118 |
| β-strand | 305-311 | 7 | 119 |
| α-helix | 314-316 | 3 | |
| α-helix | 317-323 | 7 | |
| α-helix | 324-328 | 5 | |
| α-helix | 331-333 | 3 | |
| β-strand | 369-372 | 4 | 119 |
| α-helix | 376-389 | 14 | |
| β-strand | 393-395 | 3 | 119 |
| α-helix | 402-414 | 13 | |
| β-strand | 419-422 | 4 | 119 |
| α-helix | 425-429 | 5 | |
| β-strand | 437-440 | 4 | 119 |
| α-helix | 443-444 | 2 | |
| α-helix | 447-455 | 9 | |
| β-strand | 464-470 | 7 | 119 |
| α-helix | 475-485 | 11 | |
| β-strand | 489-491 | 3 | 119 |
| β-strand | 504-507 | 4 | 119 |
| β-strand | 508 | 1 | 120 |
| α-helix | 509-510 | 2 | |
| α-helix | 511-527 | 17 | |
| α-helix | 529-548 | 20 | |
| α-helix | 550-551 | 2 | |
| α-helix | 554-565 | 12 | |
| α-helix | 567-569 | 3 | |
| β-strand | 572 | 1 | 120 |
| α-helix | 573 | 1 | |
| α-helix | 574-576 | 3 | |
| α-helix | 578-595 | 18 | |
| α-helix | 603-605 | 3 | |
| α-helix | 616-627 | 12 | |
| α-helix | 629-631 | 3 | |
| α-helix | 855-860 | 6 | |
| α-helix | 866-879 | 14 | |
Chain CB: 13 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-39 | 20 | |
| α-helix | 41-42 | 2 | |
| β-strand | 47 | 1 | 22 |
| α-helix | 53-57 | 5 | |
| β-strand | 61-67 | 7 | 23 |
| α-helix | 75-78 | 4 | |
| β-strand | 81-83 | 3 | 24 |
| β-strand | 97-101 | 5 | 25 |
| α-helix | 105-114 | 10 | |
| α-helix | 120-123 | 4 | |
| β-strand | 124-129 | 6 | 25 |
| α-helix | 130-136 | 7 | |
| α-helix | 140-149 | 10 | |
| β-strand | 152-156 | 5 | 25 |
| α-helix | 157-160 | 4 | |
| α-helix | 163-166 | 4 | |
| β-strand | 180-182 | 3 | 25 |
| α-helix | 217-228 | 12 | |
| β-strand | 231-233 | 3 | 24 |
| β-strand | 240-247 | 8 | 23 |
| α-helix | 252-265 | 14 | |
| α-helix | 266-270 | 5 | |
| β-strand | 280-284 | 5 | 23 |
| β-strand | 290-294 | 5 | 23 |
Chain Cc: 12 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-15 | 6 | |
| α-helix | 19-34 | 16 | |
| α-helix | 36-40 | 5 | |
| α-helix | 44-60 | 17 | |
| α-helix | 64-80 | 17 | |
| α-helix | 83-100 | 18 | |
| α-helix | 106-126 | 21 | |
| β-strand | 128 | 1 | 121 |
| β-strand | 150 | 1 | 121 |
| α-helix | 152-164 | 13 | |
| β-strand | 172-175 | 4 | 122 |
| β-strand | 179 | 1 | 123 |
| β-strand | 182 | 1 | 123 |
| β-strand | 185-188 | 4 | 122 |
| α-helix | 189-190 | 2 | |
| α-helix | 191-208 | 18 | |
| α-helix | 216-235 | 20 | |
| α-helix | 239-249 | 11 | |
Chain CC: 20 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 123-125 | 3 | |
| β-strand | 138-141 | 4 | 27 |
| β-strand | 147-150 | 4 | 27 |
| α-helix | 152-154 | 3 | |
