Cyrstal structure of SKIP RUN domain in complex with GTP-bound Arl8b(Q75L). Determined by X-ray diffraction at 1.65 Å resolution. Released 27 Mar 2024.
Explore 8JCA in 3D Show helices and sheets RCSB PDB PDBe
8JCA contains 23 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 19-27 | 9 | 1 |
| α-helix | 33-42 | 10 | |
| α-helix | 50-52 | 3 | |
| β-strand | 55-62 | 8 | 1 |
| β-strand | 65-72 | 8 | 1 |
| α-helix | 76-81 | 6 | |
| α-helix | 82-86 | 5 | |
| β-strand | 91-97 | 7 | 1 |
| α-helix | 101-115 | 15 | |
| α-helix | 118-120 | 3 | |
| β-strand | 125-130 | 6 | 1 |
| α-helix | 137-139 | 3 | |
| α-helix | 140-146 | 7 | |
| α-helix | 149-151 | 3 | |
| β-strand | 157-161 | 5 | 1 |
| α-helix | 170-179 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 3-27 | 25 | |
| β-strand | 35 | 1 | 2 |
| α-helix | 40-54 | 15 | |
| β-strand | 57 | 1 | 3 |
| α-helix | 60-62 | 3 | |
| α-helix | 65-68 | 4 | |
| α-helix | 69-71 | 3 | |
| α-helix | 74-81 | 8 | |
| α-helix | 89-102 | 14 | |
| α-helix | 106-115 | 10 | |
| α-helix | 117-123 | 7 | |
| β-strand | 124 | 1 | 3 |
| α-helix | 133-143 | 11 | |
| α-helix | 144-146 | 3 | |
| β-strand | 151 | 1 | 2 |
| α-helix | 158-161 | 4 | |
| α-helix | 162-164 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| ADP-ribosylation factor-like protein 8B | A | protein | 169 | Homo sapiens | Q9NVJ2 (AlphaFold model) |
| Pleckstrin homology domain-containing family M member 2 | B | protein | 165 | Homo sapiens | Q8IWE5 (AlphaFold model) |
>8JCA_1 ADP-ribosylation factor-like protein 8B (chains A) KEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGLPR FRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNA LDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
>8JCA_2 Pleckstrin homology domain-containing family M member 2 (chains B) MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPY
Mechanistic Insights into the Interactions of Arl8b with the RUN Domains of PLEKHM1 and SKIP. Qiu, X., Li, Y., Wang, Y. et al. J Mol Biol (2023) 435:168293-168293. DOI 10.1016/j.jmb.2023.168293 · PubMed
Other PDB entries of the same protein (UniProt Q9NVJ2 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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