8IK3: Stimulator of interferon genes/ligand complex

Structure of Stimulator of interferon genes/ligand complex. Determined by electron microscopy at 3.3 Å resolution. Released 17 May 2023.

Method

Electron microscopy

Resolution

3.3 Å

Organism

Homo sapiens

Chains

8

Atoms

20,938

Mol. weight

467.92 kDa

Ligands

1SY

Released

17 May 2023

Explore 8IK3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8IK3 contains 137 α-helices and 70 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 9 β-strands

Molecules and chains

>8IK3_1 Stimulator of interferon genes protein,Immune protein Tsi3 (chains A, B, C, D, E, F, G, H)
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFSLEVLFQGPVDFDKTLTHPNGLVVERPVGFDARRSAEGFRFD
EGGKLRNPRQLEVQRQDAPPPPDLASRRLGDGEARYKVEEDDGGSAGSEYRLWAAKPAGA
RWIVVSASEQSEDGEPTFALAWALLERARLQSSHHHHHHHH

Ligands and cofactors

Primary citation

The mechanism of STING autoinhibition and activation. Liu, S., Yang, B., Hou, Y. et al. Mol Cell (2023) 83:1502-1518.e10. DOI 10.1016/j.molcel.2023.03.029 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q86WV6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 6MX3 1.36 Å, Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 1
• 4EMT 1.5 Å, Crystal Structure of human STING bound to c-di-GMP
• 6UKZ 1.52 Å, STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 6
• 9CUD 1.53 Å, Human STING G230A/R293Q variant bound to diABZI-i
• 6UKU 1.68 Å, STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 3
• 7ZKU 1.7 Å, Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'd<carba>GMP)
• 8STI 1.72 Å, human STING with agonist XMT-1616
• 6MX0 1.73 Å, Crystal structure of human STING apoprotein (G230A, H232R, R293Q)
• 6UKM 1.74 Å, STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound MSA-2
• 9VZG 1.74 Å, Harnessing Noncovalent Dimerization Enables an Orally Active STING Agonist for…
• 6UL0 1.76 Å, STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 4
• 6XNP 1.77 Å, Crystal Structure of Human STING CTD complex with SR-717

Browse structure collections

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