| β-strand | 185-188 | 4 | 28 |
| β-strand | 194-196 | 3 | 28 |
| α-helix | 200-202 | 3 | |
| α-helix | 203-211 | 9 | |
| β-strand | 217-221 | 5 | 29 |
| β-strand | 228-230 | 3 | 29 |
| α-helix | 233-244 | 12 | |
| α-helix | 256-259 | 4 | |
| α-helix | 266-267 | 2 | |
| α-helix | 274-277 | 4 | |
| α-helix | 278-280 | 3 | |
| α-helix | 285-300 | 16 | |
| α-helix | 304-306 | 3 | |
| α-helix | 309-315 | 7 | |
| α-helix | 334-336 | 3 | |
| α-helix | 341-348 | 8 | |
| β-strand | 353 | 1 | 30 |
| α-helix | 361-363 | 3 | |
| α-helix | 364-372 | 9 | |
| α-helix | 374 | 1 | |
| α-helix | 390-392 | 3 | |
| α-helix | 393-396 | 4 | |
| α-helix | 399-412 | 14 | |
Chain Cd: 15 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-17 | 4 | |
| α-helix | 21-52 | 32 | |
| α-helix | 55-63 | 9 | |
| α-helix | 70-72 | 3 | |
| α-helix | 89-97 | 9 | |
| α-helix | 181-186 | 6 | |
| α-helix | 195-199 | 5 | |
| β-strand | 201-205 | 5 | 124 |
| α-helix | 212-221 | 10 | |
| β-strand | 225-227 | 3 | 124 |
| α-helix | 241-250 | 10 | |
| β-strand | 255-262 | 8 | 124 |
| β-strand | 265-273 | 9 | 124 |
| α-helix | 279-281 | 3 | |
| β-strand | 284-287 | 4 | 124 |
| β-strand | 293 | 1 | 125 |
| α-helix | 303-305 | 3 | |
| α-helix | 308-309 | 2 | |
| β-strand | 310-314 | 5 | 126 |
| α-helix | 319-331 | 13 | |
| β-strand | 342-349 | 8 | 126 |
| β-strand | 352-359 | 8 | 126 |
| β-strand | 362-364 | 3 | 127 |
| α-helix | 365-366 | 2 | |
| α-helix | 373-374 | 2 | |
| β-strand | 386-388 | 3 | 127 |
| β-strand | 396 | 1 | 125 |
| β-strand | 397-399 | 3 | 126 |
| β-strand | 401-405 | 5 | 124 |
| β-strand | 419-422 | 4 | 124 |
Chain Ce: 8 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-12 | 10 | |
| β-strand | 18-20 | 3 | 6 |
| β-strand | 26-28 | 3 | 6 |
| β-strand | 37 | 1 | 6 |
| β-strand | 50-55 | 6 | 7 |
| β-strand | 61-66 | 6 | 7 |
| α-helix | 68-70 | 3 | |
| β-strand | 79-82 | 4 | 7 |
| α-helix | 83-84 | 2 | |
| α-helix | 87-97 | 11 | |
| α-helix | 103-133 | 31 | |
| β-strand | 136-139 | 4 | 110 |
| α-helix | 143-160 | 18 | |
| α-helix | 162-176 | 15 | |
| α-helix | 188-194 | 7 | |
Chain CE: 28 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 112 | 1 | 35 |
| α-helix | 120-129 | 10 | |
| β-strand | 133 | 1 | 35 |
| α-helix | 136-140 | 5 | |
| α-helix | 142-147 | 6 | |
| β-strand | 151-153 | 3 | 36 |
| α-helix | 155-156 | 2 | |
| α-helix | 161-176 | 16 | |
| α-helix | 180-182 | 3 | |
| β-strand | 186-189 | 4 | 36 |
| α-helix | 193-206 | 14 | |
| β-strand | 214-217 | 4 | 36 |
| α-helix | 223-232 | 10 | |
| β-strand | 236-239 | 4 | 36 |
| α-helix | 241-250 | 10 | |
| β-strand | 260-264 | 5 | 36 |
| α-helix | 266-272 | 7 | |
| α-helix | 275-284 | 10 | |
| β-strand | 291-295 | 5 | 36 |
| α-helix | 301-310 | 10 | |
| β-strand | 316-318 | 3 | 36 |
| β-strand | 334-338 | 5 | 22 |
| α-helix | 341-343 | 3 | |
| α-helix | 344-354 | 11 | |
| β-strand | 359-364 | 6 | 22 |
| α-helix | 367-379 | 13 | |
| β-strand | 385-387 | 3 | 22 |
| α-helix | 393-404 | 12 | |
| β-strand | 409-414 | 6 | 22 |
| α-helix | 415-420 | 6 | |
| β-strand | 428-431 | 4 | 22 |
| α-helix | 434-435 | 2 | |
| α-helix | 438-440 | 3 | |
| α-helix | 441-445 | 5 | |
| α-helix | 446-450 | 5 | |
| β-strand | 457-462 | 6 | 22 |
| α-helix | 464-466 | 3 | |
| α-helix | 468-475 | 8 | |
| β-strand | 480-483 | 4 | 22 |
| α-helix | 487-489 | 3 | |
| α-helix | 494-503 | 10 | |
| α-helix | 505-523 | 19 | |
| α-helix | 533-535 | 3 | |
| α-helix | 538-545 | 8 | |
44 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| RNA (3341-mer) | C1 | RNA | 3341 | Chaetomium thermophilum | |
| RNA (256-mer) | C2 | RNA | 256 | Chaetomium thermophilum | |
| RNA (161-mer) | C3 | RNA | 161 | Chaetomium thermophilum | |
| Brix domain-containing protein | CA | protein | 316 | Chaetomium thermophilum | G0RXZ3 (AlphaFold model) |
| Ribosome biogenesis protein C8F11.04 | CB | protein | 391 | Chaetomium thermophilum | G0S7X0 (AlphaFold model) |
| Ribosome biogenesis protein ERB1 | CC | protein | 801 | Chaetomium thermophilum | G0SCK6 (AlphaFold model) |
| RNA helicase | CE | protein | 598 | Chaetomium thermophilum | G0RYU9 (AlphaFold model) |
| Ribosome assembly factor mrt4 | CF | protein | 270 | Chaetomium thermophilum | G0S616 |
| 60S ribosome subunit biogenesis protein NIP7 | CG | protein | 184 | Chaetomium thermophilum | G0S435 |
| Nucleolar GTP-binding protein 1 | CH | protein | 661 | Chaetomium thermophilum | G0S8F1 |
| Putative RNA-binding protein | CI | protein | 414 | Chaetomium thermophilum | G0S1H0 |
| Pescadillo homolog | CJ | protein | 679 | Chaetomium thermophilum | G0SHX6 |
42 more molecules are not listed.
Sequence of entity 1 (C1), FASTA
>8I9T_1 RNA (3341-MER) (chains C1)
GGUUGACCUCGGAUCAGGUAGGAGGACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGA
AAAGAAACCAACAGGGAUUGCCCUAGUAACGGCGAGUGAAGCGGCAACAGCUCAAAUUUG
AAAGCUGGCUUCGGCCCGCGUUGUAAUUUGGAGAGGAUGCUUUGGGCGAGGCUCCUUCUG
AGUUCCCUGGAACGGGACGCCACAGAGGGUGAGAGCCCCGUAUAGUUGGAAGCCAAGCCU
GUGUAAAGCUCCUUCGACGAGUCGAGUAGUUUGGGAAUGCUGCUCAAAAUGGGAGGUAAA
UUUCUUCUAAAGCUAAAUACCGGCCAGAGACCGAUAGCGCACAAGUAGAGUGAUCGAAAG
AUGAAAAGCACUUUGAAAAGAGGGUUAAAUAGCACGUGAAAUUGUUGAAAGGGAAGCGCU
UGUGACCAGACUUGCGCCCGGCGGAUCAUCCGGUGUUCUCACCGGUGCACUCCGCCGGGC
UCAGGCCAGCAUCGGUUCUGGCGGGGGGAUAAAGGCCCAGGGAAUGUGGCUCCUCCGGGA
GUGUUAUAGCCCUGGGUGUAAUACCCUCGCCGGGACCGAGGACCGCGCUCUGCAAGGAUG
CUGGCGUAAUGGUCACCAGCGACCCGUCUUGAAACACGGACCAAGGAGUCAAGGUUUUGC
GCGAGUGUUUGGGUGUAAAACCCGCACGCGUAAUGAAAGUGAACGUAGGUGAGAGCUUCG
GCGCAUCAUCGACCGAUCCUGAUGUAUUCGGAUGGAUUUGAGUAGGAGCGUUAAGCCUUG
GACCCGAAAGAUGGUGAACUAUGCUUGGAUAGGGUGAAGCCAGAGGAAACUCUGGUGGAG
GCUCGCAGCGGUUCUGACGUGCAAAUCGAUCGUCAAAUCUGAGCAUGGGGGCGAAAGACU
AAUCGAACCAUCUAGUAGCUGGUUACCGCCGAAGUUUCCCUCAGGAUAGCAGUGUCGACC
UUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGGGACUCGGGGGCGAUUUUUAGCCUUCAUC
CAUUCUCAAACUUUAAAUAUGUAAGAAGCCCUUGUUACUUAACUGAACGUGGGCAUUCGA
AUGUAUCGACACUAGUGGGCCAUUUUUGGUAAGCAGAACUGGCGAUGCGGGAUGAACCGA
ACGCGGGGUUAAGGUGCCGGAGUGGACGCUCAUCAGACACCACAAAAGGCGUUAGUACAU
CUUGACAGCAGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGACUGUGUAACAACUCA
CCUGCCGAAUGUACUAGCCCUGAAAAUGGAUGGCGCUCAAGCGUCCCACCCAUACCCCGC
CCUCAGGGUAGAAACGAUGCCCUGAGGAGUAGGCGGCCGUGGAGGUCAGUGACGAAGCCU
AGGGCGUGAGCCCGGGUCGAACGGCCUCUAGUGCAGAUCUUGGUGGUAGUAGCAAAUACU
UCAAUGAGAACUUGAAGGACCGAAGUGGGGAAAGGUUCCAUGUGAACAGCGGUUGGACAU
GGGUUAGUCGAUCCUAAGCCAUAGGGAAGUUCCGUUUCAAAGGGGCACUCGUGCCCCGUG
UGGCGAAAGGGAAGCCGGUUAAUAUUCCGGCACCUGGAUGUGGGUUUUGCGCGGCAACGC
AACUGAACGCGGAGACGACGGCGGGGGCCCCGGGCAGAGUUCUCUUUUCUUCUUAACGGU
CUAUCACCCUGGAAACAGUUUGUCUGGAGAUAGGGUUUAAUGGCCGGAAGAGCCCGACAC
UUCUGUCGGGUCCGGUGCGCUCUCGACGUCCCUUGAAAAUCCGCGGGAGGGAAUAAUUCU
CACGCCAGGUCGUACUCAUAACCGCAGCAGGUCCCCAAGGUGAACAGCCUCUGGUUGAUA
GAACAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGUAACUUCGGGAAAAGGAUUGGC
UCUAAGGGUUGGGCACGUUGGGCUUUGGGCGGACGCCCUGGGAGCAGAGGGCCUCUAGCC
GGGCAACCGGCCGGCGGCCCUCAGCACCCGGGGUUGAAGCCCUUAGCAGGCUUCGGCCGU
CCGGCGUGCGGUUAACAACCAACUUAGAACUGGUACGGACAGGGGGAAUCUGACUGUCUA
AUUAAAACAUAGCAUUGCGAUGGCCAGAAAGUGGUGUUGACGCAAUGUGAUUUCUGCCCA
GUGCUCUGAAUGUCAAAGUGAAGAAAUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACU
AUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAU
UAACGAGAUUCCCACUGUCCCUAUCUACUAUCUAGCGAAACCACAGCCAAGGGAACGGGC
UUGGCAAAAUCAGCGGGGAAAGAAGACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGA
AAAGACAUAGGAGGUGUAGAAUAGGUGGGAGCUUCGGCGCCAGUGAAAUACCACUACUCC
UAUUGUUUUUUUACUUAUUCAAUGAAGCGGGGCUGGACUUGCGUCCAACUUCUGGAGUUA
AGGUCCUUCGCGGGCCGACCCGGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGC
GGCACAUCUGUUAAACCAUAACGCAGGUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUC
UCCAGUAGAACAAAAGGGUAAAAGUCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACC
AUGAAAGUGUGGCCUAUCGAUCCUUUAGUCCCUCGAAAUUUGAGGCUAGAGGUGCCAGAA
AAGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUU
GAUCCUUCGAUGUCGGCUCUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUG
UUCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUA
CCCUACUGAUGAACUCGUCGCAAUGGUAAUUCAGCUUAGUACGAGAGGAACCGCUGAUUC
AGAUAAUUGGUUUUUGCGGUUGUCCGACCGGGCAGUGCCGCGAAGCUACCAUCUGCUGGA
UAAUGGCUGAACGCCUCUAAGUCAGAAUCCAUGCCAGAACGCGACGAUACUACCCGCACG
UUGUAGACGUAUAAGAAUAGGCUCCGGCCUCGUAUCCUAGCAGGCGAUUCCUCCGCCGGC
CUCGAAGUGGCCGUCGGUAAUUCGCGUAUUGCAAUUUAGACACGCGCGGGAUCAAAUCCU
UUGCAGACGACUUAGAUGUGCGAAAGGGUCCUGUAAGCAGUAGAGUAGCCUUGUUGUUAC
GAUCUGCUGAGGGUAAGCCCUCCUUCGCCUAGAUUUCCCAG
Sequence of entity 2 (C2), FASTA
>8I9T_2 RNA (256-MER) (chains C2)
AAACUUUCAACAACGGAUCUCUUGGUUCUGGCAUCGAUGAAGAACGCAGCGAAAUGCGAU
AAGUAAUGUGAAUUGCAGAAUUCCGUGAAUCAUCGAAUCUUUGAACGCACAUUGCGCCCG
CCGGUAUUCCGGCGGGCAUGCCUGUUCGAGCGUCAUUUCAACCAUCAAGCCCUGGGCUUG
UGUUGGGGACCCGCGGCUGCUCGCGGGCCCUGAAAAGCAGUGGCGGGCUCGCUGGCGGGU
GCCAGCCGUAAAACCC
Sequence of entity 3 (C3), FASTA
>8I9T_3 RNA (161-MER) (chains C3)
CAACCAUCAAGCCCUGGGCUUGUGUUGGGGACCCGCGGCUGCUCGCGGGCCCUGAAAAGC
AGUGGCGGGCUCGCUAGUCACACCGAGCGUAGUAGAACUUCUAUUCGAUCUCGCUCAGGG
CGUGCGGCGGGUGCCAGCCGUAAAACCCCAGCUUCUUCUAA
Sequence of entity 4 (CA), FASTA
>8I9T_4 Brix domain-containing protein (chains CA)
MAAVYKTIAKVTGSKEDKDKEDRSNIIAERKNKQRVLVLSSRGVTYRHRHLLNDLASMLP
HGRKDAKFDTKSRLYELCELAELYNCNNVLFFEARKGKDLYMWFSKVPNGPTVKFYAQNL
HTMEELHFQGNCLKGSRPILSFDAAFEQEPYLKVIKELFLHTFGVPQGHKKSKPFIDHVL
SFSVADGKIWVRNYEIREVEKVKGEADKREEGETEKPKAAKPGSKDTDINLIEIGPRFVL
TPIIIQEGSFGGPILYENKRFISPNKIRAELRKAKAARHHARMEQQRDLLARKRQLGLDE
STPKKKDDLDTRELFA
Sequence of entity 5 (CB), FASTA
>8I9T_5 Ribosome biogenesis protein C8F11.04 (chains CB)
MAPSTAVAKKETDAVIPVDPDQTLKACKALLAHIKKAAAAPRPDGKQNLLADEESTVAET
PIWLTLTTKKHIHDSHRLQPGKIILPHPLNTSEEISVCLITADPQRFYKNAVADEFPEDL
RAKIGRVIDISHLKAKFKAYEAQRKLFSEHDVFLADTRIINRLPKALGKTFYKTTTKRPI
PVVLMAQREKVNGKRVPAPKGKKEKRDPLENANARPIPEIVAEIRKAIGAALVHLSPSTN
TAIKVGYANWEPEKLAANIETVIRELVERFVPQKWQNVRNFYVKGPETAALPIYQTDELW
LDESKVVPDGQEPARALPGKREKANIGKKRKPLEDASQPALEETGKDERPKKKAKKTLPE
SNDDKLDKAIAERKEQLKKQKAAAKKVAADI
Sequence of entity 6 (CC), FASTA
>8I9T_6 Ribosome biogenesis protein ERB1 (chains CC)
MGSKIVEKKRKSRDSDSESDNELGDGLFDGVLSQSEDEEDYIPSSEVDEDDDDDADESAS
EDSDDSNDSEDDEVEEDDEALLSDEIPSEGESEKDQDLAESKESKQDQDKEPSEPEILEP
FVDPPRKEDEELEDRNYRIEKDANGGIRYVYDEIDPVYDSDDTDYNVPVNTIGNIPLSFY
DSYPHIGYDINGKKIMRPATGDALQNLLDSIEVPEGWTGLTDPNTGKPLNLSRDELELIR
KVQQGLIPDDVEDPYPDTVEWFTSVEEKMPLSAAPEPKRRFIPSKNEAKQIMKLVRAIRE
GRILPYKPPEEREREELEKEEEFYDLWQNEEPQPPNPMHIPAPKLPPPGYDLSYNPPPEY
LPTKEEREEWEKMDPEDREKDYLPTKYDSLRKVPAWGNFVKERFERCMDLYLAPRVRKNR
LNIDPNSLLPKLPSPDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVW
ELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASR
DILNAGFGHATNGKQQANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRG
DHFATVSPSGQRSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYD
LQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAI
RAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDID
WHPREPWCVSAGADGTARLWM
Sequence of entity 7 (CE), FASTA
>8I9T_7 RNA helicase (chains CE)
MASESSKKRKFKDSKGPKPDEAVAKPSKFKKLKRDPTPEERETSDSESGNSDGQHEPDQV
DSDGEDAVSDDGSFDEKVAHQDEDGSRPENGTDLEDVPKNDNLLPPPTNAQEFSELNLSE
KTTKAIAEMGFTKMTEIQRRAIPPALAGKDVLGAAKTGSGKTLAFLIPAVEMLSSLRFKP
RNGTGAIVVTPTRELALQIFGVARELMKYHSQTYGVVIGGANRRAEAEKLGKGVNLLIAT
PGRLLDHLQNTPFVFKNLKSLIIDEADRILEIGFEDEMRQIVKILPKEDRQTMLFSATQT
TKVEDLARISLRPGPLYINVDEEKKYSTVEGLEQGYVVVEADKRFLLLFSFLKKMAKKKI
IVFFSSCNSVKYYSELLQYIDLPVLDLHGKQKQQKRTNTFFEFCNAKSGTLICTDVAARG
LDIPQVDWIVQFDPPDDPRDYIHRVGRTARGNNGKGRSLLFLQPCELGFLAHLKAAKVPV
VEYDFPKNKILNVQSQLEKLISTNYYLNQSAKEGYRSYIHAYASHSLRSVFDVHKLDLVK
VAKSFGFSTPPRVDITLSASLSRDKKPQGRRAYGSQPRQGGRYKKVGDIPDPQPNTFG
Sequence of entity 8 (CF), FASTA
>8I9T_8 Ribosome assembly factor mrt4 (chains CF)
MPKSKRARVYHLIQVNKKGREAKERLFSNIRETIPKYQHCFVFSVDNMRNNYLKDVRHEL
NDCRIFFGKTKLMARALGTTPEEEQADGLHRLTRYLTGTVGLLFTNRDPADIESYFSNLS
QVDFARAGTVAPRTVTVPTGIVYSTGGEVPPEHDVPVSHTLEPELRRLGMPVRMIKGKVC
LGDEKGEASEGYTICKEGEVLDSRQTRLLKLFSICLSEFKVSLLGYWNSASGEVTELEAG
KTRPKREGNRRQAMNGDEIDEDQSSDEDSD
Sequence of entity 9 (CG), FASTA
>8I9T_9 60S ribosome subunit biogenesis protein NIP7 (chains CG)
MRPLTDQEMKIVLDKLANYMTDLKSLIAPLEDGDRYVFRMQKDRVYYVKLSIANIATCVA
RDKLLSLGTCLGKMTKSGKFRLHITALPILAQNARYKIWVKDNGAQPFLYGSNIVKAHVG
RWTEDCPEHSGCVVYNMADIPLGFGVTARSTAEARRLDPTGIVCFRQADCGEYLRDEDTL
FTGA
Sequence of entity 10 (CH), FASTA
>8I9T_10 Nucleolar GTP-binding protein 1 (chains CH)
MTGWKDIPPVPTAQEFIDIVLSRTQRRLPTQIRPGFKISRIRAFYTRKVKFTQETCSEKF
GAIISSFPVLSDQHPFHRDLMNILYDADHFKVALGQISTAKNLIETISRDYVRLLKYAQS
LYQCKQLKRAALGRMATLIKRLKDPLIYLDQVRQHLARLPDINPTTRTLLVAGFPNVGKS
SFVRSVTRADTPVEPYAFTTKSLFVGHLDYKYLRYQVIDTPGILDHPLEEMNTIEMQSVT
ALAHLRAAVLYFMDISEQCGFSLKAQINLFKSIKPLFANKMVFIVLNKMDIKKFEELDPE
MQQEINDLTKSGEVEILRASCATQEGVQEVKNHVCERLLVERVSQKLKAGTHSNGNIGTR
LQEVMARIHVATPMDGTTRETFIPEAVKNLKKYDKNDPNRRVLARDIEEANGGAGVFNVD
LRKDWILENPEWKYDKIPEIFDGKNVYDYIDPDIDAKLQALEEEEERLEKEGFYDEDDDL
PDEEEEEILQKAEYIREQHALIRNEAKMRKSLKNRAIIPRKAVKKPLSQLEDHLDQLGVD
TEAIGLRARAQTAQSSRGRSLVRSRGTTADPDAMDIDDGAASAKERLARSRSRARSVAAT
NRLQDGVQGTTLRSKAERQAKLAQRKMNRMARQGEADRHIHASMPKHLFSGKRTIGKTDR
R
Sequence of entity 11 (CI), FASTA
>8I9T_11 Putative RNA-binding protein (chains CI)
MAAELRKKKSKSAVADADAAISKKEKATKVTKATPKAEKRKAPEEASPVAIKKQKADKDA
VVKKAAVAAEDKIAEKPVKSVLKKETSAKAKEAAKPKKKQEKVEEEEEEALENADAAFGS
DEESELDEQTKALMDTLDDGEESDEDESKQVSTFKKGQDVGKIPTPKKAPQKQTNGDSKP
AGDSQPGVMYIARLPHGFYEHELRGYFSQFGEITRLRVVRNKKTGASRHRAFIEFADAEV
ADIAARTMDKYLLFGHILTCKIVPPAQVHPDLFKGANRRFKVVPWNKMAGRQLERPLSES
QWQVKVAKEEQRRAARAEKLKEMGYEFEAPALKVPKAKPVLENGEEEKKAIETAPAPAVE
EKESKEVAKRQAEEEVEEKAPAPKTKKVKEDKPAKEAATISAPKKGKKSKKTKS
Sequence of entity 12 (CJ), FASTA
>8I9T_12 Pescadillo homolog (chains CJ)
MGKAKKKGKSGAARNYMTRTQAVKKLQLSLPDFRKLCIWKGIYPREPRDRRKVNKSATAS
TTFYYTKDIQYLLHEPLLQKFREQKALEKKISRALGRGDVSNAARLERNANLPEKTGKPR
YTLNHIIRERYPTFQDALRDLDDCLSMLFLFANLPSTTAVPAKMIARCERLCHEFQHYLI
VTHSLRKSFLSIKGIYYQANIQGEDILWLVPYKFNQRIVGDVDFRIMGTFVEFYMTLLGF
VNYRLYTSIGLKYPPKFDQVKDDQGAELAAFSLEGLNLASQNGEQKAITNGEEHGPDPKV
QAEVDKLVAKLREEEQQANGDKTDEKGEENEGDDKPSDAIDKFEPVAPGGDVLPQPSYSS
SDPSQLFANFTFFLSRETPRQPLEFILRAFGCKRIGWDAVLGEGAFTTDESDPRITHQII
DRPVIRAAVSEDGDGEDNQTSQKLAPNGRYPGRIYVQPQWVWDSINDEELKPPELYAPGA
QLPPHLSPFVKPTQGQYDPTKPLEEQQTEAEALEAELEDAQAQQEGSDEESGSEVENDMS
VASDEEDEQEDDFGGFSDEDEEQSDEGSEEGDEEEDDDEEEEATLERQRELEAELAGKAV
SKGKPLDPKVKAKLEAKKALERKKKQEAEELERAKGMLSKKKRKLFEQMQYSNAKKNAED
AKLRAKRRRIEKEMAAKKA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 3 |
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 1 |
Primary citation
Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis. Lau, B., Huang, Z., Kellner, N. et al. EMBO Rep (2023) 24:e56910-e56910. DOI 10.15252/embr.202356910 · PubMed
Other PDB entries of the same protein (UniProt G0RXZ3 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8I9Z 2.7 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Spb4
- 8IA0 2.7 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Puf6
- 8I9X 2.8 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-1
- 8I9P 3.0 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Mak16
- 8I9R 3.1 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State 5S RNP
- 8I9V 3.1 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-2
- 8I9W 3.1 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Dbp10-3
- 8I9Y 3.1 Å, Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-2
Browse structure collections
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